This gene encodes a constant regulatory subunit of protein phosphatase 2. Protein phosphatase 2 is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regu... See more...

Aliases for PPP2R1B Gene

Aliases for PPP2R1B Gene

  • Protein Phosphatase 2 Scaffold Subunit Abeta 2 3 5
  • Serine/Threonine-Protein Phosphatase 2A 65 KDa Regulatory Subunit A Beta Isoform 3 4
  • Protein Phosphatase 2 (Formerly 2A), Regulatory Subunit A (PR 65), Beta Isoform 2
  • Protein Phosphatase 2 (Formerly 2A), Regulatory Subunit A, Beta Isoform 3
  • Protein Phosphatase 2, Structural/Regulatory Subunit A, Beta 3
  • Protein Phosphatase 2A, Regulatory Subunit A, Beta Isoform 2
  • Protein Phosphatase 2, Regulatory Subunit A, Beta 3
  • Protein Phosphatase 2 Regulatory Subunit A, Beta 2
  • PP2A, Subunit A, PR65-Beta Isoform 3
  • PP2A, Subunit A, R1-Beta Isoform 3
  • PP2A Subunit A Isoform PR65-Beta 4
  • PP2A Subunit A Isoform R1-Beta 4
  • PP2A-A-Beta 2
  • PP2A-Abeta 3
  • PR65B 3

External Ids for PPP2R1B Gene

Previous GeneCards Identifiers for PPP2R1B Gene

  • GC11M113950
  • GC11M113109
  • GC11M111631
  • GC11M111135
  • GC11M111102
  • GC11M107521
  • GC11M111613
  • GC11M111618
  • GC11M111634
  • GC11M111642
  • GC11M111656
  • GC11M111725

Summaries for PPP2R1B Gene

Entrez Gene Summary for PPP2R1B Gene

  • This gene encodes a constant regulatory subunit of protein phosphatase 2. Protein phosphatase 2 is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The constant regulatory subunit A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit. This gene encodes a beta isoform of the constant regulatory subunit A. Mutations in this gene have been associated with some lung and colon cancers. Alternatively spliced transcript variants have been described. [provided by RefSeq, Apr 2010]

GeneCards Summary for PPP2R1B Gene

PPP2R1B (Protein Phosphatase 2 Scaffold Subunit Abeta) is a Protein Coding gene. Diseases associated with PPP2R1B include Lung Cancer and Hereditary Wilms' Tumor. Among its related pathways are Wnt Signaling Pathway and Pluripotency and Activated TLR4 signalling. Gene Ontology (GO) annotations related to this gene include binding. An important paralog of this gene is PPP2R1A.

UniProtKB/Swiss-Prot Summary for PPP2R1B Gene

  • The PR65 subunit of protein phosphatase 2A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit.

Tocris Summary for PPP2R1B Gene

  • Protein Ser/Thr phosphatases are a group of enzymes that catalyze the removal of phosphate groups from serine and/or threonine residues by hydrolysis of phosphoric acid monoesters. They oppose the action of kinases and phosphorylases and are involved in signal transduction.

Gene Wiki entry for PPP2R1B Gene

Additional gene information for PPP2R1B Gene

No data available for CIViC Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PPP2R1B Gene

Genomics for PPP2R1B Gene

GeneHancer (GH) Regulatory Elements for PPP2R1B Gene

Promoters and enhancers for PPP2R1B Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PPP2R1B on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the PPP2R1B gene promoter:
  • COUP
  • COUP-TF
  • COUP-TF1
  • Evi-1
  • HNF-4alpha1
  • HNF-4alpha2
  • Pax-4a
  • Pax-6
  • RORalpha1
  • XBP-1

Genomic Locations for PPP2R1B Gene

Genomic Locations for PPP2R1B Gene
chr11:111,695,074-111,766,445
(GRCh38/hg38)
Size:
71,372 bases
Orientation:
Minus strand
chr11:111,597,632-111,637,169
(GRCh37/hg19)
Size:
39,538 bases
Orientation:
Minus strand

Genomic View for PPP2R1B Gene

Genes around PPP2R1B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PPP2R1B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PPP2R1B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PPP2R1B Gene

Proteins for PPP2R1B Gene

  • Protein details for PPP2R1B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P30154-2AAB_HUMAN
    Recommended name:
    Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform
    Protein Accession:
    P30154
    Secondary Accessions:
    • A8MY67
    • B0YJ69
    • B4DGQ6
    • B4DK91
    • B4DWW5
    • F8W8G1
    • O75620
    • Q8NHV8

