The protein encoded by this gene belongs to the phosphatase 2A regulatory subunit B family. Protein phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates wit... See more...

Aliases for PPP2R5E Gene

Aliases for PPP2R5E Gene

  • Protein Phosphatase 2 Regulatory Subunit B'Epsilon 2 3 5
  • Serine/Threonine-Protein Phosphatase 2A 56 KDa Regulatory Subunit Epsilon Isoform 3 4
  • Protein Phosphatase 2, Regulatory Subunit B (B56), Epsilon Isoform 2 3
  • B56epsilon 2 3
  • B56E 2 3
  • Serine/Threonine Protein Phosphatase 2A, 56 KDa Regulatory Subunit, Epsilon 3
  • Epsilon Isoform Of Regulatory Subunit B56, Protein Phosphatase 2A 3
  • Protein Phosphatase 2 Regulatory Subunit B', Epsilon 3
  • PP2A B Subunit Isoform PR61-Epsilon 4
  • PP2A B Subunit Isoform B56-Epsilon 4
  • PP2A B Subunit Isoform B'-Epsilon 4
  • PP2A B Subunit Isoform R5-Epsilon 4
  • PP2A, B Subunit, PR61 Epsilon 3
  • PP2A, B Subunit, B56 Epsilon 3
  • PP2A, B Subunit, B' Epsilon 3
  • PP2A, B Subunit, R5 Epsilon 3
  • PPP2R5E 5

External Ids for PPP2R5E Gene

Previous GeneCards Identifiers for PPP2R5E Gene

  • GC14M061168
  • GC14M057635
  • GC14M061831
  • GC14M062911
  • GC14M063838
  • GC14M044007

Summaries for PPP2R5E Gene

Entrez Gene Summary for PPP2R5E Gene

  • The protein encoded by this gene belongs to the phosphatase 2A regulatory subunit B family. Protein phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might modulate substrate selectivity and catalytic activity. This gene encodes an epsilon isoform of the regulatory subunit B56 subfamily. Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Aug 2013]

GeneCards Summary for PPP2R5E Gene

PPP2R5E (Protein Phosphatase 2 Regulatory Subunit B'Epsilon) is a Protein Coding gene. Among its related pathways are Negative regulation of MAPK pathway and RET signaling. Gene Ontology (GO) annotations related to this gene include binding. An important paralog of this gene is PPP2R5A.

UniProtKB/Swiss-Prot Summary for PPP2R5E Gene

  • The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.

Gene Wiki entry for PPP2R5E Gene

Additional gene information for PPP2R5E Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PPP2R5E Gene

Genomics for PPP2R5E Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for PPP2R5E Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PPP2R5E on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for PPP2R5E

Top Transcription factor binding sites by QIAGEN in the PPP2R5E gene promoter:
  • FOXO1
  • FOXO1a
  • MRF-2
  • Oct-B1
  • oct-B2
  • oct-B3
  • POU2F1
  • POU2F1a
  • POU2F2
  • POU2F2 (Oct-2.1)

Genomic Locations for PPP2R5E Gene

Genomic Locations for PPP2R5E Gene
chr14:63,371,356-63,543,395
(GRCh38/hg38)
Size:
172,040 bases
Orientation:
Minus strand
chr14:63,838,075-64,010,092
(GRCh37/hg19)
Size:
172,018 bases
Orientation:
Minus strand

Genomic View for PPP2R5E Gene

Genes around PPP2R5E on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PPP2R5E Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PPP2R5E Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PPP2R5E Gene

Proteins for PPP2R5E Gene

  • Protein details for PPP2R5E Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q16537-2A5E_HUMAN
    Recommended name:
    Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform
    Protein Accession:
    Q16537
    Secondary Accessions:
    • A4FU37
    • B7ZAW5
    • B7ZKK8
    • B7ZKK9
    • J3KQN6
    • Q52LW4

    Protein attributes for PPP2R5E Gene

    Size:
    467 amino acids
    Molecular mass:
    54699 Da
    Quaternary structure:
    • Found in a complex with at least ARL2, PPP2CB; PPP2R1A, PPP2R2A, PPP2R5E and TBCD (By similarity). PP2A consists of a common heterodimeric core enzyme, composed of a 36 kDa catalytic subunit (subunit C) and a 65 kDa constant regulatory subunit (PR65 or subunit A), that associates with a variety of regulatory subunits. Proteins that associate with the core dimer include three families of regulatory subunits B (the R2/B/PR55/B55, R3/B''/PR72/PR130/PR59 and R5/B'/B56 families), the 48 kDa variable regulatory subunit, viral proteins, and cell signaling molecules. Interacts with SGO1.

