Aliases for PPP1R3C Gene
Aliases for PPP1R3C Gene
- Protein Phosphatase 1 Regulatory Subunit 3C 2 3 5
- Protein Targeting To Glycogen 2 3 4
- Protein Phosphatase 1, Regulatory (Inhibitor) Subunit 3C 2 3
- Phosphatase 1, Regulatory Inhibitor Subunit 5 2 3
- Protein Phosphatase 1 Regulatory Subunit 5 3 4
- PP1 Subunit R5 3 4
- PPP1R5 3 4
- PTG 3 4
- Protein Phosphatase 1, Regulatory Subunit 3C 2
External Ids for PPP1R3C Gene
- HGNC: 9293
- Entrez Gene: 5507
- Ensembl: ENSG00000119938
- OMIM: 602999
- UniProtKB: Q9UQK1
Previous HGNC Symbols for PPP1R3C Gene
- PPP1R5
Previous GeneCards Identifiers for PPP1R3C Gene
- GC10M092269
- GC10M092609
- GC10M093519
- GC10M093052
- GC10M093036
- GC10M093378
- GC10M087016
Summaries for PPP1R3C Gene
-
This gene encodes a carbohydrate binding protein that is a subunit of the protein phosphatase 1 (PP1) complex. PP1 catalyzes reversible protein phosphorylation, which is important in a wide range of cellular activities. The encoded protein affects glycogen biosynthesis by activating glycogen synthase and limiting glycogen breakdown by reducing glycogen phosphorylase activity. DNA hypermethylation of this gene has been found in colorectal cancer patients. The encoded protein also interacts with the laforin protein, which is a protein tyrosine phosphatase implicated in Lafora disease. [provided by RefSeq, Sep 2016]
GeneCards Summary for PPP1R3C Gene
PPP1R3C (Protein Phosphatase 1 Regulatory Subunit 3C) is a Protein Coding gene. Diseases associated with PPP1R3C include Barre-Lieou Syndrome and Water-Clear Cell Adenoma. Among its related pathways are Glycogen storage diseases and Beta-Adrenergic Signaling. Gene Ontology (GO) annotations related to this gene include protein phosphatase binding and protein phosphatase regulator activity. An important paralog of this gene is PPP1R3B.
UniProtKB/Swiss-Prot for PPP1R3C Gene
-
Acts as a glycogen-targeting subunit for PP1 and regulates its activity. Activates glycogen synthase, reduces glycogen phosphorylase activity and limits glycogen breakdown. Dramatically increases basal and insulin-stimulated glycogen synthesis upon overexpression in a variety of cell types.
Additional gene information for PPP1R3C Gene
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PPP1R3C Gene
Genomics for PPP1R3C Gene
GeneHancer (GH) Regulatory Elements for PPP1R3C Gene
Promoters and enhancers for PPP1R3C Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around PPP1R3C on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Locations for PPP1R3C Gene
Genomic Locations for PPP1R3C Gene
- chr10:91,628,440-91,633,101
- (GRCh38/hg38)
- Size:
- 4,662 bases
- Orientation:
- Minus strand
- chr10:93,388,199-93,392,858
- (GRCh37/hg19)
Genomic View for PPP1R3C Gene
Genes around PPP1R3C on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 10q23.32 by Ensembl
- 10q23.32 by Entrez Gene
- 10q23.32 by HGNC
PPP1R3C Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for PPP1R3C Gene
Proteins for PPP1R3C Gene
-
Protein details for PPP1R3C Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9UQK1-PPR3C_HUMAN
- Recommended name:
- Protein phosphatase 1 regulatory subunit 3C
- Protein Accession:
- Q9UQK1
- B2R7X0
- O95686
Protein attributes for PPP1R3C Gene
- Size:
- 317 amino acids
- Molecular mass:
- 36445 Da
- Quaternary structure:
-
- Interacts with PPP1CC catalytic subunit of PP1 and associates with glycogen. Forms complexes with glycogen phosphorylase, glycogen synthase and phosphorylase kinase which is necessary for its regulation of PP1 activity. Also interacts with EPM2A/laforin.