    Protein attributes for PPP2R1B Gene

    Size:
    601 amino acids
    Molecular mass:
    66214 Da
    Quaternary structure:
    • PP2A consists of a common heterodimeric core enzyme, composed of a 36 kDa catalytic subunit (subunit C) and a 65 kDa constant regulatory subunit (PR65 or subunit A), that associates with a variety of regulatory subunits. Proteins that associate with the core dimer include three families of regulatory subunits B (the R2/B/PR55/B55, R3/B''/PR72/PR130/PR59 and R5/B'/B56 families), the 48 kDa variable regulatory subunit, viral proteins, and cell signaling molecules. Interacts with IPO9. Interacts with SGO1. Interacts with RAF1.
    SequenceCaution:
    • Sequence=AAA59983.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Sequence of unknown origin in the N-terminal part.; Evidence={ECO:0000305}; Sequence=BAG59103.1; Type=Frameshift; Positions=540; Evidence={ECO:0000305};

    Alternative splice isoforms for PPP2R1B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PPP2R1B Gene

Post-translational modifications for PPP2R1B Gene

  • Ubiquitination at Lys145, Lys175, Lys214, Lys284, Lys289, Lys484, Lys539, Lys558, and Lys573
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for PPP2R1B Gene

Domains & Families for PPP2R1B Gene

Protein Domains for PPP2R1B Gene

Suggested Antigen Peptide Sequences for PPP2R1B Gene

GenScript: Design optimal peptide antigens:
  • PP2A subunit A isoform R1-beta (2AAB_HUMAN)
  • cDNA FLJ53228, highly similar to Homo sapiens protein phosphatase 2 (formerly 2A), regulatory subunit A (PR 65), beta isoform (PPP2R1B), transcript variant 2, mRNA (B4DWW5_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P30154

UniProtKB/Swiss-Prot:

2AAB_HUMAN :
  • Each HEAT repeat appears to consist of two alpha helices joined by a hydrophilic region, the intrarepeat loop. The repeat units may be arranged laterally to form a rod-like structure.
  • Belongs to the phosphatase 2A regulatory subunit A family.
Domain:
  • Each HEAT repeat appears to consist of two alpha helices joined by a hydrophilic region, the intrarepeat loop. The repeat units may be arranged laterally to form a rod-like structure.
Family:
  • Belongs to the phosphatase 2A regulatory subunit A family.
genes like me logo Genes that share domains with PPP2R1B: view

Function for PPP2R1B Gene

Molecular function for PPP2R1B Gene

UniProtKB/Swiss-Prot Function:
The PR65 subunit of protein phosphatase 2A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit.
GENATLAS Biochemistry:
serine/threonine phosphatase 2 (formerly 2A),regulatory subunit A,beta isoform,65kDa,altered in human lung and colon carcinomas,see TSG11F,LOH11CR2A

Phenotypes From GWAS Catalog for PPP2R1B Gene

Gene Ontology (GO) - Molecular Function for PPP2R1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004722 contributes_to protein serine/threonine phosphatase activity IBA 21873635
GO:0005515 protein binding IPI,IEA 8392071
GO:0019888 protein phosphatase regulator activity IBA 21873635
genes like me logo Genes that share ontologies with PPP2R1B: view
genes like me logo Genes that share phenotypes with PPP2R1B: view

Human Phenotype Ontology for PPP2R1B Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for PPP2R1B Gene

MGI Knock Outs for PPP2R1B:
  • Ppp2r1b Ppp2r1b<tm1b(EUCOMM)Wtsi>

Animal Model Products

CRISPR Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for PPP2R1B Gene

Localization for PPP2R1B Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PPP2R1B gene
Compartment Confidence
cytosol 4
plasma membrane 2
cytoskeleton 2
nucleus 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Centrosome (2)
  • Cytosol (2)
  • Nucleus (2)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for PPP2R1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000159 protein phosphatase type 2A complex IBA 21873635
GO:0005737 cytoplasm IBA 21873635
GO:0045121 membrane raft IDA 21172653
GO:0070062 extracellular exosome HDA 23533145
genes like me logo Genes that share ontologies with PPP2R1B: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for PPP2R1B Gene

