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This gene encodes a constant regulatory subunit of protein phosphatase 2. Protein phosphatase 2 is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regu... See more...
Aliases for PPP2R1B Gene
Aliases for PPP2R1B Gene
- Protein Phosphatase 2 Scaffold Subunit Abeta 2 3 5
- Serine/Threonine-Protein Phosphatase 2A 65 KDa Regulatory Subunit A Beta Isoform 3 4
- PP2A-Abeta 2 3
- PR65B 2 3
- Protein Phosphatase 2 (Formerly 2A), Regulatory Subunit A (PR 65), Beta Isoform 2
- Protein Phosphatase 2, Structural/Regulatory Subunit A, Beta 3
External Ids for PPP2R1B Gene
- HGNC: 9303
- NCBI Entrez Gene: 5519
- Ensembl: ENSG00000137713
- OMIM®: 603113
- UniProtKB/Swiss-Prot: P30154
Previous GeneCards Identifiers for PPP2R1B Gene
- GC11M113950
- GC11M113109
- GC11M111631
- GC11M111135
- GC11M111102
- GC11M107521
- GC11M111613
- GC11M111618
- GC11M111634
- GC11M111642
- GC11M111656
- GC11M111725
Summaries for PPP2R1B Gene
-
This gene encodes a constant regulatory subunit of protein phosphatase 2. Protein phosphatase 2 is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The constant regulatory subunit A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit. This gene encodes a beta isoform of the constant regulatory subunit A. Mutations in this gene have been associated with some lung and colon cancers. Alternatively spliced transcript variants have been described. [provided by RefSeq, Apr 2010]
GeneCards Summary for PPP2R1B Gene
PPP2R1B (Protein Phosphatase 2 Scaffold Subunit Abeta) is a Protein Coding gene. Diseases associated with PPP2R1B include Lung Cancer and Colorectal Cancer. Among its related pathways are Beta-Adrenergic Signaling and Downstream signaling events of B Cell Receptor (BCR). Gene Ontology (GO) annotations related to this gene include binding. An important paralog of this gene is PPP2R1A.
UniProtKB/Swiss-Prot Summary for PPP2R1B Gene
-
The PR65 subunit of protein phosphatase 2A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit.
-
Protein Ser/Thr phosphatases are a group of enzymes that catalyze the removal of phosphate groups from serine and/or threonine residues by hydrolysis of phosphoric acid monoesters. They oppose the action of kinases and phosphorylases and are involved in signal transduction.
Additional gene information for PPP2R1B Gene
- HGNC (9303)
- NCBI Entrez Gene (5519)
- Ensembl (ENSG00000137713)
- OMIM® (603113)
- UniProtKB/Swiss-Prot (P30154)
- Open Targets Platform(ENSG00000137713)
- Monarch Initiative
- Search for PPP2R1B at DataMed
- Search for PPP2R1B at HumanCyc
No data available for CIViC Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PPP2R1B Gene
Genomics for PPP2R1B Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for PPP2R1B Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around PPP2R1B on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for PPP2R1B
- Top Transcription factor binding sites by QIAGEN in the PPP2R1B gene promoter:
-
- COUP
- COUP-TF
- COUP-TF1
- Evi-1
- HNF-4alpha1
- HNF-4alpha2
- Pax-4a
- Pax-6
- RORalpha1
- XBP-1
Genomic Locations for PPP2R1B Gene
Latest Assembly
- chr11:111,690,273-111,766,389
- (GRCh38/hg38)
- Size:
- 76,117 bases
- Orientation:
- Minus strand
Previous Assembly
- chr11:111,597,637-111,637,113
- (GRCh37/hg19 by Entrez Gene)
- Size:
- 39,477 bases
- Orientation:
- Minus strand
- chr11:111,597,632-111,637,151
- (GRCh37/hg19 by Ensembl)
- Size:
- 39,520 bases
- Orientation:
- Minus strand
Genomic View for PPP2R1B Gene
Genes around PPP2R1B on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 11q23.1 by HGNC
- 11q23.1 by Entrez Gene
- 11q23.1 by Ensembl
PPP2R1B Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for PPP2R1B Gene
Proteins for PPP2R1B Gene
-
Protein details for PPP2R1B Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P30154-2AAB_HUMAN
- Recommended name:
- Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform
- Protein Accession:
- P30154
- A8MY67
- B0YJ69
- B4DGQ6
- B4DK91
- B4DWW5
- F8W8G1
- O75620
- Q8NHV8
Protein attributes for PPP2R1B Gene
- Size:
- 601 amino acids
- Molecular mass:
- 66214 Da
- Quaternary structure:
-
- PP2A consists of a common heterodimeric core enzyme, composed of a 36 kDa catalytic subunit (subunit C) and a 65 kDa constant regulatory subunit (PR65 or subunit A), that associates with a variety of regulatory subunits. Proteins that associate with the core dimer include three families of regulatory subunits B (the R2/B/PR55/B55, R3/B''/PR72/PR130/PR59 and R5/B'/B56 families), the 48 kDa variable regulatory subunit, viral proteins, and cell signaling molecules. Interacts with IPO9. Interacts with SGO1. Interacts with RAF1.
