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Aliases for PPP2R3A Gene

Aliases for PPP2R3A Gene

  • Protein Phosphatase 2 Regulatory Subunit B''Alpha 2 3
  • Protein Phosphatase 2 (Formerly 2A), Regulatory Subunit B (PR 72), Alpha Isoform And (PR 130), Beta Isoform 2 3
  • Serine/Threonine-Protein Phosphatase 2A 72/130 KDa Regulatory Subunit B 3 4
  • PP2A Subunit B Isoforms B72/B130 3 4
  • PR130/Balpha1 Subunit 2 3
  • PR72/Balpha2 Subuit 2 3
  • PPP2R3 3 4
  • Serine/Threonine-Protein Phosphatase 2A Regulatory Subunit B Subunit Alpha 3
  • Protein Phosphatase 2, Regulatory Subunit B, Alpha 3
  • Protein Phosphatase 2 Regulatory Subunit Balpha 5
  • PP2A Subunit B Isoforms B-PR72/PR130 4
  • PP2A Subunit B Isoform PR72/PR130 4
  • PP2A Subunit B Isoform R3 Isoform 4
  • PP2A, Subunit B, R3 Isoform 3
  • PR130 3
  • PR72 3

External Ids for PPP2R3A Gene

Previous HGNC Symbols for PPP2R3A Gene

  • PPP2R3

Previous GeneCards Identifiers for PPP2R3A Gene

  • GC03P132624
  • GC03P136435
  • GC03P136966
  • GC03P137005
  • GC03P137167
  • GC03P135684
  • GC03P133062

Summaries for PPP2R3A Gene

Entrez Gene Summary for PPP2R3A Gene

  • This gene encodes one of the regulatory subunits of the protein phosphatase 2. Protein phosphatase 2 (formerly named type 2A) is one of the four major Ser/Thr phosphatases and is implicated in the negative control of cell growth and division. Protein phosphatase 2 holoenzymes are heterotrimeric proteins composed of a structural subunit A, a catalytic subunit C, and a regulatory subunit B. The regulatory subunit is encoded by a diverse set of genes that have been grouped into the B/PR55, B'/PR61, and B''/PR72 families. These different regulatory subunits confer distinct enzymatic specificities and intracellular localizations to the holozenzyme. The product of this gene belongs to the B'' family. The B'' family has been further divided into subfamilies. The product of this gene belongs to the alpha subfamily of regulatory subunit B''. Alternative splicing results in multiple transcript variants encoding different isoforms.[provided by RefSeq, Jun 2010]

GeneCards Summary for PPP2R3A Gene

PPP2R3A (Protein Phosphatase 2 Regulatory Subunit B''Alpha) is a Protein Coding gene. Among its related pathways are ERK Signaling and Akt Signaling. Gene Ontology (GO) annotations related to this gene include calcium ion binding. An important paralog of this gene is PPP2R3B.

UniProtKB/Swiss-Prot for PPP2R3A Gene

  • The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.

Tocris Summary for PPP2R3A Gene

  • Protein Ser/Thr phosphatases are a group of enzymes that catalyze the removal of phosphate groups from serine and/or threonine residues by hydrolysis of phosphoric acid monoesters. They oppose the action of kinases and phosphorylases and are involved in signal transduction.

