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Aliases for PPP1R3F Gene

Aliases for PPP1R3F Gene

  • Protein Phosphatase 1 Regulatory Subunit 3F 2 3 5
  • Protein Phosphatase 1, Regulatory (Inhibitor) Subunit 3F 2 3
  • R3F 3 4
  • Protein Phosphatase 1, Regulatory Subunit 3F 2
  • LL0XNC01-7P3.1 3
  • HB2E 3

External Ids for PPP1R3F Gene

Previous GeneCards Identifiers for PPP1R3F Gene

  • GC0XP047907
  • GC0XP047365
  • GC0XP048152
  • GC0XP048882
  • GC0XP049013
  • GC0XP049126
  • GC0XP046782

Summaries for PPP1R3F Gene

Entrez Gene Summary for PPP1R3F Gene

  • This gene encodes a protein that has been identified as one of several type-1 protein phosphatase (PP1) regulatory subunits. One or two of these subunits, together with the well-conserved catalytic subunit, can form the PP1 holoenzyme, where the regulatory subunit functions to regulate substrate specificity and/or targeting to a particular cellular compartment. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2010]

GeneCards Summary for PPP1R3F Gene

PPP1R3F (Protein Phosphatase 1 Regulatory Subunit 3F) is a Protein Coding gene. Among its related pathways are Beta-Adrenergic Signaling and Activation of cAMP-Dependent PKA. Gene Ontology (GO) annotations related to this gene include protein phosphatase binding and glycogen binding.

UniProtKB/Swiss-Prot for PPP1R3F Gene

  • Glycogen-targeting subunit for protein phosphatase 1 (PP1).

Additional gene information for PPP1R3F Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PPP1R3F Gene

Genomics for PPP1R3F Gene

GeneHancer (GH) Regulatory Elements for PPP1R3F Gene

Promoters and enhancers for PPP1R3F Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH0XI049266 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 550.8 -1.0 -1020 4.7 HDGF PKNOX1 SIN3A ZNF2 YY1 POLR2B E2F8 ZNF143 FOS KLF13 PPP1R3F FOXP3 ENSG00000204620 FTSJ1 PRICKLE3 ENSG00000270012 RBM3 PLP2 CACNA1F USP27X-AS1
GH0XI049292 Enhancer 0.6 ENCODE 13 +22.3 22259 0.2 ZNF282 CTCF ZNF654 ZNF189 NCOA1 REST RAD21 CC2D1A CTBP1 SKIL GAGE13 FOXP3 PPP1R3F PIR47304 ENSG00000270012
GH0XI048916 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 1.6 -350.1 -350064 5.6 HNRNPUL1 PKNOX1 FOXA2 SMAD1 ARID4B SIN3A ZNF2 ZBTB7B POLR2B ZNF213 PIM2 ENSG00000204620 FTSJ1 ENSG00000270012 RBM3 PQBP1 CCDC22 ZNF182 PLP2 OTUD5
GH0XI049840 Enhancer 0.9 ENCODE 4.3 +572.4 572429 3.8 HDAC1 ELF3 PKNOX1 FOXA2 ARID4B BMI1 RAD21 ZBTB40 RFX5 RARA CLCN5 PPP1R3F PAGE4 USP27X-AS1
GH0XI048933 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 2.1 -331.3 -331329 9.7 HDGF FOXA2 SMAD1 ARNT ZFP64 ARID4B SIN3A DMAP1 YBX1 IRF4 ENSG00000279155 PQBP1 WAS OTUD5 SLC35A2 TIMM17B PIM2 TBC1D25 ENSG00000204620 ENSG00000228343
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around PPP1R3F on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the PPP1R3F gene promoter:

Genomic Locations for PPP1R3F Gene

Genomic Locations for PPP1R3F Gene
31,633 bases
Plus strand

Genomic View for PPP1R3F Gene

Genes around PPP1R3F on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PPP1R3F Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PPP1R3F Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PPP1R3F Gene

Proteins for PPP1R3F Gene

  • Protein details for PPP1R3F Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein phosphatase 1 regulatory subunit 3F
    Protein Accession:
    Secondary Accessions:
    • A2VDJ8
    • B3KPW2
    • E9PCM3

    Protein attributes for PPP1R3F Gene

    799 amino acids
    Molecular mass:
    82798 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAI31589.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAG51824.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for PPP1R3F Gene


neXtProt entry for PPP1R3F Gene

Post-translational modifications for PPP1R3F Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for PPP1R3F Gene

Domains & Families for PPP1R3F Gene

Gene Families for PPP1R3F Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for PPP1R3F Gene

Suggested Antigen Peptide Sequences for PPP1R3F Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with PPP1R3F: view

No data available for UniProtKB/Swiss-Prot for PPP1R3F Gene

Function for PPP1R3F Gene

Molecular function for PPP1R3F Gene

UniProtKB/Swiss-Prot Function:
Glycogen-targeting subunit for protein phosphatase 1 (PP1).

