Aliases for PPP2CA Gene
Aliases for PPP2CA Gene
- Protein Phosphatase 2 Catalytic Subunit Alpha 2 3 5
- Protein Phosphatase 2 (Formerly 2A), Catalytic Subunit, Alpha Isoform 2 3
- Protein Phosphatase 2, Catalytic Subunit, Alpha Isozyme 2 3
- Replication Protein C 3 4
- PP2A-Alpha 3 4
- RP-C 3 4
- Serine/Threonine Protein Phosphatase 2A, Catalytic Subunit, Alpha Isoform 3
External Ids for PPP2CA Gene
- HGNC: 9299
- Entrez Gene: 5515
- Ensembl: ENSG00000113575
- OMIM: 176915
- UniProtKB: P67775
Previous GeneCards Identifiers for PPP2CA Gene
- GC05M133180
- GC05M134046
- GC05M133563
- GC05M133608
- GC05M133560
- GC05M128717
- GC05M133530
Summaries for PPP2CA Gene
-
This gene encodes the phosphatase 2A catalytic subunit. Protein phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. This gene encodes an alpha isoform of the catalytic subunit. [provided by RefSeq, Jul 2008]
GeneCards Summary for PPP2CA Gene
PPP2CA (Protein Phosphatase 2 Catalytic Subunit Alpha) is a Protein Coding gene. Diseases associated with PPP2CA include Usher Syndrome, Type Ic. Among its related pathways are ERK Signaling and mTOR Pathway. Gene Ontology (GO) annotations related to this gene include hydrolase activity and protein C-terminus binding. An important paralog of this gene is PPP2CB.
UniProtKB/Swiss-Prot for PPP2CA Gene
-
PP2A is the major phosphatase for microtubule-associated proteins (MAPs). PP2A can modulate the activity of phosphorylase B kinase casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase. Cooperates with SGO2 to protect centromeric cohesin from separase-mediated cleavage in oocytes specifically during meiosis I (By similarity). Can dephosphorylate SV40 large T antigen and p53/TP53. Activates RAF1 by dephosphorylating it at Ser-259.
-
Protein Ser/Thr phosphatases are a group of enzymes that catalyze the removal of phosphate groups from serine and/or threonine residues by hydrolysis of phosphoric acid monoesters. They oppose the action of kinases and phosphorylases and are involved in signal transduction.
Additional gene information for PPP2CA Gene
- Monarch Initiative
- Search for PPP2CA at DataMed
- Search for PPP2CA at HumanCyc
No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PPP2CA Gene
Genomics for PPP2CA Gene
GeneHancer (GH) Regulatory Elements for PPP2CA Gene
Promoters and enhancers for PPP2CA Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)
GeneHancers around PPP2CA on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the PPP2CA gene promoter:
-
- ATF-2
- c-Jun
- AP-1
- STAT1
- PPAR-gamma1
- PPAR-gamma2
- Arnt
- STAT1beta
- STAT1alpha
Regulatory Element Products
Genomic Locations for PPP2CA Gene
Genomic Locations for PPP2CA Gene
- chr5:134,194,334-134,226,259
- (GRCh38/hg38)
- Size:
- 31,926 bases
- Orientation:
- Minus strand
- chr5:133,530,025-133,561,950
- (GRCh37/hg19)
- Size:
- 31,926 bases
- Orientation:
- Minus strand
Genomic View for PPP2CA Gene
Genes around PPP2CA on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 5q31.1 by Entrez Gene
- 5q31.1 by HGNC
- 5q31.1 by Ensembl
PPP2CA Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for PPP2CA Gene
Proteins for PPP2CA Gene
-
Protein details for PPP2CA Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P67775-PP2AA_HUMAN
- Recommended name:
- Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform
- Protein Accession:
- P67775
- P05323
- P13197
Protein attributes for PPP2CA Gene
- Size:
- 309 amino acids
- Molecular mass:
- 35594 Da
- Cofactor:
- Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
- Quaternary structure:
-
- PP2A consists of a common heterodimeric core enzyme, composed of PPP2CA a 36 kDa catalytic subunit (subunit C) and PPP2R1A a 65 kDa constant regulatory subunit (PR65 or subunit A), that associates with a variety of regulatory subunits. Proteins that associate with the core dimer include three families of regulatory subunits B (the R2/B/PR55/B55, R3/B/PR72/PR130/PR59 and R5/B/B56 families), the 48 kDa variable regulatory subunit, viral proteins, and cell signaling molecules. Interacts with NXN; the interaction is direct (By similarity). Interacts with KCTD20 (By similarity). Interacts with BTBD10 (By similarity). Interacts with TP53, SGO1 and SGO2. Interacts with AXIN1; the interaction dephosphorylates AXIN1. Interacts with PIM3; this interaction promotes dephosphorylation, ubiquitination and proteasomal degradation of PIM3. Interacts with RAF1. Interaction with IGBP1 protects unassembled PPP2CA from degradative ubiquitination. Interacts with GSK3B (via C2 domain).
