Aliases for PPP2CB Gene
Aliases for PPP2CB Gene
- Protein Phosphatase 2 Catalytic Subunit Beta 2 3 5
- Protein Phosphatase 2 (Formerly 2A), Catalytic Subunit, Beta Isoform 2 3
- Protein Phosphatase 2, Catalytic Subunit, Beta Isozyme 2 3
- Protein Phosphatase 2A Catalytic Subunit, Beta Isoform 2 3
- PP2A-Beta 3 4
- Serine/Threonine Protein Phosphatase 2A, Catalytic Subunit, Beta Isoform 3
- Serine/Threonine-Protein Phosphatase 2A Catalytic Subunit Beta Isoform 3
External Ids for PPP2CB Gene
- HGNC: 9300
- Entrez Gene: 5516
- Ensembl: ENSG00000104695
- OMIM: 176916
- UniProtKB: P62714
Previous GeneCards Identifiers for PPP2CB Gene
- GC08M030548
- GC08M031095
- GC08M030499
- GC08M030700
- GC08M029189
- GC08M030631
Summaries for PPP2CB Gene
-
This gene encodes the phosphatase 2A catalytic subunit. Protein phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. This gene encodes a beta isoform of the catalytic subunit. [provided by RefSeq, Mar 2010]
GeneCards Summary for PPP2CB Gene
PPP2CB (Protein Phosphatase 2 Catalytic Subunit Beta) is a Protein Coding gene. Among its related pathways are ERK Signaling and mTOR Pathway. Gene Ontology (GO) annotations related to this gene include hydrolase activity and phosphoprotein phosphatase activity. An important paralog of this gene is PPP2CA.
UniProtKB/Swiss-Prot for PPP2CB Gene
-
PP2A can modulate the activity of phosphorylase B kinase casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase.
-
Protein Ser/Thr phosphatases are a group of enzymes that catalyze the removal of phosphate groups from serine and/or threonine residues by hydrolysis of phosphoric acid monoesters. They oppose the action of kinases and phosphorylases and are involved in signal transduction.
Additional gene information for PPP2CB Gene
No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PPP2CB Gene
Genomics for PPP2CB Gene
GeneHancer (GH) Regulatory Elements for PPP2CB Gene
Promoters and enhancers for PPP2CB Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around PPP2CB on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Locations for PPP2CB Gene
Genomic Locations for PPP2CB Gene
- chr8:30,774,457-30,814,314
- (GRCh38/hg38)
- Size:
- 39,858 bases
- Orientation:
- Minus strand
- chr8:30,631,973-30,671,830
- (GRCh37/hg19)
Genomic View for PPP2CB Gene
Genes around PPP2CB on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 8p12 by Entrez Gene
- 8p12 by HGNC
- 8p12 by Ensembl
PPP2CB Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for PPP2CB Gene
Proteins for PPP2CB Gene
-
Protein details for PPP2CB Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P62714-PP2AB_HUMAN
- Recommended name:
- Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform
- Protein Accession:
- P62714
- D3DSV4
- P11082
- Q6FHK5
Protein attributes for PPP2CB Gene
- Size:
- 309 amino acids
- Molecular mass:
- 35575 Da
- Cofactor:
- Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
- Quaternary structure:
-
- Found in a complex with at least ARL2, PPP2CB, PPP2R1A, PPP2R2A, PPP2R5E and TBCD. Interacts with TBCD (By similarity). PP2A consists of a common heterodimeric core enzyme (composed of a 36 kDa catalytic subunit (subunit C) and a 65 kDa constant regulatory subunit (PR65) (subunit A)) that associates with a variety of regulatory subunits. Proteins that associate with the core dimer include three families of regulatory subunits B (the R2/B/PR55/B55, R3/B/PR72/PR130/PR59 and R5/B/B56 families), the 48 kDa variable regulatory subunit, viral proteins, and cell signaling molecules. Binds PPME1. May indirectly interact with SGO1, most probably through regulatory B56 subunits. Interacts with CTTNBP2NL. Interacts with PTPA (PubMed:12952889).
Protein Expression for PPP2CB Gene
Post-translational modifications for PPP2CB Gene
- Reversibly methyl esterified on Leu-309 by leucine carboxyl methyltransferase 1 (LCMT1) and protein phosphatase methylesterase 1 (PPME1). Carboxyl methylation influences the affinity of the catalytic subunit for the different regulatory subunits, thereby modulating the PP2A holoenzymes substrate specificity, enzyme activity and cellular localization.
- Phosphorylation of either threonine (by autophosphorylation-activated protein kinase) or tyrosine results in inactivation of the phosphatase. Auto-dephosphorylation has been suggested as a mechanism for reactivation.
