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Aliases for PPP2R5A Gene

Aliases for PPP2R5A Gene

  • Protein Phosphatase 2 Regulatory Subunit B'Alpha 2 3
  • Protein Phosphatase 2, Regulatory Subunit B (B56), Alpha Isoform 2 3
  • PP2A B Subunit Isoform PR61-Alpha 3 4
  • PP2A B Subunit Isoform B56-Alpha 3 4
  • PP2A B Subunit Isoform R5-Alpha 3 4
  • PP2A B Subunit Isoform B-Alpha 3 4
  • PR61alpha 3 4
  • Serine/Threonine Protein Phosphatase 2A, 56 KDa Regulatory Subunit, Alpha Isoform 3
  • Serine/Threonine-Protein Phosphatase 2A 56 KDa Regulatory Subunit Alpha Isoform 3
  • Protein Phosphatase 2, Regulatory Subunit B, Alpha Isoform 3
  • Protein Phosphatase 2 Regulatory Subunit B, Alpha 3
  • Protein Phosphatase 2 Regulatory Subunit Balpha 5
  • PP2A, B Subunit, PR61 Alpha Isoform 3
  • PP2A, B Subunit, B56 Alpha Isoform 3
  • PP2A, B Subunit, R5 Alpha Isoform 3
  • PP2A, B Subunit, B Alpha Isoform 3
  • B56alpha 3
  • PR61A 3
  • B56A 3

External Ids for PPP2R5A Gene

Previous GeneCards Identifiers for PPP2R5A Gene

  • GC01P211138
  • GC01P208302
  • GC01P209074
  • GC01P209515
  • GC01P208847
  • GC01P210526
  • GC01P212458
  • GC01P183135

Summaries for PPP2R5A Gene

Entrez Gene Summary for PPP2R5A Gene

  • The product of this gene belongs to the phosphatase 2A regulatory subunit B family. Protein phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might modulate substrate selectivity and catalytic activity. This gene encodes an alpha isoform of the regulatory subunit B56 subfamily. Alternative transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Dec 2010]

GeneCards Summary for PPP2R5A Gene

PPP2R5A (Protein Phosphatase 2 Regulatory Subunit B'Alpha) is a Protein Coding gene. Diseases associated with PPP2R5A include Cardiomyopathy, Dilated, 1D. Among its related pathways are ERK Signaling and phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex. Gene Ontology (GO) annotations related to this gene include binding. An important paralog of this gene is PPP2R5E.

UniProtKB/Swiss-Prot for PPP2R5A Gene

  • The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.

Gene Wiki entry for PPP2R5A Gene

Additional gene information for PPP2R5A Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PPP2R5A Gene

Genomics for PPP2R5A Gene

GeneHancer (GH) Regulatory Elements for PPP2R5A Gene

Promoters and enhancers for PPP2R5A Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J212283 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 669.5 +0.4 399 4.4 FEZF1 DMAP1 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 NFYC MEF2D LOC101929541 PPP2R5A TMEM206 ANGEL2 INTS7 ENSG00000230063
GH01J212254 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 27.3 -29.7 -29731 3.6 HDGF FOXA2 MLX ZFP64 ARID4B DMAP1 ZNF48 ETS1 YY1 ZNF766 LOC101929541 PPP2R5A TMEM206 LPGAT1 ATF3 GC01P212241
GH01J212413 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 18.1 +129.5 129544 2.4 HDGF PKNOX1 MLX ARNT ARID4B SIN3A IRF4 SLC30A9 POLR2B ZNF766 TMEM206 LOC101929541 PPP2R5A PIR60492
GH01J212430 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 15.4 +146.6 146636 4.2 ARNT SIN3A YBX1 ZNF48 YY1 TCF12 POLR2B ZNF766 ZNF143 ATF7 NENF LOC105372906 LOC101929541 TMEM206 PPP2R5A DTL INTS7 ENSG00000212187 BATF3
GH01J212260 Enhancer 1.3 Ensembl ENCODE dbSUPER 25.6 -24.3 -24250 1.7 PKNOX1 FOXA2 ARNT YY1 TCF12 ZNF766 GATA2 ATF7 FOS RXRA LOC101929541 PPP2R5A FLVCR1 GC01P212241
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PPP2R5A on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the PPP2R5A gene promoter:
  • MyoD
  • p53
  • NF-Y
  • CBF(2)
  • E47
  • C/EBPbeta
  • ZID
  • AP-2alpha isoform 3

