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This gene encodes the phosphatase 2A catalytic subunit. Protein phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. This gene encodes a beta isoform of the catalytic subunit. [provided by RefSeq, Mar 2010]
PPP2CB (Protein Phosphatase 2 Catalytic Subunit Beta) is a Protein Coding gene. Among its related pathways are Beta-Adrenergic Signaling and Downstream signaling events of B Cell Receptor (BCR). Gene Ontology (GO) annotations related to this gene include hydrolase activity and phosphoprotein phosphatase activity. An important paralog of this gene is PPP2CA.
Protein Ser/Thr phosphatases are a group of enzymes that catalyze the removal of phosphate groups from serine and/or threonine residues by hydrolysis of phosphoric acid monoesters. They oppose the action of kinases and phosphorylases and are involved in signal transduction.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0004721 | phosphoprotein phosphatase activity | IEA | -- |
GO:0004722 | contributes_to protein serine/threonine phosphatase activity | IEA,TAS | 8206937 |
GO:0005515 | protein binding | IPI | 9647778 |
GO:0008022 | protein C-terminus binding | IEA | -- |
GO:0016787 | hydrolase activity | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000159 | protein phosphatase type 2A complex | IEA,TAS | 8206937 |
GO:0000775 | chromosome, centromeric region | IEA | -- |
GO:0000922 | spindle pole | IEA | -- |
GO:0005634 | nucleus | IEA | -- |
GO:0005694 | chromosome | IEA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | RET signaling |
.92
|
.92
|
2 | Activated TLR4 signalling | ||
3 | Misspliced GSK3beta mutants stabilize beta-catenin | ||
4 | Negative regulation of FGFR1 signaling | ||
5 | GAB1 signalosome |
.89
|
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006470 | protein dephosphorylation | IEA,TAS | 2849765 |
GO:0008637 | apoptotic mitochondrial changes | IEA | -- |
GO:0010288 | response to lead ion | ISS | -- |
GO:0010468 | regulation of gene expression | IEA | -- |
GO:0034976 | response to endoplasmic reticulum stress | IEA | -- |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
Vitamin E | Approved, Vet_approved | Nutra | Target | 549,557 | ||
Water | Approved | Pharma | 0 | |||
Manganese | Approved | Nutra | 64 | |||
Cyclosporin A | Approved, Investigational, Vet_approved | Pharma | Immunosuppressive agent, Calcineurin inhibitor | 0 | ||
Fe2+ | Experimental | Pharma | 0 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
---|---|---|---|---|---|---|
FK 506 |
|
104987-11-3 |
|
|
Compound | Action | Cas Number |
---|---|---|
Calcineurin Autoinhibitory Peptide | Selective calcineurin inhibitor | 148067-21-4 |
Cyclosporin A | Calcineurin inhibitor | 59865-13-3 |
FK 506 | Potent calcineurin inhibitor; immunosuppressant | 104987-11-3 |
INCA-6 | Inhibitor of calcineurin-substrate association | 3519-82-2 |
ExUns: | 1 | ^ | 2a | · | 2b | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6a | · | 6b | ^ | 7a | · | 7b | ^ | 8a | · | 8b | · | 8c |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | |||||||||||||||||||||||||
SP2: | - | ||||||||||||||||||||||||||
SP3: | - | - | |||||||||||||||||||||||||
SP4: | |||||||||||||||||||||||||||
SP5: | - | - | - | - | - | - | - | - | - | - |
This gene was present in the common ancestor of eukaryotes.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | PPP2CB 30 |
|
||
Oppossum (Monodelphis domestica) |
Mammalia | -- 31 |
|
OneToMany | |
-- 31 |
|
OneToMany | |||
Dog (Canis familiaris) |
Mammalia | PPP2CB 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | PPP2CB 30 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Ppp2cb 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Ppp2cb 30 17 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | PPP2CB 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | PPP2CA 31 |
|
OneToOne | |
PPP2CB 30 |
|
||||
Lizard (Anolis carolinensis) |
Reptilia | PPP2CB 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | ppp2cb 30 |
|
||
African clawed frog (Xenopus laevis) |
Amphibia | Xl.6686 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | ppp2cb 30 31 |
|
OneToOne | |
Dr.5120 30 |
|
||||
Fruit Fly (Drosophila melanogaster) |
Insecta | mts 31 32 |
|
OneToMany | |
CG11597 32 |
|
|
|||
Worm (Caenorhabditis elegans) |
Secernentea | F38H4.9 32 |
|
|
|
let-92 31 |
|
OneToMany | |||
pph-4.1 32 |
|
|
|||
pph-4.2 32 |
|
|
|||
C34C12.3 32 |
|
|
|||
C25A6.1 32 |
|
|
|||
C06A1.3 32 |
|
|
|||
W03D8.2 32 |
|
|
|||
Y40H4A.2 32 |
|
|
|||
C23G10.1a 32 |
|
|
|||
C23G10.1b 32 |
|
|
|||
C24H11.1 32 |
|
|
|||
C24H11.2 32 |
|
|
|||
R13A5.11 32 |
|
|
|||
F58G1.3 32 |
|
|
|||
R08A2.2 32 |
|
|
|||
F42G8.8 32 |
|
|
|||
C27B7.6 32 |
|
|
|||
F49E11.7 32 |
|
|
|||
Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | PPH22 30 31 |
|
ManyToMany | |
PPH21 31 33 |
|
ManyToMany | |||
K. Lactis Yeast (Kluyveromyces lactis) |
Saccharomycetes | KLLA0F05357g 30 |
|
||
A. gosspyii yeast (Eremothecium gossypii) |
Saccharomycetes | AGOS_ADR099C 30 |
|
||
Alicante grape (Vitis vinifera) |
eudicotyledons | Vvi.9171 30 |
|
||
Soybean (Glycine max) |
eudicotyledons | Gma.10798 30 |
|
||
Rice (Oryza sativa) |
Liliopsida | Os10g0410600 30 |
|
||
Barley (Hordeum vulgare) |
Liliopsida | Hv.6175 30 |
|
||
Wheat (Triticum aestivum) |
Liliopsida | Ta.11307 30 |
|
||
Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.11024 31 |
|
OneToMany | |
Bread mold (Neurospora crassa) |
Ascomycetes | NCU06630 30 |
|
||
Fission Yeast (Schizosaccharomyces pombe) |
Schizosaccharomycetes | ppa2 30 |
|
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv3386082 | CNV | insertion | 20981092 |
nsv1077034 | CNV | deletion | 25765185 |
nsv1144225 | CNV | deletion | 24896259 |
nsv971635 | CNV | duplication | 23825009 |
No disorders were found for PPP2CB Gene.