The product of this gene belongs to the phosphatase 2A regulatory subunit B family. Protein phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a vari... See more...

Aliases for PPP2R5C Gene

Aliases for PPP2R5C Gene

  • Protein Phosphatase 2 Regulatory Subunit B'Gamma 2 3 5
  • Serine/Threonine-Protein Phosphatase 2A 56 KDa Regulatory Subunit Gamma Isoform 3 4
  • Protein Phosphatase 2, Regulatory Subunit B (B56), Gamma Isoform 2 3
  • PP2A B Subunit Isoform PR61-Gamma 3 4
  • Renal Carcinoma Antigen NY-REN-29 3 4
  • PP2A B Subunit Isoform B56-Gamma 3 4
  • PP2A B Subunit Isoform B'-Gamma 3 4
  • PP2A B Subunit Isoform R5-Gamma 3 4
  • B56gamma 2 3
  • PR61G 2 3
  • B56G 2 3
  • Protein Phosphatase 2, Regulatory Subunit B', Gamma Isoform 3
  • Protein Phosphatase 2 Regulatory Subunit B', Gamma 3
  • B' Alpha Regulatory Subunit 3
  • KIAA0044 4
  • PPP2R5C 5

External Ids for PPP2R5C Gene

Previous GeneCards Identifiers for PPP2R5C Gene

  • GC14P099667
  • GC14P096091
  • GC14P100219
  • GC14P100266
  • GC14P101345
  • GC14P101298
  • GC14P102228
  • GC14P082408
  • GC14P101884
  • GC14P101907
  • GC14P103891
  • GC14P104092
  • GC14P104214
  • GC14P104547
  • GC14P102218
  • GC14P102385
  • GC14P102563
  • GC14P102735
  • GC14P102905
  • GC14P103081
  • GC14P103277
  • GC14P103691

Summaries for PPP2R5C Gene

Entrez Gene Summary for PPP2R5C Gene

  • The product of this gene belongs to the phosphatase 2A regulatory subunit B family. Protein phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might modulate substrate selectivity and catalytic activity. This gene encodes a gamma isoform of the regulatory subunit B56 subfamily. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

GeneCards Summary for PPP2R5C Gene

PPP2R5C (Protein Phosphatase 2 Regulatory Subunit B'Gamma) is a Protein Coding gene. Diseases associated with PPP2R5C include Ectrodactyly, Ectodermal Dysplasia, And Cleft Lip/Palate Syndrome 3. Among its related pathways are Negative regulation of MAPK pathway and RET signaling. Gene Ontology (GO) annotations related to this gene include binding. An important paralog of this gene is PPP2R5D.

UniProtKB/Swiss-Prot Summary for PPP2R5C Gene

  • The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. The PP2A-PPP2R5C holoenzyme may specifically dephosphorylate and activate TP53 and play a role in DNA damage-induced inhibition of cell proliferation. PP2A-PPP2R5C may also regulate the ERK signaling pathway through ERK dephosphorylation.

Gene Wiki entry for PPP2R5C Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PPP2R5C Gene

Genomics for PPP2R5C Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for PPP2R5C Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PPP2R5C on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for PPP2R5C

Top Transcription factor binding sites by QIAGEN in the PPP2R5C gene promoter:
  • Chx10
  • Lhx3a
  • LHX3b
  • LUN-1
  • MRF-2
  • NRSF form 1
  • NRSF form 2
  • POU2F1
  • POU2F1a
  • RelA

Genomic Locations for PPP2R5C Gene

Genomic Locations for PPP2R5C Gene
chr14:101,760,573-101,927,992
(GRCh38/hg38)
Size:
167,420 bases
Orientation:
Plus strand
chr14:102,228,135-102,394,329
(GRCh37/hg19)
Size:
166,195 bases
Orientation:
Plus strand

Genomic View for PPP2R5C Gene

Genes around PPP2R5C on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PPP2R5C Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PPP2R5C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PPP2R5C Gene

Proteins for PPP2R5C Gene

  • Protein details for PPP2R5C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13362-2A5G_HUMAN
    Recommended name:
    Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform
    Protein Accession:
    Q13362
    Secondary Accessions:
    • B4DYJ8
    • B5BUA5
    • F5GWP3
    • Q14391
    • Q15060
    • Q15174
    • Q6ZN33

