Aliases for PPP1R8 Gene
External Ids for PPP1R8 Gene
Previous GeneCards Identifiers for PPP1R8 Gene
This gene, through alternative splicing, encodes three different isoforms. Two of the protein isoforms encoded by this gene are specific inhibitors of type 1 serine/threonine protein phosphatases and can bind but not cleave RNA. The third protein isoform lacks the phosphatase inhibitory function but is a single-strand endoribonuclease comparable to RNase E of E. coli. This isoform requires magnesium for its function and cleaves specific sites in A+U-rich regions of RNA. [provided by RefSeq, Jul 2008]
GeneCards Summary for PPP1R8 Gene
PPP1R8 (Protein Phosphatase 1 Regulatory Subunit 8) is a Protein Coding gene. Diseases associated with PPP1R8 include Hyperoxaluria, Primary, Type Iii and Polycystic Kidney Disease 3 With Or Without Polycystic Liver Disease. Among its related pathways are Beta-Adrenergic Signaling and Apoptotic Pathways in Synovial Fibroblasts. Gene Ontology (GO) annotations related to this gene include RNA binding. An important paralog of this gene is SLC4A1AP.
UniProtKB/Swiss-Prot Summary for PPP1R8 Gene
Inhibitor subunit of the major nuclear protein phosphatase-1 (PP-1). It has RNA-binding activity but does not cleave RNA and may target PP-1 to RNA-associated substrates. May also be involved in pre-mRNA splicing. Binds DNA and might act as a transcriptional repressor. Seems to be required for cell proliferation.
Isoform Gamma is a site-specific single-strand endoribonuclease that cleaves single strand RNA 3' to purines and pyrimidines in A+U-rich regions. It generates 5'-phosphate termini at the site of cleavage. This isoform does not inhibit PP-1. May be implicated in mRNA splicing.