Aliases for PPP2R3B Gene
External Ids for PPP2R3B Gene
Previous HGNC Symbols for PPP2R3B Gene
Previous GeneCards Identifiers for PPP2R3B Gene
Protein phosphatase 2 (formerly named type 2A) is one of the four major Ser/Thr phosphatases and is implicated in the negative control of cell growth and division. Protein phosphatase 2 holoenzymes are heterotrimeric proteins composed of a structural subunit A, a catalytic subunit C, and a regulatory subunit B. The regulatory subunit is encoded by a diverse set of genes that have been grouped into the B/PR55, B'/PR61, and B''/PR72 families. These different regulatory subunits confer distinct enzymatic specificities and intracellular localizations to the holozenzyme. The product of this gene belongs to the B'' family. The B'' family has been further divided into subfamilies. The product of this gene belongs to the beta subfamily of regulatory subunit B''. [provided by RefSeq, Apr 2010]
GeneCards Summary for PPP2R3B Gene
PPP2R3B (Protein Phosphatase 2 Regulatory Subunit B''Beta) is a Protein Coding gene. Diseases associated with PPP2R3B include Alzheimer Disease 15 and Adjustment Disorder. Among its related pathways are Signal transduction_PKA signaling and p70S6K Signaling. Gene Ontology (GO) annotations related to this gene include calcium ion binding and protein serine/threonine phosphatase activity. An important paralog of this gene is PPP2R3A.
UniProtKB/Swiss-Prot Summary for PPP2R3B Gene
The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.
Protein Ser/Thr phosphatases are a group of enzymes that catalyze the removal of phosphate groups from serine and/or threonine residues by hydrolysis of phosphoric acid monoesters. They oppose the action of kinases and phosphorylases and are involved in signal transduction.