- SequenceCaution:
-
- Sequence=AAA59983.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Sequence of unknown origin in the N-terminal part.; Evidence={ECO:0000305}; Sequence=BAG59103.1; Type=Frameshift; Evidence={ECO:0000305};
Protein Expression for PPP2R1B Gene
Post-translational modifications for PPP2R1B Gene
Other Protein References for PPP2R1B Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibodies for research
- LifeSpan BioSciences PPP2R1B Antibody
- G Biosciences Immunotag™ PPP2R1B Antibody
-
Custom Antibody ServicesOriGene Antibodies for PPP2R1B
- Novus Biologicals Antibodies for PPP2R1B
-
Abcam antibodies for PPP2R1B
- Invitrogen Antibodies for PPP2R1B (AFLGC-Ppp2r1b)
-
Santa Cruz Biotechnology (SCBT) Antibodies for PPP2R1B
- Sino Biological Antibodies for PPP2R1B
Protein products for research
-
OriGene Purified Proteins for PPP2R1B
- Search Origene for MassSpec and Protein Over-expression Lysates for PPP2R1B
- Origene Custom Protein Services for PPP2R1B
-
Abcam proteins for PPP2R1B
Assay products for research
No data available for DME Specific Peptides for PPP2R1B Gene
Domains & Families for PPP2R1B Gene
Gene Families for PPP2R1B Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Protein Domains for PPP2R1B Gene
- InterPro:
- Blocks:
-
- HEAT repeat
- ProtoNet:
Suggested Antigen Peptide Sequences for PPP2R1B Gene
- GenScript: Design optimal peptide antigens:
-
- PP2A subunit A isoform R1-beta (2AAB_HUMAN)
- cDNA FLJ53228, highly similar to Homo sapiens protein phosphatase 2 (formerly 2A), regulatory subunit A (PR 65), beta isoform (PPP2R1B), transcript variant 2, mRNA (B4DWW5_HUMAN)
Graphical View of Domain Structure for InterPro Entry
P30154UniProtKB/Swiss-Prot:
2AAB_HUMAN :- Each HEAT repeat appears to consist of two alpha helices joined by a hydrophilic region, the intrarepeat loop. The repeat units may be arranged laterally to form a rod-like structure.
- Belongs to the phosphatase 2A regulatory subunit A family.
- Domain:
-
- Each HEAT repeat appears to consist of two alpha helices joined by a hydrophilic region, the intrarepeat loop. The repeat units may be arranged laterally to form a rod-like structure.
- Family:
-
- Belongs to the phosphatase 2A regulatory subunit A family.
Function for PPP2R1B Gene
Molecular function for PPP2R1B Gene
- UniProtKB/Swiss-Prot Function:
- The PR65 subunit of protein phosphatase 2A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit.
