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Aliases for PPP1R7 Gene

Aliases for PPP1R7 Gene

  • Protein Phosphatase 1 Regulatory Subunit 7 2 3 3 5
  • Protein Phosphatase 1, Regulatory (Inhibitor) Subunit 7 2 3
  • Protein Phosphatase 1 Regulatory Subunit 22 3 4
  • SDS22 3 4
  • Testis Secretory Sperm-Binding Protein Li 210a 3
  • Protein Phosphatase 1, Regulatory Subunit 7 2

External Ids for PPP1R7 Gene

Previous GeneCards Identifiers for PPP1R7 Gene

  • GC02M239317
  • GC02M240174
  • GC02P242108
  • GC02P242409
  • GC02P242410
  • GC02P241809
  • GC02P241737
  • GC02P233846
  • GC02P242088

Summaries for PPP1R7 Gene

Entrez Gene Summary for PPP1R7 Gene

  • This gene encodes a protein subunit that regulates the activity of the serine/threonine phosphatase, protein phosphatase-1. The encoded protein is required for completion of the mitotic cycle and for targeting protein phosphatase-1 to mitotic kinetochores. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]

GeneCards Summary for PPP1R7 Gene

PPP1R7 (Protein Phosphatase 1 Regulatory Subunit 7) is a Protein Coding gene. Among its related pathways are Activation of cAMP-Dependent PKA and PEDF Induced Signaling. Gene Ontology (GO) annotations related to this gene include enzyme regulator activity. An important paralog of this gene is LRRC9.

UniProtKB/Swiss-Prot for PPP1R7 Gene

  • Regulatory subunit of protein phosphatase 1.

Gene Wiki entry for PPP1R7 Gene

Additional gene information for PPP1R7 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PPP1R7 Gene

Genomics for PPP1R7 Gene

GeneHancer (GH) Regulatory Elements for PPP1R7 Gene

Promoters and enhancers for PPP1R7 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02J241148 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 650.7 +0.8 826 3.3 HDGF PKNOX1 FOXA2 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF213 E2F8 PASK PPP1R7 ANKMY1 ENSG00000223374 GC02P241182
GH02J241616 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 9.9 +469.4 469434 4.1 HDGF PKNOX1 ARNT GLI4 YY1 ETS1 ZNF143 FOS KLF13 SP3 THAP4 ING5 ENSG00000223374 SNED1 ENSG00000235351 MTERF4 FARP2 BOK D2HGDH DTYMK
GH02J241558 Promoter/Enhancer 2.1 EPDnew FANTOM5 Ensembl ENCODE 9.6 +410.1 410127 3.4 FOXA2 ARID4B SIN3A ZNF48 YY1 RXRA SP5 NFYC MXD4 REST BOK BOK-AS1 STK25 ANO7 PASK PPP1R7 ING5 ATG4B NEU4 LOC105373975
GH02J241108 Enhancer 1.1 Ensembl ENCODE dbSUPER 11.7 -38.9 -38903 5.3 HDGF PKNOX1 EBF1 ZBTB40 RELA POLR2A EED IKZF2 RUNX3 ZNF687 GC02M241112 PIR57971 PASK MTERF4 PPP1R7 ANO7 ENSG00000229996 LOC100422094 GC02P241081
GH02J241091 Enhancer 1.1 ENCODE dbSUPER 11.2 -56.5 -56512 2.7 CLOCK FOXA2 MLX ARID4B SIN3A DMAP1 SLC30A9 NFKBIZ RXRA SP5 PASK MTERF4 ANO7 PPP1R7 ENSG00000229996 D2HGDH GC02P241081 SNED1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PPP1R7 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the PPP1R7 gene promoter:
  • AREB6
  • AML1a
  • c-Myb
  • Pax-5
  • Egr-2
  • NF-1/L
  • NF-1

Genomic Locations for PPP1R7 Gene

Genomic Locations for PPP1R7 Gene
34,080 bases
Plus strand
34,077 bases
Plus strand

Genomic View for PPP1R7 Gene

Genes around PPP1R7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PPP1R7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PPP1R7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PPP1R7 Gene

Proteins for PPP1R7 Gene

  • Protein details for PPP1R7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein phosphatase 1 regulatory subunit 7
    Protein Accession:
    Secondary Accessions:
    • B4DFD4
    • B5MCY6
    • Q9UQE5
    • Q9UQE6
    • Q9Y6K4

    Protein attributes for PPP1R7 Gene

    360 amino acids
    Molecular mass:
    41564 Da
    Quaternary structure:
    • Interacts with PPP1CA, PPP1CB and PPP1CC/PPP1G isoform 1.

