This gene encodes the phosphatase 2A catalytic subunit. Protein phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. ... See more...

Aliases for PPP2CA Gene

Aliases for PPP2CA Gene

  • Protein Phosphatase 2 Catalytic Subunit Alpha 2 3 5
  • Serine/Threonine-Protein Phosphatase 2A Catalytic Subunit Alpha Isoform 3 4
  • Protein Phosphatase 2, Catalytic Subunit, Alpha Isozyme 2 3
  • Replication Protein C 3 4
  • EC 3.1.3.16 4 51
  • PP2A-Alpha 3 4
  • PP2Calpha 2 3
  • RP-C 3 4
  • Protein Phosphatase 2 (Formerly 2A), Catalytic Subunit, Alpha Isoform 2
  • Protein Phosphatase 2A Catalytic Subunit, Alpha Isoform 2
  • NEDLBA 3
  • PPP2CA 5
  • PP2Ac 3
  • PP2CA 3
  • PP2AC 2

External Ids for PPP2CA Gene

Previous GeneCards Identifiers for PPP2CA Gene

  • GC05M133180
  • GC05M134046
  • GC05M133563
  • GC05M133608
  • GC05M133560
  • GC05M128717
  • GC05M133530

Summaries for PPP2CA Gene

Entrez Gene Summary for PPP2CA Gene

  • This gene encodes the phosphatase 2A catalytic subunit. Protein phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. This gene encodes an alpha isoform of the catalytic subunit. [provided by RefSeq, Jul 2008]

GeneCards Summary for PPP2CA Gene

PPP2CA (Protein Phosphatase 2 Catalytic Subunit Alpha) is a Protein Coding gene. Diseases associated with PPP2CA include Neurodevelopmental Disorder And Language Delay With Or Without Structural Brain Abnormalities and Alzheimer Disease 15. Among its related pathways are Beta-Adrenergic Signaling and Association Between Physico-Chemical Features and Toxicity Associated Pathways. Gene Ontology (GO) annotations related to this gene include hydrolase activity and protein C-terminus binding. An important paralog of this gene is PPP2CB.

UniProtKB/Swiss-Prot Summary for PPP2CA Gene

  • PP2A is the major phosphatase for microtubule-associated proteins (MAPs). PP2A can modulate the activity of phosphorylase B kinase casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase. Cooperates with SGO2 to protect centromeric cohesin from separase-mediated cleavage in oocytes specifically during meiosis I (By similarity). Can dephosphorylate SV40 large T antigen and p53/TP53. Activates RAF1 by dephosphorylating it at 'Ser-259' (PubMed:10801873). Mediates dephosphorylation of WEE1, preventing its ubiquitin-mediated proteolysis, increasing WEE1 protein levels, and promoting the G2/M checkpoint (PubMed:33108758).

Tocris Summary for PPP2CA Gene

  • Protein Ser/Thr phosphatases are a group of enzymes that catalyze the removal of phosphate groups from serine and/or threonine residues by hydrolysis of phosphoric acid monoesters. They oppose the action of kinases and phosphorylases and are involved in signal transduction.

Gene Wiki entry for PPP2CA Gene

No data available for CIViC Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PPP2CA Gene