    Alternative splice isoforms for PPP2R5E Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PPP2R5E Gene

Post-translational modifications for PPP2R5E Gene

Antibody Products

  • Abcam antibodies for PPP2R5E
  • Boster Bio Antibodies for PPP2R5E
  • Santa Cruz Biotechnology (SCBT) Antibodies for PPP2R5E

No data available for DME Specific Peptides for PPP2R5E Gene

Domains & Families for PPP2R5E Gene

Gene Families for PPP2R5E Gene

Protein Domains for PPP2R5E Gene

InterPro:
Blocks:
  • Protein phosphatase 2A, regulatory B subunit (B56 family)
ProtoNet:

Suggested Antigen Peptide Sequences for PPP2R5E Gene

GenScript: Design optimal peptide antigens:
  • PP2A B subunit isoform R5-epsilon (2A5E_HUMAN)
  • Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform (B5BTZ7_HUMAN)
  • PPP2R5E protein (B7ZKK9_HUMAN)
  • Protein phosphatase 2, regulatory subunit B', epsilon isoform (Q562F2_HUMAN)
  • PPP2R5E protein (Q58EX4_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q16537

UniProtKB/Swiss-Prot:

2A5E_HUMAN :
  • Belongs to the phosphatase 2A regulatory subunit B56 family.
Family:
  • Belongs to the phosphatase 2A regulatory subunit B56 family.
genes like me logo Genes that share domains with PPP2R5E: view

Function for PPP2R5E Gene

Molecular function for PPP2R5E Gene

UniProtKB/Swiss-Prot Function:
The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.
GENATLAS Biochemistry:
protein phosphatase 2A,regulatory subunit B56 epsilon isoform,expressed in brain

Phenotypes From GWAS Catalog for PPP2R5E Gene

Gene Ontology (GO) - Molecular Function for PPP2R5E Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 15380617
GO:0019888 protein phosphatase regulator activity TAS 8703017
GO:0072542 protein phosphatase activator activity IBA 21873635
genes like me logo Genes that share ontologies with PPP2R5E: view
genes like me logo Genes that share phenotypes with PPP2R5E: view

Animal Model Products

CRISPR Products

miRNA for PPP2R5E Gene

miRTarBase miRNAs that target PPP2R5E

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PPP2R5E

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PPP2R5E Gene

Localization for PPP2R5E Gene

Subcellular locations from UniProtKB/Swiss-Prot for PPP2R5E Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PPP2R5E gene
Compartment Confidence
cytosol 5
nucleus 4
plasma membrane 1
extracellular 1
cytoskeleton 1
mitochondrion 1
endoplasmic reticulum 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for PPP2R5E Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000159 protein phosphatase type 2A complex IBA 21873635
GO:0005634 nucleus IBA 21873635
GO:0005737 cytoplasm TAS 8703017
GO:0005829 cytosol IBA,IDA --
genes like me logo Genes that share ontologies with PPP2R5E: view

Pathways & Interactions for PPP2R5E Gene

PathCards logo

SuperPathways for PPP2R5E Gene

SuperPathway Contained pathways
1 RET signaling
2 S45 mutants of beta-catenin arent phosphorylated
3 GAB1 signalosome
4 Beta-Adrenergic Signaling
.37
.37
.37
5 p70S6K Signaling
.60
.60
.54
genes like me logo Genes that share pathways with PPP2R5E: view