- SequenceCaution:
-
- Sequence=AAD33215.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
Post-translational modifications for PPP1R3C Gene
- Ubiquitinated by NHLRC1/malin in a EPM2A/laforin-dependent manner.
Other Protein References for PPP1R3C Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
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-
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-
Abcam proteins for PPP1R3C
Assay Products
No data available for DME Specific Peptides for PPP1R3C Gene
Domains & Families for PPP1R3C Gene
Gene Families for PPP1R3C Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Protein Domains for PPP1R3C Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for PPP1R3C Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q9UQK1UniProtKB/Swiss-Prot:
PPR3C_HUMAN :- The N-terminal region is required for binding to PP1, the central region is required for binding to glycogen and the C-terminal region is required for binding to glycogen phosphorylase, glycogen synthase and phosphorylase kinase.
- Domain:
-
- The N-terminal region is required for binding to PP1, the central region is required for binding to glycogen and the C-terminal region is required for binding to glycogen phosphorylase, glycogen synthase and phosphorylase kinase.
Function for PPP1R3C Gene
Molecular function for PPP1R3C Gene
- UniProtKB/Swiss-Prot Function:
- Acts as a glycogen-targeting subunit for PP1 and regulates its activity. Activates glycogen synthase, reduces glycogen phosphorylase activity and limits glycogen breakdown. Dramatically increases basal and insulin-stimulated glycogen synthesis upon overexpression in a variety of cell types.
Phenotypes From GWAS Catalog for PPP1R3C Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004722 | protein serine/threonine phosphatase activity | TAS | 8985175 |
| GO:0005515 | protein binding | IPI | 14532330 |
| GO:0019888 | protein phosphatase regulator activity | IEA | -- |
| GO:0019903 | protein phosphatase binding | IEA,ISS | -- |
Phenotypes for PPP1R3C Gene
- MGI mutant phenotypes for PPP1R3C:
- inferred from 2 alleles
- GenomeRNAi human phenotypes for PPP1R3C:
-
- Increased vaccinia virus (VACV) infection
- Decreased viability
- Decreased NF-kappaB reporter expression
- Resistant to vaccinia virus (VACV-A4L) infection
- Decreased IL-8 secretion
- Decreased focal adhesion (FA) area, decreased FA length, decreased FA mean intensity, increased number of small and round FAs, increased FA abundance
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-
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miRNA for PPP1R3C Gene
- miRTarBase miRNAs that target PPP1R3C
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- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
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- Bacterial expression: pET, pBAD, and pCS
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No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PPP1R3C Gene
Localization for PPP1R3C Gene
| Compartment | Confidence |
|---|---|
| cytosol | 5 |
| extracellular | 3 |
| cytoskeleton | 1 |
| mitochondrion | 1 |
| nucleus | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005829 | cytosol | TAS | -- |
No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for PPP1R3C Gene
Pathways & Interactions for PPP1R3C Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Activation of cAMP-Dependent PKA |
.77
|
.56
|
| 2 | Beta-Adrenergic Signaling |
.36
|
|
| 3 | Glycogen storage diseases | ||
| 4 | Glucose metabolism | ||
| 5 | Insulin resistance | ||
Pathways by source for PPP1R3C Gene
1 BioSystems pathway for PPP1R3C Gene
9 Reactome pathways for PPP1R3C Gene
2 KEGG pathways for PPP1R3C Gene
1 Tocris pathway for PPP1R3C Gene
14 Qiagen pathways for PPP1R3C Gene
Interacting Proteins for PPP1R3C Gene
Selected Interacting proteins:
Q9UQK1-PPR3C_HUMAN
ENSP00000238994
for PPP1R3C Gene via
MINT
STRING
UniProtKB
IID