    Protein attributes for PPP2R5C Gene

    Size:
    524 amino acids
    Molecular mass:
    61061 Da
    Quaternary structure:
    • PP2A consists of a common heterodimeric core enzyme, composed of PPP2CA a 36 kDa catalytic subunit (subunit C) and PPP2R1A a 65 kDa constant regulatory subunit (PR65 or subunit A), that associates with a variety of regulatory subunits. Proteins that associate with the core dimer include three families of regulatory subunits B (the R2/B/PR55/B55, R3/B''/PR72/PR130/PR59 and R5/B'/B56 families), the 48 kDa variable regulatory subunit, viral proteins, and cell signaling molecules. Interacts with PPP2CA AND PPP2R1A; the interaction is direct. Interacts with SGO1; the interaction is direct. Isoform 1 and isoform 2 interact with TP53 (phosphorylated at Ser-15 by ATM); increased upon DNA damage it drives PP2A-mediated dephosphorylation of TP53 at Thr-55. Interacts with IER3 and/or ERK kinases; regulates ERK dephosphorylation. Interacts with CIP2A; this interaction stabilizes CIP2A (PubMed:28174209).
    SequenceCaution:
    • Sequence=AAC50387.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; Sequence=BAG63760.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for PPP2R5C Gene

    Alternative splice isoforms for PPP2R5C Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PPP2R5C Gene

Post-translational modifications for PPP2R5C Gene

  • Isoform Gamma-3 is phosphorylated on serine residues. Isoform Gamma-1 phosphorylation by ERK2 is IER3-dependent and inhibits ERK dephosphorylation by PP2A-PPP2R5C.
  • Ubiquitination at Lys6
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for PPP2R5C Gene

Domains & Families for PPP2R5C Gene

Gene Families for PPP2R5C Gene

Protein Domains for PPP2R5C Gene

InterPro:
Blocks:
  • Protein phosphatase 2A, regulatory B subunit (B56 family)
ProtoNet:

Suggested Antigen Peptide Sequences for PPP2R5C Gene

GenScript: Design optimal peptide antigens:
  • Renal carcinoma antigen NY-REN-29 (2A5G_HUMAN)
  • cDNA FLJ16473 fis, clone BRHIP3026052, highly similar to Serine/threonine protein phosphatase 2A, 56 kDa regulatory subunit, gamma isoform (Q6ZN33_HUMAN)
  • Protein phosphatase 2, regulatory subunit B', gamma isoform (Q96B13_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q13362

UniProtKB/Swiss-Prot:

2A5G_HUMAN :
  • Belongs to the phosphatase 2A regulatory subunit B56 family.
Family:
  • Belongs to the phosphatase 2A regulatory subunit B56 family.
genes like me logo Genes that share domains with PPP2R5C: view

Function for PPP2R5C Gene

Molecular function for PPP2R5C Gene

UniProtKB/Swiss-Prot Function:
The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. The PP2A-PPP2R5C holoenzyme may specifically dephosphorylate and activate TP53 and play a role in DNA damage-induced inhibition of cell proliferation. PP2A-PPP2R5C may also regulate the ERK signaling pathway through ERK dephosphorylation.
UniProtKB/Swiss-Prot Induction:
Up-regulated upon DNA damage.
GENATLAS Biochemistry:
protein phosphatase 2A,regulatory subunit B56 gamma isoform,expressed in cardiac and skeletal muscle

Phenotypes From GWAS Catalog for PPP2R5C Gene

Gene Ontology (GO) - Molecular Function for PPP2R5C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 1328865
GO:0008233 peptidase activity IDA --
GO:0019888 protein phosphatase regulator activity NAS 8703017
GO:0072542 protein phosphatase activator activity IBA 21873635
genes like me logo Genes that share ontologies with PPP2R5C: view
genes like me logo Genes that share phenotypes with PPP2R5C: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PPP2R5C

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PPP2R5C Gene

Localization for PPP2R5C Gene

Subcellular locations from UniProtKB/Swiss-Prot for PPP2R5C Gene

Nucleus. Chromosome, centromere.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PPP2R5C gene
Compartment Confidence
nucleus 5
cytosol 5
golgi apparatus 4
cytoskeleton 2
plasma membrane 1
extracellular 1
mitochondrion 1
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Golgi apparatus (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for PPP2R5C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000159 protein phosphatase type 2A complex IBA,NAS 8703017
GO:0000775 chromosome, centromeric region IEA,IDA 16580887
GO:0005634 nucleus IBA,IDA 8703017
GO:0005654 nucleoplasm TAS --
GO:0005694 chromosome IEA --
genes like me logo Genes that share ontologies with PPP2R5C: view

Pathways & Interactions for PPP2R5C Gene

PathCards logo

SuperPathways for PPP2R5C Gene

SuperPathway Contained pathways
1 RET signaling
2 S45 mutants of beta-catenin arent phosphorylated
3 GAB1 signalosome
4 Beta-Adrenergic Signaling
.37
.37
.37
5 p70S6K Signaling
.60
.60
.54
genes like me logo Genes that share pathways with PPP2R5C: view