Genomic Locations for PPP2R5A Gene

Genomic Locations for PPP2R5A Gene
chr1:212,285,537-212,361,863
(GRCh38/hg38)
Size:
76,327 bases
Orientation:
Plus strand
chr1:212,458,879-212,535,205
(GRCh37/hg19)
Size:
76,327 bases
Orientation:
Plus strand

Genomic View for PPP2R5A Gene

Genes around PPP2R5A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PPP2R5A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PPP2R5A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PPP2R5A Gene

Proteins for PPP2R5A Gene

  • Protein details for PPP2R5A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15172-2A5A_HUMAN
    Recommended name:
    Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform
    Protein Accession:
    Q15172
    Secondary Accessions:
    • B2R6D2
    • B7Z7L2
    • D3DT99
    • Q2NL72
    • Q5VVB2
    • Q8TBI9

    Protein attributes for PPP2R5A Gene

    Size:
    486 amino acids
    Molecular mass:
    56194 Da
    Quaternary structure:
    • PP2A consists of a common heterodimeric core enzyme, composed of a 36 kDa catalytic subunit (subunit C) and a 65 kDa constant regulatory subunit (PR65 or subunit A), that associates with a variety of regulatory subunits. Proteins that associate with the core dimer include three families of regulatory subunits B (the R2/B/PR55/B55, R3/B/PR72/PR130/PR59 and R5/B/B56 families), the 48 kDa variable regulatory subunit, viral proteins, and cell signaling molecules. Interacts with SGO1.

    Alternative splice isoforms for PPP2R5A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PPP2R5A Gene

Post-translational modifications for PPP2R5A Gene

Other Protein References for PPP2R5A Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for PPP2R5A Gene

Domains & Families for PPP2R5A Gene

Protein Domains for PPP2R5A Gene

Graphical View of Domain Structure for InterPro Entry

Q15172

UniProtKB/Swiss-Prot:

2A5A_HUMAN :
  • Belongs to the phosphatase 2A regulatory subunit B56 family.
Family:
  • Belongs to the phosphatase 2A regulatory subunit B56 family.
genes like me logo Genes that share domains with PPP2R5A: view

Function for PPP2R5A Gene

Molecular function for PPP2R5A Gene

UniProtKB/Swiss-Prot Function:
The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.
GENATLAS Biochemistry:
protein phosphatase 2A,regulatory subunit B56 alpha isoform,expressed in cardiac and skeletal muscle

Phenotypes From GWAS Catalog for PPP2R5A Gene

Gene Ontology (GO) - Molecular Function for PPP2R5A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004721 phosphoprotein phosphatase activity IDA 24157919
GO:0005488 binding IEA --
GO:0005515 protein binding IPI 7592815
GO:0019888 protein phosphatase regulator activity TAS,IEA --
GO:0019900 kinase binding IPI 21075214
genes like me logo Genes that share ontologies with PPP2R5A: view
genes like me logo Genes that share phenotypes with PPP2R5A: view