Three dimensional structures from OCA and Proteopedia for PPP2CA Gene
Protein Expression for PPP2CA Gene
Post-translational modifications for PPP2CA Gene
- Reversibly methyl esterified on Leu-309 by leucine carboxyl methyltransferase 1 (LCMT1) and protein phosphatase methylesterase 1 (PPME1). Carboxyl methylation influences the affinity of the catalytic subunit for the different regulatory subunits, thereby modulating the PP2A holoenzymes substrate specificity, enzyme activity and cellular localization.
- Phosphorylation of either threonine (by autophosphorylation-activated protein kinase) or tyrosine results in inactivation of the phosphatase. Auto-dephosphorylation has been suggested as a mechanism for reactivation.
- May be monoubiquitinated by NOSIP.
- Ubiquitination at Lys29, posLast=2121, Lys8, and posLast=44
- Modification sites at PhosphoSitePlus
Other Protein References for PPP2CA Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- R&D Systems Antibodies for PPP2CA (PP2A)
-
Custom Antibody ServicesOriGene Antibodies for PPP2CA
- Novus Biologicals Antibodies for PPP2CA
-
Abcam antibodies for PPP2CA
- Invitrogen Antibodies for PPP2CA (AFLGC-PPP2CA)
- GeneTex PPP2CA Antibody for PPP2CA
-
Santa Cruz Biotechnology (SCBT) Antibodies for PPP2CA
Protein Products
-
OriGene Purified Proteins for PPP2CA
- Search Origene for MassSpec and Protein Over-expression Lysates for PPP2CA
- Origene Custom Protein Services for PPP2CA
- Search GeneTex for Proteins for PPP2CA
-
Abcam proteins for PPP2CA
Assay Products
- R&D Systems Activity Assays and other biochemical assays for PPP2CA (PP2A)
-
Abcam assays for PPP2CA
No data available for DME Specific Peptides for PPP2CA Gene
Domains & Families for PPP2CA Gene
Gene Families for PPP2CA Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Enzymes
- Predicted intracellular proteins
Protein Domains for PPP2CA Gene
Suggested Antigen Peptide Sequences for PPP2CA Gene
Graphical View of Domain Structure for InterPro Entry
P67775- Family:
-
- Belongs to the PPP phosphatase family. PP-1 subfamily.
Function for PPP2CA Gene
Molecular function for PPP2CA Gene
- UniProtKB/Swiss-Prot Function:
- PP2A is the major phosphatase for microtubule-associated proteins (MAPs). PP2A can modulate the activity of phosphorylase B kinase casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase. Cooperates with SGO2 to protect centromeric cohesin from separase-mediated cleavage in oocytes specifically during meiosis I (By similarity). Can dephosphorylate SV40 large T antigen and p53/TP53. Activates RAF1 by dephosphorylating it at Ser-259.
- UniProtKB/Swiss-Prot CatalyticActivity:
- [a protein]-serine/threonine phosphate + H(2)O = [a protein]-serine/threonine + phosphate.
