PPP2CB Gene (Protein Coding)

Protein Phosphatase 2 Catalytic Subunit Beta

GC08M030762
GIFtS:
46
This gene encodes the phosphatase 2A catalytic subunit. Protein phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. ... See more...

Aliases for PPP2CB Gene

Aliases for PPP2CB Gene

  • Protein Phosphatase 2 Catalytic Subunit Beta 2 3 5
  • Serine/Threonine-Protein Phosphatase 2A Catalytic Subunit Beta Isoform 3 4
  • Protein Phosphatase 2, Catalytic Subunit, Beta Isozyme 2 3
  • EC 3.1.3.16 4 51
  • PP2A-Beta 3 4
  • PP2Abeta 2 3
  • Protein Phosphatase 2 (Formerly 2A), Catalytic Subunit, Beta Isoform 2
  • Protein Phosphatase 2A Catalytic Subunit, Beta Isoform 2
  • Protein Phosphatase Type 2A Catalytic Subunit 3
  • Testicular Tissue Protein Li 146 3
  • PPP2CB 5
  • PP2CB 3

External Ids for PPP2CB Gene

Previous GeneCards Identifiers for PPP2CB Gene

  • GC08M030548
  • GC08M031095
  • GC08M030499
  • GC08M030700
  • GC08M029189
  • GC08M030631

Summaries for PPP2CB Gene

Entrez Gene Summary for PPP2CB Gene

  • This gene encodes the phosphatase 2A catalytic subunit. Protein phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. This gene encodes a beta isoform of the catalytic subunit. [provided by RefSeq, Mar 2010]

GeneCards Summary for PPP2CB Gene

PPP2CB (Protein Phosphatase 2 Catalytic Subunit Beta) is a Protein Coding gene. Among its related pathways are Beta-Adrenergic Signaling and Downstream signaling events of B Cell Receptor (BCR). Gene Ontology (GO) annotations related to this gene include hydrolase activity and phosphoprotein phosphatase activity. An important paralog of this gene is PPP2CA.

UniProtKB/Swiss-Prot Summary for PPP2CB Gene

  • PP2A can modulate the activity of phosphorylase B kinase casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase.

Tocris Summary for PPP2CB Gene

  • Protein Ser/Thr phosphatases are a group of enzymes that catalyze the removal of phosphate groups from serine and/or threonine residues by hydrolysis of phosphoric acid monoesters. They oppose the action of kinases and phosphorylases and are involved in signal transduction.

Gene Wiki entry for PPP2CB Gene

Additional gene information for PPP2CB Gene

No data available for CIViC Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PPP2CB Gene

Genomics for PPP2CB Gene

GeneHancer (GH) Regulatory Elements Pubs

Download GeneHancer 2017 data
Promoters and enhancers for PPP2CB Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH08J030810 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 281.1 +2.3 2340 3.5 TBP MXD4 FEZF1 CEBPA MNT IKZF1 SMAD5 ETS1 IRF2 MBD2 PPP2CB WRN GTF2E2 RPS15AP24 ENSG00000272375 LPGAT1P1 ENSG00000253708 PURG lnc-PPP2CB-1 HE856163
GH08J030815 Enhancer 0.6 Ensembl 263.6 -1.0 -987 0.6 IRF4 BATF STAT5A NFATC1 SCRT1 TCF7 ATF2 JUNB ZNF217 ZBED1 PPP2CB RF00017-6940 lnc-PPP2CB-1 UBXN8 GSR RNU5A-3P HSALNG0064388 RF00017-6939 TEX15
GH08J030911 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE CraniofacialAtlas 33.1 -98.0 -97964 2.2 TBP MNT IKZF1 BHLHE40 ZIC2 ARNT ZNF395 REST HCFC1 VEZF1 GTF2E2 TEX15 lnc-TEX15-1 PPP2CB lnc-WRN-2 RF00017-6939
GH08J030800 Enhancer 1.1 ENCODE dbSUPER 30.8 +11.0 10952 5.3 DEK HOMEZ KDM6A THAP11 FOXA2 SMAD4 SAP130 EP300 RXRA MIER3 PPP2CB HE856163 piR-49777 lnc-PPP2CB-1 RF00017-6939 LOC105379356
GH08J030807 Promoter/Enhancer 1.1 FANTOM5 Ensembl ENCODE dbSUPER 22.6 +5.8 5781 1.7 PRDM6 ZNF362 ZNF384 RUNX3 PPP2CB GSR HE856163 lnc-PPP2CB-1 RF00017-6939 LOC105379356
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PPP2CB on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for PPP2CB

