Aliases for PPP2R5A Gene
External Ids for PPP2R5A Gene
Previous GeneCards Identifiers for PPP2R5A Gene
The product of this gene belongs to the phosphatase 2A regulatory subunit B family. Protein phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might modulate substrate selectivity and catalytic activity. This gene encodes an alpha isoform of the regulatory subunit B56 subfamily. Alternative transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Dec 2010]
GeneCards Summary for PPP2R5A Gene
PPP2R5A (Protein Phosphatase 2 Regulatory Subunit B'Alpha) is a Protein Coding gene. Diseases associated with PPP2R5A include Cardiac Arrhythmia, Ankyrin-B-Related and Cardiomyopathy, Dilated, 1D. Among its related pathways are RET signaling and S37 mutants of beta-catenin arent phosphorylated. Gene Ontology (GO) annotations related to this gene include binding. An important paralog of this gene is PPP2R5E.
UniProtKB/Swiss-Prot Summary for PPP2R5A Gene
The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.