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005975 | carbohydrate metabolic process | IEA | -- |
| GO:0005977 | glycogen metabolic process | ISS | -- |
| GO:0005978 | glycogen biosynthetic process | TAS,IEA | -- |
| GO:0006470 | protein dephosphorylation | IEA | -- |
| GO:0043666 | regulation of phosphoprotein phosphatase activity | IEA | -- |
No data available for SIGNOR curated interactions for PPP1R3C Gene
Transcripts for PPP1R3C Gene
mRNA/cDNA for PPP1R3C Gene
- (1) REFSEQ mRNAs :
- (6) Additional mRNA sequences :
- (173) Selected AceView cDNA sequences:
- (1) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for PPP1R3C Gene
CRISPR Products
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OriGene CRISPR knockouts for PPP1R3C
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-
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Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for PPP1R3C
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-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for PPP1R3C
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Expression for PPP1R3C Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Adipose (Muscoskeletal System)
-
Hair (Integumentary System)
- Outer Root Sheath Cells Outer Root Sheath
- Bulge Stem Cells Bulge
-
Dermis (Integumentary System)
- Dermal Fibroblasts Dorsal Dermis
- Detroit 551
-
Fibroblasts
- Dermal Fibroblasts Dorsal Dermis
- Detroit 551
-
Epithelial Cells
- Outer Root Sheath Cells Outer Root Sheath
-
Brain (Nervous System)
- Protoplasmic Astrocyte Cells Neocortex
-
Glial Cells
- Protoplasmic Astrocyte Cells Neocortex
- Intermediate Mesoderm (Gastrulation Derivatives)
- Kidney (Urinary System)
- Bone (Muscoskeletal System)
- Cartilage (Muscoskeletal System)
-
Skeletal Muscle (Muscoskeletal System)
-
Testis (Reproductive System)
-
Esophagus (Gastrointestinal Tract)
-
Heart (Cardiovascular System)
mRNA differential expression in normal tissues according to GTEx for PPP1R3C Gene
This gene is overexpressed in Muscle - Skeletal (x6.0), Artery - Tibial (x4.7), and Heart - Atrial Appendage (x4.2).
NURSA nuclear receptor signaling pathways regulating expression of PPP1R3C Gene:
PPP1R3CSOURCE GeneReport for Unigene cluster for PPP1R3C Gene:
Hs.303090Evidence on tissue expression from TISSUES for PPP1R3C Gene
- Nervous system(4.8)
- Eye(4.1)
- Muscle(3.5)
- Heart(2.9)
- Liver(2.7)
- Thyroid gland(2.5)
Primer Products
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OriGene qPCR primer pairs for PPP1R3C
-
OriGene qPCR primer pairs and template standards for PPP1R3C
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No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PPP1R3C Gene
Orthologs for PPP1R3C Gene
This gene was present in the common ancestor of animals and fungi.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | PPP1R3C 33 34 |
|
||
| dog (Canis familiaris) |
Mammalia | PPP1R3C 33 34 |
|
||
| mouse (Mus musculus) |
Mammalia | Ppp1r3c 33 16 34 |
|
||
| cow (Bos Taurus) |
Mammalia | PPP1R3C 33 34 |
|
||
| rat (Rattus norvegicus) |
Mammalia | LOC100910671 33 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | PPP1R3C 34 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | PPP1R3C 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | PPP1R3C 33 34 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | PPP1R3C 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | ppp1r3c.1 33 |
|
||
| Str.11402 33 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.14255 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | ppp1r3cb 33 34 |
|
||
| ppp1r3ca 34 |
|
OneToMany | |||
| zgc73259 33 |
|
||||
| fruit fly (Drosophila melanogaster) |
Insecta | CG9238 35 34 |
|
||
| worm (Caenorhabditis elegans) |
Secernentea | H18N23.2 34 |
|
OneToMany | |
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | GIP2 36 |
|
|
|
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 34 |
|
OneToMany |
- Species where no ortholog for PPP1R3C was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for PPP1R3C Gene
