Aliases for PPP2R1A Gene
- Protein Phosphatase 2 Scaffold Subunit Aalpha 2 3 5
- Serine/Threonine-Protein Phosphatase 2A 65 KDa Regulatory Subunit A Alpha Isoform 3 4
- PP2A-Aalpha 2 3
- PP2AA 2 3
- PR65A 2 3
- Protein Phosphatase 2 (Formerly 2A), Regulatory Subunit A (PR 65), Alpha Isoform 2
- Protein Phosphatase 2A, Regulatory Subunit A, Alpha Isoform 2
- Protein Phosphatase 2A Structural Subunit A, Alpha Isoform 2
- Protein Phosphatase 2, Regulatory Subunit A, Alpha 3
External Ids for PPP2R1A Gene
Previous GeneCards Identifiers for PPP2R1A Gene
This gene encodes a constant regulatory subunit of protein phosphatase 2. Protein phosphatase 2 is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The constant regulatory subunit A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit. This gene encodes an alpha isoform of the constant regulatory subunit A. Alternatively spliced transcript variants have been described. [provided by RefSeq, Apr 2010]
GeneCards Summary for PPP2R1A Gene
PPP2R1A (Protein Phosphatase 2 Scaffold Subunit Aalpha) is a Protein Coding gene. Diseases associated with PPP2R1A include Mental Retardation, Autosomal Dominant 36 and Brachydactyly. Among its related pathways are Beta-Adrenergic Signaling and Downstream signaling events of B Cell Receptor (BCR). Gene Ontology (GO) annotations related to this gene include protein heterodimerization activity and antigen binding. An important paralog of this gene is PPP2R1B.
UniProtKB/Swiss-Prot Summary for PPP2R1A Gene
The PR65 subunit of protein phosphatase 2A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit. Upon interaction with GNA12 promotes dephosphorylation of microtubule associated protein TAU/MAPT (PubMed:15525651). Required for proper chromosome segregation and for centromeric localization of SGO1 in mitosis (PubMed:16580887).
Protein Ser/Thr phosphatases are a group of enzymes that catalyze the removal of phosphate groups from serine and/or threonine residues by hydrolysis of phosphoric acid monoesters. They oppose the action of kinases and phosphorylases and are involved in signal transduction.