- GENATLAS Biochemistry:
- serine/threonine phosphatase 2 (formerly 2A),regulatory subunit A,beta isoform,65kDa,altered in human lung and colon carcinomas,see TSG11F,LOH11CR2A
Phenotypes From GWAS Catalog for PPP2R1B Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004722 | contributes_to protein serine/threonine phosphatase activity | IBA | 21873635 |
| GO:0005515 | protein binding | IEA,IPI | 8392071 |
| GO:0019888 | protein phosphatase regulator activity | IBA | 21873635 |
Phenotypes for PPP2R1B Gene
- MGI mutant phenotypes for PPP2R1B:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for PPP2R1B:
-
- Increased vaccinia virus (VACV) infection
- no effect
- Synthetic lethal with Ras
- Decreased viability
- Decreased human papilloma virus 16 (HPV16) pseudovirus infection
- shRNA abundance <= 25%
- Decreased IL-8 secretion
- Decreased epidermal growth factor (EGF) endocytosis, decreased transferrin (TF) endocytosis
- Increased ionizing radiation sensitivity
- Decreased viability in glioblastoma multiforme (GBM) lineage
- Decreased caspase 3/7 activity
- Increased apoptosis
Animal Models for PPP2R1B Gene
- MGI Knock Outs for PPP2R1B:
-
- Ppp2r1b Ppp2r1b<tm1b(EUCOMM)Wtsi>
Animal Models for research
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for PPP2R1B - Starting at $85 >
- * PPP2R1B CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for PPP2R1B
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for PPP2R1B
-
Santa Cruz Biotechnology (SCBT) CRISPR for PPP2R1B
miRNA for PPP2R1B Gene
- miRTarBase miRNAs that target PPP2R1B
-
- hsa-miR-124-3p (MIRT022210)
- hsa-miR-7-5p (MIRT025691)
- hsa-miR-423-3p (MIRT042516)
- hsa-miR-16-5p (MIRT051305)
- hsa-miR-1-3p (MIRT394616)
- hsa-miR-206 (MIRT394617)
- hsa-miR-613 (MIRT394618)
- hsa-miR-6505-5p (MIRT452137)
- hsa-miR-5579-3p (MIRT452138)
- hsa-miR-30e-5p (MIRT452139)
- hsa-miR-30d-5p (MIRT452140)
- hsa-miR-30c-5p (MIRT452141)
- hsa-miR-30b-5p (MIRT452142)
- hsa-miR-30a-5p (MIRT452143)
- hsa-miR-5192 (MIRT452144)
- hsa-miR-4644 (MIRT452145)
- hsa-miR-4306 (MIRT452146)
- hsa-miR-185-5p (MIRT452147)
- hsa-miR-3134 (MIRT452148)
- hsa-miR-8082 (MIRT452149)
- hsa-miR-4534 (MIRT452150)
- hsa-miR-4756-3p (MIRT452151)
- hsa-miR-380-3p (MIRT452152)
- hsa-miR-411-3p (MIRT452153)
- hsa-miR-379-3p (MIRT452154)
- hsa-miR-4495 (MIRT452155)
- hsa-miR-208b-5p (MIRT452156)
- hsa-miR-208a-5p (MIRT452157)
- mmu-miR-5102 (MIRT593729)
- mmu-miR-1199-5p (MIRT593730)
- hsa-miR-574-5p (MIRT606891)
- hsa-miR-632 (MIRT606892)
- hsa-miR-4288 (MIRT606893)
- hsa-miR-3977 (MIRT606894)
- hsa-miR-6867-5p (MIRT606895)
- hsa-miR-4711-3p (MIRT606896)
- hsa-miR-346 (MIRT606897)
- hsa-miR-5010-3p (MIRT608583)
- hsa-miR-147a (MIRT608584)
- hsa-miR-6818-5p (MIRT608585)
- hsa-miR-8068 (MIRT608586)
- hsa-miR-4307 (MIRT608587)
- hsa-miR-576-5p (MIRT622615)
- hsa-miR-4263 (MIRT622616)
- hsa-miR-664b-3p (MIRT622617)
- hsa-miR-579-3p (MIRT622618)
- hsa-miR-5696 (MIRT622619)
- hsa-miR-153-5p (MIRT622620)
- hsa-miR-1250-3p (MIRT622621)
- hsa-miR-587 (MIRT734747)
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for PPP2R1B
- Browse OriGene Inhibitory RNA Products For PPP2R1B
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PPP2R1B
Clone products for research
- Applied Biological Materials (abm): Clones for PPP2R1B - Starting at $45 >
- * PPP2R1B as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
-
- MG209317