Gene Ontology (GO) - Molecular Function for PPP1R3F Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0019903 protein phosphatase binding IPI 21668450
GO:2001069 glycogen binding IDA 21668450
genes like me logo Genes that share ontologies with PPP1R3F: view
genes like me logo Genes that share phenotypes with PPP1R3F: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PPP1R3F Gene

Localization for PPP1R3F Gene

Subcellular locations from UniProtKB/Swiss-Prot for PPP1R3F Gene

Membrane; Single-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PPP1R3F gene
Compartment Confidence
nucleus 3
cytosol 2
plasma membrane 1
mitochondrion 1
peroxisome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for PPP1R3F Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IDA 21668450
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with PPP1R3F: view

Pathways & Interactions for PPP1R3F Gene

genes like me logo Genes that share pathways with PPP1R3F: view

Pathways by source for PPP1R3F Gene

Gene Ontology (GO) - Biological Process for PPP1R3F Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005979 regulation of glycogen biosynthetic process IDA 21668450
GO:2000465 regulation of glycogen (starch) synthase activity IDA 21668450
genes like me logo Genes that share ontologies with PPP1R3F: view

No data available for SIGNOR curated interactions for PPP1R3F Gene

Drugs & Compounds for PPP1R3F Gene

No Compound Related Data Available

Transcripts for PPP1R3F Gene

Unigene Clusters for PPP1R3F Gene

Protein phosphatase 1, regulatory subunit 3F:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for PPP1R3F Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b · 5c
SP1: - -
SP2: -
SP4: -

Relevant External Links for PPP1R3F Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PPP1R3F Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PPP1R3F Gene

Protein differential expression in normal tissues from HIPED for PPP1R3F Gene

This gene is overexpressed in Frontal cortex (39.1), Retina (23.5), and Fetal Brain (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for PPP1R3F Gene

Protein tissue co-expression partners for PPP1R3F Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of PPP1R3F Gene:


SOURCE GeneReport for Unigene cluster for PPP1R3F Gene:


mRNA Expression by UniProt/SwissProt for PPP1R3F Gene:

Tissue specificity: Expressed in brain, skeletal muscle and heart.

Evidence on tissue expression from TISSUES for PPP1R3F Gene

  • Nervous system(4.4)
  • Eye(2.7)
genes like me logo Genes that share expression patterns with PPP1R3F: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for PPP1R3F Gene

Orthologs for PPP1R3F Gene

This gene was present in the common ancestor of chordates.

Orthologs for PPP1R3F Gene

Organism Taxonomy Gene Similarity Type Details
(Canis familiaris)
Mammalia PPP1R3F 33 34
  • 90.72 (n)
(Bos Taurus)
Mammalia PPP1R3F 33 34
  • 88.23 (n)
(Mus musculus)
Mammalia Ppp1r3f 33 16 34
  • 84.67 (n)
(Monodelphis domestica)
Mammalia PPP1R3F 34
  • 42 (a)
(Ornithorhynchus anatinus)
Mammalia PPP1R3F 34
  • 35 (a)
(Anolis carolinensis)
Reptilia PPP1R3F 34
  • 25 (a)
Species where no ortholog for PPP1R3F was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for PPP1R3F Gene

Gene Tree for PPP1R3F (if available)
Gene Tree for PPP1R3F (if available)

Paralogs for PPP1R3F Gene

No data available for Paralogs for PPP1R3F Gene

Variants for PPP1R3F Gene

Sequence variations from dbSNP and Humsavar for PPP1R3F Gene

SNP ID Clin Chr 0X pos Variation AA Info Type
rs1000512240 -- 49,279,876(+) C/A intron_variant
rs1000584959 -- 49,288,739(+) G/A/T genic_downstream_transcript_variant, intron_variant
rs1000851017 -- 49,296,169(+) T/G genic_downstream_transcript_variant, intron_variant
rs1001002971 -- 49,272,154(+) T/C 5_prime_UTR_variant, intron_variant
rs1001069848 -- 49,271,850(+) G/A genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for PPP1R3F Gene

Variant ID Type Subtype PubMed ID
esv32909 CNV gain+loss 17666407
nsv469734 CNV gain+loss 16826518
nsv471602 CNV gain 15918152
nsv528292 CNV gain 19592680

Variation tolerance for PPP1R3F Gene

Residual Variation Intolerance Score: 82.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.85; 58.83% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PPP1R3F Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PPP1R3F Gene

Disorders for PPP1R3F Gene

Additional Disease Information for PPP1R3F

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for PPP1R3F Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PPP1R3F Gene

Publications for PPP1R3F Gene

  1. R3F, a novel membrane-associated glycogen targeting subunit of protein phosphatase 1 regulates glycogen synthase in astrocytoma cells in response to glucose and extracellular signals. (PMID: 21668450) Kelsall IR … Cohen PT (Journal of neurochemistry 2011) 3 4 58
  2. Genetic variants harbored in the forkhead box protein 3 locus increase hay fever risk. (PMID: 20398921) Suttner K … Kabesch M (The Journal of allergy and clinical immunology 2010) 3 44 58
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  4. Regulator-driven functional diversification of protein phosphatase-1 in eukaryotic evolution. (PMID: 11948623) Ceulemans H … Bollen M (BioEssays : news and reviews in molecular, cellular and developmental biology 2002) 2 3 58
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58

Products for PPP1R3F Gene

Sources for PPP1R3F Gene

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