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This gene encodes a constant regulatory subunit of protein phosphatase 2. Protein phosphatase 2 is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The constant regulatory subunit A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit. This gene encodes a beta isoform of the constant regulatory subunit A. Mutations in this gene have been associated with some lung and colon cancers. Alternatively spliced transcript variants have been described. [provided by RefSeq, Apr 2010]
PPP2R1B (Protein Phosphatase 2 Scaffold Subunit Abeta) is a Protein Coding gene. Diseases associated with PPP2R1B include Lung Cancer and Colorectal Cancer. Among its related pathways are Beta-Adrenergic Signaling and Downstream signaling events of B Cell Receptor (BCR). Gene Ontology (GO) annotations related to this gene include binding. An important paralog of this gene is PPP2R1A.
Protein Ser/Thr phosphatases are a group of enzymes that catalyze the removal of phosphate groups from serine and/or threonine residues by hydrolysis of phosphoric acid monoesters. They oppose the action of kinases and phosphorylases and are involved in signal transduction.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0004722 | contributes_to protein serine/threonine phosphatase activity | IBA | 21873635 |
GO:0005515 | protein binding | IEA,IPI | 8392071 |
GO:0019888 | protein phosphatase regulator activity | IBA | 21873635 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000159 | protein phosphatase type 2A complex | IBA | 21873635 |
GO:0005737 | cytoplasm | IBA | 21873635 |
GO:0008287 | protein serine/threonine phosphatase complex | IBA | 21873635 |
GO:0045121 | membrane raft | IDA | 21172653 |
GO:0070062 | extracellular exosome | HDA | 23533145 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | RET signaling |
.92
|
.92
|
2 | Activated TLR4 signalling | ||
3 | Misspliced GSK3beta mutants stabilize beta-catenin | ||
4 | GAB1 signalosome |
.89
|
|
5 | Cyclins and Cell Cycle Regulation |
Cyclins and Cell Cycle Regulation
.67
Cell Cycle Control by BTG Proteins
.36
|
.31
|
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006470 | protein dephosphorylation | IEA | -- |
GO:0043666 | regulation of phosphoprotein phosphatase activity | IEA | -- |
GO:0060561 | apoptotic process involved in morphogenesis | IMP | 21172653 |
GO:2001241 | positive regulation of extrinsic apoptotic signaling pathway in absence of ligand | IMP | 21172653 |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
Cyclosporin A | Approved, Investigational, Vet_approved | Pharma | Immunosuppressive agent, Calcineurin inhibitor | 0 | ||
Calcineurin Autoinhibitory Peptide | Pharma | CaMKII inhibitor, Selective calcineurin inhibitor | 0 | |||
INCA-6 | Pharma | Selective calcineurin-NFAT signaling inhibitor, Inhibitor of calcineurin-substrate association | 0 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
---|---|---|---|---|---|---|
FK 506 |
|
104987-11-3 |
|
|
Compound | Action | Cas Number |
---|---|---|
Calcineurin Autoinhibitory Peptide | Selective calcineurin inhibitor | 148067-21-4 |
Cyclosporin A | Calcineurin inhibitor | 59865-13-3 |
FK 506 | Potent calcineurin inhibitor; immunosuppressant | 104987-11-3 |
INCA-6 | Inhibitor of calcineurin-substrate association | 3519-82-2 |
ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6a | · | 6b | ^ | 7 | ^ | 8a | · | 8b | ^ | 9 | ^ | 10a | · | 10b | ^ | 11 | ^ | 12a | · | 12b | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17 | ^ | 18 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
SP2: | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
SP3: | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
SP4: | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
SP5: | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
SP6: | |||||||||||||||||||||||||||||||||||||||||||||||||||
SP7: |
This gene was present in the common ancestor of eukaryotes.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | PPP2R1B 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | PPP2R1B 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | PPP2R1B 30 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | PPP2R1B 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Ppp2r1b 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Ppp2r1b 30 17 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | PPP2R1B 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | pdgfb 30 |
|
||
African clawed frog (Xenopus laevis) |
Amphibia | ppp2r1b-prov 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | ppp2r1a 31 |
|
OneToMany | |
ppp2r1b 30 31 |
|
OneToMany | |||
Fruit Fly (Drosophila melanogaster) |
Insecta | Pp2A-29B 31 32 |
|
OneToMany | |
Worm (Caenorhabditis elegans) |
Secernentea | F48E8.5 32 |
|
|
|
paa-1 31 |
|
OneToMany | |||
Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | TPD3 31 33 |
|
OneToMany | |
Thale Cress (Arabidopsis thaliana) |
eudicotyledons | PP2AA3 30 |
|
||
Soybean (Glycine max) |
eudicotyledons | Gma.7498 30 |
|
||
Rice (Oryza sativa) |
Liliopsida | Os09g0249700 30 |
|
||
Corn (Zea mays) |
Liliopsida | Zm.2099 30 |
|
||
Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.8422 31 |
|
OneToMany |
SNP ID | Clinical significance and condition | Chr 11 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs1318084062 | A colon adenocarcinoma |
p.Val545Ala |
|||
rs142771326 | A lung cancer patient |
p.Gly8Arg |
|||
rs1442893893 | A colorectal cancer patient |
p.Ser365Pro |
|||
rs17113207 | Benign: not provided | 111,720,918(-) |
A/G NM_015191.3(SIK2):c.1800A>G (p.Gln600=) |
SYNONYMOUS | |
rs1805076 | Pathogenic: Lung carcinoma. A lung cancer patient | 111,764,842(-) |
C/Tp.Gly90Asp NM_002716.5(PPP2R1B):c.269G>A (p.Gly90Asp) |
MISSENSE_VARIANT,INTRON |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv3580116 | CNV | gain | 25503493 |
nsv832269 | CNV | loss | 17160897 |
Disorder | Aliases | PubMed IDs |
---|---|---|
lung cancer |
|
|
colorectal cancer |
|
|
cervical cancer |
|
|