Gene Wiki entry for PPP2R3A Gene

Additional gene information for PPP2R3A Gene

No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PPP2R3A Gene

Genomics for PPP2R3A Gene

GeneHancer (GH) Regulatory Elements for PPP2R3A Gene

Promoters and enhancers for PPP2R3A Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03J135963 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE 657.5 +0.3 281 3.9 KLF17 SIN3A ZNF2 ZNF335 GLIS2 EGR1 EGR2 SMARCA5 SP3 NR2F2 PPP2R3A LOC100420050 GC03P135691
GH03J136022 Promoter/Enhancer 0.9 EPDnew Ensembl 650.2 +57.2 57228 0.6 GATA3 ZNF26 PPP2R3A LOC100420050
GH03J136785 Enhancer 1 Ensembl ENCODE 5.7 +821.1 821058 2.3 RFX5 YY1 SMARCC2 RCOR1 FOS USF2 CEBPB ZNF592 NR2F2 ZNF148 ENSG00000242968 SLC35G2 NCK1 IL20RB IL20RB-AS1 ENSG00000273486 PPP2R3A GC03M136767
GH03J135990 Enhancer 0.7 Ensembl ENCODE 6.8 +26.2 26205 2.3 JUND PRDM6 POLR2A JUN FOSL2 FEZF1 FOS PPP2R3A LOC100420050
GH03J135973 Enhancer 0.6 Ensembl ENCODE 7.1 +8.6 8591 1.9 ZFP69B ZNF692 PPP2R3A LOC100420050 GC03P135691
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PPP2R3A on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the PPP2R3A gene promoter:
  • GATA-3
  • E2F
  • E2F-1
  • E2F-2
  • E2F-3a
  • E2F-4
  • E2F-5
  • E47
  • Hand1
  • FAC1

Genomic Locations for PPP2R3A Gene

Genomic Locations for PPP2R3A Gene
chr3:135,965,673-136,147,910
(GRCh38/hg38)
Size:
182,238 bases
Orientation:
Plus strand
chr3:135,684,515-135,866,752
(GRCh37/hg19)
Size:
182,238 bases
Orientation:
Plus strand

Genomic View for PPP2R3A Gene

Genes around PPP2R3A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PPP2R3A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PPP2R3A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PPP2R3A Gene

Proteins for PPP2R3A Gene

  • Protein details for PPP2R3A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q06190-P2R3A_HUMAN
    Recommended name:
    Serine/threonine-protein phosphatase 2A regulatory subunit B subunit alpha
    Protein Accession:
    Q06190
    Secondary Accessions:
    • A8KAE7
    • B4DNU1
    • B7ZAE3
    • Q06189
    • Q9NPQ5

    Protein attributes for PPP2R3A Gene

    Size:
    1150 amino acids
    Molecular mass:
    130278 Da
    Quaternary structure:
    • PP2A consists of a common heterodimeric core enzyme, composed of a 36 kDa catalytic subunit (subunit C) and a 65 kDa constant regulatory subunit (PR65 or subunit A), that associates with a variety of regulatory subunits. Proteins that associate with the core dimer include three families of regulatory subunits B (the R2/B/PR55/B55, R3/B/PR72/PR130/PR59 and R5/B/B56 families), the 48 kDa variable regulatory subunit, viral proteins, and cell signaling molecules.

    Three dimensional structures from OCA and Proteopedia for PPP2R3A Gene

    Alternative splice isoforms for PPP2R3A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PPP2R3A Gene

Post-translational modifications for PPP2R3A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for PPP2R3A Gene

Domains & Families for PPP2R3A Gene

Gene Families for PPP2R3A Gene

Protein Domains for PPP2R3A Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with PPP2R3A: view

No data available for UniProtKB/Swiss-Prot for PPP2R3A Gene

Function for PPP2R3A Gene

Molecular function for PPP2R3A Gene

UniProtKB/Swiss-Prot Function:
The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.

Phenotypes From GWAS Catalog for PPP2R3A Gene

Gene Ontology (GO) - Molecular Function for PPP2R3A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005509 calcium ion binding IEA --
GO:0005515 protein binding IPI 9847399
GO:0019888 protein phosphatase regulator activity TAS 8392071
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with PPP2R3A: view
genes like me logo Genes that share phenotypes with PPP2R3A: view

Animal Models for PPP2R3A Gene

MGI Knock Outs for PPP2R3A:

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PPP2R3A Gene

Localization for PPP2R3A Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PPP2R3A gene
Compartment Confidence
nucleus 3
cytosol 3
mitochondrion 2
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for PPP2R3A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000159 protein phosphatase type 2A complex ISS 1849734
genes like me logo Genes that share ontologies with PPP2R3A: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for PPP2R3A Gene

