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Aliases for PPP2R2A Gene

Aliases for PPP2R2A Gene

  • Protein Phosphatase 2 Regulatory Subunit Balpha 2 3 5
  • PP2A Subunit B Isoform Alpha 2 4
  • Serine/Threonine-Protein Phosphatase 2A 55 KDa Regulatory Subunit B Alpha Isoform 3
  • Protein Phosphatase 2 (Formerly 2A), Regulatory Subunit B (PR 52), Alpha Isoform 2
  • Protein Phosphatase 2, Regulatory Subunit B, Alpha 3
  • PP2A Subunit B Isoform PR55-Alpha 4
  • PP2A Subunit B Isoform B55-Alpha 4
  • PP2A Subunit B Isoform R2-Alpha 4
  • PR55alpha 3
  • B55ALPHA 3
  • PR52A 3
  • PR55A 3
  • B55A 3

External Ids for PPP2R2A Gene

Previous GeneCards Identifiers for PPP2R2A Gene

  • GC08P025922
  • GC08P026502
  • GC08P026170
  • GC08P025099
  • GC08P024693

Summaries for PPP2R2A Gene

Entrez Gene Summary for PPP2R2A Gene

  • The product of this gene belongs to the phosphatase 2 regulatory subunit B family. Protein phosphatase 2 is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might modulate substrate selectivity and catalytic activity. This gene encodes an alpha isoform of the regulatory subunit B55 subfamily. Alternatively spliced transcript variants have been described. [provided by RefSeq, Apr 2010]

GeneCards Summary for PPP2R2A Gene

PPP2R2A (Protein Phosphatase 2 Regulatory Subunit Balpha) is a Protein Coding gene. Among its related pathways are ERK Signaling and Akt Signaling. Gene Ontology (GO) annotations related to this gene include protein serine/threonine phosphatase activity. An important paralog of this gene is PPP2R2D.

UniProtKB/Swiss-Prot for PPP2R2A Gene

  • The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.

Tocris Summary for PPP2R2A Gene

  • Protein Ser/Thr phosphatases are a group of enzymes that catalyze the removal of phosphate groups from serine and/or threonine residues by hydrolysis of phosphoric acid monoesters. They oppose the action of kinases and phosphorylases and are involved in signal transduction.

Gene Wiki entry for PPP2R2A Gene

Additional gene information for PPP2R2A Gene

No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PPP2R2A Gene

Genomics for PPP2R2A Gene

GeneHancer (GH) Regulatory Elements for PPP2R2A Gene

Promoters and enhancers for PPP2R2A Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH08J026290 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 650.7 +2.5 2501 6.9 HDGF PKNOX1 FOXA2 ARNT ARID4B SIN3A ZNF2 YY1 POLR2B ZNF143 PPP2R2A SDAD1P1 ENSG00000253476 GC08M026286
GH08J026264 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 13.9 -25.3 -25250 3.7 HDAC1 PKNOX1 ARNT GATA2 FOS CREM CEBPB ZNF592 ZNF148 ZNF217 PPP2R2A LOC100129404
GH08J026329 Enhancer 1.3 Ensembl ENCODE dbSUPER 11.3 +39.2 39193 3.1 FOXA2 ARID4B ETS1 ATF7 FOS SP5 MIER2 KAT8 NFIL3 ATF4 SDAD1P1 PPP2R2A ENSG00000253476 BNIP3L PNMA2 DPYSL2 GC08M026286
GH08J026374 Enhancer 1.3 FANTOM5 Ensembl ENCODE 10.2 +82.9 82892 0.8 HDAC1 ATF1 MZF1 ZNF2 RAD21 RFX5 CHAMP1 ZNF121 ZSCAN5C SCRT2 SDAD1P1 PPP2R2A BNIP3L GC08M026286
GH08J026203 Enhancer 1 Ensembl ENCODE dbSUPER 11 -86.9 -86882 1.4 JUN USF2 ZNF398 EP300 BRCA1 ATF2 FOXA1 MITF SP1 GATA3 PPP2R2A LOC105379336 RNA5SP258
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PPP2R2A on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the PPP2R2A gene promoter:
  • Egr-1
  • ATF-2
  • GATA-3
  • FOXD3
  • MZF-1
  • FOXO1a
  • FOXO1
  • SREBP-1b
  • SREBP-1a
  • SREBP-1c

Genomic Locations for PPP2R2A Gene

Genomic Locations for PPP2R2A Gene
81,190 bases
Plus strand
81,190 bases
Plus strand

Genomic View for PPP2R2A Gene

Genes around PPP2R2A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PPP2R2A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PPP2R2A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PPP2R2A Gene

Proteins for PPP2R2A Gene

  • Protein details for PPP2R2A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform
    Protein Accession:
    Secondary Accessions:
    • B2RBU8
    • B4E1T7
    • P50409
    • Q00007

    Protein attributes for PPP2R2A Gene

    447 amino acids
    Molecular mass:
    51692 Da
    Quaternary structure:
    • Found in a complex with at least ARL2, PPP2CB, PPP2R1A, PPP2R2A, PPP2R5E and TBCD (By similarity). PP2A consists of a common heterodimeric core enzyme, composed of a 36 kDa catalytic subunit (subunit C) and a 65 kDa constant regulatory subunit (PR65 or subunit A), that associates with a variety of regulatory subunits. Proteins that associate with the core dimer include three families of regulatory subunits B (the R2/B/PR55/B55, R3/B/PR72/PR130/PR59 and R5/B/B56 families), the 48 kDa variable regulatory subunit, viral proteins, and cell signaling molecules (By similarity). Interacts with TP53 (PubMed:17245430). Interacts with IER5 (PubMed:25816751).

