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This gene encodes the phosphatase 2A catalytic subunit. Protein phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. This gene encodes an alpha isoform of the catalytic subunit. [provided by RefSeq, Jul 2008]
PPP2CA (Protein Phosphatase 2 Catalytic Subunit Alpha) is a Protein Coding gene. Diseases associated with PPP2CA include Neurodevelopmental Disorder And Language Delay With Or Without Structural Brain Abnormalities and Alzheimer Disease 15. Among its related pathways are Association Between Physico-Chemical Features and Toxicity Associated Pathways and Negative regulation of MAPK pathway. Gene Ontology (GO) annotations related to this gene include hydrolase activity and protein C-terminus binding. An important paralog of this gene is PPP2CB.
Protein Ser/Thr phosphatases are a group of enzymes that catalyze the removal of phosphate groups from serine and/or threonine residues by hydrolysis of phosphoric acid monoesters. They oppose the action of kinases and phosphorylases and are involved in signal transduction.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0004721 | phosphoprotein phosphatase activity | IEA,TAS | 28386764 |
GO:0004722 | protein serine/threonine phosphatase activity | TAS | 10640627 |
GO:0005515 | protein binding | IPI | 1328865 |
GO:0008022 | protein C-terminus binding | IEA | -- |
GO:0016787 | hydrolase activity | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000159 | protein phosphatase type 2A complex | IEA,TAS | 11007961 |
GO:0000775 | chromosome, centromeric region | IEA | -- |
GO:0000922 | spindle pole | IEA | -- |
GO:0005634 | nucleus | NAS | 11007961 |
GO:0005694 | chromosome | IEA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | RET signaling |
.92
|
.92
|
2 | Activated TLR4 signalling | ||
3 | S45 mutants of beta-catenin arent phosphorylated | ||
4 | Negative regulation of FGFR3 signaling | ||
5 | GAB1 signalosome |
.89
|
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000184 | nuclear-transcribed mRNA catabolic process, nonsense-mediated decay | TAS | -- |
GO:0000188 | inactivation of MAPK activity | NAS | 11007961 |
GO:0001932 | regulation of protein phosphorylation | NAS | 28386764 |
GO:0006275 | regulation of DNA replication | NAS | 11007961 |
GO:0006355 | regulation of transcription, DNA-templated | NAS | 11007961 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
---|---|---|---|---|---|---|
Phosphate |
|
14066-19-4, 14265-44-2 |
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FK 506 |
|
104987-11-3 |
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|
Compound | Action | Cas Number |
---|---|---|
Calcineurin Autoinhibitory Peptide | Selective calcineurin inhibitor | 148067-21-4 |
Cyclosporin A | Calcineurin inhibitor | 59865-13-3 |
FK 506 | Potent calcineurin inhibitor; immunosuppressant | 104987-11-3 |
INCA-6 | Inhibitor of calcineurin-substrate association | 3519-82-2 |
ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | · | 5c | ^ | 6 | ^ | 7a | · | 7b | · | 7c | ^ | 8 | ^ | 9a | · | 9b | ^ | 10 | ^ | 11 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | - | - | - | ||||||||||||||||||||||||||||||
SP2: | |||||||||||||||||||||||||||||||||||
SP3: | - | - | - | - | |||||||||||||||||||||||||||||||
SP4: | - | - | - | - | - | ||||||||||||||||||||||||||||||
SP5: | - | - | - | ||||||||||||||||||||||||||||||||
SP6: | - | - | - | ||||||||||||||||||||||||||||||||
SP7: | - | - | |||||||||||||||||||||||||||||||||
SP8: | - | - |
This gene was present in the common ancestor of eukaryotes.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Oppossum (Monodelphis domestica) |
Mammalia | PPP2CA 31 |
