The product of this gene belongs to the phosphatase 2A regulatory subunit B family. Protein phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a vari... See more...

Aliases for PPP2R5B Gene

Aliases for PPP2R5B Gene

  • Protein Phosphatase 2 Regulatory Subunit B'Beta 2 3 5
  • Serine/Threonine-Protein Phosphatase 2A 56 KDa Regulatory Subunit Beta Isoform 3 4
  • PP2A B Subunit Isoform PR61-Beta 3 4
  • PP2A B Subunit Isoform B56-Beta 3 4
  • PP2A B Subunit Isoform B'-Beta 3 4
  • PP2A B Subunit Isoform R5-Beta 3 4
  • B56beta 2 3
  • PR61B 2 3
  • B56B 2 3
  • Serine/Threonine Protein Phosphatase 2A, 56 KDa Regulatory Subunit, Beta Isoform 2
  • Protein Phosphatase 2, Regulatory Subunit B (B56), Beta Isoform 2
  • Protein Phosphatase 2, Regulatory Subunit B', Beta Isoform 3
  • Protein Phosphatase 2 Regulatory Subunit B', Beta 3
  • PP2A, B Subunit, PR61 Beta Isoform 2
  • PP2A, B Subunit, B56 Beta Isoform 2
  • PP2A, B Subunit, B' Beta Isoform 2
  • PP2A, B Subunit, R5 Beta Isoform 2
  • FLJ35411 2
  • PPP2R5B 5

External Ids for PPP2R5B Gene

Previous GeneCards Identifiers for PPP2R5B Gene

  • GC11P067208
  • GC11P066373
  • GC11P064942
  • GC11P064468
  • GC11P064469
  • GC11P064448
  • GC11P064692
  • GC11P061019

Summaries for PPP2R5B Gene

Entrez Gene Summary for PPP2R5B Gene

  • The product of this gene belongs to the phosphatase 2A regulatory subunit B family. Protein phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might modulate substrate selectivity and catalytic activity. This gene encodes a beta isoform of the regulatory subunit B56 subfamily. [provided by RefSeq, Jul 2008]

GeneCards Summary for PPP2R5B Gene

PPP2R5B (Protein Phosphatase 2 Regulatory Subunit B'Beta) is a Protein Coding gene. Among its related pathways are Negative regulation of MAPK pathway and RET signaling. Gene Ontology (GO) annotations related to this gene include binding. An important paralog of this gene is PPP2R5A.

UniProtKB/Swiss-Prot Summary for PPP2R5B Gene

  • As the regulatory component of the serine/threonine-protein phosphatase 2A (PP2A) holoenzyme, modulates substrate specificity, subcellular localization, and responsiveness to phosphorylation. The phosphorylated form mediates the interaction between PP2A and AKT1, leading to AKT1 dephosphorylation.

Gene Wiki entry for PPP2R5B Gene

Additional gene information for PPP2R5B Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PPP2R5B Gene

Genomics for PPP2R5B Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for PPP2R5B Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PPP2R5B on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for PPP2R5B

Top Transcription factor binding sites by QIAGEN in the PPP2R5B gene promoter:
  • C/EBPalpha
  • Egr-3
  • FOXC1
  • Ik-3
  • NF-1
  • p53
  • Sp1
  • TBP
  • YY1

Genomic Locations for PPP2R5B Gene

Genomic Locations for PPP2R5B Gene
chr11:64,917,553-64,934,478
(GRCh38/hg38)
Size:
16,926 bases
Orientation:
Plus strand
chr11:64,685,025-64,701,950
(GRCh37/hg19)
Size:
16,926 bases
Orientation:
Plus strand

Genomic View for PPP2R5B Gene

Genes around PPP2R5B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PPP2R5B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PPP2R5B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PPP2R5B Gene

Proteins for PPP2R5B Gene

  • Protein details for PPP2R5B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15173-2A5B_HUMAN
    Recommended name:
    Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform
    Protein Accession:
    Q15173
    Secondary Accessions:
    • Q13853

    Protein attributes for PPP2R5B Gene

    Size:
    497 amino acids
    Molecular mass:
    57393 Da
    Quaternary structure:
    • Component of the serine/threonine-protein phosphatase 2A complex (PP2A). This complex consists of a common heterodimeric core enzyme, composed of a 36 kDa catalytic subunit (subunit C) and a 65 kDa constant scaffold subunit (PR65 or subunit A), that associates with a variety of regulatory subunits. Proteins that associate with the core dimer include three families of regulatory subunits B (the R2/B/PR55/B55, R3/B''/PR72/PR130/PR59 and R5/B'/B56 families), the 48 kDa variable regulatory subunit, viral proteins, and cell signaling molecules (PubMed:23135275). Interacts with SGO1 (PubMed:16541025). Interacts with AKT1 (PubMed:21329884). Interacts with CUL3 and KLHL15; this interaction leads to proteasomal degradation (PubMed:23135275).