- May be monoubiquitinated by NOSIP.
- Ubiquitination at posLast=2121
- Modification sites at PhosphoSitePlus
Other Protein References for PPP2CB Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for PPP2CB
- Invitrogen Antibodies for PPP2CB
- GeneTex PPP2CB Antibody for PPP2CB
-
Boster Bio Antibodies for PPP2CB
-
Santa Cruz Biotechnology (SCBT) Antibodies for PPP2CB
Protein Products
-
OriGene Purified Proteins for PPP2CB
- Search Origene for MassSpec and Protein Over-expression Lysates for PPP2CB
- Origene Custom Protein Services for PPP2CB
- Search GeneTex for Proteins for PPP2CB
Assay Products
No data available for DME Specific Peptides for PPP2CB Gene
Domains & Families for PPP2CB Gene
Gene Families for PPP2CB Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Enzymes
- Predicted intracellular proteins
Protein Domains for PPP2CB Gene
Suggested Antigen Peptide Sequences for PPP2CB Gene
Graphical View of Domain Structure for InterPro Entry
P62714- Family:
-
- Belongs to the PPP phosphatase family. PP-1 subfamily.
Function for PPP2CB Gene
Molecular function for PPP2CB Gene
- UniProtKB/Swiss-Prot Function:
- PP2A can modulate the activity of phosphorylase B kinase casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase.
- UniProtKB/Swiss-Prot CatalyticActivity:
- [a protein]-serine/threonine phosphate + H(2)O = [a protein]-serine/threonine + phosphate.
- GENATLAS Biochemistry:
- protein phosphatase 2A,catalytic subunit,beta isoform
Enzyme Numbers (IUBMB) for PPP2CB Gene
Phenotypes From GWAS Catalog for PPP2CB Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004721 | phosphoprotein phosphatase activity | IEA | -- |
| GO:0004722 | contributes_to protein serine/threonine phosphatase activity | TAS,ISS | 8206937 |
| GO:0005515 | protein binding | IPI | 9647778 |
| GO:0008022 | protein C-terminus binding | IEA | -- |
| GO:0016787 | hydrolase activity | IEA | -- |
Phenotypes for PPP2CB Gene
- MGI mutant phenotypes for PPP2CB:
- inferred from 2 alleles
- GenomeRNAi human phenotypes for PPP2CB:
-
- Decreased focal adhesion (FA) area, decreased FA length, decreased FA mean intensity, increased number of small and round FAs, increased FA abundance
- Negative genetic interaction between KRASG13D/+ and KRAS+/-
- Upregulation of Wnt/beta-catenin pathway after WNT3A stimulation
- Increased cilium length after serum starvation
- Decreased ionizing radiation sensitivity
- Decreased viability
- no effect
- Increased vaccinia virus (VACV) infection
- Apoptosis resistance
- Decreased melanin production
- Decreased homologous recombination repair frequency
- Mildly decreased CFP-tsO45G cell surface transport
- Strongly decreased CFP-tsO45G cell surface transport
- Decreased hepcidin::fluc mRNA expression
- shRNA abundance <= 50%
- Increased viability with MLN4924 (a NAE inhibitor)
Animal Models for PPP2CB Gene
- MGI Knock Outs for PPP2CB:
-
- Ppp2cb Ppp2cb<tm1.1Nju>
Animal Model Products
-
Taconic Biosciences Mouse Models for PPP2CB
- Cyagen custom Knockout/knockin (KOKI) mouse models for PPP2CB
-
CRISPR Products
-
OriGene CRISPR knockouts for PPP2CB
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for PPP2CB
- genomics-online: gRNA clones - Search results for 133 available PPP2CA gene related products
- Overview of 133 available PPP2CA gene related products
- Applied Biological Materials CRISPR for PPP2CB
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for PPP2CB
- GenScript: Design CRISPR guide RNA sequences for PPP2CB
miRNA for PPP2CB Gene
- miRTarBase miRNAs that target PPP2CB
-
- hsa-mir-425-5p (MIRT016657)
- hsa-mir-421 (MIRT039452)
- hsa-mir-183-5p (MIRT438391)
- hsa-mir-218-5p (MIRT439916)
- hsa-mir-4753-3p (MIRT555316)
- hsa-mir-549a (MIRT555317)
- hsa-mir-302d-5p (MIRT555318)
- hsa-mir-302b-5p (MIRT555319)
- hsa-mir-6814-5p (MIRT555320)
- hsa-mir-130b-5p (MIRT555321)
- hsa-mir-216b-5p (MIRT555322)
- hsa-mir-548b-3p (MIRT555323)
- hsa-mir-150-5p (MIRT555324)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for PPP2CB
- Browse OriGene Inhibitory RNA Products For PPP2CB
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PPP2CB
- genomics-online: shRNA clones - Search results for 133 available PPP2CA gene related products
- Overview of 133 available PPP2CA gene related products
Clone Products
- Sino Biological Human cDNA Clone for PPP2CB
- VectorBuilder custom plasmid, inducible vectors for PPP2CB
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for PPP2CB
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for PPP2CB
- Applied Biological Materials Clones for PPP2CB
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PPP2CB Gene
Localization for PPP2CB Gene
Subcellular locations from UniProtKB/Swiss-Prot for PPP2CB Gene
- Cytoplasm. Nucleus. Chromosome, centromere. Cytoplasm, cytoskeleton, spindle pole. Note=In prometaphase cells, but not in anaphase cells, localizes at centromeres. During mitosis, also found at spindle poles.