Pathways by source for PPP2R5C Gene

4 GeneGo (Thomson Reuters) pathways for PPP2R5C Gene
  • Cell cycle Regulation of G1/S transition (part 1)
  • Neurophysiological process Glutamate regulation of Dopamine D1A receptor signaling
  • Regulation of CFTR activity (norm and CF)
  • Signal transduction_PKA signaling
25 Qiagen pathways for PPP2R5C Gene
  • Akt Signaling
  • BAD Phosphorylation
  • Beta-Adrenergic Signaling
  • Breast Cancer Regulation by Stathmin1
  • CDK5 Pathway

SIGNOR curated interactions for PPP2R5C Gene

Activates:
Inactivates:
Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for PPP2R5C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006470 protein dephosphorylation IBA 21873635
GO:0007165 signal transduction NAS 8703017
GO:0008285 negative regulation of cell proliferation IDA 17245430
GO:0014066 regulation of phosphatidylinositol 3-kinase signaling TAS --
GO:0016485 protein processing IDA --
genes like me logo Genes that share ontologies with PPP2R5C: view

Drugs & Compounds for PPP2R5C Gene

(2) Drugs for PPP2R5C Gene - From: DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
(2S,3S,4E,6E,8S,9S)-3-amino-9-methoxy-2,6,8-trimethyl-10-phenyldeca-4,6-dienoic acid Experimental Pharma Target 0
2,6,8-Trimethyl-3-Amino-9-Benzyl-9-Methoxynonanoic Acid Experimental Pharma Target 0
genes like me logo Genes that share compounds with PPP2R5C: view

Transcripts for PPP2R5C Gene

mRNA/cDNA for PPP2R5C Gene

11 REFSEQ mRNAs :
19 NCBI additional mRNA sequence :
33 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PPP2R5C

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for PPP2R5C Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c · 3d ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17 ^
SP1: - - - - - - - - - -
SP2:
SP3: - - - - - - - - - -
SP4: -
SP5: - - -
SP6: -
SP7: - - - - -
SP8: - - - - - - -
SP9:
SP10: - - - - -
SP11: - - -
SP12: - - - - - - - -
SP13:

ExUns: 18a · 18b ^ 19a · 19b · 19c
SP1:
SP2: -
SP3:
SP4: -
SP5:
SP6: - -
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:

Relevant External Links for PPP2R5C Gene

GeneLoc Exon Structure for
PPP2R5C

Expression for PPP2R5C Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PPP2R5C Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for PPP2R5C Gene

This gene is overexpressed in Breast (14.1), Peripheral blood mononuclear cells (11.7), Brain (8.7), and Bone (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for PPP2R5C Gene



Protein tissue co-expression partners for PPP2R5C Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for PPP2R5C

SOURCE GeneReport for Unigene cluster for PPP2R5C Gene:

Hs.368264

mRNA Expression by UniProt/SwissProt for PPP2R5C Gene:

Q13362-2A5G_HUMAN
Tissue specificity: Highest levels in heart, skeletal muscle and brain. Lower levels in pancreas, kidney, lung and placenta. Very low levels in liver.

Evidence on tissue expression from TISSUES for PPP2R5C Gene

  • Nervous system(4.9)
  • Bone marrow(4.5)
  • Eye(4.2)
  • Lung(2.8)
  • Skin(2.8)
  • Muscle(2.7)
  • Heart(2.7)
  • Intestine(2.5)
  • Lymph node(2.4)
  • Spleen(2.4)
  • Kidney(2.3)
  • Thyroid gland(2.2)
  • Liver(2.2)
  • Blood(2)
genes like me logo Genes that share expression patterns with PPP2R5C: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for PPP2R5C Gene

Orthologs for PPP2R5C Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PPP2R5C Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia PPP2R5C 31
  • 100 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia PPP2R5C 31
  • 94 (a)
OneToOne
Mouse
(Mus musculus)
Mammalia Ppp2r5c 31
  • 94 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia PPP2R5C 31
  • 90 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia PPP2R5C 31
  • 89 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia PPP2R5C 31
  • 84 (a)
OneToOne
Chicken
(Gallus gallus)
Aves PPP2R5C 31
  • 90 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia PPP2R5C 31
  • 85 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.11152 30
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia MGC76127 30
Zebrafish
(Danio rerio)
Actinopterygii ppp2r5cb 31
  • 80 (a)
OneToOne
Fruit Fly
(Drosophila melanogaster)
Insecta BcDNA:LD34343 32
  • 73 (a)
PP2A-B' 31 32
  • 37 (a)
OneToMany
Worm
(Caenorhabditis elegans)
Secernentea W08G11.4 32
  • 66 (a)
C13G3.3a 32
  • 64 (a)
C13G3.3b 32
  • 64 (a)
pptr-2 31
  • 55 (a)
OneToMany
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RTS1 31 33
  • 35 (a)
OneToMany
Thale Cress
(Arabidopsis thaliana)
eudicotyledons AT5G25510 30
  • 54.87 (n)
Rice
(Oryza sativa)
Liliopsida Os05g0555100 30
  • 57.1 (n)
Os.27452 30
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.2648 31
  • 61 (a)
OneToMany
Sea Vase
(Ciona intestinalis)
Ascidiacea Cin.3438 30
Species where no ortholog for PPP2R5C was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for PPP2R5C Gene