    Alternative splice isoforms for PPP1R7 Gene


neXtProt entry for PPP1R7 Gene

Post-translational modifications for PPP1R7 Gene

  • Ubiquitination at posLast=244244, posLast=222222, posLast=178178, Lys175, posLast=168168, Lys162, posLast=111111, and posLast=9090
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for PPP1R7 Gene

Domains & Families for PPP1R7 Gene

Gene Families for PPP1R7 Gene

Suggested Antigen Peptide Sequences for PPP1R7 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the SDS22 family.
  • Belongs to the SDS22 family.
genes like me logo Genes that share domains with PPP1R7: view

Function for PPP1R7 Gene

Molecular function for PPP1R7 Gene

UniProtKB/Swiss-Prot Function:
Regulatory subunit of protein phosphatase 1.
GENATLAS Biochemistry:
protein phosphatase 1,41.6kDa,regulatory subunit 7,yeast sds 22 homolog

Gene Ontology (GO) - Molecular Function for PPP1R7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 17353931
GO:0019888 protein phosphatase regulator activity TAS 7498485
GO:0030234 enzyme regulator activity NAS 10231361
genes like me logo Genes that share ontologies with PPP1R7: view
genes like me logo Genes that share phenotypes with PPP1R7: view

Animal Model Products

CRISPR Products

miRNA for PPP1R7 Gene

miRTarBase miRNAs that target PPP1R7

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PPP1R7

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PPP1R7 Gene

Localization for PPP1R7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PPP1R7 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PPP1R7 gene
Compartment Confidence
extracellular 5
nucleus 5
cytoskeleton 2
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for PPP1R7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus TAS,HDA 21630459
GO:0005694 chromosome IDA 22801782
GO:0005737 cytoplasm TAS 7498485
GO:0070062 extracellular exosome HDA 19056867
genes like me logo Genes that share ontologies with PPP1R7: view

Pathways & Interactions for PPP1R7 Gene

genes like me logo Genes that share pathways with PPP1R7: view

Pathways by source for PPP1R7 Gene

Gene Ontology (GO) - Biological Process for PPP1R7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007059 chromosome segregation IEA --
GO:0008150 biological_process ND --
GO:0035307 positive regulation of protein dephosphorylation IMP 22801782
GO:0043666 regulation of phosphoprotein phosphatase activity IEA --
GO:0050790 regulation of catalytic activity IEA --
genes like me logo Genes that share ontologies with PPP1R7: view

No data available for SIGNOR curated interactions for PPP1R7 Gene

Drugs & Compounds for PPP1R7 Gene

No Compound Related Data Available

Transcripts for PPP1R7 Gene

Unigene Clusters for PPP1R7 Gene

Protein phosphatase 1, regulatory subunit 7:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PPP1R7

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for PPP1R7 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c · 6d · 6e ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b
SP1: - - - - - - -
SP2: - - - - - -
SP3: - - - - - - -
SP4: - - - - - - - - - -
SP5: - - - - - - - -
SP6: - - - - - - -
SP7: - - - -
SP8: -
SP9: - - - - -
SP10: - - -
SP11: - -
SP12: - - - -
SP13: - -

Relevant External Links for PPP1R7 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PPP1R7 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PPP1R7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for PPP1R7 Gene

This gene is overexpressed in Skin (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for PPP1R7 Gene

Protein tissue co-expression partners for PPP1R7 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of PPP1R7 Gene:


SOURCE GeneReport for Unigene cluster for PPP1R7 Gene:


mRNA Expression by UniProt/SwissProt for PPP1R7 Gene:

Tissue specificity: Widely expressed.

