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Aliases for PPP2R2C Gene

Aliases for PPP2R2C Gene

  • Protein Phosphatase 2 Regulatory Subunit Bgamma 2 3 5
  • Protein Phosphatase 2 (Formerly 2A), Regulatory Subunit B (PR 52), Gamma Isoform 2 3
  • PP2A Subunit B Isoform Gamma 2 4
  • IMYPNO1 3 4
  • Serine/Threonine-Protein Phosphatase 2A 55 KDa Regulatory Subunit B Gamma Isoform 3
  • Gamma Isoform Of Regulatory Subunit B55, Protein Phosphatase 2 3
  • Phosphoprotein Phosphatase 2A BR Gamma Regulatory Chain 3
  • Protein Phosphatase 2, Regulatory Subunit B, Gamma 3
  • Protein Phosphatase 2A1 B Gamma Subunit 3
  • PP2A, Subunit B, PR55-Gamma Isoform 3
  • PP2A, Subunit B, B55-Gamma Isoform 3
  • PP2A, Subunit B, R2-Gamma Isoform 3
  • PP2A Subunit B Isoform PR55-Gamma 4
  • PP2A, Subunit B, B-Gamma Isoform 3
  • PP2A Subunit B Isoform B55-Gamma 4
  • PP2A Subunit B Isoform R2-Gamma 4
  • B55-GAMMA 3
  • B55gamma 3
  • IMYPNO 3
  • PR55G 3
  • PR52 3

External Ids for PPP2R2C Gene

Previous GeneCards Identifiers for PPP2R2C Gene

  • GC04M006220
  • GC04M006419
  • GC04M006317
  • GC04M006386
  • GC04M006441

Summaries for PPP2R2C Gene

Entrez Gene Summary for PPP2R2C Gene

  • The product of this gene belongs to the phosphatase 2 regulatory subunit B family. Protein phosphatase 2 is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might modulate substrate selectivity and catalytic activity. This gene encodes a gamma isoform of the regulatory subunit B55 subfamily. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

GeneCards Summary for PPP2R2C Gene

PPP2R2C (Protein Phosphatase 2 Regulatory Subunit Bgamma) is a Protein Coding gene. Among its related pathways are ERK Signaling and Akt Signaling. An important paralog of this gene is PPP2R2B.

UniProtKB/Swiss-Prot for PPP2R2C Gene

  • The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.

Tocris Summary for PPP2R2C Gene

  • Protein Ser/Thr phosphatases are a group of enzymes that catalyze the removal of phosphate groups from serine and/or threonine residues by hydrolysis of phosphoric acid monoesters. They oppose the action of kinases and phosphorylases and are involved in signal transduction.

Gene Wiki entry for PPP2R2C Gene

Additional gene information for PPP2R2C Gene

No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PPP2R2C Gene

Genomics for PPP2R2C Gene

GeneHancer (GH) Regulatory Elements for PPP2R2C Gene

Promoters and enhancers for PPP2R2C Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH04J006472 Promoter/Enhancer 0.8 EPDnew dbSUPER 650.2 +91.2 91234 0.1 ZBTB26 GC04P006472 PPP2R2C GC04P006459
GH04J006563 Promoter 0.7 EPDnew 650.7 +0.0 29 0.1 ZNF335 ZBTB8A EZH2 PPP2R2C GC04P006500
GH04J006564 Enhancer 0.6 FANTOM5 659.5 -0.9 -858 0.4 ZNF335 ZFHX2 KLF17 KLF7 ZNF398 EZH2 PPP2R2C TBC1D14 JAKMIP1 LOC105374365
GH04J006221 Enhancer 0.9 FANTOM5 ENCODE 25.4 +341.5 341505 0.4 SCRT1 SP3 HLF SIN3A ZNF335 SP1 ZFHX2 GLIS2 GLIS1 SCRT2 LOC105374364 PPP2R2C JAKMIP1 CRMP1 MRFAP1L1 PIR53262 LINC02495
GH04J006493 Enhancer 0.5 FANTOM5 28.6 +69.7 69690 0.1 MXI1 KLF1 PKNOX1 RFX1 POLR2A BMI1 PPP2R2C JAKMIP1 GC04P006499 GC04P006472
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PPP2R2C on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the PPP2R2C gene promoter:
  • AhR
  • GATA-1
  • Elk-1
  • Arnt
  • Ik-2
  • RP58
  • Ik-3
  • AML1a
  • deltaCREB
  • CREB