    Three dimensional structures from OCA and Proteopedia for PPP2R2A Gene

    Alternative splice isoforms for PPP2R2A Gene


neXtProt entry for PPP2R2A Gene

Post-translational modifications for PPP2R2A Gene

  • Ubiquitination at Lys105
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for PPP2R2A Gene

Domains & Families for PPP2R2A Gene

Gene Families for PPP2R2A Gene

Protein Domains for PPP2R2A Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the phosphatase 2A regulatory subunit B family.
  • Belongs to the phosphatase 2A regulatory subunit B family.
genes like me logo Genes that share domains with PPP2R2A: view

Function for PPP2R2A Gene

Molecular function for PPP2R2A Gene

UniProtKB/Swiss-Prot Function:
The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.
GENATLAS Biochemistry:
protein phosphatase 2 (formerly 2A),regulatory subunit B (PR52),alpha isoform

Phenotypes From GWAS Catalog for PPP2R2A Gene

Gene Ontology (GO) - Molecular Function for PPP2R2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004722 protein serine/threonine phosphatase activity IDA,TAS --
GO:0005515 protein binding IPI,IEA 9847399
GO:0019888 protein phosphatase regulator activity IEA,TAS 1849734
GO:0048156 tau protein binding IEA --
GO:0051721 protein phosphatase 2A binding IEA --
genes like me logo Genes that share ontologies with PPP2R2A: view
genes like me logo Genes that share phenotypes with PPP2R2A: view

Animal Model Products

miRNA for PPP2R2A Gene

miRTarBase miRNAs that target PPP2R2A

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PPP2R2A Gene

Localization for PPP2R2A Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PPP2R2A gene
Compartment Confidence
nucleus 5
cytosol 5
extracellular 1
mitochondrion 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for PPP2R2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000159 protein phosphatase type 2A complex IDA,IEA 1849734
GO:0005654 nucleoplasm TAS --
GO:0005829 cytosol TAS,IBA --
genes like me logo Genes that share ontologies with PPP2R2A: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for PPP2R2A Gene

Pathways & Interactions for PPP2R2A Gene

genes like me logo Genes that share pathways with PPP2R2A: view

Gene Ontology (GO) - Biological Process for PPP2R2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000086 G2/M transition of mitotic cell cycle TAS --
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS --
GO:0000278 mitotic cell cycle IBA --
GO:0006470 protein dephosphorylation IDA 1849734
GO:0007084 mitotic nuclear envelope reassembly TAS --
genes like me logo Genes that share ontologies with PPP2R2A: view

No data available for SIGNOR curated interactions for PPP2R2A Gene

Drugs & Compounds for PPP2R2A Gene

(4) Drugs for PPP2R2A Gene - From: DrugBank and Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Cyclosporin A Approved, Investigational, Vet_approved Pharma Antagonist, Inhibition, Inhibitor Immunosuppressant drug, Immunosuppressive agent, Calcineurin inhibitor 0
2,6,8-Trimethyl-3-Amino-9-Benzyl-9-Methoxynonanoic Acid Experimental Pharma Target 0
Calcineurin Autoinhibitory Peptide Pharma CaMKII inhibitor, Selective calcineurin inhibitor 0
INCA-6 Pharma Selective calcineurin-NFAT signaling inhibitor, Inhibitor of calcineurin-substrate association 0

(1) Additional Compounds for PPP2R2A Gene - From: Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
FK 506

(4) Tocris Compounds for PPP2R2A Gene

Compound Action Cas Number
Calcineurin Autoinhibitory Peptide Selective calcineurin inhibitor 148067-21-4
Cyclosporin A Calcineurin inhibitor 59865-13-3
FK 506 Potent calcineurin inhibitor; immunosuppressant 104987-11-3
INCA-6 Inhibitor of calcineurin-substrate association 3519-82-2
genes like me logo Genes that share compounds with PPP2R2A: view

Transcripts for PPP2R2A Gene

Unigene Clusters for PPP2R2A Gene

Protein phosphatase 2, regulatory subunit B, alpha:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for PPP2R2A Gene

No ASD Table

Relevant External Links for PPP2R2A Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PPP2R2A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PPP2R2A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for PPP2R2A Gene

Protein tissue co-expression partners for PPP2R2A Gene

NURSA nuclear receptor signaling pathways regulating expression of PPP2R2A Gene:


SOURCE GeneReport for Unigene cluster for PPP2R2A Gene:


mRNA Expression by UniProt/SwissProt for PPP2R2A Gene:

Tissue specificity: Expressed in all tissues examined.

