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Aliases for PPP1R3G Gene

Aliases for PPP1R3G Gene

  • Protein Phosphatase 1 Regulatory Subunit 3G 2 3 3 5
  • Protein Phosphatase 1, Regulatory (Inhibitor) Subunit 3G 2 3
  • Putative Protein Phosphatase 1 Regulatory Inhibitor Subunit 3G 3
  • Protein Phosphatase 1, Regulatory Subunit 3G 2

External Ids for PPP1R3G Gene

Previous GeneCards Identifiers for PPP1R3G Gene

  • GC00U991023
  • GC06P005033
  • GC06U901017
  • GC06P004960

Summaries for PPP1R3G Gene

GeneCards Summary for PPP1R3G Gene

PPP1R3G (Protein Phosphatase 1 Regulatory Subunit 3G) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include protein phosphatase binding and glycogen binding. An important paralog of this gene is PPP1R3D.

UniProtKB/Swiss-Prot for PPP1R3G Gene

  • Glycogen-targeting subunit for protein phosphatase 1 (PP1). Involved in the regulation of hepatic glycogenesis in a manner coupled to the fasting-feeding cycle and distinct from other glycogen-targeting subunits (By similarity).

Additional gene information for PPP1R3G Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PPP1R3G Gene

Genomics for PPP1R3G Gene

GeneHancer (GH) Regulatory Elements for PPP1R3G Gene

Promoters and enhancers for PPP1R3G Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH06J005080 Promoter/Enhancer 1.7 Ensembl ENCODE 650.7 -1.4 -1435 6.1 PKNOX1 CLOCK FOXA2 MLX ARNT ZFP64 ARID4B DMAP1 SLC30A9 ATF7 PPP1R3G LYRM4 LOC442155 LYRM4-AS1
GH06J006005 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE 4.9 +922.9 922890 4 ATF1 SIN3A ZNF2 YY1 GLIS2 ZNF213 ZNF143 ATF7 KLF13 SP3 NRN1 LOC442155 PPP1R3G GC06M005970 LOC105374898 GC06P005986
GH06J005124 Enhancer 0.8 ENCODE 7 +41.0 40994 1.7 FOXA2 NFIB ZSCAN9 RARA CREM EGR2 NFYC RAD51 NFIC MXD3 GC06M005124 PPP1R3G PIR53269 LYRM4-AS1 LYRM4
GH06J005456 Enhancer 0.7 Ensembl ENCODE 4.8 +372.6 372622 0.5 SP1 ATF3 RXRA HNF4A LOC101927972 PPP1R3G GC06P005402 FARS2
GH06J005112 Enhancer 0.4 ENCODE 7.7 +28.1 28081 0.2 FOSL1 MEIS2 JUND LYRM4 PPP1R3G PIR53269 GC06P005094 LYRM4-AS1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PPP1R3G on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the PPP1R3G gene promoter:
  • MEF-2A
  • aMEF-2
  • Arnt
  • Nkx2-2
  • C/EBPalpha
  • NF-1
  • Max
  • c-Myc
  • YY1
  • NF-1/L

Genomic Locations for PPP1R3G Gene

Genomic Locations for PPP1R3G Gene
chr6:5,084,581-5,089,487
(GRCh38/hg38)
Size:
4,907 bases
Orientation:
Plus strand
chr6:5,085,720-5,087,455
(GRCh37/hg19)
Size:
1,736 bases
Orientation:
Plus strand

Genomic View for PPP1R3G Gene

Genes around PPP1R3G on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PPP1R3G Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PPP1R3G Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PPP1R3G Gene

Proteins for PPP1R3G Gene

  • Protein details for PPP1R3G Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    B7ZBB8-PP13G_HUMAN
    Recommended name:
    Protein phosphatase 1 regulatory subunit 3G
    Protein Accession:
    B7ZBB8

    Protein attributes for PPP1R3G Gene

    Size:
    358 amino acids
    Molecular mass:
    38019 Da
    Quaternary structure:
    No Data Available

neXtProt entry for PPP1R3G Gene

Post-translational modifications for PPP1R3G Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PPP1R3G Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for PPP1R3G Gene

Domains & Families for PPP1R3G Gene

Gene Families for PPP1R3G Gene

Protein Domains for PPP1R3G Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for PPP1R3G Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with PPP1R3G: view

No data available for UniProtKB/Swiss-Prot for PPP1R3G Gene

Function for PPP1R3G Gene

Molecular function for PPP1R3G Gene

UniProtKB/Swiss-Prot Function:
Glycogen-targeting subunit for protein phosphatase 1 (PP1). Involved in the regulation of hepatic glycogenesis in a manner coupled to the fasting-feeding cycle and distinct from other glycogen-targeting subunits (By similarity).