Pathways & Interactions for PPP2R1B Gene

PathCards logo

SuperPathways for PPP2R1B Gene

SuperPathway Contained pathways
1 RET signaling
2 Activated TLR4 signalling
3 Misspliced GSK3beta mutants stabilize beta-catenin
4 PI3K/AKT activation
5 Cyclins and Cell Cycle Regulation
.67
.36
.31
genes like me logo Genes that share pathways with PPP2R1B: view

Pathways by source for PPP2R1B Gene

25 Qiagen pathways for PPP2R1B Gene
  • Akt Signaling
  • BAD Phosphorylation
  • Beta-Adrenergic Signaling
  • Breast Cancer Regulation by Stathmin1
  • CDK5 Pathway

SIGNOR curated interactions for PPP2R1B Gene

Activates:

Gene Ontology (GO) - Biological Process for PPP2R1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006470 protein dephosphorylation IEA --
GO:0043666 regulation of phosphoprotein phosphatase activity IEA --
GO:0060561 apoptotic process involved in morphogenesis IMP 21172653
GO:2001241 positive regulation of extrinsic apoptotic signaling pathway in absence of ligand IMP 21172653
genes like me logo Genes that share ontologies with PPP2R1B: view

Drugs & Compounds for PPP2R1B Gene

(5) Drugs for PPP2R1B Gene - From: Tocris and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Cyclosporin A Approved, Investigational, Vet_approved Pharma Antagonist, Inhibition, Inhibitor Immunosuppressive agent, Calcineurin inhibitor 0
Calcineurin Autoinhibitory Peptide Pharma CaMKII inhibitor, Selective calcineurin inhibitor 0
INCA-6 Pharma Selective calcineurin-NFAT signaling inhibitor, Inhibitor of calcineurin-substrate association 0

(2) Additional Compounds for PPP2R1B Gene - From: Novoseek and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
FK 506
104987-11-3

(4) Tocris Compounds for PPP2R1B Gene

Compound Action Cas Number
Calcineurin Autoinhibitory Peptide Selective calcineurin inhibitor 148067-21-4
Cyclosporin A Calcineurin inhibitor 59865-13-3
FK 506 Potent calcineurin inhibitor; immunosuppressant 104987-11-3
INCA-6 Inhibitor of calcineurin-substrate association 3519-82-2
genes like me logo Genes that share compounds with PPP2R1B: view

Transcripts for PPP2R1B Gene

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for PPP2R1B Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18
SP1: - -
SP2: -
SP3: - - -
SP4: - - -
SP5: - -
SP6:
SP7:

Relevant External Links for PPP2R1B Gene

GeneLoc Exon Structure for
PPP2R1B
ECgene alternative splicing isoforms for
PPP2R1B

Expression for PPP2R1B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PPP2R1B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PPP2R1B Gene

This gene is overexpressed in Liver (x14.1).

Protein differential expression in normal tissues from HIPED for PPP2R1B Gene

This gene is overexpressed in Bone (41.8), Testis (7.6), and Brain (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for PPP2R1B Gene



NURSA nuclear receptor signaling pathways regulating expression of PPP2R1B Gene:

PPP2R1B

SOURCE GeneReport for Unigene cluster for PPP2R1B Gene:

Hs.584790

Evidence on tissue expression from TISSUES for PPP2R1B Gene

  • Nervous system(4.7)
  • Liver(4.4)
  • Lung(2.3)

Phenotype-based relationships between genes and organs from Gene ORGANizer for PPP2R1B Gene

Germ Layers:
  • endoderm
Systems:
  • respiratory
Regions:
Thorax:
  • lung
genes like me logo Genes that share expression patterns with PPP2R1B: view

No data available for Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for PPP2R1B Gene

Orthologs for PPP2R1B Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PPP2R1B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PPP2R1B 33 32
  • 99.75 (n)
OneToOne
dog
(Canis familiaris)
Mammalia PPP2R1B 33 32
  • 91.91 (n)
OneToOne
cow
(Bos Taurus)
Mammalia PPP2R1B 33 32
  • 91.64 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PPP2R1B 33
  • 91 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ppp2r1b 32
  • 88.89 (n)
mouse
(Mus musculus)
Mammalia Ppp2r1b 17 33 32
  • 87.96 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia PPP2R1B 33
  • 87 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia pdgfb 32
  • 76.97 (n)
African clawed frog
(Xenopus laevis)
Amphibia ppp2r1b-prov 32
zebrafish
(Danio rerio)
Actinopterygii ppp2r1a 33
  • 88 (a)
OneToMany
ppp2r1b 33 32
  • 74.21 (n)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Pp2A-29B 33 34
  • 65 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea F48E8.5 34
  • 62 (a)
paa-1 33
  • 61 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TPD3 35 33
  • 42 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons PP2AA3 32
  • 57.36 (n)
soybean
(Glycine max)
eudicotyledons Gma.7498 32
rice
(Oryza sativa)
Liliopsida Os09g0249700 32
  • 58.26 (n)
corn
(Zea mays)
Liliopsida Zm.2099 32
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8422 33
  • 67 (a)
OneToMany
Species where no ortholog for PPP2R1B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PPP2R1B Gene