Animal Model Products

miRNA for PPP2R5A Gene

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PPP2R5A Gene

Localization for PPP2R5A Gene

Subcellular locations from UniProtKB/Swiss-Prot for PPP2R5A Gene

Cytoplasm. Nucleus. Chromosome, centromere. Note=From mitotic prophase to metaphase, localizes at the inner centromere between a pair of sister kinetochores. Decreased expression at the onset of anaphase. {ECO:0000269 PubMed:16541025}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PPP2R5A gene
Compartment Confidence
cytoskeleton 5
cytosol 5
nucleus 4
extracellular 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for PPP2R5A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000159 protein phosphatase type 2A complex IDA 17245430
GO:0000775 chromosome, centromeric region IEA --
GO:0005634 nucleus IEA --
GO:0005694 chromosome IEA --
GO:0005737 cytoplasm IDA,TAS 21075214
genes like me logo Genes that share ontologies with PPP2R5A: view

Pathways & Interactions for PPP2R5A Gene

SuperPathways for PPP2R5A Gene

SuperPathway Contained pathways
1 RET signaling
2 phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex
3 PI3K/AKT activation
4 Beta-Adrenergic Signaling
5 p70S6K Signaling
genes like me logo Genes that share pathways with PPP2R5A: view

SIGNOR curated interactions for PPP2R5A Gene

Activates:
Is activated by:

Gene Ontology (GO) - Biological Process for PPP2R5A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006470 protein dephosphorylation IDA 24157919
GO:0007165 signal transduction IEA --
GO:0035307 positive regulation of protein dephosphorylation IMP 21075214
GO:0043666 regulation of phosphoprotein phosphatase activity IEA --
GO:0090219 negative regulation of lipid kinase activity IMP 21075214
genes like me logo Genes that share ontologies with PPP2R5A: view

Drugs & Compounds for PPP2R5A Gene

No Compound Related Data Available

Transcripts for PPP2R5A Gene

mRNA/cDNA for PPP2R5A Gene

Unigene Clusters for PPP2R5A Gene

Protein phosphatase 2, regulatory subunit B, alpha:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for PPP2R5A Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13
SP1:
SP2: -

Relevant External Links for PPP2R5A Gene

GeneLoc Exon Structure for
PPP2R5A
ECgene alternative splicing isoforms for
PPP2R5A

Expression for PPP2R5A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PPP2R5A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for PPP2R5A Gene

This gene is overexpressed in Peripheral blood mononuclear cells (10.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for PPP2R5A Gene



Protein tissue co-expression partners for PPP2R5A Gene

NURSA nuclear receptor signaling pathways regulating expression of PPP2R5A Gene:

PPP2R5A

SOURCE GeneReport for Unigene cluster for PPP2R5A Gene:

Hs.744012

mRNA Expression by UniProt/SwissProt for PPP2R5A Gene:

Q15172-2A5A_HUMAN
Tissue specificity: Widely expressed with the highest expression in heart and skeletal muscle.

Evidence on tissue expression from TISSUES for PPP2R5A Gene

  • Nervous system(4.6)
  • Liver(4.3)
genes like me logo Genes that share expression patterns with PPP2R5A: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for PPP2R5A Gene

Orthologs for PPP2R5A Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PPP2R5A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PPP2R5A 34 33
  • 99.4 (n)
OneToOne
dog
(Canis familiaris)
Mammalia PPP2R5A 34 33
  • 96.77 (n)
OneToOne
cow
(Bos Taurus)
Mammalia PPP2R5A 34 33
  • 96.28 (n)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PPP2R5A 34
  • 94 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PPP2R5A 34
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ppp2r5a 16 34 33
  • 91.81 (n)
rat
(Rattus norvegicus)
Mammalia Ppp2r5a 33
  • 90.6 (n)
chicken
(Gallus gallus)
Aves PPP2R5A 34 33
  • 87.97 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PPP2R5A 34
  • 84 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ppp2r5a 33
  • 81.76 (n)
Str.7303 33
zebrafish
(Danio rerio)
Actinopterygii ppp2r5a 34 33
  • 71.82 (n)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta BcDNA:LD34343 35
  • 79 (a)
wdb 34
  • 66 (a)
OneToMany
PP2A-B' 35
  • 65 (a)
worm
(Caenorhabditis elegans)
Secernentea W08G11.4 35
  • 66 (a)
pptr-1 34
  • 58 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RTS1 34
  • 32 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G21650 33
  • 56.03 (n)
rice
(Oryza sativa)
Liliopsida Os08g0122000 33
  • 57.18 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 50 (a)
ManyToMany
Species where no ortholog for PPP2R5A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PPP2R5A Gene