- GENATLAS Biochemistry:
- protein phosphatase 2A,catalytic subunit,alpha isoform,antagonizing cdc2/CCNB1 complex which regulates the G2-M transition in the cell cycle
Enzyme Numbers (IUBMB) for PPP2CA Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004721 | phosphoprotein phosphatase activity | IEA,TAS | 28386764 |
| GO:0004722 | protein serine/threonine phosphatase activity | TAS | 10640627 |
| GO:0005515 | protein binding | IPI | 1328865 |
| GO:0008022 | protein C-terminus binding | IEA | -- |
| GO:0016787 | hydrolase activity | IEA | -- |
Phenotypes for PPP2CA Gene
- MGI mutant phenotypes for PPP2CA:
- inferred from 5 alleles
- GenomeRNAi human phenotypes for PPP2CA:
-
- Condensed cis-Golgi
- Increased shRNA abundance (Z-score > 2)
- Increased mitotic exit time
- Dynamic nuclei (hole, folded or small irregular)
- Decreased focal adhesion (FA) area, decreased FA length, decreased FA mean intensity, increased number of small and round FAs, increased FA abundance
- Upregulation of Wnt/beta-catenin pathway after WNT3A stimulation
- Decreased viability
- no effect
- Increased vaccinia virus (VACV) infection
- Decreased shRNA abundance (Z-score < -2)
- Apoptosis resistance
- Decreased viability after Maraba virus infection
- Increased cell number in S
- Increased viability
- Increased transferrin (TF) endocytosis
Animal Models for PPP2CA Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for PPP2CA
-
CRISPR Products
-
OriGene CRISPR knockouts for PPP2CA
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for PPP2CA
- genomics-online: gRNA clones - Search results for available PPP2CA gene related products
- Applied Biological Materials CRISPR for PPP2CA
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for PPP2CA
- GenScript: Design CRISPR guide RNA sequences for PPP2CA
miRNA for PPP2CA Gene
- miRTarBase miRNAs that target PPP2CA
-
- hsa-mir-340-3p (MIRT043848)
- hsa-mir-197-3p (MIRT048079)
- hsa-mir-153-5p (MIRT311674)
- hsa-mir-4777-5p (MIRT506066)
- hsa-mir-526a (MIRT506067)
- hsa-mir-523-5p (MIRT506068)
- hsa-mir-522-5p (MIRT506069)
- hsa-mir-520c-5p (MIRT506070)
- hsa-mir-519c-5p (MIRT506071)
- hsa-mir-519b-5p (MIRT506072)
- hsa-mir-519a-5p (MIRT506073)
- hsa-mir-518f-5p (MIRT506074)
- hsa-mir-518e-5p (MIRT506075)
- hsa-mir-518d-5p (MIRT506076)
- hsa-mir-4766-3p (MIRT506077)
- hsa-mir-3152-3p (MIRT506078)
- hsa-mir-4305 (MIRT506079)
- hsa-mir-889-3p (MIRT512473)
- hsa-mir-107 (MIRT512474)
- hsa-mir-103a-3p (MIRT512475)
- hsa-mir-545-3p (MIRT512476)
- hsa-mir-96-3p (MIRT512477)
- hsa-mir-5583-3p (MIRT512478)
- hsa-mir-4517 (MIRT512479)
- hsa-mir-3646 (MIRT512480)
- hsa-mir-548c-3p (MIRT512481)
- hsa-mir-8081 (MIRT546991)
- hsa-mir-6869-5p (MIRT546992)
- hsa-mir-185-3p (MIRT546993)
- hsa-mir-4283 (MIRT546994)
- hsa-mir-4656 (MIRT546995)
- hsa-mir-4489 (MIRT546996)
- hsa-mir-5186 (MIRT546997)
- hsa-mir-3675-5p (MIRT546998)
- hsa-mir-9500 (MIRT546999)
- hsa-mir-6822-5p (MIRT547000)
- hsa-mir-6750-5p (MIRT547001)
- hsa-mir-5584-5p (MIRT547002)
- hsa-mir-548g-3p (MIRT547003)
- hsa-mir-548av-3p (MIRT547004)
- hsa-mir-630 (MIRT555325)
- hsa-mir-4670-3p (MIRT555326)
- hsa-mir-7705 (MIRT555327)
- hsa-mir-522-3p (MIRT555328)
- hsa-mir-224-3p (MIRT555329)
- hsa-mir-4694-3p (MIRT555330)
- hsa-mir-6079 (MIRT561720)
- hsa-mir-584-5p (MIRT561722)
- hsa-mir-92a-1-5p (MIRT561723)
- hsa-mir-671-5p (MIRT561724)
- hsa-mir-6828-5p (MIRT561725)
- hsa-mir-758-5p (MIRT561726)
- hsa-mir-218-2-3p (MIRT561727)
- hsa-mir-33a-3p (MIRT571780)
- hsa-mir-670-5p (MIRT571781)
- hsa-mir-4732-3p (MIRT571782)
- hsa-mir-345-3p (MIRT571783)
- hsa-mir-3133 (MIRT571784)
- hsa-mir-553 (MIRT571785)
- hsa-mir-188-5p (MIRT571786)
- hsa-mir-4319 (MIRT571787)
- hsa-mir-6866-3p (MIRT571788)
- hsa-mir-125b-5p (MIRT571789)
- hsa-mir-125a-5p (MIRT571790)
- hsa-mir-186-3p (MIRT763197)
- hsa-mir-216a-5p (MIRT763883)
- hsa-mir-513c-5p (MIRT773415)