- MG219372
- MR209317
- MR209317L3
- MR209317L4
- MR219372
- MR219372L3
- MR219372L4
- MR230908
- RC205346
- RC205346L1
- RC205346L2
- RC205346L3
- RC205346L4
- RC215175
- RC215175L3
- RC215175L4
- RC230138
- RC230138L3
- RC230138L4
- RC230265
- RC230265L3
- RC230265L4
- RC230334
- RC230334L3
- RC230334L4
- RG205346
- RG215175
- RG230138
- RG230265
- RG230334
- RR202007
- RR202007L3
- RR202007L4
- MR209317L3V
- MR209317L4V
- MR219372L3V
- MR219372L4V
- RC205346L1V
- RC205346L2V
- RC205346L3V
- RC205346L4V
- RC215175L3V
- RC215175L4V
- RC230138L3V
- RC230138L4V
- RC230265L3V
- RC230265L4V
- RC230334L3V
- RC230334L4V
- RR202007L3V
- RR202007L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for PPP2R1B
- Addgene plasmids for PPP2R1B
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for PPP2R1B
Cell Lines for research
-
Horizon Cell Lines for PPP2R1B
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PPP2R1B Gene
Localization for PPP2R1B Gene
| Compartment | Confidence |
|---|---|
| extracellular | 4 |
| cytosol | 4 |
| plasma membrane | 3 |
| cytoskeleton | 3 |
| nucleus | 3 |
| mitochondrion | 1 |
| endoplasmic reticulum | 1 |
| endosome | 1 |
| lysosome | 1 |
- Cytosol (2)
- Plasma membrane (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000159 | protein phosphatase type 2A complex | IBA | 21873635 |
| GO:0005737 | cytoplasm | IBA | 21873635 |
| GO:0008287 | protein serine/threonine phosphatase complex | IBA | 21873635 |
| GO:0045121 | membrane raft | IDA | 21172653 |
| GO:0070062 | extracellular exosome | HDA | 23533145 |
No data available for Subcellular locations from UniProtKB/Swiss-Prot for PPP2R1B Gene
Pathways & Interactions for PPP2R1B Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | RET signaling |
.92
|
.92
|
| 2 | Activated TLR4 signalling | ||
| 3 | Misspliced GSK3beta mutants stabilize beta-catenin | ||
| 4 | GAB1 signalosome |
.89
|
|
| 5 | Cyclins and Cell Cycle Regulation |
Cyclins and Cell Cycle Regulation
.67
Cell Cycle Control by BTG Proteins
.36
|
.31
|
Pathways by source for PPP2R1B Gene
2 BioSystems pathways for PPP2R1B Gene
140 Reactome pathways for PPP2R1B Gene
14 KEGG pathways for PPP2R1B Gene
2 GeneGo (Thomson Reuters) pathways for PPP2R1B Gene
- Neurophysiological process Glutamate regulation of Dopamine D1A receptor signaling
- Regulation of CFTR activity (norm and CF)
25 Qiagen pathways for PPP2R1B Gene
- Akt Signaling
- BAD Phosphorylation
- Beta-Adrenergic Signaling
- Breast Cancer Regulation by Stathmin1
- CDK5 Pathway
Interacting Proteins for PPP2R1B Gene
Selected Interacting proteins:
P30154-2AAB_HUMAN
ENSP00000311344
for PPP2R1B Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for PPP2R1B
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006470 | protein dephosphorylation | IEA | -- |
| GO:0043666 | regulation of phosphoprotein phosphatase activity | IEA | -- |
| GO:0060561 | apoptotic process involved in morphogenesis | IMP | 21172653 |
| GO:2001241 | positive regulation of extrinsic apoptotic signaling pathway in absence of ligand | IMP | 21172653 |
Drugs & Compounds for PPP2R1B Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Cyclosporin A | Approved, Investigational, Vet_approved | Pharma | Immunosuppressive agent, Calcineurin inhibitor | 0 | ||
| Calcineurin Autoinhibitory Peptide | Pharma | CaMKII inhibitor, Selective calcineurin inhibitor | 0 | |||