ENSEMBL:
Gene Tree for PPP2R5C (if available)
TreeFam:
Gene Tree for PPP2R5C (if available)
Aminode:
Evolutionary constrained regions (ECRs) for PPP2R5C: view image

Paralogs for PPP2R5C Gene

Paralogs for PPP2R5C Gene

(23) SIMAP similar genes for PPP2R5C Gene using alignment to 17 proteins:

  • 2A5G_HUMAN
  • G3V292_HUMAN
  • G3V2U3_HUMAN
  • G3V5T2_HUMAN
  • H0YJ12_HUMAN
  • H0YJ35_HUMAN
  • H0YJ49_HUMAN
  • H0YJ75_HUMAN
  • H0YJU0_HUMAN
  • H0YJZ3_HUMAN
  • H0YK25_HUMAN
  • H0YK26_HUMAN
  • H0YN58_HUMAN
  • H0YN84_HUMAN
  • H0YNJ3_HUMAN
  • H0YNR8_HUMAN
  • Q96B13_HUMAN

Pseudogenes.org Pseudogenes for PPP2R5C Gene

genes like me logo Genes that share paralogs with PPP2R5C: view

Variants for PPP2R5C Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for PPP2R5C Gene

SNP ID Clinical significance and condition Chr 14 pos Variation AA Info Type
666303 Likely Pathogenic: Intellectual disability 101,882,230(+) G/A MISSENSE_VARIANT
741990 Likely Benign: not provided 101,856,810(+) A/G SYNONYMOUS_VARIANT,FIVE_PRIME_UTR_VARIANT
776862 Benign: not provided 101,882,276(+) C/T INTRON_VARIANT
781151 Benign: not provided 101,883,515(+) A/C SYNONYMOUS_VARIANT
781152 Benign: not provided 101,901,715(+) G/C INTRON_VARIANT

Additional dbSNP identifiers (rs#s) for PPP2R5C Gene

Structural Variations from Database of Genomic Variants (DGV) for PPP2R5C Gene

Variant ID Type Subtype PubMed ID
dgv1137n106 CNV deletion 24896259
dgv1138n106 CNV deletion 24896259
esv2565595 CNV insertion 19546169
esv2656703 CNV deletion 23128226
esv2749146 CNV deletion 23290073
esv2749147 CNV deletion 23290073
esv3552066 CNV deletion 23714750
esv3568442 CNV gain 25503493
esv3581408 CNV loss 25503493
esv3635536 CNV loss 21293372
esv3635537 CNV gain 21293372
nsv1038990 CNV gain 25217958
nsv1069820 CNV deletion 25765185
nsv1070239 CNV deletion 25765185
nsv1070658 CNV deletion 25765185
nsv1113672 CNV deletion 24896259
nsv1131076 CNV deletion 24896259
nsv1136182 CNV deletion 24896259
nsv512375 CNV loss 21212237
nsv518045 CNV loss 19592680
nsv84885 CNV deletion 16902084
nsv952250 CNV deletion 24416366
nsv952251 CNV deletion 24416366
nsv974372 CNV duplication 23825009

Variation tolerance for PPP2R5C Gene

Residual Variation Intolerance Score: 26.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.87; 83.68% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PPP2R5C Gene

Human Gene Mutation Database (HGMD)
PPP2R5C
SNPedia medical, phenotypic, and genealogical associations of SNPs for
PPP2R5C

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PPP2R5C Gene

Disorders for PPP2R5C Gene

MalaCards: The human disease database

(1) MalaCards diseases for PPP2R5C Gene - From: DISEASES

- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for PPP2R5C

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with PPP2R5C: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PPP2R5C Gene

Publications for PPP2R5C Gene

  1. Identification of a new family of protein phosphatase 2A regulatory subunits. (PMID: 7592815) McCright B … Virshup DM (The Journal of biological chemistry 1995) 2 3 4
  2. Oncoprotein CIP2A is stabilized via interaction with tumor suppressor PP2A/B56. (PMID: 28174209) Wang J … Westermarck J (EMBO reports 2017) 3 4
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 41
  4. A genome-wide scan for common alleles affecting risk for autism. (PMID: 20663923) Anney R … Hallmayer J (Human molecular genetics 2010) 3 41
  5. Serine 15 phosphorylation of p53 directs its interaction with B56gamma and the tumor suppressor activity of B56gamma-specific protein phosphatase 2A. (PMID: 17967874) Shouse GP … Liu X (Molecular and cellular biology 2008) 3 4

Products for PPP2R5C Gene

Sources for PPP2R5C Gene