| Compartment | Confidence |
|---|---|
| extracellular | 5 |
| cytosol | 5 |
| nucleus | 4 |
| cytoskeleton | 3 |
- Nucleoplasm (3)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000159 | protein phosphatase type 2A complex | TAS | 8206937 |
| GO:0000775 | chromosome, centromeric region | IEA | -- |
| GO:0000922 | spindle pole | IEA | -- |
| GO:0005634 | nucleus | IEA | -- |
| GO:0005694 | chromosome | IEA | -- |
Pathways & Interactions for PPP2CB Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | RET signaling |
.92
|
.92
|
| 2 | Activated TLR4 signalling | ||
| 3 | phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex | ||
| 4 | Negative regulation of FGFR1 signaling | ||
| 5 | PI3K/AKT activation |
.89
|
|
Pathways by source for PPP2CB Gene
1 Sino Biological pathway for PPP2CB Gene
1 GeneTex pathway for PPP2CB Gene
7 BioSystems pathways for PPP2CB Gene
16 KEGG pathways for PPP2CB Gene
12 GeneGo (Thomson Reuters) pathways for PPP2CB Gene
5 Tocris pathways for PPP2CB Gene
24 Qiagen pathways for PPP2CB Gene
Interacting Proteins for PPP2CB Gene
Selected Interacting proteins:
P62714-PP2AB_HUMAN
ENSP00000221138
for PPP2CB Gene via
MINT
IID
UniProtKB
STRING
GPS-Prot Interaction Network for PPP2CB
SIGNOR curated interactions for PPP2CB Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006470 | protein dephosphorylation | IEA,TAS | 2849765 |
| GO:0008637 | apoptotic mitochondrial changes | IEA | -- |
| GO:0010288 | response to lead ion | ISS | -- |
| GO:0010468 | regulation of gene expression | IEA | -- |
| GO:0034976 | response to endoplasmic reticulum stress | IEA | -- |
Drugs & Compounds for PPP2CB Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Vitamin E | Approved, Vet_approved | Nutra | Target | 434,438 | ||
| alpha-Tocopherol acetate | Approved, Vet_approved | Nutra | Target | 0 | ||
| alpha-Tocopherol succinate | Approved, Vet_approved | Nutra | Target | 0 | ||
| Phosphoric acid | Approved | Pharma | 0 | |||
| Water | Approved | Pharma | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| Fe2+ |
|
15438-31-0 |
|
|||
| Phosphate |
|
14265-44-2 |
|
|||
| FK 506 |
|
104987-11-3 |
|
|
(4) Tocris Compounds for PPP2CB Gene
| Compound | Action | Cas Number |
|---|---|---|
| Calcineurin Autoinhibitory Peptide | Selective calcineurin inhibitor | 148067-21-4 |
| Cyclosporin A | Calcineurin inhibitor | 59865-13-3 |
| FK 506 | Potent calcineurin inhibitor; immunosuppressant | 104987-11-3 |
| INCA-6 | Inhibitor of calcineurin-substrate association | 3519-82-2 |
(3) ApexBio Compounds for PPP2CB Gene
| Compound | Action | Cas Number |
|---|---|---|
| DL-AP3 | Glutamate receptor antagonist and HPSP inhibitor | 20263-06-3 |
| Microcystin-LR | Inhibitor of protein phosphatase PP1/PP2A,potent and selective | 101043-37-2 |
| Sal 003 | Cellular phosphatase complex inhibitor | 1164470-53-4 |
Transcripts for PPP2CB Gene
mRNA/cDNA for PPP2CB Gene
- (379) Selected AceView cDNA sequences:
- (7) Additional mRNA sequences :
- (2) REFSEQ mRNAs :
- (10) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000221138 2006 bps (uc003xik.4)
- ENST00000518243 577 bps (uc064ltu.1)
- ENST00000518532 566 bps (uc064ltq.1)
- ENST00000518564 691 bps (uc064ltp.1)
- ENST00000520056 755 bps (uc064ltv.1)
Unigene Clusters for PPP2CB Gene
- Protein phosphatase 2, catalytic subunit, beta isozyme:
- Representative Sequences:
CRISPR Products
-
OriGene CRISPR knockouts for PPP2CB
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for PPP2CB
- genomics-online: gRNA clones - Search results for 133 available PPP2CA gene related products
- Overview of 133 available PPP2CA gene related products
- Applied Biological Materials CRISPR for PPP2CB
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for PPP2CB
- GenScript: Design CRISPR guide RNA sequences for PPP2CB
