Free for academic non-profit institutions. Other users need a Commercial license

Aliases for PPP2R3C Gene

Aliases for PPP2R3C Gene

  • Protein Phosphatase 2 Regulatory Subunit B''Gamma 2 3
  • Protein Phosphatase 2 (Formerly 2A), Regulatory Subunit B 2 3
  • Protein Phosphatase Subunit G5PR 3 4
  • C14orf10 3 4
  • Serine/Threonine-Protein Phosphatase 2A Regulatory Subunit B Subunit Gamma 3
  • Protein Phosphatase 2, Regulatory Subunit B, Gamma 3
  • Protein Phosphatase 2 Regulatory Subunit Bgamma 5
  • Rhabdomyosarcoma Antigen MU-RMS-40.6A/6C 4
  • Rhabdomyosarcoma Antigen MU-RMS-40.6A 3
  • Rhabdomyosarcoma Antigen Mu-RMS-40.6C 3
  • Chromosome 14 Open Reading Frame 10 2
  • G4-1 3
  • G5pr 3
  • G5PR 4

External Ids for PPP2R3C Gene

Previous HGNC Symbols for PPP2R3C Gene

  • C14orf10

Previous GeneCards Identifiers for PPP2R3C Gene

  • GC14M034625
  • GC14M035554
  • GC14M015667

Summaries for PPP2R3C Gene

Entrez Gene Summary for PPP2R3C Gene

  • This gene encodes a regulatory subunit of the serine/threonine phosphatase, protein phosphatase 2. This protein is localized to both nuclear and cytoplasmic regions depending on cell cycle phase. Homozygous conditional knockout mice for this gene exhibit reduced numbers and impaired proliferation of immune system B cells. This protein may regulate the expression of the P-glycoprotein ATP-binding cassette transporter through its phosphatase activity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2015]

GeneCards Summary for PPP2R3C Gene

PPP2R3C (Protein Phosphatase 2 Regulatory Subunit B''Gamma) is a Protein Coding gene. Diseases associated with PPP2R3C include Holoprosencephaly. Among its related pathways are AMP-activated Protein Kinase (AMPK) Signaling and Aldosterone synthesis and secretion. Gene Ontology (GO) annotations related to this gene include calcium ion binding. An important paralog of this gene is PPP2R3A.

UniProtKB/Swiss-Prot for PPP2R3C Gene

  • May regulate MCM3AP phosphorylation through phosphatase recruitment. May act as a negative regulator of ABCB1 expression and function through the dephosphorylation of ABCB1 by TFPI2/PPP2R3C complex. May play a role in the activation-induced cell death of B-cells.

Tocris Summary for PPP2R3C Gene

  • Protein Ser/Thr phosphatases are a group of enzymes that catalyze the removal of phosphate groups from serine and/or threonine residues by hydrolysis of phosphoric acid monoesters. They oppose the action of kinases and phosphorylases and are involved in signal transduction.

