Aliases for PPP2R3A Gene
- PR72 2 3
- Protein Phosphatase 2 (Formerly 2A), Regulatory Subunit B'' (PR 72), Alpha Isoform And (PR 130), Beta Isoform 2
- Protein Phosphatase 2, Regulatory Subunit B'', Alpha 3
- PP2A Subunit B Isoforms B''-PR72/PR130 4
- PP2A Subunit B Isoform PR72/PR130 4
- PP2A Subunit B Isoform R3 Isoform 4
- PP2A Subunit B Isoforms B72/B130 4
- PPP2R3A 5
External Ids for PPP2R3A Gene
Previous HGNC Symbols for PPP2R3A Gene
Previous GeneCards Identifiers for PPP2R3A Gene
This gene encodes one of the regulatory subunits of the protein phosphatase 2. Protein phosphatase 2 (formerly named type 2A) is one of the four major Ser/Thr phosphatases and is implicated in the negative control of cell growth and division. Protein phosphatase 2 holoenzymes are heterotrimeric proteins composed of a structural subunit A, a catalytic subunit C, and a regulatory subunit B. The regulatory subunit is encoded by a diverse set of genes that have been grouped into the B/PR55, B'/PR61, and B''/PR72 families. These different regulatory subunits confer distinct enzymatic specificities and intracellular localizations to the holozenzyme. The product of this gene belongs to the B'' family. The B'' family has been further divided into subfamilies. The product of this gene belongs to the alpha subfamily of regulatory subunit B''. Alternative splicing results in multiple transcript variants encoding different isoforms.[provided by RefSeq, Jun 2010]
GeneCards Summary for PPP2R3A Gene
PPP2R3A (Protein Phosphatase 2 Regulatory Subunit B''Alpha) is a Protein Coding gene. Diseases associated with PPP2R3A include Ventricular Tachycardia, Catecholaminergic Polymorphic, 2 and Alzheimer Disease 15. Among its related pathways are Ceramide Pathway and Cyclins and Cell Cycle Regulation. Gene Ontology (GO) annotations related to this gene include calcium ion binding. An important paralog of this gene is PPP2R3B.
UniProtKB/Swiss-Prot Summary for PPP2R3A Gene
The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.
Protein Ser/Thr phosphatases are a group of enzymes that catalyze the removal of phosphate groups from serine and/or threonine residues by hydrolysis of phosphoric acid monoesters. They oppose the action of kinases and phosphorylases and are involved in signal transduction.