Genomics for PPP2CA Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for PPP2CA Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH05J134223 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 256.5 +0.7 687 6.4 ZSCAN16 CHD2 TBP ZBTB10 SP1 FEZF1 MNT IKZF1 SMAD5 ZNF217 PPP2CA ENSG00000270177 ENSG00000272772 MIR3661 SKP1 lnc-SKP1-1 ENSG00000273345
GH05J134200 Promoter 0.4 EPDnew 250.3 +25.7 25720 0.1 RBM22 HSALNG0044953 lnc-SKP1-3 PPP2CA lnc-SKP1-1 SKP1 ENSG00000272772
GH05J134197 Promoter 0.3 EPDnew 262.2 +28.9 28861 0.1 PPP2CA SKP1 HSALNG0044953 piR-42491-181 ENSG00000272772
GH05J134546 Enhancer 1.4 FANTOM5 ENCODE dbSUPER 11.6 -326.0 -325986 10.1 NR2C1 DEK BRCA1 ZBTB7B ZIC2 CEBPB ZNF513 ARNT ELK1 ZNF521 DDX46 CAMLG PPP2CA JADE2 SEC24A CATSPER3 C5orf66 UBE2B TXNDC15 CDKL3
GH05J134289 Enhancer 0.8 ENCODE 11.1 -63.6 -63632 0.1 CEBPA NR2C1 DEK ZNF217 CTCF HOMEZ CEBPB REST CUX1 TRIM22 SKP1 JADE2 PPP2CA ENSG00000248559 CDKN2AIPNL RPS10P11 DDX46 piR-46389-014 piR-52079-171 UBE2B
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PPP2CA on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for PPP2CA

Top Transcription factor binding sites by QIAGEN in the PPP2CA gene promoter:
  • AP-1
  • Arnt
  • ATF-2
  • c-Jun
  • PPAR-gamma1
  • PPAR-gamma2
  • STAT1
  • STAT1alpha
  • STAT1beta

Genomic Locations for PPP2CA Gene

Latest Assembly
chr5:134,194,332-134,226,073
(GRCh38/hg38)
Size:
31,742 bases
Orientation:
Minus strand

Previous Assembly
chr5:133,530,023-133,561,764
(GRCh37/hg19 by Entrez Gene)
Size:
31,742 bases
Orientation:
Minus strand

chr5:133,530,025-133,561,833
(GRCh37/hg19 by Ensembl)
Size:
31,809 bases
Orientation:
Minus strand

Genomic View for PPP2CA Gene

Genes around PPP2CA on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PPP2CA Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PPP2CA Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PPP2CA Gene

Proteins for PPP2CA Gene

  • Protein details for PPP2CA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P67775-PP2AA_HUMAN
    Recommended name:
    Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform
    Protein Accession:
    P67775
    Secondary Accessions:
    • P05323
    • P13197

    Protein attributes for PPP2CA Gene

    Size:
    309 amino acids
    Molecular mass:
    35594 Da
    Cofactor:
    Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
    Quaternary structure:
    • PP2A consists of a common heterodimeric core enzyme, composed of PPP2CA a 36 kDa catalytic subunit (subunit C) and PPP2R1A a 65 kDa constant regulatory subunit (PR65 or subunit A), that associates with a variety of regulatory subunits. Proteins that associate with the core dimer include three families of regulatory subunits B (the R2/B/PR55/B55, R3/B''/PR72/PR130/PR59 and R5/B'/B56 families), the 48 kDa variable regulatory subunit, viral proteins, and cell signaling molecules (PubMed:18394995, PubMed:30595372). Interacts with NXN; the interaction is direct (By similarity). Interacts with KCTD20 (By similarity). Interacts with BTBD10 (By similarity). Interacts with SGO1 and SGO2 (PubMed:16580887, PubMed:16541025, PubMed:17485487). Interacts with TP53 (PubMed:17245430). Interacts with AXIN1; the interaction dephosphorylates AXIN1. Interacts with PIM3; this interaction promotes dephosphorylation, ubiquitination and proteasomal degradation of PIM3. Interacts with RAF1. Interaction with IGBP1 protects unassembled PPP2CA from degradative ubiquitination. Interacts with GSK3B (via C2 domain). Interacts with MFHAS1; retains PPP2CA into the cytoplasm and excludes it from the nucleus (PubMed:28609714). Interacts with PABIR1/FAM122A (PubMed:27588481). Interacts with ADCY8; interaction is phosphatase activity-dependent; antagonizes interaction between ADCY8 and calmodulin (PubMed:16258073). Interacts with CRTC3 (when phosphorylated at 'Ser-391') (PubMed:30611118). Interacts with SPRY2; the interaction is inhibited by TESK1 interaction with SPRY2, possibly by vesicular sequestration of SPRY2 (PubMed:17974561). Interacts with TRAF3IP3 (PubMed:30115741).
    Miscellaneous:
    • [Isoform 2]: Catalytically inactive, shows enhanced binding to IGBP1, and does not interact with the scaffolding subunit PPP2R1A.