Pathways by source for PPP2R5E Gene

4 GeneGo (Thomson Reuters) pathways for PPP2R5E Gene
  • Cell cycle Regulation of G1/S transition (part 1)
  • Neurophysiological process Glutamate regulation of Dopamine D1A receptor signaling
  • Regulation of CFTR activity (norm and CF)
  • Signal transduction_PKA signaling
25 Qiagen pathways for PPP2R5E Gene
  • Akt Signaling
  • BAD Phosphorylation
  • Beta-Adrenergic Signaling
  • Breast Cancer Regulation by Stathmin1
  • CDK5 Pathway

Gene Ontology (GO) - Biological Process for PPP2R5E Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006470 protein dephosphorylation IBA 21873635
GO:0007165 signal transduction IEA --
GO:0031952 regulation of protein autophosphorylation IBA 21873635
GO:0043666 regulation of phosphoprotein phosphatase activity IEA --
genes like me logo Genes that share ontologies with PPP2R5E: view

No data available for SIGNOR curated interactions for PPP2R5E Gene

Drugs & Compounds for PPP2R5E Gene

No Compound Related Data Available

Transcripts for PPP2R5E Gene

mRNA/cDNA for PPP2R5E Gene

6 REFSEQ mRNAs :
25 NCBI additional mRNA sequence :
7 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PPP2R5E

Alternative Splicing Database (ASD) splice patterns (SP) for PPP2R5E Gene

ExUns: 1 ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14a · 14b ^ 15a · 15b
SP1: - - - -
SP2: - - - -
SP3: - - - - -
SP4: - -
SP5: -
SP6: -
SP7: - - -

Relevant External Links for PPP2R5E Gene

GeneLoc Exon Structure for
PPP2R5E

Expression for PPP2R5E Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PPP2R5E Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for PPP2R5E Gene

This gene is overexpressed in Fetal Brain (11.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for PPP2R5E Gene



Protein tissue co-expression partners for PPP2R5E Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for PPP2R5E

SOURCE GeneReport for Unigene cluster for PPP2R5E Gene:

Hs.334868

Evidence on tissue expression from TISSUES for PPP2R5E Gene

  • Nervous system(4.6)
  • Eye(4.2)
  • Heart(2.3)
  • Muscle(2.1)
  • Kidney(2.1)
  • Spleen(2)
  • Skin(2)
genes like me logo Genes that share expression patterns with PPP2R5E: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PPP2R5E Gene

Orthologs for PPP2R5E Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PPP2R5E Gene

Organism Taxonomy Gene Similarity Type Details
Oppossum
(Monodelphis domestica)
Mammalia PPP2R5E 31
  • 100 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia PPP2R5E 31
  • 100 (a)
OneToOne
Chimpanzee
(Pan troglodytes)
Mammalia PPP2R5E 30 31
  • 99.93 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia PPP2R5E 30 31
  • 98.07 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia PPP2R5E 30 31
  • 97.64 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Ppp2r5e 30 17 31
  • 95.86 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Ppp2r5e 30
  • 95.57 (n)
Chicken
(Gallus gallus)
Aves PPP2R5E 30 31
  • 92.36 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia PPP2R5E 31
  • 100 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia ppp2r5e 30
  • 86.58 (n)
MGC76234 30
African clawed frog
(Xenopus laevis)
Amphibia Xl.6938 30
Zebrafish
(Danio rerio)
Actinopterygii ppp2r5ea 31
  • 90 (a)
OneToMany
ppp2r5eb 30 31
  • 79.87 (n)
OneToMany
efnb3 30
Rainbow Trout
(Oncorhynchus mykiss)
Actinopterygii Omy.12118 30
Fruit Fly
(Drosophila melanogaster)
Insecta BcDNA:LD34343 32
  • 77 (a)
PP2A-B' 32
  • 67 (a)
wdb 30 31
  • 64.14 (n)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004096 30
  • 64.85 (n)
Worm
(Caenorhabditis elegans)
Secernentea W08G11.4 32
  • 67 (a)
pptr-1 30 31
  • 61.32 (n)
OneToMany
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RTS1 31
  • 33 (a)
OneToMany
Thale Cress
(Arabidopsis thaliana)
eudicotyledons ATB' BETA 30
  • 57.41 (n)
Soybean
(Glycine max)
eudicotyledons Gma.7938 30
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 51 (a)
ManyToMany
Species where no ortholog for PPP2R5E was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for PPP2R5E Gene