- hsa-mir-514b-5p (MIRT773432)
- hsa-mir-548as-3p (MIRT774208)
- hsa-mir-548u (MIRT774544)
- hsa-mir-7161-5p (MIRT781672)
- hsa-mir-8087 (MIRT782435)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for PPP2CA
- Browse OriGene Inhibitory RNA Products For PPP2CA
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PPP2CA
- genomics-online: shRNA clones - Search results for available PPP2CA gene related products
Clone Products
- Sino Biological Human cDNA Clone for PPP2CA
- Addgene plasmids for PPP2CA
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for PPP2CA
- genomics-online: cdna clones - Search results for available PPP2CA gene related products
- orf clones - Search results for available PPP2CA gene related products
- Applied Biological Materials Clones for PPP2CA
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
No data available for Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PPP2CA Gene
Localization for PPP2CA Gene
Subcellular locations from UniProtKB/Swiss-Prot for PPP2CA Gene
- Cytoplasm. Nucleus. Chromosome, centromere. Cytoplasm, cytoskeleton, spindle pole. Note=In prometaphase cells, but not in anaphase cells, localizes at centromeres. During mitosis, also found at spindle poles. Centromeric localization requires the presence of SGO2 (By similarity). {ECO:0000250}.
| Compartment | Confidence |
|---|---|
| extracellular | 5 |
| cytoskeleton | 5 |
| mitochondrion | 5 |
| nucleus | 5 |
| cytosol | 5 |
| plasma membrane | 3 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000159 | protein phosphatase type 2A complex | TAS | 11007961 |
| GO:0000775 | chromosome, centromeric region | IEA | -- |
| GO:0000922 | spindle pole | IEA | -- |
| GO:0005634 | nucleus | NAS | 11007961 |
| GO:0005694 | chromosome | IEA | -- |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for PPP2CA Gene
Pathways & Interactions for PPP2CA Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | RET signaling |
.92
|
.92
|
| 2 | Activated TLR4 signalling | ||
| 3 | phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex | ||
| 4 | Negative regulation of FGFR1 signaling | ||
| 5 | PI3K/AKT activation |
.89
|
|
Pathways by source for PPP2CA Gene
2 Sino Biological pathways for PPP2CA Gene
1 GeneTex pathway for PPP2CA Gene
14 BioSystems pathways for PPP2CA Gene
154 Reactome pathways for PPP2CA Gene
1 PharmGKB pathway for PPP2CA Gene
16 KEGG pathways for PPP2CA Gene
12 GeneGo (Thomson Reuters) pathways for PPP2CA Gene
3 R&D Systems pathways for PPP2CA Gene
5 Tocris pathways for PPP2CA Gene
24 Qiagen pathways for PPP2CA Gene
2 Cell Signaling Technology pathways for PPP2CA Gene
Interacting Proteins for PPP2CA Gene
Selected Interacting proteins:
P67775-PP2AA_HUMAN
ENSP00000418447
for PPP2CA Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for PPP2CA
SIGNOR curated interactions for PPP2CA Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000184 | nuclear-transcribed mRNA catabolic process, nonsense-mediated decay | TAS | -- |
| GO:0000188 | inactivation of MAPK activity | NAS | 11007961 |
| GO:0001932 | regulation of protein phosphorylation | NAS | 28386764 |
| GO:0006275 | regulation of DNA replication | NAS | 11007961 |
| GO:0006355 | regulation of transcription, DNA-templated | NAS | 11007961 |
Drugs & Compounds for PPP2CA Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Vitamin E | Approved, Vet_approved | Nutra | Target | 434,438 | ||
| alpha-Tocopherol acetate | Approved, Vet_approved | Nutra | Target | 0 | ||
| alpha-Tocopherol succinate | Approved, Vet_approved | Nutra | Target | 0 | ||
| Phosphoric acid | Approved | Pharma | 0 | |||
| Water | Approved | Pharma | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| Fe2+ |
|
15438-31-0 |
|
|||
| Phosphate |
|
14265-44-2 |
|
|||
| FK 506 |
|
104987-11-3 |
|
|
(4) Tocris Compounds for PPP2CA Gene
| Compound | Action | Cas Number |
|---|---|---|