Gene Ontology (GO) - Molecular Function for PPP1R3G Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0019903 protein phosphatase binding IEA --
GO:2001069 glycogen binding IEA --
genes like me logo Genes that share ontologies with PPP1R3G: view
genes like me logo Genes that share phenotypes with PPP1R3G: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PPP1R3G

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PPP1R3G Gene

Localization for PPP1R3G Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PPP1R3G gene
Compartment Confidence
nucleus 2
cytosol 2
extracellular 1

Gene Ontology (GO) - Cellular Components for PPP1R3G Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with PPP1R3G: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for PPP1R3G Gene

Pathways & Interactions for PPP1R3G Gene

SuperPathways for PPP1R3G Gene

No Data Available

Gene Ontology (GO) - Biological Process for PPP1R3G Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0042593 glucose homeostasis IEA --
GO:0045725 positive regulation of glycogen biosynthetic process IEA --
GO:2000467 positive regulation of glycogen (starch) synthase activity IEA --
genes like me logo Genes that share ontologies with PPP1R3G: view

No data available for Pathways by source and SIGNOR curated interactions for PPP1R3G Gene

Drugs & Compounds for PPP1R3G Gene

No Compound Related Data Available

Transcripts for PPP1R3G Gene

mRNA/cDNA for PPP1R3G Gene

(1) REFSEQ mRNAs :
(0) Additional mRNA sequences :
-
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for PPP1R3G Gene

Protein phosphatase 1, regulatory subunit 3G:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PPP1R3G

Alternative Splicing Database (ASD) splice patterns (SP) for PPP1R3G Gene

No ASD Table

Relevant External Links for PPP1R3G Gene

GeneLoc Exon Structure for
PPP1R3G
ECgene alternative splicing isoforms for
PPP1R3G

Expression for PPP1R3G Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PPP1R3G Gene

mRNA differential expression in normal tissues according to GTEx for PPP1R3G Gene

This gene is overexpressed in Liver (x4.5).

Protein differential expression in normal tissues from HIPED for PPP1R3G Gene

This gene is overexpressed in Adipocyte (37.9), Platelet (15.1), and Heart (8.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for PPP1R3G Gene



Protein tissue co-expression partners for PPP1R3G Gene

NURSA nuclear receptor signaling pathways regulating expression of PPP1R3G Gene:

PPP1R3G

SOURCE GeneReport for Unigene cluster for PPP1R3G Gene:

Hs.653089

Evidence on tissue expression from TISSUES for PPP1R3G Gene

  • Liver(4.2)
genes like me logo Genes that share expression patterns with PPP1R3G: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PPP1R3G Gene

Orthologs for PPP1R3G Gene

This gene was present in the common ancestor of animals.

Orthologs for PPP1R3G Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PPP1R3G 34 33
  • 98.98 (n)
OneToOne
cow
(Bos Taurus)
Mammalia PPP1R3G 34 33
  • 79.4 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ppp1r3g 33
  • 75.05 (n)
mouse
(Mus musculus)
Mammalia Ppp1r3g 16 34 33
  • 74.37 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 31 (a)
ManyToMany
chicken
(Gallus gallus)
Aves PPP1R3G 33
  • 70.26 (n)
-- 34
  • 23 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 31 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii LOC100330524 33
  • 53.82 (n)
CT573202.1 34
  • 27 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta Gbs-76A 34
  • 12 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea CC8.2 34
  • 19 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.50 34
  • 14 (a)
OneToMany
Species where no ortholog for PPP1R3G was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for PPP1R3G Gene

ENSEMBL:
Gene Tree for PPP1R3G (if available)
TreeFam:
Gene Tree for PPP1R3G (if available)
Aminode:
Evolutionary constrained regions (ECRs) for PPP1R3G: view image

Paralogs for PPP1R3G Gene

Paralogs for PPP1R3G Gene

genes like me logo Genes that share paralogs with PPP1R3G: view

Variants for PPP1R3G Gene

Sequence variations from dbSNP and Humsavar for PPP1R3G Gene

SNP ID Clin Chr 06 pos Variation AA Info Type
rs1000113569 -- 5,086,536(+) T/C coding_sequence_variant, missense_variant
rs1000229711 -- 5,084,895(+) C/T upstream_transcript_variant
rs1000296485 -- 5,085,112(+) G/A upstream_transcript_variant
rs1001381654 -- 5,085,791(+) G/A coding_sequence_variant, synonymous_variant
rs1001592064 -- 5,086,169(+) C/T coding_sequence_variant, synonymous_variant

Structural Variations from Database of Genomic Variants (DGV) for PPP1R3G Gene

Variant ID Type Subtype PubMed ID
nsv1017380 CNV gain 25217958
nsv462622 CNV gain 19166990
nsv600871 CNV gain 21841781
nsv600872 CNV gain 21841781

Variation tolerance for PPP1R3G Gene

Gene Damage Index Score: 2.39; 42.35% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PPP1R3G Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PPP1R3G

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PPP1R3G Gene

Disorders for PPP1R3G Gene

Additional Disease Information for PPP1R3G

No disorders were found for PPP1R3G Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PPP1R3G Gene

Publications for PPP1R3G Gene

  1. Regulator-driven functional diversification of protein phosphatase-1 in eukaryotic evolution. (PMID: 11948623) Ceulemans H … Bollen M (BioEssays : news and reviews in molecular, cellular and developmental biology 2002) 2 3 4 58
  2. An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. (PMID: 24275569) Bian Y … Zou H (Journal of proteomics 2014) 4 58
  3. Protein phosphatase 1α interacting proteins in the human brain. (PMID: 22321011) Esteves SL … da Cruz e Silva EF (Omics : a journal of integrative biology 2012) 3 58
  4. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall AJ … Beck S (Nature 2003) 4 58

Products for PPP1R3G Gene

  • Biorbyt antibodies for PPP1R3G

Sources for PPP1R3G Gene

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