ENSEMBL:
Gene Tree for PPP2R5E (if available)
TreeFam:
Gene Tree for PPP2R5E (if available)
Aminode:
Evolutionary constrained regions (ECRs) for PPP2R5E: view image

Paralogs for PPP2R5E Gene

Paralogs for PPP2R5E Gene

(4) SIMAP similar genes for PPP2R5E Gene using alignment to 7 proteins:

  • 2A5E_HUMAN
  • B5BTZ7_HUMAN
  • B7ZKK9_HUMAN
  • J3KQN6_HUMAN
  • Q562F2_HUMAN
  • Q58EX4_HUMAN
  • Q86XZ2_HUMAN
genes like me logo Genes that share paralogs with PPP2R5E: view

Variants for PPP2R5E Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for PPP2R5E Gene

SNP ID Clinical significance and condition Chr 14 pos Variation AA Info Type
768658 Benign: not provided 63,384,503(-) G/A NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS_VARIANT
769862 Benign: not provided 63,389,678(-) T/C NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS_VARIANT
786620 Benign: not provided 63,415,211(-) G/T NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS_VARIANT

Additional dbSNP identifiers (rs#s) for PPP2R5E Gene

Structural Variations from Database of Genomic Variants (DGV) for PPP2R5E Gene

Variant ID Type Subtype PubMed ID
dgv137n21 CNV gain 19592680
dgv1925n100 CNV gain 25217958
dgv257n27 CNV gain 19166990
dgv3723n54 CNV gain 21841781
dgv642e212 CNV gain 25503493
dgv87e55 CNV gain 17911159
dgv88e55 CNV gain 17911159
esv2120827 CNV deletion 18987734
esv2533003 CNV deletion 19546169
esv2657638 CNV deletion 23128226
esv2659005 CNV deletion 23128226
esv2670321 CNV deletion 23128226
esv2673552 CNV deletion 23128226
esv2748775 CNV deletion 23290073
esv2748776 CNV deletion 23290073
esv2748777 CNV deletion 23290073
esv2761522 CNV gain 21179565
esv3298 CNV loss 18987735
esv3551646 CNV deletion 23714750
esv3551647 CNV deletion 23714750
esv3634723 CNV gain 21293372
esv3634725 CNV loss 21293372
esv3634726 CNV gain 21293372
esv3634727 CNV gain 21293372
esv3634728 CNV loss 21293372
esv3634729 CNV loss 21293372
nsv1051684 CNV gain 25217958
nsv1069802 CNV deletion 25765185
nsv519574 CNV gain 19592680
nsv832815 CNV gain 17160897
nsv952851 CNV deletion 24416366
nsv977473 CNV duplication 23825009

Variation tolerance for PPP2R5E Gene

Residual Variation Intolerance Score: 20.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.30; 6.78% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PPP2R5E Gene

Human Gene Mutation Database (HGMD)
PPP2R5E
SNPedia medical, phenotypic, and genealogical associations of SNPs for
PPP2R5E

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PPP2R5E Gene

Disorders for PPP2R5E Gene

Additional Disease Information for PPP2R5E

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform

No disorders were found for PPP2R5E Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PPP2R5E Gene

Publications for PPP2R5E Gene

  1. Association between single nucleotide polymorphism-genotype and outcome of patients with chronic lymphocytic leukemia in a randomized chemotherapy trial. (PMID: 21659360) Wade R … Houlston RS (Haematologica 2011) 3 41
  2. Protein phosphatase 2A subunit gene haplotypes and proliferative breast disease modify breast cancer risk. (PMID: 19890961) Dupont WD … Smith JR (Cancer 2010) 3 41
  3. Shugoshin collaborates with protein phosphatase 2A to protect cohesin. (PMID: 16541025) Kitajima TS … Watanabe Y (Nature 2006) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  5. The variable subunit associated with protein phosphatase 2A0 defines a novel multimember family of regulatory subunits. (PMID: 8694763) Zolnierowicz S … Hemmings BA (The Biochemical journal 1996) 3 4

Products for PPP2R5E Gene

Sources for PPP2R5E Gene