Genomic Locations for PPP2R2C Gene

Genomic Locations for PPP2R2C Gene
243,023 bases
Minus strand
243,023 bases
Minus strand

Genomic View for PPP2R2C Gene

Genes around PPP2R2C on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PPP2R2C Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PPP2R2C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PPP2R2C Gene

Proteins for PPP2R2C Gene

  • Protein details for PPP2R2C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B gamma isoform
    Protein Accession:
    Secondary Accessions:
    • A8MSY7
    • B7Z3Y1
    • Q7Z4V7
    • Q8NEC4
    • Q9H3G7

    Protein attributes for PPP2R2C Gene

    447 amino acids
    Molecular mass:
    51515 Da
    Quaternary structure:
    • PP2A consists of a common heterodimeric core enzyme, composed of a 36 kDa catalytic subunit (subunit C) and a 65 kDa constant regulatory subunit (PR65 or subunit A), that associates with a variety of regulatory subunits. Proteins that associate with the core dimer include three families of regulatory subunits B (the R2/B/PR55/B55, R3/B/PR72/PR130/PR59 and R5/B/B56 families), the 48 kDa variable regulatory subunit, viral proteins, and cell signaling molecules (By similarity). Interacts with IER5 (PubMed:25816751).

    Alternative splice isoforms for PPP2R2C Gene


neXtProt entry for PPP2R2C Gene

Post-translational modifications for PPP2R2C Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for PPP2R2C Gene

Domains & Families for PPP2R2C Gene

Gene Families for PPP2R2C Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the phosphatase 2A regulatory subunit B family.
  • Belongs to the phosphatase 2A regulatory subunit B family.
genes like me logo Genes that share domains with PPP2R2C: view

Function for PPP2R2C Gene

Molecular function for PPP2R2C Gene

UniProtKB/Swiss-Prot Function:
The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.
GENATLAS Biochemistry:
protein phosphatase 2A (formerly 2A),regulatory subunit B,gamma isoform

Phenotypes From GWAS Catalog for PPP2R2C Gene

Gene Ontology (GO) - Molecular Function for PPP2R2C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004722 contributes_to protein serine/threonine phosphatase activity IBA --
GO:0005515 protein binding IPI 19156129
GO:0019888 protein phosphatase regulator activity NAS,IBA 10945473
genes like me logo Genes that share ontologies with PPP2R2C: view
genes like me logo Genes that share phenotypes with PPP2R2C: view

Animal Model Products

miRNA for PPP2R2C Gene

miRTarBase miRNAs that target PPP2R2C

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PPP2R2C Gene

Localization for PPP2R2C Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PPP2R2C gene
Compartment Confidence
cytosol 5
nucleus 2
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for PPP2R2C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000159 protein phosphatase type 2A complex NAS 10945473
GO:0005829 cytosol IBA --
genes like me logo Genes that share ontologies with PPP2R2C: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for PPP2R2C Gene

Pathways & Interactions for PPP2R2C Gene

genes like me logo Genes that share pathways with PPP2R2C: view

Gene Ontology (GO) - Biological Process for PPP2R2C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000278 mitotic cell cycle IBA --
GO:0032502 developmental process IBA --
GO:0043666 regulation of phosphoprotein phosphatase activity IEA --
GO:0070262 peptidyl-serine dephosphorylation IBA --
genes like me logo Genes that share ontologies with PPP2R2C: view

No data available for SIGNOR curated interactions for PPP2R2C Gene

Drugs & Compounds for PPP2R2C Gene

(3) Drugs for PPP2R2C Gene - From: Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Cyclosporin A Approved, Investigational, Vet_approved Pharma Antagonist, Inhibition, Inhibitor Immunosuppressant drug, Immunosuppressive agent, Calcineurin inhibitor 0
Calcineurin Autoinhibitory Peptide Pharma CaMKII inhibitor, Selective calcineurin inhibitor 0
INCA-6 Pharma Selective calcineurin-NFAT signaling inhibitor, Inhibitor of calcineurin-substrate association 0