| Calcineurin Autoinhibitory Peptide | Selective calcineurin inhibitor | 148067-21-4 |
| Cyclosporin A | Calcineurin inhibitor | 59865-13-3 |
| FK 506 | Potent calcineurin inhibitor; immunosuppressant | 104987-11-3 |
| INCA-6 | Inhibitor of calcineurin-substrate association | 3519-82-2 |
Drug Products
Transcripts for PPP2CA Gene
mRNA/cDNA for PPP2CA Gene
- (2) REFSEQ mRNAs :
- (10) Additional mRNA sequences :
- (636) Selected AceView cDNA sequences:
- (6) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000481195 4649 bps (uc003kze.4)
- ENST00000472253 574 bps (uc063han.1)
- ENST00000495833 739 bps (uc063hao.1)
- ENST00000522385 585 bps (uc063hap.1)
- ENST00000523082 510 bps (uc063haq.1)
Unigene Clusters for PPP2CA Gene
- Protein phosphatase 2, catalytic subunit, alpha isozyme:
- Representative Sequences:
CRISPR Products
-
OriGene CRISPR knockouts for PPP2CA
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for PPP2CA
- genomics-online: gRNA clones - Search results for available PPP2CA gene related products
- Applied Biological Materials CRISPR for PPP2CA
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for PPP2CA
- GenScript: Design CRISPR guide RNA sequences for PPP2CA
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for PPP2CA
- Browse OriGene Inhibitory RNA Products For PPP2CA
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PPP2CA
- genomics-online: shRNA clones - Search results for available PPP2CA gene related products
Clone Products
- Sino Biological Human cDNA Clone for PPP2CA
- Addgene plasmids for PPP2CA
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for PPP2CA
- genomics-online: cdna clones - Search results for available PPP2CA gene related products
- orf clones - Search results for available PPP2CA gene related products
- Applied Biological Materials Clones for PPP2CA
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | · | 5c | ^ | 6 | ^ | 7a | · | 7b | · | 7c | ^ | 8 | ^ | 9a | · | 9b | ^ | 10 | ^ | 11 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | ||||||||||||||||||||||||||||||
| SP2: | |||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | |||||||||||||||||||||||||||||||
| SP4: | - | - | - | - | - | ||||||||||||||||||||||||||||||
| SP5: | - | - | - | ||||||||||||||||||||||||||||||||
| SP6: | - | - | - | ||||||||||||||||||||||||||||||||
| SP7: | - | - | |||||||||||||||||||||||||||||||||
| SP8: | - | - |
Expression for PPP2CA Gene
This gene is overexpressed in Cervix (8.2).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for PPP2CA Gene
NURSA nuclear receptor signaling pathways regulating expression of PPP2CA Gene:
PPP2CASOURCE GeneReport for Unigene cluster for PPP2CA Gene:
Hs.105818Evidence on tissue expression from TISSUES for PPP2CA Gene
- Nervous system(4.9)
- Lung(4.7)
- Liver(4.6)
- Kidney(3.5)
- Pancreas(3.1)
- Intestine(2.9)
- Muscle(2.4)
- Heart(2.3)
- Blood(2.1)
- Skin(2.1)
Primer Products
-
OriGene qPCR primer pairs for PPP2CA
-
OriGene qPCR primer pairs and template standards for PPP2CA
- genomics-online: primer clones - Search results for available PPP2CA gene related products
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PPP2CA Gene
Orthologs for PPP2CA Gene
This gene was present in the common ancestor of eukaryotes.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| oppossum (Monodelphis domestica) |
Mammalia | PPP2CA 34 |
|
OneToOne | |
| chimpanzee (Pan troglodytes) |
Mammalia | PPP2CA 34 33 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | PPP2CA 34 33 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | PPP2CA 33 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Ppp2ca 33 |
|
||
| mouse (Mus musculus) |
Mammalia | Ppp2ca 16 34 33 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | PPP2CA 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | PPP2CA 34 33 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | PPP2CA 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | ppp2ca 33 |
|
||
| MGC75638 33 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | ppp2ca-prov 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | ppp2ca 34 |
|
OneToOne | |
| zgc:56064 33 |
|
||||
| rainbow trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.10181 33 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | mts 34 35 33 |
|
OneToMany | |
| CG11597 35 |
|
|
|||
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP010172 33 |
|
||
| worm (Caenorhabditis elegans) |
Secernentea | F38H4.9 35 |
|
|
|
| let-92 34 33 |
|
OneToMany | |||
| pph-4.2 35 |
|
|
|||
| pph-4.1 35 |
|
|
|||
| C34C12.3 35 |
|
|
|||
| C25A6.1 35 |
|
|
|||
| C06A1.3 35 |
|
|
|||
| W03D8.2 35 |
|
|
|||
| C24H11.1 35 |
|
|
|||
| C24H11.2 35 |
|
|
|||
| Y40H4A.2 35 |
|
|
|||
| R13A5.11 35 |
|
|
|||
| F58G1.3 35 |
|
|
|||
| F42G8.8 35 |
|
|
|||
| F49E11.7 35 |
|
|
|||
| C27B7.6 35 |
|
|
|||
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | PPH21 34 |
|
ManyToMany | |
| PPH22 34 |
|
ManyToMany | |||
| thale cress (Arabidopsis thaliana) |
eudicotyledons | PP2A-1 33 |
|
||
| soybean (Glycine max) |
eudicotyledons | Gma.10697 33 |
|
||
| rice (Oryza sativa) |
Liliopsida | Os06g0574500 33 |
|
||
| corn (Zea mays) |
Liliopsida | Zm.9014 33 |
|
||
| sea squirt (Ciona savignyi) |
Ascidiacea | CSA.11024 34 |
|
OneToMany | |
| Cin.5327 33 |
|
||||
| fission yeast (Schizosaccharomyces pombe) |
Schizosaccharomycetes | ppa1 33 |
|
||
| sea squirt (Ciona intestinalis) |
Ascidiacea | Cin.5327 33 |
|
- Species where no ortholog for PPP2CA was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Evolution for PPP2CA Gene
- ENSEMBL:
- Gene Tree for PPP2CA (if available)
- TreeFam:
- Gene Tree for PPP2CA (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for PPP2CA: view image
Paralogs for PPP2CA Gene
(11) SIMAP similar genes for PPP2CA Gene using alignment to 5 proteins:
- PP2AA_HUMAN
- B3KUN1_HUMAN
- E5RHP4_HUMAN
- E7ESG8_HUMAN
- Q6I9T8_HUMAN
Pseudogenes.org Pseudogenes for PPP2CA Gene
Variants for PPP2CA Gene
| SNP ID | Clin | Chr 05 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs864622012 | uncertain-significance, Malignant tumor of prostate | 134,197,778(-) | GAAG/G | coding_sequence_variant, inframe_deletion | |
| rs148071386 | uncertain-significance, not specified | 134,200,433(-) | G/A | coding_sequence_variant, stop_gained | |
| rs1000046540 | -- | 134,209,394(-) | A/T | intron_variant | |
| rs1000058427 | -- | 134,213,889(-) | G/A | intron_variant | |
| rs1000151518 | -- | 134,216,559(-) | T/G | intron_variant |
Residual Variation Intolerance Score:
37.9% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for PPP2CA Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PPP2CA Gene
Disorders for PPP2CA Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| usher syndrome, type ic |
|
|
Search PPP2CA in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for PPP2CA
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for PPP2CA Gene
Publications for PPP2CA Gene
- Methylated C-terminal leucine residue of PP2A catalytic subunit is important for binding of regulatory Balpha subunit. (PMID: 10191253) Bryant JC … Wadzinski BE (The Biochemical journal 1999) 3 4 22 58
- The catalytic subunit of protein phosphatase 2A is carboxyl-methylated in vivo. (PMID: 8206937) Favre B … Hemmings BA (The Journal of biological chemistry 1994) 3 4 22 58
- Monoubiquitination promotes calpain cleavage of the protein phosphatase 2A (PP2A) regulatory subunit α4, altering PP2A stability and microtubule-associated protein phosphorylation. (PMID: 22613722) Watkins GR … Wadzinski BE (The Journal of biological chemistry 2012) 3 4 58
- Identification and characterization of an alternatively spliced isoform of the human protein phosphatase 2Aα catalytic subunit. (PMID: 22167190) Migueleti DL … Zanchin NI (The Journal of biological chemistry 2012) 3 4 58