Top Transcription factor binding sites by QIAGEN in the PPP2CB gene promoter:
  • AREB6
  • c-Rel
  • COMP1
  • LUN-1
  • POU2F1
  • POU2F1a
  • RelA
  • RSRFC4
  • STAT1
  • TBP

Genomic Locations for PPP2CB Gene

Latest Assembly
chr8:30,774,457-30,814,314
(GRCh38/hg38)
Size:
39,858 bases
Orientation:
Minus strand

Previous Assembly
chr8:30,643,132-30,670,334
(GRCh37/hg19 by Entrez Gene)
Size:
27,203 bases
Orientation:
Minus strand

chr8:30,631,973-30,671,830
(GRCh37/hg19 by Ensembl)
Size:
39,858 bases
Orientation:
Minus strand

Genomic View for PPP2CB Gene

Genes around PPP2CB on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PPP2CB Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PPP2CB Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for PPP2CB Gene

Proteins for PPP2CB Gene

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  • Protein details for PPP2CB Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P62714-PP2AB_HUMAN
    Recommended name:
    Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform
    Protein Accession:
    P62714
    Secondary Accessions:
    • D3DSV4
    • P11082
    • Q6FHK5

    Protein attributes for PPP2CB Gene

    Size:
    309 amino acids
    Molecular mass:
    35575 Da
    Cofactor:
    Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
    Quaternary structure:
    • Found in a complex with at least ARL2, PPP2CB, PPP2R1A, PPP2R2A, PPP2R5E and TBCD. Interacts with TBCD (By similarity). PP2A consists of a common heterodimeric core enzyme (composed of a 36 kDa catalytic subunit (subunit C) and a 65 kDa constant regulatory subunit (PR65) (subunit A)) that associates with a variety of regulatory subunits. Proteins that associate with the core dimer include three families of regulatory subunits B (the R2/B/PR55/B55, R3/B''/PR72/PR130/PR59 and R5/B'/B56 families), the 48 kDa variable regulatory subunit, viral proteins, and cell signaling molecules. Binds PPME1. May indirectly interact with SGO1, most probably through regulatory B56 subunits. Interacts with CTTNBP2NL. Interacts with PTPA (PubMed:12952889).

neXtProt entry for PPP2CB Gene

Protein Expression for PPP2CB Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Selected DME Specific Peptides for PPP2CB Gene

P62714:
  • FCLHGGLSP
  • LCEKAKEIL
  • DLLWSDP
  • YGFYDEC
  • RAHQLVMEG
  • PAPRRGEP
  • FTKELDQW
  • PDTNYLF
  • SAPNYCYRC
  • LLVALKVRY
  • NYLFMGD
  • TIFSAPNY
  • FLQFDPAPR
  • SVETVTLLV
  • HGQFHDL
  • RGNHESRQ
  • QEVPHEG
  • ELFRIGG
  • GDYVDRG
  • GWGISPRGAG
  • FTDLFDYLPLTAL
  • SPRGAGYTFG
  • CGDVHGQ
  • CPVTVCGD

Post-translational modifications for PPP2CB Gene

  • Reversibly methyl esterified on Leu-309 by leucine carboxyl methyltransferase 1 (LCMT1) and protein phosphatase methylesterase 1 (PPME1). Carboxyl methylation influences the affinity of the catalytic subunit for the different regulatory subunits, thereby modulating the PP2A holoenzyme's substrate specificity, enzyme activity and cellular localization.
  • Phosphorylation of either threonine (by autophosphorylation-activated protein kinase) or tyrosine results in inactivation of the phosphatase. Auto-dephosphorylation has been suggested as a mechanism for reactivation.
  • May be monoubiquitinated by NOSIP.
  • Ubiquitination at Lys21
  • Modification sites at PhosphoSitePlus

Other Protein References for PPP2CB Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibodies for research

Domains & Families for PPP2CB Gene

Gene Families for PPP2CB Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for PPP2CB Gene

InterPro:
Blocks:
  • Serine/threonine-specific protein phosphatase and bis(5-nucleosyl)-tetraphosphatase
ProtoNet:

Suggested Antigen Peptide Sequences for PPP2CB Gene

GenScript: Design optimal peptide antigens:
  • Serine/threonine-protein phosphatase (E5RFI3_HUMAN)
  • Serine/threonine-protein phosphatase (E5RHC1_HUMAN)
  • Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform (PP2AB_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P62714

