Protein phosphatase 2 (formerly named type 2A) is one of the four major Ser/Thr phosphatases and is implicated in the negative control of cell growth and division. Protein phosphatase 2 holoenzymes are heterotrimeric proteins composed of a structural subunit A, a catalytic subunit C, and a regulatory subunit B. The regulatory subunit is encoded by a diverse set of genes that ha... See more...

Aliases for PPP2R3B Gene

Aliases for PPP2R3B Gene

  • Protein Phosphatase 2 Regulatory Subunit B''Beta 2 3 5
  • Serine/Threonine-Protein Phosphatase 2A Regulatory Subunit B'' Subunit Beta 3 4
  • Protein Phosphatase 2 (Formerly 2A), Regulatory Subunit B'', Beta 2 3
  • PPP2R3LY 2 3
  • PPP2R3L 3 4
  • PR48 2 3
  • PR70 2 3
  • Serine/Threonine Protein Phosphatase 2A, 48kDa Regulatory Subunit B 3
  • Protein Phosphatase 2, Regulatory Subunit B'', Beta 3
  • Protein Phosphatase 2A 48 KDa Regulatory Subunit 4
  • PP2A, Subunit B, PR48 Isoform 3
  • PP2A Subunit B Isoform PR48 4
  • NY-REN-8 Antigen 3
  • PPP2R3B 5
  • NYREN8 3

External Ids for PPP2R3B Gene

Previous HGNC Symbols for PPP2R3B Gene

  • PPP2R3L

Previous GeneCards Identifiers for PPP2R3B Gene

  • GC00U991190
  • GC0YU900001
  • GC0XM000264

Summaries for PPP2R3B Gene

Entrez Gene Summary for PPP2R3B Gene

  • Protein phosphatase 2 (formerly named type 2A) is one of the four major Ser/Thr phosphatases and is implicated in the negative control of cell growth and division. Protein phosphatase 2 holoenzymes are heterotrimeric proteins composed of a structural subunit A, a catalytic subunit C, and a regulatory subunit B. The regulatory subunit is encoded by a diverse set of genes that have been grouped into the B/PR55, B'/PR61, and B''/PR72 families. These different regulatory subunits confer distinct enzymatic specificities and intracellular localizations to the holozenzyme. The product of this gene belongs to the B'' family. The B'' family has been further divided into subfamilies. The product of this gene belongs to the beta subfamily of regulatory subunit B''. [provided by RefSeq, Apr 2010]

GeneCards Summary for PPP2R3B Gene

PPP2R3B (Protein Phosphatase 2 Regulatory Subunit B''Beta) is a Protein Coding gene. Diseases associated with PPP2R3B include Alzheimer Disease 15 and Adjustment Disorder. Among its related pathways are Signal transduction_PKA signaling and p70S6K Signaling. Gene Ontology (GO) annotations related to this gene include calcium ion binding and protein serine/threonine phosphatase activity. An important paralog of this gene is PPP2R3A.

UniProtKB/Swiss-Prot Summary for PPP2R3B Gene

  • The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.

Tocris Summary for PPP2R3B Gene

  • Protein Ser/Thr phosphatases are a group of enzymes that catalyze the removal of phosphate groups from serine and/or threonine residues by hydrolysis of phosphoric acid monoesters. They oppose the action of kinases and phosphorylases and are involved in signal transduction.

Gene Wiki entry for PPP2R3B Gene

Additional gene information for PPP2R3B Gene

No data available for CIViC Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PPP2R3B Gene

Genomics for PPP2R3B Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for PPP2R3B Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH0XJ000385 Promoter 1.5 Ensembl CraniofacialAtlas 600.7 +0.4 426 2.6 BRCA1 HNRNPL CREB1 GATAD2A ATF7 ZNF629 TFE3 IKZF1 NFKBIZ ZNF692 ENSG00000275287 ENSG00000281849 PPP2R3B piR-32287-167 piR-52832 GTPBP6
GH0XJ000438 Enhancer 0.3 Ensembl 12.6 -50.8 -50774 0.2 RAD21 EZH2 PPP2R3B piR-33863-161 piR-35002-161 LOC102724521 SHOX
GH0XJ000437 Enhancer 0.3 CraniofacialAtlas 12.6 -50.3 -50339 0.4 RAD21 EZH2 PPP2R3B piR-33863-161 piR-35002-161 LOC102724521 lnc-PLCXD1-3 SHOX
GH0XJ000439 Enhancer 0.2 Ensembl 12.6 -51.2 -51174 0.2 PPP2R3B piR-33863-161 piR-35002-161 LOC102724521 SHOX
GH0XJ000372 Promoter/Enhancer 1.4 Ensembl CraniofacialAtlas dbSUPER 0.4 +14.6 14626 4.6 RBFOX2 EZH2 SCRT2 KMT2B MGA ZFX ZBTB20 TCF7 CTBP1 USF1 GTPBP6 LINC00685 piR-52832 PPP2R3B ENSG00000281849
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PPP2R3B on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for PPP2R3B