Evidence on tissue expression from TISSUES for PPP2R2A Gene

  • Nervous system(4.8)
  • Lung(4.5)
  • Liver(4.3)
  • Blood(4.1)
genes like me logo Genes that share expression patterns with PPP2R2A: view

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for PPP2R2A Gene

Orthologs for PPP2R2A Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PPP2R2A Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia PPP2R2A 34 33
  • 99.93 (n)
(Monodelphis domestica)
Mammalia PPP2R2A 34
  • 99 (a)
(Ornithorhynchus anatinus)
Mammalia PPP2R2A 34
  • 97 (a)
(Canis familiaris)
Mammalia PPP2R2A 34 33
  • 96.57 (n)
(Bos Taurus)
Mammalia PPP2R2A 34 33
  • 96.5 (n)
(Mus musculus)
Mammalia Ppp2r2a 16 34 33
  • 93.93 (n)
(Rattus norvegicus)
Mammalia Ppp2r2a 33
  • 93.03 (n)
(Gallus gallus)
Aves PPP2R2A 34 33
  • 89.14 (n)
(Anolis carolinensis)
Reptilia PPP2R2A 34
  • 99 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia ppp2r2a 33
  • 78.43 (n)
Str.6179 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.734 33
(Danio rerio)
Actinopterygii ppp2r2ab 34
  • 92 (a)
PPP2R2A (2 of 2) 34
  • 80 (a)
ppp2r2d 33
  • 76.93 (n)
wufd19g04 33
fruit fly
(Drosophila melanogaster)
Insecta tws 34 35
  • 70 (a)
(Caenorhabditis elegans)
Secernentea sur-6 34
  • 60 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CDC55 34
  • 46 (a)
(Glycine max)
eudicotyledons Gma.7239 33
(Triticum aestivum)
Liliopsida Ta.21357 33
(Hordeum vulgare)
Liliopsida Hv.3832 33
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6047 34
  • 69 (a)
Species where no ortholog for PPP2R2A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for PPP2R2A Gene

Gene Tree for PPP2R2A (if available)
Gene Tree for PPP2R2A (if available)
Evolutionary constrained regions (ECRs) for PPP2R2A: view image

Paralogs for PPP2R2A Gene

Paralogs for PPP2R2A Gene

(3) SIMAP similar genes for PPP2R2A Gene using alignment to 6 proteins:

  • E5RJV2_HUMAN Pseudogenes for PPP2R2A Gene

genes like me logo Genes that share paralogs with PPP2R2A: view

Variants for PPP2R2A Gene

Sequence variations from dbSNP and Humsavar for PPP2R2A Gene

SNP ID Clin Chr 08 pos Variation AA Info Type
rs1000034981 -- 26,362,496(+) C/T intron_variant
rs1000061152 -- 26,314,032(+) A/C intron_variant
rs1000086513 -- 26,303,385(+) A/G intron_variant
rs1000137222 -- 26,306,305(+) G/A intron_variant
rs1000156121 -- 26,294,449(+) A/G genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for PPP2R2A Gene

Variant ID Type Subtype PubMed ID
esv2495705 CNV insertion 19546169
esv3305259 CNV mobile element insertion 20981092
esv3309120 CNV mobile element insertion 20981092
esv3324782 CNV insertion 20981092
esv3572648 CNV loss 25503493
esv3616666 OTHER inversion 21293372
esv3616698 CNV loss 21293372
esv3616699 CNV loss 21293372
nsv1076075 CNV deletion 25765185
nsv473268 CNV novel sequence insertion 20440878
nsv831273 CNV loss 17160897
nsv951118 CNV duplication 24416366

Variation tolerance for PPP2R2A Gene

Residual Variation Intolerance Score: 39.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.31; 6.84% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PPP2R2A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PPP2R2A Gene

Disorders for PPP2R2A Gene

Additional Disease Information for PPP2R2A

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for PPP2R2A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PPP2R2A Gene

Publications for PPP2R2A Gene

  1. Structure of the 55-kDa regulatory subunit of protein phosphatase 2A: evidence for a neuronal-specific isoform. (PMID: 1849734) Mayer RE … Hemmings BA (Biochemistry 1991) 2 3 4 58
  2. HSF1 transcriptional activity is modulated by IER5 and PP2A/B55. (PMID: 25816751) Ishikawa Y … Sakurai H (FEBS letters 2015) 3 4 58
  3. Protein phosphatase 2A subunit gene haplotypes and proliferative breast disease modify breast cancer risk. (PMID: 19890961) Dupont WD … Smith JR (Cancer 2010) 3 44 58
  4. A specific PP2A regulatory subunit, B56gamma, mediates DNA damage-induced dephosphorylation of p53 at Thr55. (PMID: 17245430) Li HH … Liu X (The EMBO journal 2007) 3 4 58
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58

Products for PPP2R2A Gene

Sources for PPP2R2A Gene

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