UniProtKB/Swiss-Prot:

PP2AB_HUMAN :
  • Belongs to the PPP phosphatase family. PP-1 subfamily.
Family:
  • Belongs to the PPP phosphatase family. PP-1 subfamily.
genes like me logo Genes that share domains with PPP2CB: view

Function for PPP2CB Gene

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Molecular function for PPP2CB Gene

UniProtKB/Swiss-Prot Function:
PP2A can modulate the activity of phosphorylase B kinase casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=H2O + O-phospho-L-seryl-[protein] = L-seryl-[protein] + phosphate; Xref=Rhea:RHEA:20629, Rhea:RHEA-COMP:9863, Rhea:RHEA-COMP:11604, ChEBI:CHEBI:15377, ChEBI:CHEBI:29999, ChEBI:CHEBI:43474, ChEBI:CHEBI:83421; EC=3.1.3.16;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate; Xref=Rhea:RHEA:47004, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15377, ChEBI:CHEBI:30013, ChEBI:CHEBI:43474, ChEBI:CHEBI:61977; EC=3.1.3.16;.
GENATLAS Biochemistry:
protein phosphatase 2A,catalytic subunit,beta isoform

Enzyme Numbers (IUBMB) for PPP2CB Gene

Phenotypes From GWAS Catalog for PPP2CB Gene

Gene Ontology (GO) - Molecular Function for PPP2CB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004721 phosphoprotein phosphatase activity IEA --
GO:0004722 contributes_to protein serine/threonine phosphatase activity IEA,TAS 8206937
GO:0005515 protein binding IPI 9647778
GO:0008022 protein C-terminus binding IEA --
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with PPP2CB: view
genes like me logo Genes that share phenotypes with PPP2CB: view

Animal Models for PPP2CB Gene

MGI Knock Outs for PPP2CB:

Animal Models for research

  • Taconic Biosciences Mouse Models for PPP2CB

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PPP2CB

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PPP2CB Gene

Localization for PPP2CB Gene

Subcellular locations from UniProtKB/Swiss-Prot for PPP2CB Gene

Cytoplasm. Nucleus. Chromosome, centromere. Cytoplasm, cytoskeleton, spindle pole. Note=In prometaphase cells, but not in anaphase cells, localizes at centromeres. During mitosis, also found at spindle poles.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PPP2CB gene
Compartment Confidence
cytosol 5
cytoskeleton 4
nucleus 4
extracellular 2
plasma membrane 1
mitochondrion 1
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for PPP2CB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000159 protein phosphatase type 2A complex IEA,TAS 8206937
GO:0000775 chromosome, centromeric region IEA --
GO:0000922 spindle pole IEA --
GO:0005634 nucleus IEA --
GO:0005694 chromosome IEA --
genes like me logo Genes that share ontologies with PPP2CB: view