(1) Additional Compounds for PPP2R2C Gene - From: Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
FK 506

(4) Tocris Compounds for PPP2R2C Gene

Compound Action Cas Number
Calcineurin Autoinhibitory Peptide Selective calcineurin inhibitor 148067-21-4
Cyclosporin A Calcineurin inhibitor 59865-13-3
FK 506 Potent calcineurin inhibitor; immunosuppressant 104987-11-3
INCA-6 Inhibitor of calcineurin-substrate association 3519-82-2
genes like me logo Genes that share compounds with PPP2R2C: view

Transcripts for PPP2R2C Gene

Unigene Clusters for PPP2R2C Gene

Protein phosphatase 2, regulatory subunit B, gamma:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for PPP2R2C Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9a · 9b · 9c ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17
SP1: - - - -
SP2: - - - - - - - - -
SP3: - -
SP4: - -
SP6: - - - - - - -
SP7: - - - -
SP8: - - - - -

Relevant External Links for PPP2R2C Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PPP2R2C Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PPP2R2C Gene

mRNA differential expression in normal tissues according to GTEx for PPP2R2C Gene

This gene is overexpressed in Brain - Cortex (x4.9), Brain - Frontal Cortex (BA9) (x4.8), Brain - Anterior cingulate cortex (BA24) (x4.3), Brain - Nucleus accumbens (basal ganglia) (x4.1), and Brain - Spinal cord (cervical c-1) (x4.1).

Protein differential expression in normal tissues from HIPED for PPP2R2C Gene

This gene is overexpressed in Heart (42.5) and Frontal cortex (26.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for PPP2R2C Gene

Protein tissue co-expression partners for PPP2R2C Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of PPP2R2C Gene:


SOURCE GeneReport for Unigene cluster for PPP2R2C Gene:


Evidence on tissue expression from TISSUES for PPP2R2C Gene

  • Nervous system(5)
genes like me logo Genes that share expression patterns with PPP2R2C: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PPP2R2C Gene

Orthologs for PPP2R2C Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PPP2R2C Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia PPP2R2C 34 33
  • 99.85 (n)
(Monodelphis domestica)
Mammalia PPP2R2C 34
  • 95 (a)
(Canis familiaris)
Mammalia PPP2R2C 34 33
  • 92.1 (n)
(Bos Taurus)
Mammalia PPP2R2C 34 33
  • 91.55 (n)
(Rattus norvegicus)
Mammalia Ppp2r2c 33
  • 91.16 (n)
(Mus musculus)
Mammalia Ppp2r2c 16 34 33
  • 90.92 (n)
(Ornithorhynchus anatinus)
Mammalia PPP2R2C 34
  • 82 (a)
(Gallus gallus)
Aves PPP2R2C 34 33
  • 80.58 (n)
(Anolis carolinensis)
Reptilia PPP2R2C 34
  • 90 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia ppp2r2c 33
  • 77.7 (n)
(Danio rerio)
Actinopterygii ppp2r2c 34
  • 80 (a)
ppp2r2ca 33
  • 76.33 (n)
BX470131.1 34
  • 76 (a)
fruit fly
(Drosophila melanogaster)
Insecta tws 34 35
  • 64 (a)
(Caenorhabditis elegans)
Secernentea sur-6 34
  • 56 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CDC55 34
  • 44 (a)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.13045 33
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6047 34
  • 64 (a)
Species where no ortholog for PPP2R2C was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PPP2R2C Gene

Gene Tree for PPP2R2C (if available)
Gene Tree for PPP2R2C (if available)
Evolutionary constrained regions (ECRs) for PPP2R2C: view image

Paralogs for PPP2R2C Gene

Paralogs for PPP2R2C Gene

(3) SIMAP similar genes for PPP2R2C Gene using alignment to 3 proteins:

  • D6R943_HUMAN
  • L8ECI7_HUMAN Pseudogenes for PPP2R2C Gene

genes like me logo Genes that share paralogs with PPP2R2C: view

Variants for PPP2R2C Gene

Sequence variations from dbSNP and Humsavar for PPP2R2C Gene

SNP ID Clin Chr 04 pos Variation AA Info Type
rs10000024 -- 6,423,539(-) A/G genic_upstream_transcript_variant, intron_variant
rs1000014818 -- 6,470,834(-) G/A genic_upstream_transcript_variant, intron_variant
rs1000020151 -- 6,371,575(-) T/C genic_upstream_transcript_variant, intron_variant
rs1000023460 -- 6,461,736(-) T/C genic_upstream_transcript_variant, intron_variant
rs1000055518 -- 6,357,437(-) C/A/T genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for PPP2R2C Gene

Variant ID Type Subtype PubMed ID
dgv2718n106 CNV deletion 24896259
dgv856n67 CNV loss 20364138
esv1422471 CNV deletion 17803354
esv2223041 CNV deletion 18987734
esv23635 CNV loss 19812545
esv2674049 CNV deletion 23128226
esv2674888 CNV deletion 23128226
esv2726998 CNV deletion 23290073
esv2726999 CNV deletion 23290073
esv2727000 CNV deletion 23290073
esv2727001 CNV deletion 23290073
esv2727002 CNV deletion 23290073
esv2727003 CNV deletion 23290073
esv2763841 CNV loss 21179565
esv27681 CNV gain 19812545
esv28719 CNV loss 19812545
esv3303924 CNV mobile element insertion 20981092
esv3332100 CNV duplication 20981092
esv3357928 CNV insertion 20981092
esv3416034 CNV duplication 20981092
esv34196 OTHER inversion 12058347
esv3563325 CNV deletion 23714750
esv3563326 CNV deletion 23714750
esv3569270 CNV loss 25503493
esv3599502 CNV loss 21293372
esv3599503 CNV loss 21293372
nsv1008105 CNV gain 25217958
nsv10438 CNV gain 18304495
nsv1073725 CNV deletion 25765185
nsv1074144 CNV deletion 25765185
nsv1074682 CNV deletion 25765185
nsv1112847 CNV deletion 24896259
nsv1121622 CNV deletion 24896259
nsv1126680 CNV deletion 24896259
nsv1128031 CNV deletion 24896259
nsv1130810 CNV deletion 24896259
nsv1145022 CNV deletion 24896259
nsv1145762 CNV deletion 26484159
nsv290117 CNV deletion 16902084
nsv291891 CNV deletion 16902084
nsv4213 CNV insertion 18451855
nsv4214 CNV insertion 18451855
nsv469711 CNV loss 16826518
nsv527210 CNV gain 19592680
nsv593499 CNV loss 21841781
nsv593500 CNV loss 21841781
nsv593501 CNV loss 21841781
nsv829847 CNV gain 17160897
nsv829849 CNV loss 17160897
nsv949777 CNV deletion 24416366
nsv949778 CNV deletion 24416366
nsv955822 CNV deletion 24416366

Variation tolerance for PPP2R2C Gene

Residual Variation Intolerance Score: 9.32% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.43; 9.43% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PPP2R2C Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PPP2R2C Gene

Disorders for PPP2R2C Gene

Additional Disease Information for PPP2R2C

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for PPP2R2C Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PPP2R2C Gene

Publications for PPP2R2C Gene

  1. Molecular cloning and mapping of the brain-abundant B1gamma subunit of protein phosphatase 2A, PPP2R2C, to human chromosome 4p16. (PMID: 10945473) Hu P … Zhao S (Genomics 2000) 2 3 4 58
  2. Genomic structure and localization of the human protein phosphatase 2A BRgamma regulatory subunit. (PMID: 10574460) Torres R … Polymeropoulos MH (DNA research : an international journal for rapid publication of reports on genes and genomes 1999) 2 3 4 58
  3. HSF1 transcriptional activity is modulated by IER5 and PP2A/B55. (PMID: 25816751) Ishikawa Y … Sakurai H (FEBS letters 2015) 3 4 58
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  5. Genetic variant near IRS1 is associated with type 2 diabetes, insulin resistance and hyperinsulinemia. (PMID: 19734900) Rung J … Sladek R (Nature genetics 2009) 3 44 58

Products for PPP2R2C Gene

Sources for PPP2R2C Gene

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