Aliases for PPP1R37 Gene

Aliases for PPP1R37 Gene

  • Protein Phosphatase 1 Regulatory Subunit 37 2 3 4 5
  • Leucine-Rich Repeat-Containing Protein 68 3 4
  • Leucine Rich Repeat Containing 68 2 3
  • LRRC68 3 4
  • Protein Phosphatase 1, Regulatory Subunit 37 2
  • KIAA1986 4

External Ids for PPP1R37 Gene

Previous HGNC Symbols for PPP1R37 Gene

  • LRRC68

Previous GeneCards Identifiers for PPP1R37 Gene

  • GC19P045597

Summaries for PPP1R37 Gene

GeneCards Summary for PPP1R37 Gene

PPP1R37 (Protein Phosphatase 1 Regulatory Subunit 37) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include phosphatase binding and protein phosphatase inhibitor activity. An important paralog of this gene is CARMIL3.

UniProtKB/Swiss-Prot Summary for PPP1R37 Gene

  • Inhibits phosphatase activity of protein phosphatase 1 (PP1) complexes.

Additional gene information for PPP1R37 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PPP1R37 Gene

Genomics for PPP1R37 Gene

GeneHancer (GH) Regulatory Elements for PPP1R37 Gene

Promoters and enhancers for PPP1R37 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J045089 Promoter/Enhancer 2.1 Ensembl ENCODE CraniofacialAtlas dbSUPER 771.8 +1.4 1381 6 ZNF785 SIN3A ZNF24 SP1 ZBTB40 CTCF ZBTB6 RBPJ POLR2A USF2 PPP1R37 GEMIN7-AS1 lnc-GEMIN7-1 ZNF225 ZNF227 ZNF226 ZNF235 ZNF180 ENSG00000186019 GEMIN7
GH19J045143 Promoter 0.5 EPDnew 750.2 +52.2 52249 0.1 CTCF ZNF362 PPP1R37 RF00017-2999 ENSG00000267044 MARK4
GH19J045146 Promoter 0.5 EPDnew 750.2 +55.3 55253 0.1 ZNF692 ZFP69B RF00017-2999 PPP1R37 ENSG00000267044 MARK4
GH19J045144 Promoter 0.3 EPDnew 750.2 +53.5 53513 0.1 PPP1R37 RF00017-2999 ENSG00000267044 MARK4
GH19J045477 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 23.3 +386.7 386704 3 GTF3C2 SIN3A ZNF24 ZBTB40 CTCF ZBTB6 MLX POLR2A ATF1 ZNF217 ERCC1 lnc-ERCC1-1 TRU-TCA1-1 piR-35407 ZNF180 CCDC61 CLASRP ENSG00000269148 FBXO46 ENSG00000268810
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PPP1R37 on UCSC Golden Path with GeneCards custom track

Genomic Locations for PPP1R37 Gene

Genomic Locations for PPP1R37 Gene
chr19:45,091,396-45,148,077
(GRCh38/hg38)
Size:
56,682 bases
Orientation:
Plus strand
chr19:45,594,654-45,651,335
(GRCh37/hg19)
Size:
56,682 bases
Orientation:
Plus strand

Genomic View for PPP1R37 Gene

Genes around PPP1R37 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PPP1R37 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PPP1R37 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PPP1R37 Gene

Proteins for PPP1R37 Gene

  • Protein details for PPP1R37 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75864-PPR37_HUMAN
    Recommended name:
    Protein phosphatase 1 regulatory subunit 37
    Protein Accession:
    O75864
    Secondary Accessions:
    • B5MDA4
    • Q8IWK3
    • Q8TF16

    Protein attributes for PPP1R37 Gene

    Size:
    691 amino acids
    Molecular mass:
    74767 Da
    Quaternary structure:
    • Interacts with PPP1CA.
    SequenceCaution:
    • Sequence=AAC62258.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=BAB85572.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for PPP1R37 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PPP1R37 Gene

Post-translational modifications for PPP1R37 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PPP1R37 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for PPP1R37 Gene

Domains & Families for PPP1R37 Gene

Gene Families for PPP1R37 Gene

Protein Domains for PPP1R37 Gene

Suggested Antigen Peptide Sequences for PPP1R37 Gene

GenScript: Design optimal peptide antigens:
  • Leucine-rich repeat-containing protein 68 (LRC68_HUMAN)

Graphical View of Domain Structure for InterPro Entry

O75864

UniProtKB/Swiss-Prot:

PPR37_HUMAN :
  • Belongs to the PPP1R37 family.
Family:
  • Belongs to the PPP1R37 family.
genes like me logo Genes that share domains with PPP1R37: view

Function for PPP1R37 Gene

Molecular function for PPP1R37 Gene

UniProtKB/Swiss-Prot Function:
Inhibits phosphatase activity of protein phosphatase 1 (PP1) complexes.