|
OneToOne | |
Chimpanzee (Pan troglodytes) |
Mammalia | PPP2CA 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | PPP2CA 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | PPP2CA 30 |
|
||
Rat (Rattus norvegicus) |
Mammalia | Ppp2ca 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Ppp2ca 30 17 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | PPP2CA 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | PPP2CA 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | PPP2CA 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | ppp2ca 30 |
|
||
MGC75638 30 |
|
||||
African clawed frog (Xenopus laevis) |
Amphibia | ppp2ca-prov 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | ppp2ca 31 |
|
OneToOne | |
zgc:56064 30 |
|
||||
Rainbow Trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.10181 30 |
|
||
Fruit Fly (Drosophila melanogaster) |
Insecta | mts 30 31 32 |
|
OneToMany | |
CG11597 32 |
|
|
|||
African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP010172 30 |
|
||
Worm (Caenorhabditis elegans) |
Secernentea | F38H4.9 32 |
|
|
|
let-92 30 31 |
|
OneToMany | |||
pph-4.1 32 |
|
|
|||
pph-4.2 32 |
|
|
|||
C34C12.3 32 |
|
|
|||
C25A6.1 32 |
|
|
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C06A1.3 32 |
|
|
|||
W03D8.2 32 |
|
|
|||
C24H11.1 32 |
|
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C24H11.2 32 |
|
|
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Y40H4A.2 32 |
|
|
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F58G1.3 32 |
|
|
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R13A5.11 32 |
|
|
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F42G8.8 32 |
|
|
|||
C27B7.6 32 |
|
|
|||
F49E11.7 32 |
|
|
|||
Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | PPH21 31 |
|
ManyToMany | |
PPH22 31 |
|
ManyToMany | |||
Thale Cress (Arabidopsis thaliana) |
eudicotyledons | PP2A-1 30 |
|
||
Soybean (Glycine max) |
eudicotyledons | Gma.10697 30 |
|
||
Rice (Oryza sativa) |
Liliopsida | Os06g0574500 30 |
|
||
Corn (Zea mays) |
Liliopsida | Zm.9014 30 |
|
||
Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.11024 31 |
|
OneToMany | |
Fission Yeast (Schizosaccharomyces pombe) |
Schizosaccharomycetes | ppa1 30 |
|
||
Sea Vase (Ciona intestinalis) |
Ascidiacea | Cin.5327 30 |
|
SNP ID | Clinical significance and condition | Chr 05 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
692143 | Uncertain Significance: NEURODEVELOPMENTAL DISORDER AND LANGUAGE DELAY WITH OR WITHOUT STRUCTURAL BRAIN ABNORMALITIES | 134,206,055(-) | C/A | MISSENSE_VARIANT,NON_CODING_TRANSCRIPT_VARIANT,FIVE_PRIME_UTR_VARIANT | |
692144 | Likely Pathogenic: NEURODEVELOPMENTAL DISORDER AND LANGUAGE DELAY WITH OR WITHOUT STRUCTURAL BRAIN ABNORMALITIES | 134,201,943(-) | C/G | MISSENSE_VARIANT,NON_CODING_TRANSCRIPT_VARIANT | |
692145 | Likely Pathogenic: NEURODEVELOPMENTAL DISORDER AND LANGUAGE DELAY WITH OR WITHOUT STRUCTURAL BRAIN ABNORMALITIES | 134,200,406(-) | C/G | MISSENSE_VARIANT,NON_CODING_TRANSCRIPT_VARIANT | |
692146 | Likely Pathogenic: NEURODEVELOPMENTAL DISORDER AND LANGUAGE DELAY WITH OR WITHOUT STRUCTURAL BRAIN ABNORMALITIES | 134,200,405(-) | T/A | MISSENSE_VARIANT,NON_CODING_TRANSCRIPT_VARIANT | |
692147 | Likely Pathogenic: NEURODEVELOPMENTAL DISORDER AND LANGUAGE DELAY WITH OR WITHOUT STRUCTURAL BRAIN ABNORMALITIES | 134,201,968(-) | C/G | MISSENSE_VARIANT,NON_CODING_TRANSCRIPT_VARIANT |
Disorder | Aliases | PubMed IDs |
---|---|---|
neurodevelopmental disorder and language delay with or without structural brain abnormalities |
|
|
alzheimer disease 15 |
|
|
syndromic intellectual disability |
|
|
neuronal ceroid lipofuscinosis |
|
|
breast cancer |
|
|