Top Transcription factor binding sites by QIAGEN in the PPP2R3B gene promoter:
  • CUTL1
  • PPAR-alpha
  • RP58
  • STAT5A
  • YY1

Genomic Locations for PPP2R3B Gene

Genomic Locations for PPP2R3B Gene
chrX:333,933-387,327
(GRCh38/hg38)
Size:
53,395 bases
Orientation:
Minus strand
chrX:294,668-347,690
(GRCh37/hg19)
Size:
53,023 bases
Orientation:
Minus strand

Genomic View for PPP2R3B Gene

Genes around PPP2R3B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PPP2R3B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PPP2R3B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PPP2R3B Gene

Proteins for PPP2R3B Gene

  • Protein details for PPP2R3B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y5P8-P2R3B_HUMAN
    Recommended name:
    Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta
    Protein Accession:
    Q9Y5P8
    Secondary Accessions:
    • Q6P4G9
    • Q7RTT1
    • Q96H01

    Protein attributes for PPP2R3B Gene

    Size:
    575 amino acids
    Molecular mass:
    65061 Da
    Quaternary structure:
    • PP2A consists of a common heterodimeric core enzyme, composed of a 36 kDa catalytic subunit (subunit C) and a 65 kDa constant regulatory subunit (PR65 or subunit A), that associates with a variety of regulatory subunits. Proteins that associate with the core dimer include three families of regulatory subunits B (the R2/B/PR55/B55, R3/B''/PR72/PR130/PR59 and R5/B'/B56 families), the 48 kDa variable regulatory subunit, viral proteins, and cell signaling molecules. Interacts with N-terminal region of CDC6. Interacts with NOD2 (PubMed:27812135).
    SequenceCaution:
    • Sequence=AAD38515.1; Type=Erroneous initiation; Evidence={ECO:0000305};
    Miscellaneous:
    • The gene coding for this protein is located in the pseudoautosomal region 1 (PAR1) of X and Y chromosomes.

    Three dimensional structures from OCA and Proteopedia for PPP2R3B Gene

    Alternative splice isoforms for PPP2R3B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PPP2R3B Gene

Post-translational modifications for PPP2R3B Gene

  • Ubiquitination at Lys170 and Lys179
  • Modification sites at PhosphoSitePlus

Other Protein References for PPP2R3B Gene

No data available for DME Specific Peptides for PPP2R3B Gene

Domains & Families for PPP2R3B Gene

Protein Domains for PPP2R3B Gene

Suggested Antigen Peptide Sequences for PPP2R3B Gene

GenScript: Design optimal peptide antigens:
  • Protein phosphatase 2A 48 kDa regulatory subunit (P2R3B_HUMAN)
  • PPP2R3B protein (Q96FD8_HUMAN)
genes like me logo Genes that share domains with PPP2R3B: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for PPP2R3B Gene

Function for PPP2R3B Gene

Molecular function for PPP2R3B Gene

UniProtKB/Swiss-Prot Function:
The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.

Gene Ontology (GO) - Molecular Function for PPP2R3B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005509 calcium ion binding IEA --
GO:0005515 protein binding IPI 9847399
GO:0019888 protein phosphatase regulator activity TAS,ISS --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with PPP2R3B: view
genes like me logo Genes that share phenotypes with PPP2R3B: view

Animal Model Products

CRISPR Products

miRNA for PPP2R3B Gene

miRTarBase miRNAs that target PPP2R3B

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PPP2R3B

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PPP2R3B Gene

Localization for PPP2R3B Gene

Subcellular locations from UniProtKB/Swiss-Prot for PPP2R3B Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PPP2R3B gene
Compartment Confidence
nucleus 4
cytosol 2
plasma membrane 1
extracellular 1
cytoskeleton 1
mitochondrion 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for PPP2R3B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000159 protein phosphatase type 2A complex IBA,ISS --
GO:0005634 nucleus TAS 10629059
GO:0005654 nucleoplasm TAS --
genes like me logo Genes that share ontologies with PPP2R3B: view