Pathways & Interactions for PPP2CB Gene

PathCards logo

SuperPathways for PPP2CB Gene

SuperPathway Contained pathways
1 RET signaling
Frs2-mediated activation
.95
GRB2 events in EGFR signaling
.95
MAPK1/MAPK3 signaling
.95
Prolonged ERK activation events
.95
RAF/MAP kinase cascade
.95
SHC1 events in EGFR signaling
.95
Signaling by Leptin
.95
SOS-mediated signalling
.95
VEGFR2 mediated cell proliferation
.95
ARMS-mediated activation
.95
Signalling to ERKs
.95
Signalling to p38 via RIT and RIN
.95
Signalling to RAS
.95
Interleukin receptor SHC signaling
.95
Interleukin-3, 5 and GM-CSF signaling
.94
Interleukin-2 signaling
.94
Downstream signal transduction
.94
Signaling by PDGF
.94
DAP12 signaling
.92
RET signaling
.92
Insulin receptor signalling cascade
.92
Signaling by Insulin receptor
.92
IRS-mediated signalling
.91
Signaling by EGFR
.90
FCERI mediated MAPK activation
.90
IGF1R signaling cascade
.90
IRS-related events triggered by IGF1R
.90
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
.90
DAP12 interactions
.89
NCAM signaling for neurite out-growth
.89
NGF signalling via TRKA from the plasma membrane
.87
MAPK family signaling cascades
.87
Signaling by SCF-KIT
.85
Signalling by NGF
.81
Fc epsilon receptor (FCERI) signaling
.79
VEGFA-VEGFR2 Pathway
.78
Signaling by VEGF
.76
Gastrin-CREB signalling pathway via PKC and MAPK
.55
2 Activated TLR4 signalling
Toll Like Receptor 9 (TLR9) Cascade
.94
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
.94
Activated TLR4 signalling
.91
Toll Like Receptor 4 (TLR4) Cascade
.91
MyD88 cascade initiated on plasma membrane
.88
Toll Like Receptor 10 (TLR10) Cascade
.88
Toll Like Receptor 5 (TLR5) Cascade
.88
MyD88 dependent cascade initiated on endosome
.86
Toll Like Receptor 7/8 (TLR7/8) Cascade
.86
MyD88-independent TLR3/TLR4 cascade
.86
Toll Like Receptor 3 (TLR3) Cascade
.86
TRIF-mediated TLR3/TLR4 signaling
.86
MyD88-Mal cascade initiated on plasma membrane
.85
Toll Like Receptor 2 (TLR2) Cascade
.85
Toll Like Receptor TLR1-TLR2 Cascade
.85
Toll Like Receptor TLR6-TLR2 Cascade
.85
Toll-Like Receptors Cascades
.82
MAP kinase activation in TLR cascade
.76
3 Misspliced GSK3beta mutants stabilize beta-catenin
Misspliced GSK3beta mutants stabilize beta-catenin
.93
truncated APC mutants destabilize the destruction complex
.93
Disassembly of the destruction complex and recruitment of AXIN to the membrane
.47
Signaling by WNT in cancer
.43
CTLA4 inhibitory signaling
.33
AMER1 mutants destabilize the destruction complex
.01
APC truncation mutants have impaired AXIN binding
.01
AXIN missense mutants destabilize the destruction complex
.01
AXIN mutants destabilize the destruction complex, activating WNT signaling
.01
Beta-catenin phosphorylation cascade
.01
phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex
.01
S33 mutants of beta-catenin arent phosphorylated
.01
S37 mutants of beta-catenin arent phosphorylated
.01
S45 mutants of beta-catenin arent phosphorylated
.01
T41 mutants of beta-catenin arent phosphorylated
.01
Truncations of AMER1 destabilize the destruction complex
.01
4 Negative regulation of FGFR1 signaling
Signaling by FGFR3
.84
Signaling by FGFR4
.84
Negative regulation of FGFR3 signaling
.82
Negative regulation of FGFR4 signaling
.82
Negative regulation of FGFR1 signaling
.81
Negative regulation of FGFR2 signaling
.81
Signaling by FGFR1
.70
Spry regulation of FGF signaling
.01
5 GAB1 signalosome
Negative regulation of the PI3K/AKT network
.93
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
.93
PIP3 activates AKT signaling
.91
Role of LAT2/NTAL/LAB on calcium mobilization
.91
GAB1 signalosome
.89
PI3K/AKT activation
.89
genes like me logo Genes that share pathways with PPP2CB: view

Pathways by source for PPP2CB Gene

1 Sino Biological pathway for PPP2CB Gene
12 GeneGo (Thomson Reuters) pathways for PPP2CB Gene
  • Apoptosis and survival BAD phosphorylation
  • Cell cycle Regulation of G1/S transition (part 1)
  • Cell cycle Start of DNA replication in early S phase
  • Development Beta-adrenergic receptors regulation of ERK
  • Development Beta-adrenergic receptors signaling via cAMP
24 Qiagen pathways for PPP2CB Gene
  • Akt Signaling
  • AMPK Enzyme Complex Pathway
  • BAD Phosphorylation
  • Beta-Adrenergic Signaling
  • Breast Cancer Regulation by Stathmin1
1 GeneTex pathway for PPP2CB Gene

SIGNOR curated interactions for PPP2CB Gene

Activates:
Inactivates:
Is activated by:
Is inactivated by:
Other effect:

Gene Ontology (GO) - Biological Process for PPP2CB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006470 protein dephosphorylation IEA,TAS 2849765
GO:0008637 apoptotic mitochondrial changes IEA --
GO:0010288 response to lead ion ISS --
GO:0010468 regulation of gene expression IEA --
GO:0034976 response to endoplasmic reticulum stress IEA --
genes like me logo Genes that share ontologies with PPP2CB: view

Drugs & Compounds for PPP2CB Gene

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(11) Drugs for PPP2CB Gene - From: DrugBank, ApexBio, HMDB, and Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Vitamin E Approved, Vet_approved Nutra Target 549,557
Water Approved Pharma 0
Manganese Approved Nutra 64
Cyclosporin A Approved, Investigational, Vet_approved Pharma Immunosuppressive agent, Calcineurin inhibitor 0
Fe2+ Experimental Pharma 0