Variants for PPP1R3C Gene
| SNP ID | Clin | Chr 10 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs193920921 | uncertain-significance, Malignant tumor of prostate | 91,630,423(-) | T/C | coding_sequence_variant, missense_variant | |
| rs1000013909 | -- | 91,633,256(-) | G/T | upstream_transcript_variant | |
| rs1000087325 | -- | 91,633,492(-) | C/G | upstream_transcript_variant | |
| rs1001480145 | -- | 91,628,175(-) | G/A | downstream_transcript_variant | |
| rs1002220190 | -- | 91,634,127(-) | C/T | upstream_transcript_variant |
Residual Variation Intolerance Score:
43.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
2.09;
38.16% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for PPP1R3C Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for PPP1R3C Gene
Disorders for PPP1R3C Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| barre-lieou syndrome |
|
|
| water-clear cell adenoma |
|
|
| myoclonic epilepsy of lafora |
|
|
| androgenic alopecia |
|
|
Search PPP1R3C in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for PPP1R3C
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for PPP1R3C Gene
Publications for PPP1R3C Gene
- Amino acid sequence of a novel protein phosphatase 1 binding protein (R5) which is related to the liver- and muscle-specific glycogen binding subunits of protein phosphatase 1. (PMID: 8985175) Doherty MJ … Cohen PT (FEBS letters 1996) 2 3 4 58
- A PTG variant contributes to a milder phenotype in Lafora disease. (PMID: 21738631) Guerrero R … Gómez-Garre P (PloS one 2011) 3 4 58
- Malin decreases glycogen accumulation by promoting the degradation of protein targeting to glycogen (PTG). (PMID: 18070875) Worby CA … Dixon JE (The Journal of biological chemistry 2008) 3 4 58
- A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PMID: 16385451) Grupe A … Goate A (American journal of human genetics 2006) 3 44 58
- Laforin, the dual-phosphatase responsible for Lafora disease, interacts with R5 (PTG), a regulatory subunit of protein phosphatase-1 that enhances glycogen accumulation. (PMID: 14532330) Fernández-Sánchez ME … Rodríguez de Córdoba S (Human molecular genetics 2003) 3 4 58
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- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for 25 available PPP1R3C Antibodies ranked by validation data
- Compare Top PPP1R3C Antibodies
- antibodies-online: Search results for available PPP1R3C related products ranked by validation data
- antibodies-online: Search results for 6 available PPP1R3C Proteins ranked by validation data
- Compare Top PPP1R3C Proteins
- Search GeneTex for Antibodies for PPP1R3C
- Search GeneTex for Proteins for PPP1R3C
- ViGene Biosciences adenoviral particle packaged cDNA for PPP1R3C gene
- ViGene Biosciences lentiviral particle packaged cDNA for PPP1R3C gene
- ViGene Biosciences ready-to-package AAV shRNAs for PPP1R3C gene
- Search ViGene Biosciences for PPP1R3C
- Browse Santa Cruz Biotechnology (SCBT) Antibodies
- Search Santa Cruz Biotechnology (SCBT) for PPP1R3C siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for PPP1R3C
- Horizon Cell Lines for PPP1R3C
- genomics-online: cdna clones - Search results for 122 available PPP1R3C gene related products
- Overview of 122 available PPP1R3C gene related products
- orf clones - Search results for 122 available PPP1R3C gene related products
- Overview of 122 available PPP1R3C gene related products
- genomics-online: gRNA clones - Search results for 122 available PPP1R3C gene related products
- Overview of 122 available PPP1R3C gene related products
- genomics-online: primer clones - Search results for 122 available PPP1R3C gene related products
- Overview of 122 available PPP1R3C gene related products
- genomics-online: shRNA clones - Search results for 122 available PPP1R3C gene related products
- Overview of 122 available PPP1R3C gene related products
Sources for PPP1R3C Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew