Aliases for PPP2CA Gene
External Ids for PPP2CA Gene
Previous GeneCards Identifiers for PPP2CA Gene
This gene encodes the phosphatase 2A catalytic subunit. Protein phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. This gene encodes an alpha isoform of the catalytic subunit. [provided by RefSeq, Jul 2008]
GeneCards Summary for PPP2CA Gene
PPP2CA (Protein Phosphatase 2 Catalytic Subunit Alpha) is a Protein Coding gene. Diseases associated with PPP2CA include Neurodevelopmental Disorder And Language Delay With Or Without Structural Brain Abnormalities and Alzheimer Disease 15. Among its related pathways are Beta-Adrenergic Signaling and Association Between Physico-Chemical Features and Toxicity Associated Pathways. Gene Ontology (GO) annotations related to this gene include hydrolase activity and protein C-terminus binding. An important paralog of this gene is PPP2CB.
UniProtKB/Swiss-Prot Summary for PPP2CA Gene
PP2A is the major phosphatase for microtubule-associated proteins (MAPs). PP2A can modulate the activity of phosphorylase B kinase casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase. Cooperates with SGO2 to protect centromeric cohesin from separase-mediated cleavage in oocytes specifically during meiosis I (By similarity). Can dephosphorylate SV40 large T antigen and p53/TP53. Activates RAF1 by dephosphorylating it at 'Ser-259' (PubMed:10801873). Mediates dephosphorylation of WEE1, preventing its ubiquitin-mediated proteolysis, increasing WEE1 protein levels, and promoting the G2/M checkpoint (PubMed:33108758).
Protein Ser/Thr phosphatases are a group of enzymes that catalyze the removal of phosphate groups from serine and/or threonine residues by hydrolysis of phosphoric acid monoesters. They oppose the action of kinases and phosphorylases and are involved in signal transduction.