(1) Additional Compounds for PPP2CB Gene - From: Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
FK 506
104987-11-3

(4) Tocris Compounds for PPP2CB Gene

Compound Action Cas Number
Calcineurin Autoinhibitory Peptide Selective calcineurin inhibitor 148067-21-4
Cyclosporin A Calcineurin inhibitor 59865-13-3
FK 506 Potent calcineurin inhibitor; immunosuppressant 104987-11-3
INCA-6 Inhibitor of calcineurin-substrate association 3519-82-2

(2) ApexBio Compounds for PPP2CB Gene

Compound Action Cas Number
DL-AP3 Glutamate receptor antagonist and HPSP inhibitor 20263-06-3
Sal 003 Cellular phosphatase complex inhibitor 1164470-53-4
genes like me logo Genes that share compounds with PPP2CB: view

Drug products for research

Transcripts for PPP2CB Gene

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mRNA/cDNA for PPP2CB Gene

2 REFSEQ mRNAs :
11 NCBI additional mRNA sequence :
10 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PPP2CB

Alternative Splicing Database (ASD) splice patterns (SP) for PPP2CB Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b · 8c
SP1: - -
SP2: -
SP3: - -
SP4:
SP5: - - - - - - - - - -

Relevant External Links for PPP2CB Gene

GeneLoc Exon Structure for
PPP2CB

Expression for PPP2CB Gene

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  1. Primer products for research
  2. Gene Expression Assays for research

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PPP2CB Gene

mRNA expression in normal human tissues for PPP2CB Gene
mRNA expression by BioGPS for PPP2CB GenemRNA expression by GTEx for PPP2CB Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for PPP2CB Gene

This gene is overexpressed in Uterus (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for PPP2CB Gene



Protein tissue co-expression partners for PPP2CB Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for PPP2CB

SOURCE GeneReport for Unigene cluster for PPP2CB Gene:

Hs.491440

Evidence on tissue expression from TISSUES for PPP2CB Gene

  • Nervous system(4.6)
  • Kidney(4.5)
  • Liver(4.5)
  • Heart(2.3)
  • Skin(2.3)
  • Muscle(2.2)
  • Lung(2.1)
  • Intestine(2.1)
genes like me logo Genes that share expression patterns with PPP2CB: view

Primer products for research

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PPP2CB Gene

Orthologs for PPP2CB Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PPP2CB Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
 Mammalia PPP2CB 30
  • 99.89 (n)
Oppossum
(Monodelphis domestica)
 Mammalia -- 31
  • 99 (a)
 OneToMany
-- 31
  • 68 (a)
 OneToMany
Dog
(Canis familiaris)
 Mammalia PPP2CB 30 31
  • 95.15 (n)
 OneToOne
Cow
(Bos Taurus)
 Mammalia PPP2CB 30 31
  • 93.2 (n)
 OneToOne
Rat
(Rattus norvegicus)
 Mammalia Ppp2cb 30
  • 93.1 (n)
Mouse
(Mus musculus)
 Mammalia Ppp2cb 30 17 31
  • 92.13 (n)
 OneToOne
Platypus
(Ornithorhynchus anatinus)
 Mammalia PPP2CB 31
  • 92 (a)
 OneToOne
Chicken
(Gallus gallus)
 Aves PPP2CA 31
  • 97 (a)
 OneToOne
PPP2CB 30
  • 87.27 (n)
Lizard
(Anolis carolinensis)
 Reptilia PPP2CB 31
  • 98 (a)
 OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
 Amphibia ppp2cb 30
  • 84.47 (n)
African clawed frog
(Xenopus laevis)
 Amphibia Xl.6686 30
Zebrafish
(Danio rerio)
 Actinopterygii ppp2cb 30 31
  • 81.45 (n)
 OneToOne
Dr.5120 30
Fruit Fly
(Drosophila melanogaster)
 Insecta mts 31 32
  • 94 (a)
 OneToMany
CG11597 32
  • 51 (a)
Worm
(Caenorhabditis elegans)
 Secernentea F38H4.9 32
  • 89 (a)
let-92 31
  • 86 (a)
 OneToMany
pph-4.1 32
  • 63 (a)
pph-4.2 32
  • 61 (a)
C34C12.3 32
  • 52 (a)
C25A6.1 32
  • 44 (a)
C06A1.3 32
  • 40 (a)
W03D8.2 32
  • 40 (a)
Y40H4A.2 32
  • 39 (a)
C23G10.1a 32
  • 38 (a)
C23G10.1b 32
  • 38 (a)
C24H11.1 32
  • 38 (a)
C24H11.2 32
  • 38 (a)
R13A5.11 32
  • 37 (a)
F58G1.3 32
  • 36 (a)
R08A2.2 32
  • 35 (a)
F42G8.8 32
  • 34 (a)
C27B7.6 32
  • 33 (a)
F49E11.7 32
  • 32 (a)
Baker's yeast
(Saccharomyces cerevisiae)
 Saccharomycetes PPH22 30 31
  • 66.67 (n)
 ManyToMany
PPH21 31 33
  • 62 (a)
 ManyToMany
K. Lactis Yeast
(Kluyveromyces lactis)
 Saccharomycetes KLLA0F05357g 30
  • 66.56 (n)
A. gosspyii yeast
(Eremothecium gossypii)
 Saccharomycetes AGOS_ADR099C 30
  • 64.57 (n)
Alicante grape
(Vitis vinifera)
 eudicotyledons Vvi.9171 30
Soybean
(Glycine max)
 eudicotyledons Gma.10798 30
Rice
(Oryza sativa)
 Liliopsida Os10g0410600 30
  • 71.44 (n)
Barley
(Hordeum vulgare)
 Liliopsida Hv.6175 30
Wheat
(Triticum aestivum)
 Liliopsida Ta.11307 30
Sea Squirt
(Ciona savignyi)
 Ascidiacea CSA.11024 31
  • 90 (a)
 OneToMany
Bread mold
(Neurospora crassa)
 Ascomycetes NCU06630 30
  • 70 (n)
Fission Yeast
(Schizosaccharomyces pombe)
 Schizosaccharomycetes ppa2 30
  • 68.73 (n)
Species where no ortholog for PPP2CB was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for PPP2CB Gene