Evidence on tissue expression from TISSUES for PPP1R7 Gene

  • Nervous system(4.9)
  • Liver(4.3)
  • Lung(3)
genes like me logo Genes that share expression patterns with PPP1R7: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for PPP1R7 Gene

Orthologs for PPP1R7 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PPP1R7 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia PPP1R7 34 33
  • 99.54 (n)
(Ornithorhynchus anatinus)
Mammalia PPP1R7 34
  • 92 (a)
(Canis familiaris)
Mammalia PPP1R7 33
  • 91.3 (n)
-- 34
  • 84 (a)
-- 34
  • 56 (a)
(Bos Taurus)
Mammalia PPP1R7 34 33
  • 88.52 (n)
(Rattus norvegicus)
Mammalia Ppp1r7 33
  • 88.33 (n)
(Mus musculus)
Mammalia Ppp1r7 16 34 33
  • 88.06 (n)
(Gallus gallus)
Aves PPP1R7 34 33
  • 78.44 (n)
(Anolis carolinensis)
Reptilia PPP1R7 34
  • 78 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia ppp1r7 33
  • 67.92 (n)
Str.6727 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.19668 33
(Danio rerio)
Actinopterygii ppp1r7 34 33
  • 70.51 (n)
Dr.4202 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.185 33
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009839 33
  • 58.48 (n)
fruit fly
(Drosophila melanogaster)
Insecta sds22 34 35 33
  • 55.98 (n)
(Caenorhabditis elegans)
Secernentea T09A5.9 35 33
  • 52.68 (n)
sds-22 34
  • 45 (a)
C06A8.6 34 35
  • 40 (a)
K10D2.8 34
  • 36 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AER104W 33
  • 54.21 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D02816g 33
  • 53.36 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SDS22 36 34 33
  • 51.44 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G19680 33
  • 49.88 (n)
(Oryza sativa)
Liliopsida Os02g0230100 33
  • 48.98 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5923 34
  • 61 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU08385 33
  • 55.6 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes sds22 33
  • 51.43 (n)
Species where no ortholog for PPP1R7 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PPP1R7 Gene

Gene Tree for PPP1R7 (if available)
Gene Tree for PPP1R7 (if available)
Evolutionary constrained regions (ECRs) for PPP1R7: view image

Paralogs for PPP1R7 Gene

Paralogs for PPP1R7 Gene

(2) SIMAP similar genes for PPP1R7 Gene using alignment to 9 proteins:

  • C9J177_HUMAN
  • C9JD73_HUMAN
  • H7C003_HUMAN
  • H7C118_HUMAN
  • H7C3Q5_HUMAN
genes like me logo Genes that share paralogs with PPP1R7: view

Variants for PPP1R7 Gene

Sequence variations from dbSNP and Humsavar for PPP1R7 Gene

SNP ID Clin Chr 02 pos Variation AA Info Type
rs1000007756 -- 241,164,981(+) G/A intron_variant
rs1000010692 -- 241,149,177(+) G/A upstream_transcript_variant
rs1000041848 -- 241,148,985(+) C/A upstream_transcript_variant
rs1000074803 -- 241,177,384(+) T/G genic_downstream_transcript_variant, intron_variant
rs1000195562 -- 241,153,976(+) T/G genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for PPP1R7 Gene

Variant ID Type Subtype PubMed ID
esv2423265 CNV insertion 19546169
esv26576 CNV loss 19812545
esv3397077 CNV duplication 20981092
esv3575345 CNV gain 25503493
nsv3241 CNV insertion 18451855
nsv508900 CNV insertion 20534489
nsv512791 CNV insertion 21212237

Variation tolerance for PPP1R7 Gene

Residual Variation Intolerance Score: 49.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.84; 17.68% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PPP1R7 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PPP1R7 Gene

Disorders for PPP1R7 Gene

Additional Disease Information for PPP1R7

No disorders were found for PPP1R7 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PPP1R7 Gene

Publications for PPP1R7 Gene

  1. Structure and splice products of the human gene encoding sds22, a putative mitotic regulator of protein phosphatase-1. (PMID: 10231361) Ceulemans H … Bollen M (European journal of biochemistry 1999) 2 3 4 22 58
  2. Molecular cloning of a human polypeptide related to yeast sds22, a regulator of protein phosphatase-1. (PMID: 7498485) Renouf S … Bollen M (FEBS letters 1995) 2 3 4 58
  3. A complex of catalytically inactive protein phosphatase-1 sandwiched between Sds22 and inhibitor-3. (PMID: 17630778) Lesage B … Bollen M (Biochemistry 2007) 3 22 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. Binding of the concave surface of the Sds22 superhelix to the alpha 4/alpha 5/alpha 6-triangle of protein phosphatase-1. (PMID: 12226088) Ceulemans H … Bollen M (The Journal of biological chemistry 2002) 3 4 58

Products for PPP1R7 Gene

Sources for PPP1R7 Gene

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