    Three dimensional structures from OCA and Proteopedia for PPP2CA Gene

    Alternative splice isoforms for PPP2CA Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PPP2CA Gene

Selected DME Specific Peptides for PPP2CA Gene

P67775:
  • FCLHGGLSP
  • LCEKAKEIL
  • DLLWSDP
  • YGFYDEC
  • RAHQLVMEG
  • PAPRRGEP
  • FTKELDQW
  • PDTNYLF
  • SAPNYCYRC
  • LLVALKVRY
  • NYLFMGD
  • TIFSAPNY
  • FLQFDPAPR
  • SVETVTLLV
  • HGQFHDL
  • RGNHESRQ
  • QEVPHEG
  • ELFRIGG
  • GDYVDRG
  • GWGISPRGAG
  • QLSESQV
  • FTDLFDYLPLTAL
  • SPRGAGYTFG
  • CGDVHGQ
  • LDQWIEQLNEC
  • CPVTVCGD

Post-translational modifications for PPP2CA Gene

  • Reversibly methyl esterified on Leu-309 by leucine carboxyl methyltransferase 1 (LCMT1) and protein phosphatase methylesterase 1 (PPME1). Carboxyl methylation influences the affinity of the catalytic subunit for the different regulatory subunits, thereby modulating the PP2A holoenzyme's substrate specificity, enzyme activity and cellular localization.
  • Phosphorylation of either threonine (by autophosphorylation-activated protein kinase) or tyrosine results in inactivation of the phosphatase. Auto-dephosphorylation has been suggested as a mechanism for reactivation.
  • Polyubiquitinated, leading to its degradation by the proteasome.
  • Ubiquitination at Lys4, Lys8, Lys21, and Lys29
  • Modification sites at PhosphoSitePlus

Other Protein References for PPP2CA Gene

Antibodies for research

Domains & Families for PPP2CA Gene

Gene Families for PPP2CA Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for PPP2CA Gene

InterPro:
Blocks:
  • Serine/threonine-specific protein phosphatase and bis(5-nucleosyl)-tetraphosphatase
ProtoNet:

Suggested Antigen Peptide Sequences for PPP2CA Gene

GenScript: Design optimal peptide antigens:
  • Serine/threonine-protein phosphatase (B3KUN1_HUMAN)
  • Serine/threonine-protein phosphatase (E5RHP4_HUMAN)
  • Serine/threonine-protein phosphatase (E7ESG8_HUMAN)
  • Replication protein C (PP2AA_HUMAN)
  • Serine/threonine-protein phosphatase (Q6I9T8_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P67775

UniProtKB/Swiss-Prot:

PP2AA_HUMAN :
  • Belongs to the PPP phosphatase family. PP-1 subfamily.
Family:
  • Belongs to the PPP phosphatase family. PP-1 subfamily.
genes like me logo Genes that share domains with PPP2CA: view