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for PPP2CB
- Browse OriGene Inhibitory RNA Products For PPP2CB
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PPP2CB
- genomics-online: shRNA clones - Search results for 133 available PPP2CA gene related products
- Overview of 133 available PPP2CA gene related products
Clone Products
- Sino Biological Human cDNA Clone for PPP2CB
- VectorBuilder custom plasmid, inducible vectors for PPP2CB
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for PPP2CB
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for PPP2CB
- Applied Biological Materials Clones for PPP2CB
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1 | ^ | 2a | · | 2b | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6a | · | 6b | ^ | 7a | · | 7b | ^ | 8a | · | 8b | · | 8c |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | |||||||||||||||||||||||||
| SP2: | - | ||||||||||||||||||||||||||
| SP3: | - | - | |||||||||||||||||||||||||
| SP4: | |||||||||||||||||||||||||||
| SP5: | - | - | - | - | - | - | - | - | - | - |
Expression for PPP2CB Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Intestine (Gastrointestinal Tract)
- Brain (Nervous System)
-
Adipose (Muscoskeletal System)
-
Ovary (Reproductive System)
-
Liver (Hepatobiliary System)
-
Esophagus (Gastrointestinal Tract)
-
Adrenal Gland (Endocrine System)
-
Testis (Reproductive System)
-
Kidney (Urinary System)
-
Lung (Respiratory System)
-
Gall Bladder (Hepatobiliary System)
-
Thyroid (Endocrine System)
-
Placenta (Extraembryonic Tissues)
-
Prostate (Endocrine System)
-
Uterus (Reproductive System)
This gene is overexpressed in Uterus (6.4).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for PPP2CB Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of PPP2CB Gene:
PPP2CBSOURCE GeneReport for Unigene cluster for PPP2CB Gene:
Hs.491440Evidence on tissue expression from TISSUES for PPP2CB Gene
- Nervous system(4.5)
- Kidney(4.4)
- Liver(4.4)
- Eye(2)
Primer Products
-
OriGene qPCR primer pairs for PPP2CB
-
OriGene qPCR primer pairs and template standards for PPP2CB
- genomics-online: primer clones - Search results for 133 available PPP2CA gene related products
- Overview of 133 available PPP2CA gene related products
Gene Expression Assay Products
No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PPP2CB Gene
Orthologs for PPP2CB Gene
This gene was present in the common ancestor of eukaryotes.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | PPP2CB 33 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | -- 34 |
|
OneToMany | |
| -- 34 |
|
OneToMany | |||
| dog (Canis familiaris) |
Mammalia | PPP2CB 34 33 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | PPP2CB 34 33 |
|
OneToOne | |
| rat (Rattus norvegicus) |
Mammalia | Ppp2cb 33 |
|
||
| mouse (Mus musculus) |
Mammalia | Ppp2cb 16 34 33 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | PPP2CB 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | PPP2CA 34 |
|
OneToOne | |
| PPP2CB 33 |
|
||||
| lizard (Anolis carolinensis) |
Reptilia | PPP2CB 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | ppp2cb 33 |
|
||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.6686 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | ppp2cb 34 33 |
|
OneToOne | |
| Dr.5120 33 |
|
||||
| fruit fly (Drosophila melanogaster) |
Insecta | mts 34 35 |
|
OneToMany | |
| CG11597 35 |
|
|
|||
| worm (Caenorhabditis elegans) |
Secernentea | F38H4.9 35 |
|
|
|
| let-92 34 |
|
OneToMany | |||
| pph-4.1 35 |
|
|
|||
| pph-4.2 35 |
|
|
|||
| C34C12.3 35 |
|
|
|||
| C25A6.1 35 |
|
|
|||
| C06A1.3 35 |
|
|
|||
| W03D8.2 35 |
|
|
|||
| Y40H4A.2 35 |
|
|
|||
| C23G10.1a 35 |
|
|
|||
| C24H11.2 35 |
|
|
|||
| C24H11.1 35 |
|
|
|||
| C23G10.1b 35 |
|
|
|||
| R13A5.11 35 |
|
|
|||
| F58G1.3 35 |
|
|
|||
| R08A2.2 35 |
