Aliases for PPP1R3C Gene
External Ids for PPP1R3C Gene
Previous HGNC Symbols for PPP1R3C Gene
Previous GeneCards Identifiers for PPP1R3C Gene
This gene encodes a carbohydrate binding protein that is a subunit of the protein phosphatase 1 (PP1) complex. PP1 catalyzes reversible protein phosphorylation, which is important in a wide range of cellular activities. The encoded protein affects glycogen biosynthesis by activating glycogen synthase and limiting glycogen breakdown by reducing glycogen phosphorylase activity. DNA hypermethylation of this gene has been found in colorectal cancer patients. The encoded protein also interacts with the laforin protein, which is a protein tyrosine phosphatase implicated in Lafora disease. [provided by RefSeq, Sep 2016]
GeneCards Summary for PPP1R3C Gene
PPP1R3C (Protein Phosphatase 1 Regulatory Subunit 3C) is a Protein Coding gene. Diseases associated with PPP1R3C include Myoclonic Epilepsy Of Lafora and Bjornstad Syndrome. Among its related pathways are Activation of cAMP-Dependent PKA and Beta-Adrenergic Signaling. Gene Ontology (GO) annotations related to this gene include protein phosphatase binding and protein phosphatase regulator activity. An important paralog of this gene is PPP1R3B.
UniProtKB/Swiss-Prot Summary for PPP1R3C Gene
Acts as a glycogen-targeting subunit for PP1 and regulates its activity. Activates glycogen synthase, reduces glycogen phosphorylase activity and limits glycogen breakdown. Dramatically increases basal and insulin-stimulated glycogen synthesis upon overexpression in a variety of cell types.