Function for PPP2CA Gene

Molecular function for PPP2CA Gene

UniProtKB/Swiss-Prot Function:
PP2A is the major phosphatase for microtubule-associated proteins (MAPs). PP2A can modulate the activity of phosphorylase B kinase casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase. Cooperates with SGO2 to protect centromeric cohesin from separase-mediated cleavage in oocytes specifically during meiosis I (By similarity). Can dephosphorylate SV40 large T antigen and p53/TP53. Activates RAF1 by dephosphorylating it at 'Ser-259' (PubMed:10801873). Mediates dephosphorylation of WEE1, preventing its ubiquitin-mediated proteolysis, increasing WEE1 protein levels, and promoting the G2/M checkpoint (PubMed:33108758).
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=H2O + O-phospho-L-seryl-[protein] = L-seryl-[protein] + phosphate; Xref=Rhea:RHEA:20629, Rhea:RHEA-COMP:9863, Rhea:RHEA-COMP:11604, ChEBI:CHEBI:15377, ChEBI:CHEBI:29999, ChEBI:CHEBI:43474, ChEBI:CHEBI:83421; EC=3.1.3.16; Evidence={ECO:0000269|PubMed:1848668};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate; Xref=Rhea:RHEA:47004, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15377, ChEBI:CHEBI:30013, ChEBI:CHEBI:43474, ChEBI:CHEBI:61977; EC=3.1.3.16; Evidence={ECO:0000269|PubMed:30595372, ECO:0000269|PubMed:30611118};.
GENATLAS Biochemistry:
protein phosphatase 2A,catalytic subunit,alpha isoform,antagonizing cdc2/CCNB1 complex which regulates the G2-M transition in the cell cycle

Enzyme Numbers (IUBMB) for PPP2CA Gene

Phenotypes From GWAS Catalog for PPP2CA Gene

Gene Ontology (GO) - Molecular Function for PPP2CA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004721 phosphoprotein phosphatase activity IEA,TAS 28386764
GO:0004722 protein serine/threonine phosphatase activity IEA,TAS 10640627
GO:0005515 protein binding IPI 1328865
GO:0008022 protein C-terminus binding IEA --
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with PPP2CA: view
genes like me logo Genes that share phenotypes with PPP2CA: view

Human Phenotype Ontology for PPP2CA Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for PPP2CA Gene

MGI Knock Outs for PPP2CA:

miRNA for PPP2CA Gene

miRTarBase miRNAs that target PPP2CA

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PPP2CA

No data available for Transcription Factor Targets and HOMER Transcription for PPP2CA Gene

Localization for PPP2CA Gene

Subcellular locations from UniProtKB/Swiss-Prot for PPP2CA Gene

Cytoplasm. Nucleus. Chromosome, centromere. Cytoplasm, cytoskeleton, spindle pole. Note=In prometaphase cells, but not in anaphase cells, localizes at centromeres. During mitosis, also found at spindle poles. Centromeric localization requires the presence of SGO2 (By similarity). {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PPP2CA gene
Compartment Confidence
cytoskeleton 5
mitochondrion 5
nucleus 5
cytosol 5
extracellular 4
plasma membrane 3
endoplasmic reticulum 2
peroxisome 1
endosome 1
lysosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for PPP2CA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000159 protein phosphatase type 2A complex IEA,TAS 11007961
GO:0000775 chromosome, centromeric region IEA --
GO:0000922 spindle pole IEA --
GO:0005634 nucleus NAS 11007961
GO:0005694 chromosome IEA --
genes like me logo Genes that share ontologies with PPP2CA: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for PPP2CA Gene

Pathways & Interactions for PPP2CA Gene

PathCards logo

SuperPathways for PPP2CA Gene

SuperPathway Contained pathways
1 RET signaling
2 Activated TLR4 signalling
3 Misspliced GSK3beta mutants stabilize beta-catenin
4 Negative regulation of FGFR1 signaling
5 GAB1 signalosome
genes like me logo Genes that share pathways with PPP2CA: view

Pathways by source for PPP2CA Gene

3 Sino Biological pathways for PPP2CA Gene
1 PharmGKB pathway for PPP2CA Gene
12 GeneGo (Thomson Reuters) pathways for PPP2CA Gene
  • Apoptosis and survival BAD phosphorylation
  • Cell cycle Regulation of G1/S transition (part 1)
  • Cell cycle Start of DNA replication in early S phase
  • Development Beta-adrenergic receptors regulation of ERK
  • Development Beta-adrenergic receptors signaling via cAMP
1 R&D Systems pathway for PPP2CA Gene
24 Qiagen pathways for PPP2CA Gene
  • Akt Signaling
  • AMPK Enzyme Complex Pathway
  • BAD Phosphorylation
  • Beta-Adrenergic Signaling
  • Breast Cancer Regulation by Stathmin1
2 Cell Signaling Technology pathways for PPP2CA Gene
1 GeneTex pathway for PPP2CA Gene

Gene Ontology (GO) - Biological Process for PPP2CA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS --
GO:0000188 inactivation of MAPK activity NAS 11007961
GO:0001932 regulation of protein phosphorylation NAS 28386764
GO:0006275 regulation of DNA replication NAS 11007961
GO:0006355 regulation of transcription, DNA-templated NAS 11007961
genes like me logo Genes that share ontologies with PPP2CA: view

Drugs & Compounds for PPP2CA Gene

(19) Drugs for PPP2CA Gene - From: DrugBank, ApexBio, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Vitamin E Approved, Vet_approved Nutra Target 549,557
Magnesium Approved, Experimental, Investigational Pharma 0
Water Approved Pharma 0
Manganese Approved Nutra 64
Cyclosporin A Approved, Investigational, Vet_approved Pharma Immunosuppressive agent, Calcineurin inhibitor 0

(2) Additional Compounds for PPP2CA Gene - From: Novoseek and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
FK 506
104987-11-3

(4) Tocris Compounds for PPP2CA Gene

Compound Action Cas Number
Calcineurin Autoinhibitory Peptide Selective calcineurin inhibitor 148067-21-4
Cyclosporin A Calcineurin inhibitor 59865-13-3
FK 506 Potent calcineurin inhibitor; immunosuppressant 104987-11-3
INCA-6 Inhibitor of calcineurin-substrate association 3519-82-2

(3) ApexBio Compounds for PPP2CA Gene

Compound Action Cas Number
Ceramide Protein phosphatase and CAPP modulator 3102-57-6
DL-AP3 Glutamate receptor antagonist and HPSP inhibitor 20263-06-3
Sal 003 Cellular phosphatase complex inhibitor 1164470-53-4
genes like me logo Genes that share compounds with PPP2CA: view

Drug products for research

Transcripts for PPP2CA Gene

mRNA/cDNA for PPP2CA Gene

2 REFSEQ mRNAs :
13 NCBI additional mRNA sequence :
6 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PPP2CA

Alternative Splicing Database (ASD) splice patterns (SP) for PPP2CA Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b · 7c ^ 8 ^ 9a · 9b ^ 10 ^ 11
SP1: - - - - -
SP2:
SP3: - - - -
SP4: - - - - -
SP5: - - -
SP6: - - -
SP7: - -
SP8: - -

Relevant External Links for PPP2CA Gene

GeneLoc Exon Structure for
PPP2CA

Expression for PPP2CA Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PPP2CA Gene

Protein differential expression in normal tissues from HIPED for PPP2CA Gene

This gene is overexpressed in Cervix (8.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for PPP2CA Gene



Protein tissue co-expression partners for PPP2CA Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for PPP2CA

SOURCE GeneReport for Unigene cluster for PPP2CA Gene:

Hs.105818

Evidence on tissue expression from TISSUES for PPP2CA Gene

  • Nervous system(4.9)
  • Lung(4.8)
  • Liver(4.6)
  • Kidney(3.8)
  • Pancreas(3.3)
  • Intestine(3.3)
  • Skin(3)
  • Muscle(2.8)
  • Heart(2.7)
  • Blood(2.7)
  • Eye(2.5)
  • Bone marrow(2.4)
  • Spleen(2.3)
  • Adrenal gland(2.2)
  • Lymph node(2.2)
  • Stomach(2.2)
genes like me logo Genes that share expression patterns with PPP2CA: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PPP2CA Gene

Orthologs for PPP2CA Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PPP2CA Gene

Organism Taxonomy Gene Similarity Type Details
Oppossum
(Monodelphis domestica)
Mammalia PPP2CA 31
  • 100 (a)
OneToOne
Chimpanzee
(Pan troglodytes)
Mammalia PPP2CA 30 31
  • 99.68 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia PPP2CA 30 31
  • 96.87 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia PPP2CA 30
  • 96.44 (n)
Rat
(Rattus norvegicus)
Mammalia Ppp2ca 30
  • 94.39 (n)
Mouse
(Mus musculus)
Mammalia Ppp2ca 30 17 31
  • 94.28 (n)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia PPP2CA 31
  • 93 (a)
OneToOne
Chicken
(Gallus gallus)
Aves PPP2CA 30 31
  • 88.67 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia PPP2CA 31
  • 99 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia ppp2ca 30
  • 85.11 (n)
MGC75638 30
African clawed frog
(Xenopus laevis)
Amphibia ppp2ca-prov 30
Zebrafish
(Danio rerio)
Actinopterygii ppp2ca 31
  • 97 (a)
OneToOne
zgc:56064 30
  • 79.94 (n)
Rainbow Trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10181 30
Fruit Fly
(Drosophila melanogaster)
Insecta mts 30 31 32
  • 73.03 (n)
OneToMany
CG11597 32
  • 52 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010172 30
  • 72.71 (n)
Worm
(Caenorhabditis elegans)
Secernentea F38H4.9 32
  • 89 (a)
let-92 30 31
  • 73.4 (n)
OneToMany
pph-4.1 32
  • 62 (a)
pph-4.2 32
  • 62 (a)
C34C12.3 32
  • 52 (a)
C25A6.1 32
  • 43 (a)
C06A1.3 32
  • 41 (a)
W03D8.2 32
  • 40 (a)
C24H11.1 32
  • 38 (a)
C24H11.2 32
  • 38 (a)
Y40H4A.2 32
  • 38 (a)
F58G1.3 32
  • 36 (a)
R13A5.11 32
  • 36 (a)
F42G8.8 32
  • 34 (a)
C27B7.6 32
  • 32 (a)
F49E11.7 32
  • 32 (a)
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PPH21 31
  • 62 (a)
ManyToMany
PPH22 31
  • 61 (a)
ManyToMany
Thale Cress
(Arabidopsis thaliana)
eudicotyledons PP2A-1 30
  • 70.65 (n)
Soybean
(Glycine max)
eudicotyledons Gma.10697 30
Rice
(Oryza sativa)
Liliopsida Os06g0574500 30
  • 70.21 (n)
Corn
(Zea mays)
Liliopsida Zm.9014 30
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.11024 31
  • 92 (a)
OneToMany
Fission Yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes ppa1 30
  • 70.65 (n)
Sea Vase
(Ciona intestinalis)
Ascidiacea Cin.5327 30
Species where no ortholog for PPP2CA was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for PPP2CA Gene

ENSEMBL:
Gene Tree for PPP2CA (if available)
TreeFam:
Gene Tree for PPP2CA (if available)
Aminode:
Evolutionary constrained regions (ECRs) for PPP2CA: view image

Paralogs for PPP2CA Gene

(11) SIMAP similar genes for PPP2CA Gene using alignment to 5 proteins:

  • PP2AA_HUMAN
  • B3KUN1_HUMAN
  • E5RHP4_HUMAN
  • E7ESG8_HUMAN
  • Q6I9T8_HUMAN

Pseudogenes.org Pseudogenes for PPP2CA Gene

genes like me logo Genes that share paralogs with PPP2CA: view

Variants for PPP2CA Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for PPP2CA Gene

SNP ID Clinical significance and condition Chr 05 pos Variation AA Info Type
rs148071386 Conflicting Interpretations: Neurodevelopmental disorder and language delay with or without structural brain abnormalities; not specified 134,200,433(-) G/A
NM_002715.4(PPP2CA):c.640C>T (p.Arg214Ter)
NONSENSE,NON_CODING_TRANSCRIPT
rs1561733474 Neurodevelopmental disorder and language delay with or without structural brain abnormalities (NEDLBA) [MIM:618354]. Likely Pathogenic: Neurodevelopmental disorder and language delay with or without structural brain abnormalities 134,199,149(-) p.Tyr265CysT/C
MISSENSE_VARIANT,NON_CODING_TRANSCRIPT
rs1561734750 Pathogenic: Neurodevelopmental disorder and language delay with or without structural brain abnormalities 134,201,895(-) TA/T
NM_002715.4(PPP2CA):c.438del (p.Phe146fs)
FRAMESHIFT_VARIANT,NON_CODING_TRANSCRIPT
rs1561734790 Pathogenic: Neurodevelopmental disorder and language delay with or without structural brain abnormalities 134,201,961(-) G/A
NM_002715.4(PPP2CA):c.373C>T (p.Gln125Ter)
NONSENSE,NON_CODING_TRANSCRIPT
rs1561737008 Pathogenic/Likely Pathogenic: Neurodevelopmental disorder and language delay with or without structural brain abnormalities. Neurodevelopmental disorder and language delay with or without structural brain abnormalities (NEDLBA) [MIM:618354] 134,205,971(-) T/Cp.Asp88Gly
NM_002715.4(PPP2CA):c.263A>G (p.Asp88Gly)
MISSENSE_VARIANT,NON_CODING_TRANSCRIPT

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for PPP2CA Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for PPP2CA Gene

Variant ID Type Subtype PubMed ID
nsv599732 CNV loss 21841781

Variation tolerance for PPP2CA Gene

Residual Variation Intolerance Score: 37.9% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PPP2CA Gene

Human Gene Mutation Database (HGMD)
PPP2CA
SNPedia medical, phenotypic, and genealogical associations of SNPs for
PPP2CA

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PPP2CA Gene

Disorders for PPP2CA Gene

MalaCards: The human disease database

(8) MalaCards diseases for PPP2CA Gene - From: OMI, CVR, GTR, SWI, COP, and GCD

- elite association - COSMIC cancer census association via MalaCards

UniProtKB/Swiss-Prot

PP2AA_HUMAN
  • Neurodevelopmental disorder and language delay with or without structural brain abnormalities (NEDLBA) [MIM:618354]: An autosomal dominant neurodevelopmental disorder characterized by global developmental delay with onset in infancy and additional variable features including hypotonia, epilepsy, brain abnormalities such as ventriculomegaly and a small corpus callosum, and autism spectrum disorder. {ECO:0000269 PubMed:30595372}. Note=The disease is caused by variants affecting the gene represented in this entry.

Additional Disease Information for PPP2CA

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with PPP2CA: view

No data available for Genatlas for PPP2CA Gene

Publications for PPP2CA Gene

  1. De Novo Mutations Affecting the Catalytic Cα Subunit of PP2A, PPP2CA, Cause Syndromic Intellectual Disability Resembling Other PP2A-Related Neurodevelopmental Disorders. (PMID: 30595372) Reynhout S … Vissers LELM (American journal of human genetics 2019) 3 4 74
  2. Methylated C-terminal leucine residue of PP2A catalytic subunit is important for binding of regulatory Balpha subunit. (PMID: 10191253) Bryant JC … Wadzinski BE (The Biochemical journal 1999) 3 4 23
  3. The catalytic subunit of protein phosphatase 2A is carboxyl-methylated in vivo. (PMID: 8206937) Favre B … Hemmings BA (The Journal of biological chemistry 1994) 3 4 23
  4. CHK1 Inhibitor Blocks Phosphorylation of FAM122A and Promotes Replication Stress. (PMID: 33108758) Li F … D'Andrea AD (Molecular cell 2020) 3 4
  5. Mitogenic Signals Stimulate the CREB Coactivator CRTC3 through PP2A Recruitment. (PMID: 30611118) Sonntag T … Montminy M (iScience 2019) 3 4

Products for PPP2CA Gene