| INCA-6 | Pharma | Selective calcineurin-NFAT signaling inhibitor, Inhibitor of calcineurin-substrate association | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| FK 506 |
|
104987-11-3 |
|
|
(4) Tocris Compounds for PPP2R1B Gene
| Compound | Action | Cas Number |
|---|---|---|
| Calcineurin Autoinhibitory Peptide | Selective calcineurin inhibitor | 148067-21-4 |
| Cyclosporin A | Calcineurin inhibitor | 59865-13-3 |
| FK 506 | Potent calcineurin inhibitor; immunosuppressant | 104987-11-3 |
| INCA-6 | Inhibitor of calcineurin-substrate association | 3519-82-2 |
Transcripts for PPP2R1B Gene
mRNA/cDNA for PPP2R1B Gene
- 5 REFSEQ mRNAs :
- 14 NCBI additional mRNA sequence :
- 12 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000311129 2082 nts (view in UCSC)
- ENST00000341980 1953 nts (view in UCSC)
- ENST00000393055 1525 nts (view in UCSC)
- ENST00000426998 1888 nts (view in UCSC)
- ENST00000526287 101 nts (view in UCSC)
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for PPP2R1B - Starting at $85 >
- * PPP2R1B CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for PPP2R1B
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for PPP2R1B
-
Santa Cruz Biotechnology (SCBT) CRISPR for PPP2R1B
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for PPP2R1B
- Browse OriGene Inhibitory RNA Products For PPP2R1B
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PPP2R1B
Clone products for research
- Applied Biological Materials (abm): Clones for PPP2R1B - Starting at $45 >
- * PPP2R1B as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
-
- MG209317
- MG219372
- MR209317
- MR209317L3
- MR209317L4
- MR219372
- MR219372L3
- MR219372L4
- MR230908
- RC205346
- RC205346L1
- RC205346L2
- RC205346L3
- RC205346L4
- RC215175
- RC215175L3
- RC215175L4
- RC230138
- RC230138L3
- RC230138L4
- RC230265
- RC230265L3
- RC230265L4
- RC230334
- RC230334L3
- RC230334L4
- RG205346
- RG215175
- RG230138
- RG230265
- RG230334
- RR202007
- RR202007L3
- RR202007L4
- MR209317L3V
- MR209317L4V
- MR219372L3V
- MR219372L4V
- RC205346L1V
- RC205346L2V
- RC205346L3V
- RC205346L4V
- RC215175L3V
- RC215175L4V
- RC230138L3V
- RC230138L4V
- RC230265L3V
- RC230265L4V
- RC230334L3V
- RC230334L4V
- RR202007L3V
- RR202007L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for PPP2R1B
- Addgene plasmids for PPP2R1B
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for PPP2R1B
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6a | · | 6b | ^ | 7 | ^ | 8a | · | 8b | ^ | 9 | ^ | 10a | · | 10b | ^ | 11 | ^ | 12a | · | 12b | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17 | ^ | 18 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP5: | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP6: | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP7: |
Relevant External Links for PPP2R1B Gene
- GeneLoc Exon Structure for
- PPP2R1B
Expression for PPP2R1B Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Testis (Reproductive System)
- Leydig Cells Testis Interstitium
- Brain (Nervous System)
- Thyroid (Endocrine System)
- Intestine (Gastrointestinal Tract)
- Pancreas (Endocrine System)
- Ovary (Reproductive System)
- Blood (Hematopoietic System)
- Eye (Sensory Organs)
- Mesenchymal Stem Cells
-
Liver (Hepatobiliary System)
mRNA differential expression in normal tissues according to GTEx for PPP2R1B Gene
This gene is overexpressed in Liver (x14.1).