Pathways & Interactions for PPP2R3A Gene

genes like me logo Genes that share pathways with PPP2R3A: view

Gene Ontology (GO) - Biological Process for PPP2R3A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006470 protein dephosphorylation ISS 1849734
GO:0043666 regulation of phosphoprotein phosphatase activity IEA --
GO:0061053 somite development ISS 16567647
genes like me logo Genes that share ontologies with PPP2R3A: view

No data available for SIGNOR curated interactions for PPP2R3A Gene

Drugs & Compounds for PPP2R3A Gene

(3) Drugs for PPP2R3A Gene - From: Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Cyclosporin A Approved, Investigational, Vet_approved Pharma Antagonist, Inhibition, Inhibitor Immunosuppressant drug, Immunosuppressive agent, Calcineurin inhibitor 0
Calcineurin Autoinhibitory Peptide Pharma CaMKII inhibitor, Selective calcineurin inhibitor 0
INCA-6 Pharma Selective calcineurin-NFAT signaling inhibitor, Inhibitor of calcineurin-substrate association 0

(1) Additional Compounds for PPP2R3A Gene - From: Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
FK 506
104987-11-3

(4) Tocris Compounds for PPP2R3A Gene

Compound Action Cas Number
Calcineurin Autoinhibitory Peptide Selective calcineurin inhibitor 148067-21-4
Cyclosporin A Calcineurin inhibitor 59865-13-3
FK 506 Potent calcineurin inhibitor; immunosuppressant 104987-11-3
INCA-6 Inhibitor of calcineurin-substrate association 3519-82-2
genes like me logo Genes that share compounds with PPP2R3A: view

Transcripts for PPP2R3A Gene

Unigene Clusters for PPP2R3A Gene

Protein phosphatase 2, regulatory subunit B, alpha:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for PPP2R3A Gene

No ASD Table

Relevant External Links for PPP2R3A Gene

GeneLoc Exon Structure for
PPP2R3A
ECgene alternative splicing isoforms for
PPP2R3A

Expression for PPP2R3A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PPP2R3A Gene

mRNA differential expression in normal tissues according to GTEx for PPP2R3A Gene

This gene is overexpressed in Muscle - Skeletal (x6.6) and Heart - Left Ventricle (x4.9).

Protein differential expression in normal tissues from HIPED for PPP2R3A Gene

This gene is overexpressed in Neutrophil (20.0), Adrenal (18.8), Peripheral blood mononuclear cells (16.0), and Platelet (7.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for PPP2R3A Gene



Protein tissue co-expression partners for PPP2R3A Gene

NURSA nuclear receptor signaling pathways regulating expression of PPP2R3A Gene:

PPP2R3A

SOURCE GeneReport for Unigene cluster for PPP2R3A Gene:

Hs.518155

mRNA Expression by UniProt/SwissProt for PPP2R3A Gene:

Q06190-P2R3A_HUMAN
Tissue specificity: Expressed in heart, brain, placenta, lung, muscle and kidney.

Evidence on tissue expression from TISSUES for PPP2R3A Gene

  • Nervous system(4.3)
  • Lung(4.2)
genes like me logo Genes that share expression patterns with PPP2R3A: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for PPP2R3A Gene