ENSEMBL:
Gene Tree for PPP2R1B (if available)
TreeFam:
Gene Tree for PPP2R1B (if available)
Aminode:
Evolutionary constrained regions (ECRs) for PPP2R1B: view image

Paralogs for PPP2R1B Gene

Paralogs for PPP2R1B Gene

(1) SIMAP similar genes for PPP2R1B Gene using alignment to 6 proteins:

  • 2AAB_HUMAN
  • E9PHZ6_HUMAN
  • E9PNM7_HUMAN
  • E9PPI5_HUMAN
  • H0YDG7_HUMAN
  • J3KR29_HUMAN
genes like me logo Genes that share paralogs with PPP2R1B: view

Variants for PPP2R1B Gene

Sequence variations from dbSNP and Humsavar for PPP2R1B Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1318084062 A colon adenocarcinoma 111,742,586(-) A/G coding_sequence_variant, missense_variant
rs142771326 A lung cancer patient 111,766,340(-) C/G/T coding_sequence_variant, missense_variant
rs1442893893 A colorectal cancer patient 111,753,514(-) A/G coding_sequence_variant, intron_variant, missense_variant
rs1805076 pathogenic, Lung cancer, A lung cancer patient 111,764,842(-) C/T coding_sequence_variant, intron_variant, missense_variant
rs973682124 A lung cancer patient 111,743,419(-) T/C coding_sequence_variant, missense_variant

Structural Variations from Database of Genomic Variants (DGV) for PPP2R1B Gene

Variant ID Type Subtype PubMed ID
esv3580116 CNV gain 25503493
nsv832269 CNV loss 17160897

Variation tolerance for PPP2R1B Gene

Residual Variation Intolerance Score: 70.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.84; 58.73% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PPP2R1B Gene

Human Gene Mutation Database (HGMD)
PPP2R1B
SNPedia medical, phenotypic, and genealogical associations of SNPs for
PPP2R1B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PPP2R1B Gene

Disorders for PPP2R1B Gene

MalaCards: The human disease database

(4) MalaCards diseases for PPP2R1B Gene - From: HGMD, OMIM, ClinVar, GTR, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
lung cancer
  • adenocarcinoma of lung
hereditary wilms' tumor
  • wt1
colorectal cancer
  • crc
cervical cancer
  • cervical cancer, somatic
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for PPP2R1B

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with PPP2R1B: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PPP2R1B Gene

Publications for PPP2R1B Gene

  1. Genomic organization and precise physical location of protein phosphatase 2A regulatory subunit A beta isoform gene on chromosome band 11q23. (PMID: 9795170) Baysal BE … Richard CW (Gene 1998) 2 3 4 23 56
  2. Mutation analysis of the tumor suppressor gene PPP2R1B in human cervical cancer. (PMID: 17343570) Yeh LS … Tsai FJ (International journal of gynecological cancer : official journal of the International Gynecological Cancer Society 2007) 3 23 43 56
  3. The glycine 90 to aspartate alteration in the Abeta subunit of PP2A (PPP2R1B) associates with breast cancer and causes a deficit in protein function. (PMID: 16276521) Esplin ED … Evans GA (Genes, chromosomes & cancer 2006) 3 23 43 56
  4. Alterations in the suppressor gene PPP2R1B in parathyroid hyperplasias and adenomas. (PMID: 11996789) Hemmer S … Joensuu H (Cancer genetics and cytogenetics 2002) 3 4 23 56
  5. A high-resolution integrated map spanning the SDHD gene at 11q23: a 1.1-Mb BAC contig, a partial transcript map and 15 new repeat polymorphisms in a tumour-suppressor region. (PMID: 11313745) Baysal BE … Devlin B (European journal of human genetics : EJHG 2001) 3 4 23 56

Products for PPP2R1B Gene