    Alternative splice isoforms for PPP2R5B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PPP2R5B Gene

Post-translational modifications for PPP2R5B Gene

  • Ubiquitinated by E3 CUL3-KLHL15 complex; this modification leads to proteasomal degradation.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PPP2R5B Gene

Antibody Products

  • Abcam antibodies for PPP2R5B
  • Boster Bio Antibodies for PPP2R5B

No data available for DME Specific Peptides for PPP2R5B Gene

Domains & Families for PPP2R5B Gene

Gene Families for PPP2R5B Gene

Protein Domains for PPP2R5B Gene

InterPro:
Blocks:
  • Protein phosphatase 2A, regulatory B subunit (B56 family)
ProtoNet:

Suggested Antigen Peptide Sequences for PPP2R5B Gene

GenScript: Design optimal peptide antigens:
  • PP2A B subunit isoform R5-beta (2A5B_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q15173

UniProtKB/Swiss-Prot:

2A5B_HUMAN :
  • Belongs to the phosphatase 2A regulatory subunit B56 family.
Family:
  • Belongs to the phosphatase 2A regulatory subunit B56 family.
genes like me logo Genes that share domains with PPP2R5B: view

Function for PPP2R5B Gene

Molecular function for PPP2R5B Gene

UniProtKB/Swiss-Prot Function:
As the regulatory component of the serine/threonine-protein phosphatase 2A (PP2A) holoenzyme, modulates substrate specificity, subcellular localization, and responsiveness to phosphorylation. The phosphorylated form mediates the interaction between PP2A and AKT1, leading to AKT1 dephosphorylation.
UniProtKB/Swiss-Prot Induction:
By retinoic acid; in neuroblastoma cell lines.
GENATLAS Biochemistry:
protein phosphatase 2B,regulatory subunit B56 beta isoform,expressed in brain,with CAG repeat,excluded as a candidate gene for MEN1

Phenotypes From GWAS Catalog for PPP2R5B Gene

Gene Ontology (GO) - Molecular Function for PPP2R5B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 7592815
GO:0019888 protein phosphatase regulator activity IEA,TAS 8703017
GO:0072542 protein phosphatase activator activity IBA 21873635
genes like me logo Genes that share ontologies with PPP2R5B: view
genes like me logo Genes that share phenotypes with PPP2R5B: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PPP2R5B

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for PPP2R5B Gene

Localization for PPP2R5B Gene

Subcellular locations from UniProtKB/Swiss-Prot for PPP2R5B Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PPP2R5B gene
Compartment Confidence
nucleus 4
cytosol 4
plasma membrane 1
extracellular 1
cytoskeleton 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for PPP2R5B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000159 protein phosphatase type 2A complex IEA,IBA 21873635
GO:0005634 nucleus IBA 21873635
GO:0005737 cytoplasm TAS 8703017
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with PPP2R5B: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for PPP2R5B Gene

Pathways & Interactions for PPP2R5B Gene

PathCards logo

SuperPathways for PPP2R5B Gene

SuperPathway Contained pathways
1 RET signaling
2 S45 mutants of beta-catenin arent phosphorylated
3 GAB1 signalosome
4 Beta-Adrenergic Signaling
.37
.37
.37
5 p70S6K Signaling
.60
.60
.54
genes like me logo Genes that share pathways with PPP2R5B: view

Pathways by source for PPP2R5B Gene

4 GeneGo (Thomson Reuters) pathways for PPP2R5B Gene
  • Cell cycle Regulation of G1/S transition (part 1)
  • Neurophysiological process Glutamate regulation of Dopamine D1A receptor signaling
  • Regulation of CFTR activity (norm and CF)
  • Signal transduction_PKA signaling
25 Qiagen pathways for PPP2R5B Gene
  • Akt Signaling
  • BAD Phosphorylation
  • Beta-Adrenergic Signaling
  • Breast Cancer Regulation by Stathmin1
  • CDK5 Pathway

SIGNOR curated interactions for PPP2R5B Gene

Activates:
Inactivates:

Gene Ontology (GO) - Biological Process for PPP2R5B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001932 regulation of protein phosphorylation IEA --
GO:0006470 protein dephosphorylation IBA 21873635
GO:0007165 signal transduction IEA --
GO:0010469 regulation of signaling receptor activity IEA --
GO:0010976 positive regulation of neuron projection development IEA --
genes like me logo Genes that share ontologies with PPP2R5B: view

