Aliases for PPP2R2A Gene
External Ids for PPP2R2A Gene
Previous GeneCards Identifiers for PPP2R2A Gene
The product of this gene belongs to the phosphatase 2 regulatory subunit B family. Protein phosphatase 2 is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might modulate substrate selectivity and catalytic activity. This gene encodes an alpha isoform of the regulatory subunit B55 subfamily. Alternatively spliced transcript variants have been described. [provided by RefSeq, Apr 2010]
GeneCards Summary for PPP2R2A Gene
PPP2R2A (Protein Phosphatase 2 Regulatory Subunit Balpha) is a Protein Coding gene. Diseases associated with PPP2R2A include Alzheimer Disease 15 and Lung Cancer. Among its related pathways are Signal transduction_PKA signaling and Cyclin A/B1 associated events during G2/M transition. Gene Ontology (GO) annotations related to this gene include protein serine/threonine phosphatase activity. An important paralog of this gene is PPP2R2D.
UniProtKB/Swiss-Prot Summary for PPP2R2A Gene
The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.
Protein Ser/Thr phosphatases are a group of enzymes that catalyze the removal of phosphate groups from serine and/or threonine residues by hydrolysis of phosphoric acid monoesters. They oppose the action of kinases and phosphorylases and are involved in signal transduction.