Phenotypes From GWAS Catalog for PPP1R37 Gene

Gene Ontology (GO) - Molecular Function for PPP1R37 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004864 protein phosphatase inhibitor activity IEA --
GO:0005515 protein binding IPI 15231748
genes like me logo Genes that share ontologies with PPP1R37: view

Phenotypes for PPP1R37 Gene

genes like me logo Genes that share phenotypes with PPP1R37: view

Animal Model Products

CRISPR Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PPP1R37 Gene

Localization for PPP1R37 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PPP1R37 gene
Compartment Confidence
cytosol 3
nucleus 2

Subcellular locations from the

Human Protein Atlas (HPA)

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for PPP1R37 Gene

Pathways & Interactions for PPP1R37 Gene

PathCards logo

SuperPathways for PPP1R37 Gene

No Data Available

Gene Ontology (GO) - Biological Process for PPP1R37 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010923 negative regulation of phosphatase activity IDA 19389623
GO:0032515 negative regulation of phosphoprotein phosphatase activity IEA --
genes like me logo Genes that share ontologies with PPP1R37: view

No data available for Pathways by source and SIGNOR curated interactions for PPP1R37 Gene

Drugs & Compounds for PPP1R37 Gene

No Compound Related Data Available

Transcripts for PPP1R37 Gene

mRNA/cDNA for PPP1R37 Gene

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for PPP1R37 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12
SP1: -
SP2:
SP3: - - -
SP4:
SP5:

Relevant External Links for PPP1R37 Gene

GeneLoc Exon Structure for
PPP1R37
ECgene alternative splicing isoforms for
PPP1R37

Expression for PPP1R37 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PPP1R37 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for PPP1R37 Gene

This gene is overexpressed in Fetal Brain (23.2), Platelet (15.0), Retina (11.6), and Peripheral blood mononuclear cells (7.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for PPP1R37 Gene



Protein tissue co-expression partners for PPP1R37 Gene

NURSA nuclear receptor signaling pathways regulating expression of PPP1R37 Gene:

PPP1R37

SOURCE GeneReport for Unigene cluster for PPP1R37 Gene:

Hs.285363

Evidence on tissue expression from TISSUES for PPP1R37 Gene

  • Intestine(4.2)
  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with PPP1R37: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PPP1R37 Gene

Orthologs for PPP1R37 Gene

This gene was present in the common ancestor of animals.

Orthologs for PPP1R37 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LRRC68 32
  • 99.09 (n)
PPP1R37 33
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PPP1R37 33 32
  • 89.77 (n)
OneToOne
dog
(Canis familiaris)
Mammalia PPP1R37 33 32
  • 87.65 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ppp1r37 32
  • 83.7 (n)
mouse
(Mus musculus)
Mammalia Ppp1r37 17 33 32
  • 83.65 (n)
oppossum
(Monodelphis domestica)
Mammalia PPP1R37 33
  • 74 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PPP1R37 33
  • 56 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PPP1R37 33
  • 69 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ppp1r37 32
  • 67.31 (n)
zebrafish
(Danio rerio)
Actinopterygii ppp1r37 33 33 32
  • 64.71 (n)
OneToMany
PPP1R37 (3 of 3) 33
  • 51 (a)
OneToMany
Dr.20530 32
fruit fly
(Drosophila melanogaster)
Insecta CG31635 33
  • 9 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea F28C1.3 33
  • 19 (a)
OneToOne
Species where no ortholog for PPP1R37 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PPP1R37 Gene

ENSEMBL:
Gene Tree for PPP1R37 (if available)
TreeFam:
Gene Tree for PPP1R37 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for PPP1R37: view image

Paralogs for PPP1R37 Gene

Paralogs for PPP1R37 Gene

genes like me logo Genes that share paralogs with PPP1R37: view

Variants for PPP1R37 Gene

Sequence variations from dbSNP and Humsavar for PPP1R37 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs765288398 benign, not specified 45,145,823(+) T/C coding_sequence_variant, non_coding_transcript_variant, synonymous_variant
rs1000010832 -- 45,108,283(+) G/A intron_variant
rs1000059203 -- 45,136,661(+) C/A intron_variant
rs1000111050 -- 45,114,855(+) C/T intron_variant
rs1000132894 -- 45,141,791(+) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for PPP1R37 Gene

Variant ID Type Subtype PubMed ID
esv3644499 CNV loss 21293372
nsv522341 CNV loss 19592680
nsv828563 CNV gain 20364138
nsv833842 CNV loss 17160897
nsv833843 CNV loss 17160897
nsv953587 CNV deletion 24416366

Variation tolerance for PPP1R37 Gene

Gene Damage Index Score: 4.19; 61.87% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PPP1R37 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PPP1R37

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PPP1R37 Gene

Disorders for PPP1R37 Gene

Additional Disease Information for PPP1R37

No disorders were found for PPP1R37 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PPP1R37 Gene

Publications for PPP1R37 Gene

  1. Docking motif-guided mapping of the interactome of protein phosphatase-1. (PMID: 19389623) Hendrickx A … Bollen M (Chemistry & biology 2009) 3 4 56
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 56
  3. Prediction of the coding sequences of unidentified human genes. XXII. The complete sequences of 50 new cDNA clones which code for large proteins. (PMID: 11853319) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 2001) 3 4 56
  4. The Functional Proximal Proteome of Oncogenic Ras Includes mTORC2. (PMID: 30639242) Kovalski JR … Khavari PA (Molecular cell 2019) 3 56
  5. Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function. (PMID: 29467282) Heidelberger JB … Beli P (EMBO reports 2018) 3 56

Products for PPP1R37 Gene

Sources for PPP1R37 Gene