Drugs & Compounds for PPP2R5B Gene

No Compound Related Data Available

Transcripts for PPP2R5B Gene

mRNA/cDNA for PPP2R5B Gene

1 REFSEQ mRNAs :
5 NCBI additional mRNA sequence :
5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PPP2R5B

Alternative Splicing Database (ASD) splice patterns (SP) for PPP2R5B Gene

No ASD Table

Relevant External Links for PPP2R5B Gene

GeneLoc Exon Structure for
PPP2R5B

Expression for PPP2R5B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PPP2R5B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for PPP2R5B Gene

This gene is overexpressed in Fetal Brain (19.5), Plasma (18.6), and Spinal cord (10.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for PPP2R5B Gene



Protein tissue co-expression partners for PPP2R5B Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for PPP2R5B

SOURCE GeneReport for Unigene cluster for PPP2R5B Gene:

Hs.75199

mRNA Expression by UniProt/SwissProt for PPP2R5B Gene:

Q15173-2A5B_HUMAN
Tissue specificity: Highest expression in brain.

Evidence on tissue expression from TISSUES for PPP2R5B Gene

  • Nervous system(4.8)
  • Muscle(2)
genes like me logo Genes that share expression patterns with PPP2R5B: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for PPP2R5B Gene

Orthologs for PPP2R5B Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PPP2R5B Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia PPP2R5B 30 31
  • 99.66 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia PPP2R5B 30 31
  • 94.02 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia PPP2R5B 30 31
  • 93.96 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Ppp2r5b 30 17 31
  • 92.42 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Ppp2r5b 30
  • 92.09 (n)
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia ppp2r5b 30
  • 76.03 (n)
Zebrafish
(Danio rerio)
Actinopterygii PPP2R5B 31
  • 80 (a)
OneToOne
LOC562282 30
  • 76.32 (n)
Fruit Fly
(Drosophila melanogaster)
Insecta BcDNA:LD34343 32
  • 75 (a)
wdb 31
  • 62 (a)
OneToMany
Worm
(Caenorhabditis elegans)
Secernentea W08G11.4 32
  • 64 (a)
pptr-1 31
  • 56 (a)
OneToMany
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RTS1 31
  • 32 (a)
OneToMany
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.10909 30
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 51 (a)
ManyToMany
Species where no ortholog for PPP2R5B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for PPP2R5B Gene

ENSEMBL:
Gene Tree for PPP2R5B (if available)
TreeFam:
Gene Tree for PPP2R5B (if available)
Aminode:
Evolutionary constrained regions (ECRs) for PPP2R5B: view image

Paralogs for PPP2R5B Gene

Paralogs for PPP2R5B Gene

(4) SIMAP similar genes for PPP2R5B Gene using alignment to 3 proteins:

  • 2A5B_HUMAN
  • E9PNY3_HUMAN
  • E9PQN5_HUMAN
genes like me logo Genes that share paralogs with PPP2R5B: view

Variants for PPP2R5B Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for PPP2R5B Gene

SNP ID Clinical significance and condition Chr 11 pos Variation AA Info Type
rs747411292 Uncertain Significance: not provided 64,927,887(+) C/T MISSENSE_VARIANT

Additional dbSNP identifiers (rs#s) for PPP2R5B Gene

Structural Variations from Database of Genomic Variants (DGV) for PPP2R5B Gene

Variant ID Type Subtype PubMed ID
nsv526181 CNV gain 19592680
nsv528506 CNV loss 19592680
nsv555208 CNV loss 21841781

Variation tolerance for PPP2R5B Gene

Residual Variation Intolerance Score: 17.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.56; 12.11% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PPP2R5B Gene

Human Gene Mutation Database (HGMD)
PPP2R5B
SNPedia medical, phenotypic, and genealogical associations of SNPs for
PPP2R5B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PPP2R5B Gene

Disorders for PPP2R5B Gene

No disorders were found for PPP2R5B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PPP2R5B Gene

Publications for PPP2R5B Gene

  1. Identification of a new family of protein phosphatase 2A regulatory subunits. (PMID: 7592815) McCright B … Virshup DM (The Journal of biological chemistry 1995) 2 3 4
  2. Selective proteasomal degradation of the B'β subunit of protein phosphatase 2A by the E3 ubiquitin ligase adaptor Kelch-like 15. (PMID: 23135275) Oberg EA … Strack S (The Journal of biological chemistry 2012) 3 4
  3. Shugoshin collaborates with protein phosphatase 2A to protect cohesin. (PMID: 16541025) Kitajima TS … Watanabe Y (Nature 2006) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  5. Mapping of the gene encoding the B56 beta subunit of protein phosphatase 2A (PPP2R5B) to a 0.5-Mb region of chromosome 11q13 and its exclusion as a candidate gene for multiple endocrine neoplasia type 1 (MEN1). (PMID: 9272177) Forbes SA … Kas K (Human genetics 1997) 3 23

Products for PPP2R5B Gene

Sources for PPP2R5B Gene