Gene Wiki entry for PPP2R3C Gene

Additional gene information for PPP2R3C Gene

No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PPP2R3C Gene

Genomics for PPP2R3C Gene

GeneHancer (GH) Regulatory Elements for PPP2R3C Gene

Promoters and enhancers for PPP2R3C Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH14J035120 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 682.8 +0.1 75 3.8 CLOCK ZFP64 DMAP1 IRF4 YY1 SLC30A9 E2F8 ZNF143 SP3 NFYC PPP2R3C KIAA0391 ENSG00000258790 RPS19P3 EAPP NFKBIA FAM177A1 BAZ1A
GH14J035044 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 28.3 +75.8 75840 3.5 HDGF FOXA2 SMAD1 MLX ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 FAM177A1 PPP2R3C EAPP RPS19P3 RALGAPA1 RNU1-27P BAZ1A LOC101927178
GH14J035291 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 21.7 -170.9 -170895 5.5 HDGF PKNOX1 MLX ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 PSMA6 GC14P035292 GC14P035293 PPP2R3C EAPP RPS19P3 NFKBIA FAM177A1 KIAA0391 RALGAPA1
GH14J035330 Enhancer 1.8 FANTOM5 Ensembl ENCODE dbSUPER 20.5 -214.4 -214423 12.3 PKNOX1 FOXA2 MLX ZFP64 ARID4B NEUROD1 SIN3A DMAP1 YY1 SLC30A9 GC14P035335 PSMA6 NFKBIA BAZ1A PPP2R3C EAPP FAM177A1 RPS19P3 SPTSSA KIAA0391
GH14J035049 Enhancer 1.1 Ensembl ENCODE 31.9 +72.0 71978 1.2 PKNOX1 FOXA2 ARNT ARID4B ZNF48 YY1 ATF7 RXRA REST ZNF592 PPP2R3C EAPP RNU1-27P FAM177A1 LOC101927178
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PPP2R3C on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the PPP2R3C gene promoter:
  • C/EBPbeta
  • PPAR-gamma2
  • PPAR-gamma1
  • AML1a
  • Olf-1
  • LCR-F1
  • SRY
  • CUTL1
  • TBP

Genomic Locations for PPP2R3C Gene

Genomic Locations for PPP2R3C Gene
37,051 bases
Minus strand
37,051 bases
Minus strand

Genomic View for PPP2R3C Gene

Genes around PPP2R3C on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PPP2R3C Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PPP2R3C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PPP2R3C Gene

Proteins for PPP2R3C Gene

  • Protein details for PPP2R3C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Serine/threonine-protein phosphatase 2A regulatory subunit B subunit gamma
    Protein Accession:
    Secondary Accessions:
    • B4DEN7
    • D3DS97
    • D3DS98
    • Q5GJ55
    • Q5GJ56
    • Q6P4G2
    • Q86TZ3
    • Q9NWR9

    Protein attributes for PPP2R3C Gene

    453 amino acids
    Molecular mass:
    53316 Da
    Quaternary structure:
    • Interacts with MCM3AP/GANP. Interacts with PPP5C, and the phosphatase 2A core enzyme composed of the PPP2CA catalytic subunit and the constant regulatory subunit PPP2R1A. Finds in a complex with ABCB1, TFPI2 and PPP2R3C; leading to the dephosphorylation of ABCB1.
    • Sequence=AAT44532.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAT44533.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for PPP2R3C Gene


neXtProt entry for PPP2R3C Gene

Post-translational modifications for PPP2R3C Gene

  • Ubiquitination at posLast=341341
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for PPP2R3C Gene

Domains & Families for PPP2R3C Gene

Gene Families for PPP2R3C Gene

Protein Domains for PPP2R3C Gene

Suggested Antigen Peptide Sequences for PPP2R3C Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with PPP2R3C: view

No data available for UniProtKB/Swiss-Prot for PPP2R3C Gene

Function for PPP2R3C Gene

Molecular function for PPP2R3C Gene

UniProtKB/Swiss-Prot Function:
May regulate MCM3AP phosphorylation through phosphatase recruitment. May act as a negative regulator of ABCB1 expression and function through the dephosphorylation of ABCB1 by TFPI2/PPP2R3C complex. May play a role in the activation-induced cell death of B-cells.

Phenotypes From GWAS Catalog for PPP2R3C Gene

Gene Ontology (GO) - Molecular Function for PPP2R3C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with PPP2R3C: view
genes like me logo Genes that share phenotypes with PPP2R3C: view

Animal Model Products

miRNA for PPP2R3C Gene

miRTarBase miRNAs that target PPP2R3C

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PPP2R3C Gene

Localization for PPP2R3C Gene

Subcellular locations from UniProtKB/Swiss-Prot for PPP2R3C Gene

Nucleus. Cytoplasm. Note=Excluded from the nucleoli. Localization is cell cycle-dependent. Localizes to the cytoplasm during cytokinesis. {ECO:0000269 PubMed:15820313}.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PPP2R3C gene
Compartment Confidence
cytoskeleton 5
nucleus 5
cytosol 5
golgi apparatus 4