- An approach based on a genome-wide association study reveals candidate loci for narcolepsy. (PMID: 20677014) Shimada M … Tokunaga K (Human genetics 2010) 3 44 58
Products for PPP2CA Gene
- R&D Systems Antibodies for PPP2CA (PP2A)
- Browse R&D Systems for Human Recombinant Proteins
- R&D Systems Activity Assays and other biochemical assays for PPP2CA (PP2A)
- Browse Human Proteins and Enzymes
- Browse Primary Antibodies
- Browse Proteins and Enzymes
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- Browse Proteome Profiler Antibody Arrays
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- Custom Antibody ServicesOriGene Antibodies for PPP2CA
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for PPP2CA
- Search Origene for MassSpec and Protein Over-expression Lysates for PPP2CA
- Origene Custom Protein Services for PPP2CA
- Origene shrna, sirna, and RNAi products in human, mouse, rat for PPP2CA
- Browse OriGene Inhibitory RNA Products For PPP2CA
- OriGene qPCR primer pairs for PPP2CA
- OriGene qPCR primer pairs and template standards for PPP2CA
- OriGene CRISPR knockouts for PPP2CA
- OriGene ORF clones in human for PPP2CA
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For PPP2CA
- GenScript: Next-day shipping of latest version cDNA ORF clones for PPP2CA in any vector
- GenScript Custom Purified and Recombinant Proteins Services for PPP2CA
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- GenScript Custom overexpressing Cell Line Services for PPP2CA
- GenScript: Design CRISPR guide RNA sequences for PPP2CA
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
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- Sino Biological Human cDNA Clone for PPP2CA
- Browse Sino Biological Recombinant Proteins
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- Browse cDNA Clones
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for PPP2CA
- Novus Biologicals proteins and lysates for PPP2CA
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Abcam antibodies for PPP2CA
- Abcam proteins for PPP2CA
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- Find your target
- Browse Primary Antibodies
- Browse Conjugated Primary Antibodies
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- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- Invitrogen Antibodies for PPP2CA (AFLGC-PPP2CA)
- Cyagen custom Knockout/knockin (KOKI) mouse models for PPP2CA
- Addgene plasmids for PPP2CA
- antibodies-online: Search results for 4 available PPP2CA Antibodies ranked by validation data
- Compare Top PPP2CA Antibodies
- antibodies-online: Search results for 5 available PPP2CA Elisa Kits ranked by validation data
- Compare Top PPP2CA Elisa Kits
- antibodies-online: Search results for 10 available PPP2CA Proteins ranked by validation data
- Compare Top PPP2CA Proteins
- GeneTex PPP2CA Antibody for PPP2CA
- Search GeneTex for Proteins for PPP2CA
- Santa Cruz Biotechnology (SCBT) Antibodies for PPP2CA
- Search Santa Cruz Biotechnology (SCBT) for PPP2CA siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for PPP2CA
- genomics-online: cdna clones - Search results for available PPP2CA gene related products
- orf clones - Search results for available PPP2CA gene related products
- genomics-online: gRNA clones - Search results for available PPP2CA gene related products
- genomics-online: primer clones - Search results for available PPP2CA gene related products
- genomics-online: shRNA clones - Search results for available PPP2CA gene related products
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for PPP2CA
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for PPP2CA
- GeneCopoeia miRNA 3'UTR Target clone products for PPP2CA
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PPP2CA
Sources for PPP2CA Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104)