Pathways & Interactions for PPP2R3B Gene

PathCards logo

SuperPathways for PPP2R3B Gene

SuperPathway Contained pathways
1 Cyclins and Cell Cycle Regulation
.67
.36
.31
2 Beta-Adrenergic Signaling
.37
.37
.37
3 p70S6K Signaling
.60
.60
.54
4 PI3K-Akt signaling pathway
5 ERK Signaling
.61
.49
genes like me logo Genes that share pathways with PPP2R3B: view

Pathways by source for PPP2R3B Gene

4 GeneGo (Thomson Reuters) pathways for PPP2R3B Gene
  • Cell cycle Regulation of G1/S transition (part 1)
  • Neurophysiological process Glutamate regulation of Dopamine D1A receptor signaling
  • Regulation of CFTR activity (norm and CF)
  • Signal transduction_PKA signaling
25 Qiagen pathways for PPP2R3B Gene
  • Akt Signaling
  • BAD Phosphorylation
  • Beta-Adrenergic Signaling
  • Breast Cancer Regulation by Stathmin1
  • CDK5 Pathway

Gene Ontology (GO) - Biological Process for PPP2R3B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006470 protein dephosphorylation IBA,ISS --
GO:0007050 cell cycle arrest TAS 10629059
GO:0043666 regulation of phosphoprotein phosphatase activity IEA --
genes like me logo Genes that share ontologies with PPP2R3B: view

No data available for SIGNOR curated interactions for PPP2R3B Gene

Drugs & Compounds for PPP2R3B Gene

(5) Drugs for PPP2R3B Gene - From: HMDB and Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Water Approved Pharma 0
Cyclosporin A Approved, Investigational, Vet_approved Pharma Antagonist, Inhibitor, Inhibition Immunosuppressive agent, Calcineurin inhibitor 0
Calcium Nutra 6556
Calcineurin Autoinhibitory Peptide Pharma CaMKII inhibitor, Selective calcineurin inhibitor 0
INCA-6 Pharma Selective calcineurin-NFAT signaling inhibitor, Inhibitor of calcineurin-substrate association 0

(2) Additional Compounds for PPP2R3B Gene - From: HMDB and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Phosphate
  • [po(OH)3]
  • Acide phosphorique
  • Acidum phosphoricum
  • H3PO4
  • Orthophosphoric acid
14066-19-4, 14265-44-2
FK 506
104987-11-3

(4) Tocris Compounds for PPP2R3B Gene

Compound Action Cas Number
Calcineurin Autoinhibitory Peptide Selective calcineurin inhibitor 148067-21-4
Cyclosporin A Calcineurin inhibitor 59865-13-3
FK 506 Potent calcineurin inhibitor; immunosuppressant 104987-11-3
INCA-6 Inhibitor of calcineurin-substrate association 3519-82-2
genes like me logo Genes that share compounds with PPP2R3B: view

Transcripts for PPP2R3B Gene

mRNA/cDNA for PPP2R3B Gene

2 REFSEQ mRNAs :
18 NCBI additional mRNA sequence :
10 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PPP2R3B

Alternative Splicing Database (ASD) splice patterns (SP) for PPP2R3B Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14
SP1: - -
SP2:
SP3: -
SP4:
SP5:
SP6:

Relevant External Links for PPP2R3B Gene

GeneLoc Exon Structure for
PPP2R3B

Expression for PPP2R3B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PPP2R3B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for PPP2R3B Gene

This gene is overexpressed in Fetal Liver (57.5) and Testis (11.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for PPP2R3B Gene



Protein tissue co-expression partners for PPP2R3B Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for PPP2R3B

SOURCE GeneReport for Unigene cluster for PPP2R3B Gene:

Hs.124942

Evidence on tissue expression from TISSUES for PPP2R3B Gene

  • Nervous system(4.4)
  • Muscle(2.2)
  • Heart(2.2)
genes like me logo Genes that share expression patterns with PPP2R3B: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PPP2R3B Gene

Orthologs for PPP2R3B Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PPP2R3B Gene