ENSEMBL:
Gene Tree for PPP2R5A (if available)
TreeFam:
Gene Tree for PPP2R5A (if available)
Aminode:
Evolutionary constrained regions (ECRs) for PPP2R5A: view image

Paralogs for PPP2R5A Gene

Paralogs for PPP2R5A Gene

(4) SIMAP similar genes for PPP2R5A Gene using alignment to 1 proteins:

  • 2A5A_HUMAN
genes like me logo Genes that share paralogs with PPP2R5A: view

Variants for PPP2R5A Gene

Sequence variations from dbSNP and Humsavar for PPP2R5A Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000014943 -- 212,341,226(+) C/T intron_variant
rs1000032992 -- 212,296,234(+) A/C genic_upstream_transcript_variant, intron_variant
rs1000049739 -- 212,290,203(+) T/G genic_upstream_transcript_variant, intron_variant
rs1000108083 -- 212,346,557(+) T/C intron_variant
rs1000201381 -- 212,314,842(+) A/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for PPP2R5A Gene

Variant ID Type Subtype PubMed ID
dgv259n106 CNV deletion 24896259
dgv7n6 CNV deletion 16902084
dgv804n54 CNV loss 21841781
dgv805n54 CNV gain+loss 21841781
dgv806n54 CNV gain 21841781
esv1467950 CNV deletion 17803354
esv2411059 CNV deletion 18987734
esv2464712 CNV deletion 19546169
esv2671226 CNV deletion 23128226
esv2722473 CNV deletion 23290073
esv2722484 CNV deletion 23290073
esv27948 CNV loss 19812545
esv2847791 CNV deletion 24192839
esv3546133 CNV deletion 23714750
esv3588749 CNV loss 21293372
esv7385 CNV loss 19470904
esv990359 CNV deletion 20482838
nsv1068478 CNV deletion 25765185
nsv1110034 CNV deletion 24896259
nsv1142791 CNV deletion 24896259
nsv4454 CNV insertion 18451855
nsv511729 CNV loss 21212237
nsv549139 CNV gain 21841781
nsv549140 CNV loss 21841781
nsv945282 CNV duplication 23825009
nsv952077 CNV duplication 24416366
nsv954209 CNV deletion 24416366

Variation tolerance for PPP2R5A Gene

Residual Variation Intolerance Score: 18.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.06; 37.77% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PPP2R5A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PPP2R5A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PPP2R5A Gene

Disorders for PPP2R5A Gene

MalaCards: The human disease database

(1) MalaCards diseases for PPP2R5A Gene - From: DISEASES

Disorder Aliases PubMed IDs
cardiomyopathy, dilated, 1d
  • cmd1d
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for PPP2R5A

genes like me logo Genes that share disorders with PPP2R5A: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PPP2R5A Gene

Publications for PPP2R5A Gene

  1. Identification of a new family of protein phosphatase 2A regulatory subunits. (PMID: 7592815) McCright B … Virshup DM (The Journal of biological chemistry 1995) 2 3 4 58
  2. Shugoshin collaborates with protein phosphatase 2A to protect cohesin. (PMID: 16541025) Kitajima TS … Watanabe Y (Nature 2006) 3 4 58
  3. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4 58
  4. Screening and identification of proteins interacting with nucleostemin. (PMID: 16097049) Yang HX … Shou CC (World journal of gastroenterology 2005) 3 22 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58

Products for PPP2R5A Gene

Sources for PPP2R5A Gene