Orthologs for PPP2R3A Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PPP2R3A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PPP2R3A 34 33
  • 99.71 (n)
OneToOne
dog
(Canis familiaris)
Mammalia PPP2R3A 34 33
  • 91.88 (n)
OneToOne
cow
(Bos Taurus)
Mammalia LOC787607 33
  • 91.04 (n)
PPP2R3A 34
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ppp2r3a 16 34 33
  • 87.5 (n)
rat
(Rattus norvegicus)
Mammalia Ppp2r3a 33
  • 87.27 (n)
oppossum
(Monodelphis domestica)
Mammalia PPP2R3A 34
  • 76 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PPP2R3A 34
  • 76 (a)
OneToOne
chicken
(Gallus gallus)
Aves PPP2R3A 34 33
  • 68.28 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PPP2R3A 34
  • 60 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ppp2r3a 33
  • 73.02 (n)
African clawed frog
(Xenopus laevis)
Amphibia LOC398609 33
zebrafish
(Danio rerio)
Actinopterygii LOC565849 33
  • 60.96 (n)
ppp2r3a 34
  • 54 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG4733 34 35
  • 35 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea C06G1.5 35 33
  • 50.6 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G28900 33
  • 54.21 (n)
rice
(Oryza sativa)
Liliopsida Os10g0476600 33
  • 52.33 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.1843 34
  • 57 (a)
OneToMany
Species where no ortholog for PPP2R3A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PPP2R3A Gene

ENSEMBL:
Gene Tree for PPP2R3A (if available)
TreeFam:
Gene Tree for PPP2R3A (if available)
Aminode:
Evolutionary constrained regions (ECRs) for PPP2R3A: view image

Paralogs for PPP2R3A Gene

Paralogs for PPP2R3A Gene

(2) SIMAP similar genes for PPP2R3A Gene using alignment to 6 proteins:

  • P2R3A_HUMAN
  • A0JLT3_HUMAN
  • A0PJH4_HUMAN
  • F6URX5_HUMAN
  • H7C1M1_HUMAN
  • Q6P0N9_HUMAN
genes like me logo Genes that share paralogs with PPP2R3A: view

Variants for PPP2R3A Gene

Sequence variations from dbSNP and Humsavar for PPP2R3A Gene

SNP ID Clin Chr 03 pos Variation AA Info Type
rs1000010131 -- 136,144,098(+) G/A genic_downstream_transcript_variant, intron_variant
rs1000022693 -- 135,973,966(+) T/C genic_upstream_transcript_variant, intron_variant
rs1000060470 -- 136,104,003(+) A/T genic_downstream_transcript_variant, intron_variant
rs1000080129 -- 135,977,174(+) G/T genic_upstream_transcript_variant, intron_variant
rs1000083902 -- 136,062,368(+) A/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for PPP2R3A Gene

Variant ID Type Subtype PubMed ID
esv2421767 CNV deletion 20811451
esv2669411 CNV deletion 23128226
esv3597878 CNV gain 21293372
esv3597881 CNV loss 21293372
nsv1123692 CNV deletion 24896259
nsv4023 CNV deletion 18451855
nsv4024 CNV insertion 18451855
nsv460860 CNV gain 19166990
nsv591829 CNV gain 21841781
nsv829732 CNV gain 17160897

Variation tolerance for PPP2R3A Gene

Residual Variation Intolerance Score: 79.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 11.39; 92.74% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PPP2R3A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PPP2R3A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PPP2R3A Gene

Disorders for PPP2R3A Gene

Additional Disease Information for PPP2R3A

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for PPP2R3A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PPP2R3A Gene

Publications for PPP2R3A Gene

  1. Structure and expression of a 72-kDa regulatory subunit of protein phosphatase 2A. Evidence for different size forms produced by alternative splicing. (PMID: 8392071) Hendrix P … Hemmings BA (The Journal of biological chemistry 1993) 2 3 4 22 58
  2. Diversity in genomic organisation, developmental regulation and distribution of the murine PR72/B" subunits of protein phosphatase 2A. (PMID: 18715506) Zwaenepoel K … Janssens V (BMC genomics 2008) 3 22 58
  3. HDAC1 and HDAC2 integrate checkpoint kinase phosphorylation and cell fate through the phosphatase-2A subunit PR130. (PMID: 29472538) Göder A … Krämer OH (Nature communications 2018) 3 58
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  5. Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators. (PMID: 27880917) St-Denis N … Gingras AC (Cell reports 2016) 3 58

Products for PPP2R3A Gene

Sources for PPP2R3A Gene

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