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleus (3)
  • Golgi apparatus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for PPP2R3C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005737 cytoplasm IEA --
GO:0005794 Golgi apparatus IDA --
GO:0005813 centrosome IDA 21399614
GO:0005819 spindle IBA --
genes like me logo Genes that share ontologies with PPP2R3C: view

Pathways & Interactions for PPP2R3C Gene

genes like me logo Genes that share pathways with PPP2R3C: view

Gene Ontology (GO) - Biological Process for PPP2R3C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000226 microtubule cytoskeleton organization IBA --
GO:0001782 B cell homeostasis IEA,IBA --
GO:0002759 regulation of antimicrobial humoral response IEA --
GO:0030865 cortical cytoskeleton organization IBA --
GO:0032147 activation of protein kinase activity IEA --
genes like me logo Genes that share ontologies with PPP2R3C: view

No data available for SIGNOR curated interactions for PPP2R3C Gene

Drugs & Compounds for PPP2R3C Gene

(3) Drugs for PPP2R3C Gene - From: Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Cyclosporin A Approved, Investigational, Vet_approved Pharma Antagonist, Inhibition, Inhibitor Immunosuppressant drug, Immunosuppressive agent, Calcineurin inhibitor 0
Calcineurin Autoinhibitory Peptide Pharma CaMKII inhibitor, Selective calcineurin inhibitor 0
INCA-6 Pharma Selective calcineurin-NFAT signaling inhibitor, Inhibitor of calcineurin-substrate association 0

(1) Additional Compounds for PPP2R3C Gene - From: Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
FK 506

(4) Tocris Compounds for PPP2R3C Gene

Compound Action Cas Number
Calcineurin Autoinhibitory Peptide Selective calcineurin inhibitor 148067-21-4
Cyclosporin A Calcineurin inhibitor 59865-13-3
FK 506 Potent calcineurin inhibitor; immunosuppressant 104987-11-3
INCA-6 Inhibitor of calcineurin-substrate association 3519-82-2
genes like me logo Genes that share compounds with PPP2R3C: view

Transcripts for PPP2R3C Gene

Unigene Clusters for PPP2R3C Gene

Protein phosphatase 2, regulatory subunit B, gamma:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for PPP2R3C Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3a · 3b · 3c ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13a · 13b ^ 14a · 14b
SP1: - - - - - - - -
SP2: - - - - - - -
SP3: - - - -
SP4: -
SP5: - -
SP6: - - - - - -
SP9: - - - -

Relevant External Links for PPP2R3C Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PPP2R3C Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PPP2R3C Gene

Protein differential expression in normal tissues from HIPED for PPP2R3C Gene

This gene is overexpressed in Testis (30.3), Fetal heart (25.3), and CD8 Tcells (6.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for PPP2R3C Gene

Protein tissue co-expression partners for PPP2R3C Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of PPP2R3C Gene:


SOURCE GeneReport for Unigene cluster for PPP2R3C Gene:


mRNA Expression by UniProt/SwissProt for PPP2R3C Gene:

Tissue specificity: Ubiquitously expressed in brain and other tissues.

Evidence on tissue expression from TISSUES for PPP2R3C Gene

  • Nervous system(4.8)
  • Bone marrow(4.3)
  • Adrenal gland(2.6)
  • Pancreas(2.4)
genes like me logo Genes that share expression patterns with PPP2R3C: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for PPP2R3C Gene

