Aliases for PPP2R1B Gene
- Protein Phosphatase 2 Scaffold Subunit Abeta 2 3 5
- Serine/Threonine-Protein Phosphatase 2A 65 KDa Regulatory Subunit A Beta Isoform 3 4
- PP2A-Abeta 2 3
- PR65B 2 3
- Protein Phosphatase 2 (Formerly 2A), Regulatory Subunit A (PR 65), Beta Isoform 2
- Protein Phosphatase 2, Structural/Regulatory Subunit A, Beta 3
External Ids for PPP2R1B Gene
Previous GeneCards Identifiers for PPP2R1B Gene
This gene encodes a constant regulatory subunit of protein phosphatase 2. Protein phosphatase 2 is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The constant regulatory subunit A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit. This gene encodes a beta isoform of the constant regulatory subunit A. Mutations in this gene have been associated with some lung and colon cancers. Alternatively spliced transcript variants have been described. [provided by RefSeq, Apr 2010]
GeneCards Summary for PPP2R1B Gene
PPP2R1B (Protein Phosphatase 2 Scaffold Subunit Abeta) is a Protein Coding gene. Diseases associated with PPP2R1B include Lung Cancer and Colorectal Cancer. Among its related pathways are RET signaling and S37 mutants of beta-catenin arent phosphorylated. Gene Ontology (GO) annotations related to this gene include binding. An important paralog of this gene is PPP2R1A.
UniProtKB/Swiss-Prot Summary for PPP2R1B Gene
The PR65 subunit of protein phosphatase 2A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit.
Protein Ser/Thr phosphatases are a group of enzymes that catalyze the removal of phosphate groups from serine and/or threonine residues by hydrolysis of phosphoric acid monoesters. They oppose the action of kinases and phosphorylases and are involved in signal transduction.