|
|
|||
| F42G8.8 35 |
|
|
|||
| C27B7.6 35 |
|
|
|||
| F49E11.7 35 |
|
|
|||
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | PPH22 34 33 |
|
ManyToMany | |
| PPH21 36 34 |
|
||||
| K. lactis yeast (Kluyveromyces lactis) |
Saccharomycetes | KLLA0F05357g 33 |
|
||
| A. gosspyii yeast (Ashbya gossypii) |
Saccharomycetes | AGOS_ADR099C 33 |
|
||
| soybean (Glycine max) |
eudicotyledons | Gma.10798 33 |
|
||
| Alicante grape (Vitis vinifera) |
eudicotyledons | Vvi.9171 33 |
|
||
| rice (Oryza sativa) |
Liliopsida | Os10g0410600 33 |
|
||
| wheat (Triticum aestivum) |
Liliopsida | Ta.11307 33 |
|
||
| barley (Hordeum vulgare) |
Liliopsida | Hv.6175 33 |
|
||
| sea squirt (Ciona savignyi) |
Ascidiacea | CSA.11024 34 |
|
OneToMany | |
| bread mold (Neurospora crassa) |
Ascomycetes | NCU06630 33 |
|
||
| fission yeast (Schizosaccharomyces pombe) |
Schizosaccharomycetes | ppa2 33 |
|
- Species where no ortholog for PPP2CB was found in the sources mined by GeneCards:
-
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- beta proteobacteria (Neisseria meningitidis)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
Evolution for PPP2CB Gene
- ENSEMBL:
- Gene Tree for PPP2CB (if available)
- TreeFam:
- Gene Tree for PPP2CB (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for PPP2CB: view image
Paralogs for PPP2CB Gene
(11) SIMAP similar genes for PPP2CB Gene using alignment to 6 proteins:
- PP2AB_HUMAN
- E5RFI3_HUMAN
- E5RHC1_HUMAN
- E5RJX4_HUMAN
- H0YBN9_HUMAN
- H0YC23_HUMAN
Pseudogenes.org Pseudogenes for PPP2CB Gene
Variants for PPP2CB Gene
| SNP ID | Clin | Chr 08 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000034624 | -- | 30,806,210(-) | G/A | intron_variant | |
| rs1000154240 | -- | 30,812,288(-) | C/T | intron_variant | |
| rs1000227299 | -- | 30,789,005(-) | C/A | intron_variant | |
| rs1000323652 | -- | 30,806,421(-) | G/A/T | intron_variant | |
| rs1000324121 | -- | 30,799,860(-) | C/T | intron_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv3386082 | CNV | insertion | 20981092 |
| nsv1077034 | CNV | deletion | 25765185 |
| nsv1144225 | CNV | deletion | 24896259 |
| nsv971635 | CNV | duplication | 23825009 |
Residual Variation Intolerance Score:
51.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.21;
4.63% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for PPP2CB Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- PPP2CB
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PPP2CB Gene
Disorders for PPP2CB Gene
Additional Disease Information for PPP2CB
No disorders were found for PPP2CB Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PPP2CB Gene
Publications for PPP2CB Gene
- A PP2A phosphatase high density interaction network identifies a novel striatin-interacting phosphatase and kinase complex linked to the cerebral cavernous malformation 3 (CCM3) protein. (PMID: 18782753) Goudreault M … Gingras AC (Molecular & cellular proteomics : MCP 2009) 3 4 22 58
- The catalytic subunit of protein phosphatase 2A is carboxyl-methylated in vivo. (PMID: 8206937) Favre B … Hemmings BA (The Journal of biological chemistry 1994) 3 4 22 58
- Structure and transcriptional regulation of protein phosphatase 2A catalytic subunit genes. (PMID: 1846293) Khew-Goodall Y … Hemmings BA (Biochemistry 1991) 3 4 22 58
- Shugoshin collaborates with protein phosphatase 2A to protect cohesin. (PMID: 16541025) Kitajima TS … Watanabe Y (Nature 2006) 3 4 58
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
Products for PPP2CB Gene
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- antibodies-online: Search results for 103 available PPP2CA Antibodies ranked by validation data
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- GeneTex PPP2CB Antibody for PPP2CB
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