This gene is overexpressed in Bone (41.8), Testis (7.6), and Brain (6.6).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for PPP2R1B Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for PPP2R1B
SOURCE GeneReport for Unigene cluster for PPP2R1B Gene:
Hs.584790Evidence on tissue expression from TISSUES for PPP2R1B Gene
- Nervous system(4.8)
- Liver(4.5)
- Intestine(2.1)
Phenotype-based relationships between genes and organs from Gene ORGANizer for PPP2R1B Gene
Germ Layers:
- endoderm
Systems:
- respiratory
Regions:
Thorax:
- lung
Primer products for research
-
OriGene qPCR primer pairs for PPP2R1B
-
OriGene qPCR primer pairs and template standards for PPP2R1B
Gene Expression Assays for research
No data available for Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for PPP2R1B Gene
Orthologs for PPP2R1B Gene
This gene was present in the common ancestor of eukaryotes.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | PPP2R1B 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | PPP2R1B 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | PPP2R1B 30 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | PPP2R1B 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Ppp2r1b 30 |
|
||
| Mouse (Mus musculus) |
Mammalia | Ppp2r1b 30 17 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | PPP2R1B 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | pdgfb 30 |
|
||
| African clawed frog (Xenopus laevis) |
Amphibia | ppp2r1b-prov 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | ppp2r1a 31 |
|
OneToMany | |
| ppp2r1b 30 31 |
|
OneToMany | |||
| Fruit Fly (Drosophila melanogaster) |
Insecta | Pp2A-29B 31 32 |
|
OneToMany | |
| Worm (Caenorhabditis elegans) |
Secernentea | F48E8.5 32 |
|
|
|
| paa-1 31 |
|
OneToMany | |||
| Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | TPD3 31 33 |
|
OneToMany | |
| Thale Cress (Arabidopsis thaliana) |
eudicotyledons | PP2AA3 30 |
|
||
| Soybean (Glycine max) |
eudicotyledons | Gma.7498 30 |
|
||
| Rice (Oryza sativa) |
Liliopsida | Os09g0249700 30 |
|
||
| Corn (Zea mays) |
Liliopsida | Zm.2099 30 |
|
||
| Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.8422 31 |
|
OneToMany |
- Species where no ortholog for PPP2R1B was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Lizard (Anolis carolinensis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
Evolution for PPP2R1B Gene
- ENSEMBL:
- Gene Tree for PPP2R1B (if available)
- TreeFam:
- Gene Tree for PPP2R1B (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for PPP2R1B: view image
Paralogs for PPP2R1B Gene
Variants for PPP2R1B Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for PPP2R1B Gene
| SNP ID | Clinical significance and condition | Chr 11 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1318084062 | A colon adenocarcinoma |
p.Val545Ala |
|||
| rs142771326 | A lung cancer patient |
p.Gly8Arg |
|||
| rs1442893893 | A colorectal cancer patient |
p.Ser365Pro |
|||
| rs17113207 | Benign: not provided | 111,720,918(-) |
A/G NM_015191.3(SIK2):c.1800A>G (p.Gln600=) |
SYNONYMOUS | |
| rs1805076 | Pathogenic: Lung carcinoma. A lung cancer patient | 111,764,842(-) |
C/Tp.Gly90Asp NM_002716.5(PPP2R1B):c.269G>A (p.Gly90Asp) |
MISSENSE_VARIANT,INTRON |
All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv3580116 | CNV | gain | 25503493 |
| nsv832269 | CNV | loss | 17160897 |
Residual Variation Intolerance Score:
70.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
3.84;
58.73% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for PPP2R1B Gene
SNP Genotyping and Copy Number Assays for research
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PPP2R1B Gene
Disorders for PPP2R1B Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| lung cancer |
|
|
| colorectal cancer |
|
|
| cervical cancer |
|
|
Search PPP2R1B in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for PPP2R1B
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- Atlas
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for PPP2R1B Gene
Publications for PPP2R1B Gene
- Alterations in the suppressor gene PPP2R1B in parathyroid hyperplasias and adenomas. (PMID: 11996789) Hemmer S … Joensuu H (Cancer genetics and cytogenetics 2002) 3 4 23 74
- Alterations of the PPP2R1B gene in human lung and colon cancer. (PMID: 9765152) Wang SS … Evans GA (Science (New York, N.Y.) 1998) 3 4 23 74
- Genomic organization and precise physical location of protein phosphatase 2A regulatory subunit A beta isoform gene on chromosome band 11q23. (PMID: 9795170) Baysal BE … Richard CW (Gene 1998) 2 3 4 23
- Mutation analysis of the tumor suppressor gene PPP2R1B in human cervical cancer. (PMID: 17343570) Yeh LS … Tsai FJ (International journal of gynecological cancer : official journal of the International Gynecological Cancer Society 2007) 3 23 41
- The glycine 90 to aspartate alteration in the Abeta subunit of PP2A (PPP2R1B) associates with breast cancer and causes a deficit in protein function. (PMID: 16276521) Esplin ED … Evans GA (Genes, chromosomes & cancer 2006) 3 23 41
ExternalLinks
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Sources for PPP2R1B Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM® (Updated: 05-Mar-2021)
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42)