ENSEMBL:
Gene Tree for PPP2CB (if available)
TreeFam:
Gene Tree for PPP2CB (if available)
Aminode:
Evolutionary constrained regions (ECRs) for PPP2CB: view image

Paralogs for PPP2CB Gene

Paralogs for PPP2CB Gene

(11) SIMAP similar genes for PPP2CB Gene using alignment to 6 proteins:

  • PP2AB_HUMAN
  • E5RFI3_HUMAN
  • E5RHC1_HUMAN
  • E5RJX4_HUMAN
  • H0YBN9_HUMAN
  • H0YC23_HUMAN

Pseudogenes.org Pseudogenes for PPP2CB Gene

genes like me logo Genes that share paralogs with PPP2CB: view

Variants for PPP2CB Gene

Products:

  1. SNP Genotyping and Copy Number Assays for research

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for PPP2CB Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for PPP2CB Gene

Variant ID Type Subtype PubMed ID
esv3386082 CNV insertion 20981092
nsv1077034 CNV deletion 25765185
nsv1144225 CNV deletion 24896259
nsv971635 CNV duplication 23825009

Variation tolerance for PPP2CB Gene

Residual Variation Intolerance Score: 51.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.21; 4.63% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PPP2CB Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PPP2CB

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for PPP2CB Gene

Disorders for PPP2CB Gene

Additional Disease Information for PPP2CB

Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform

No disorders were found for PPP2CB Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PPP2CB Gene

Publications for PPP2CB Gene

  1. A PP2A phosphatase high density interaction network identifies a novel striatin-interacting phosphatase and kinase complex linked to the cerebral cavernous malformation 3 (CCM3) protein. (PMID: 18782753) Goudreault M … Gingras AC (Molecular & cellular proteomics : MCP 2009) 3 4 23
  2. The catalytic subunit of protein phosphatase 2A is carboxyl-methylated in vivo. (PMID: 8206937) Favre B … Hemmings BA (The Journal of biological chemistry 1994) 3 4 23
  3. Structure and transcriptional regulation of protein phosphatase 2A catalytic subunit genes. (PMID: 1846293) Khew-Goodall Y … Hemmings BA (Biochemistry 1991) 3 4 23
  4. Shugoshin collaborates with protein phosphatase 2A to protect cohesin. (PMID: 16541025) Kitajima TS … Watanabe Y (Nature 2006) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4

ExternalLinks

View latest publications for PPP2CB gene in Mastermind

Products for PPP2CB Gene

Sources for PPP2CB Gene