Orthologs for PPP2R3C Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PPP2R3C Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia PPP2R3C 34 33
  • 99.63 (n)
(Monodelphis domestica)
Mammalia PPP2R3C 34
  • 96 (a)
(Ornithorhynchus anatinus)
Mammalia PPP2R3C 34
  • 95 (a)
(Canis familiaris)
Mammalia PPP2R3C 34 33
  • 93.75 (n)
(Bos Taurus)
Mammalia PPP2R3C 34 33
  • 93.52 (n)
(Rattus norvegicus)
Mammalia Ppp2r3c 33
  • 90.43 (n)
(Mus musculus)
Mammalia Ppp2r3c 16 34 33
  • 90.29 (n)
(Gallus gallus)
Aves PPP2R3C 34 33
  • 82.15 (n)
(Anolis carolinensis)
Reptilia PPP2R3C 34
  • 89 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia ppp2r3c 33
  • 76.19 (n)
Str.17328 33
African clawed frog
(Xenopus laevis)
Amphibia MGC68494 33
(Danio rerio)
Actinopterygii ppp2r3c 34 33
  • 73.44 (n)
zgc55473 33
thale cress
(Arabidopsis thaliana)
eudicotyledons FASS 33
  • 50.23 (n)
(Oryza sativa)
Liliopsida Os05g0149800 33
  • 52 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 79 (a)
Cin.1229 33
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.1229 33
Species where no ortholog for PPP2R3C was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PPP2R3C Gene

Gene Tree for PPP2R3C (if available)
Gene Tree for PPP2R3C (if available)
Evolutionary constrained regions (ECRs) for PPP2R3C: view image

Paralogs for PPP2R3C Gene

Paralogs for PPP2R3C Gene

(1) SIMAP similar genes for PPP2R3C Gene using alignment to 11 proteins:

  • G3V228_HUMAN
  • G3V2K1_HUMAN
  • G3V3T9_HUMAN
  • G3V3V5_HUMAN
  • G3V561_HUMAN
  • G3V5U8_HUMAN
  • H0YJ16_HUMAN
  • H0YJV0_HUMAN Pseudogenes for PPP2R3C Gene

genes like me logo Genes that share paralogs with PPP2R3C: view

Variants for PPP2R3C Gene

Sequence variations from dbSNP and Humsavar for PPP2R3C Gene

SNP ID Clin Chr 14 pos Variation AA Info Type
rs1000017804 -- 35,096,319(-) A/G intron_variant
rs1000137131 -- 35,109,214(-) G/A intron_variant
rs1000215315 -- 35,109,783(-) C/G intron_variant
rs1000275881 -- 35,086,065(-) T/C genic_downstream_transcript_variant, intron_variant
rs1000289957 -- 35,090,860(-) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for PPP2R3C Gene

Variant ID Type Subtype PubMed ID
dgv1868n100 CNV gain 25217958
esv3584249 CNV gain 25503493
esv3892499 CNV loss 25118596
nsv1042625 CNV gain 25217958
nsv564263 CNV loss 21841781
nsv564264 CNV gain 21841781
nsv564265 CNV loss 21841781

Variation tolerance for PPP2R3C Gene

Residual Variation Intolerance Score: 26.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.52; 11.23% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PPP2R3C Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PPP2R3C Gene

Disorders for PPP2R3C Gene

MalaCards: The human disease database

(1) MalaCards diseases for PPP2R3C Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
  • holoprosencephaly sequence
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for PPP2R3C

genes like me logo Genes that share disorders with PPP2R3C: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PPP2R3C Gene

Publications for PPP2R3C Gene

  1. MCM3-binding GANP DNA-primase is associated with a novel phosphatase component G5PR. (PMID: 12167160) Kono Y … Sakaguchi N (Genes to cells : devoted to molecular & cellular mechanisms 2002) 2 3 4 58
  2. Protein phosphatase complex PP5/PPP2R3C dephosphorylates P-glycoprotein/ABCB1 and down-regulates the expression and function. (PMID: 24333728) Katayama K … Sugimoto Y (Cancer letters 2014) 3 4 58
  3. Protein phosphatase subunit G5PR is needed for inhibition of B cell receptor-induced apoptosis. (PMID: 16129705) Xing Y … Sakaguchi N (The Journal of experimental medicine 2005) 2 3 58
  4. Defining a holoprosencephaly locus on human chromosome 14q13 and characterization of potential candidate genes. (PMID: 15820313) Kamnasaran D … Cox DW (Genomics 2005) 3 4 58
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58

Products for PPP2R3C Gene

Sources for PPP2R3C Gene

Loading form....