Organism Taxonomy Gene Similarity Type Details
Cow
(Bos Taurus)
Mammalia PPP2R3B 31
  • 89 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia -- 31
  • 86 (a)
OneToMany
PPP2R3B 30
  • 84.42 (n)
-- 31
  • 82 (a)
OneToMany
Oppossum
(Monodelphis domestica)
Mammalia PPP2R3B 31
  • 78 (a)
OneToOne
Mouse
(Mus musculus)
Mammalia Gm20783 31
  • 74 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia PPP2R3B 31
  • 62 (a)
OneToOne
Chicken
(Gallus gallus)
Aves PPP2R3B 30 31
  • 68.29 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia PPP2R3B 31
  • 64 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia ppp2r3b 30
  • 63.24 (n)
Zebrafish
(Danio rerio)
Actinopterygii ppp2r3b 30 31
  • 64.55 (n)
OneToOne
Fruit Fly
(Drosophila melanogaster)
Insecta CG4733 30 31
  • 64.34 (n)
OneToMany
Worm
(Caenorhabditis elegans)
Secernentea C06G1.5 31
  • 27 (a)
OneToOne
Thale Cress
(Arabidopsis thaliana)
eudicotyledons AT5G44090 30
  • 46.45 (n)
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.1843 31
  • 52 (a)
OneToMany
Sea Vase
(Ciona intestinalis)
Ascidiacea Cin.1088 30
Species where no ortholog for PPP2R3B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for PPP2R3B Gene

ENSEMBL:
Gene Tree for PPP2R3B (if available)
TreeFam:
Gene Tree for PPP2R3B (if available)
Aminode:
Evolutionary constrained regions (ECRs) for PPP2R3B: view image

Paralogs for PPP2R3B Gene

Paralogs for PPP2R3B Gene

(2) SIMAP similar genes for PPP2R3B Gene using alignment to 3 proteins:

  • P2R3B_HUMAN
  • C9JMU6_HUMAN
  • Q96FD8_HUMAN

Pseudogenes.org Pseudogenes for PPP2R3B Gene

genes like me logo Genes that share paralogs with PPP2R3B: view

Variants for PPP2R3B Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for PPP2R3B Gene

SNP ID Clinical significance and condition Chr 0X pos Variation AA Info Type
rs1133520 - p.Ala519Val
rs3813594 - p.Asp163Glu

Additional dbSNP identifiers (rs#s) for PPP2R3B Gene

Structural Variations from Database of Genomic Variants (DGV) for PPP2R3B Gene

Variant ID Type Subtype PubMed ID
esv25834 CNV gain+loss 19812545
esv2758854 CNV gain 17122850
esv27923 CNV loss 19812545
esv2970457 CNV duplication 24192839
esv2971568 CNV duplication 24192839
esv3237070 CNV deletion 24192839
esv3558398 CNV deletion 23714750
esv3558400 CNV deletion 23714750
nsv1075347 CNV deletion 25765185
nsv1077209 CNV deletion 25765185
nsv1077210 CNV deletion 25765185
nsv1077211 CNV deletion 25765185
nsv1115915 CNV duplication 24896259
nsv1119623 CNV deletion 24896259
nsv1122254 CNV deletion 24896259
nsv1122255 CNV deletion 24896259
nsv1133777 CNV deletion 24896259
nsv1141721 CNV duplication 24896259
nsv1146387 CNV duplication 26484159
nsv1152582 CNV duplication 26484159
nsv1153900 CNV duplication 26484159
nsv953716 CNV duplication 24416366
nsv955210 CNV duplication 24416366

Variation tolerance for PPP2R3B Gene

Residual Variation Intolerance Score: 80% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.66; 86.37% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PPP2R3B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PPP2R3B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PPP2R3B Gene

Disorders for PPP2R3B Gene

MalaCards: The human disease database

(2) MalaCards diseases for PPP2R3B Gene - From: DISEASES

Disorder Aliases PubMed IDs
alzheimer disease 15
  • ad15
adjustment disorder
  • adjustment disease
- elite association - COSMIC cancer census association via MalaCards
genes like me logo Genes that share disorders with PPP2R3B: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PPP2R3B Gene

Publications for PPP2R3B Gene

  1. PR48, a novel regulatory subunit of protein phosphatase 2A, interacts with Cdc6 and modulates DNA replication in human cells. (PMID: 10629059) Yan Z … Williams RS (Molecular and cellular biology 2000) 3 4 23
  2. Characterization and Genetic Analyses of New Genes Coding for NOD2 Interacting Proteins. (PMID: 27812135) Thiébaut R … Ollendorff V (PloS one 2016) 3 4
  3. Identification and characterization of B"-subunits of protein phosphatase 2 A in Xenopus laevis oocytes and adult tissues. (PMID: 12605688) Stevens I … Van Hoof C (European journal of biochemistry 2003) 3 4
  4. Elevated DNA sequence diversity in the genomic region of the phosphatase PPP2R3L gene in the human pseudoautosomal region. (PMID: 11173861) Schiebel K … Rappold G (Cytogenetics and cell genetics 2000) 2 3
  5. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3

Products for PPP2R3B Gene

  • Biorbyt antibodies for PPP2R3B
  • Signalway Proteins for PPP2R3B

Sources for PPP2R3B Gene