Aliases for PPP1R37 Gene

Aliases for PPP1R37 Gene

  • Protein Phosphatase 1 Regulatory Subunit 37 2 3 4 5
  • Leucine-Rich Repeat-Containing Protein 68 3 4
  • Leucine Rich Repeat Containing 68 2 3
  • LRRC68 3 4
  • Protein Phosphatase 1, Regulatory Subunit 37 2
  • KIAA1986 4
  • PPP1R37 5

External Ids for PPP1R37 Gene

Previous HGNC Symbols for PPP1R37 Gene

  • LRRC68

Previous GeneCards Identifiers for PPP1R37 Gene

  • GC19P045597

Summaries for PPP1R37 Gene

GeneCards Summary for PPP1R37 Gene

PPP1R37 (Protein Phosphatase 1 Regulatory Subunit 37) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include phosphatase binding and protein phosphatase inhibitor activity. An important paralog of this gene is CARMIL2.

UniProtKB/Swiss-Prot Summary for PPP1R37 Gene

  • Inhibits phosphatase activity of protein phosphatase 1 (PP1) complexes.

Additional gene information for PPP1R37 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PPP1R37 Gene

Genomics for PPP1R37 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for PPP1R37 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J045089 Promoter/Enhancer 2.1 Ensembl ENCODE CraniofacialAtlas dbSUPER 612.3 +1.4 1381 6 SP1 CREB1 CTCF TEAD4 PRDM10 ZNF629 TFE3 RFX1 LEF1 IKZF1 PPP1R37 GEMIN7-AS1 lnc-GEMIN7-1 ZNF180 ZNF225 ZNF224 ZNF234 CCDC61 GEMIN7 ZNF235
GH19J045146 Promoter 0.6 EPDnew 600.2 +55.3 55253 0.1 ZNF692 SPI1 ZFP69B RF00017-3001 PPP1R37 ENSG00000267044 NKPD1 MARK4
GH19J045143 Promoter 0.5 EPDnew 600.2 +52.2 52249 0.1 CTCF ZNF362 PPP1R37 RF00017-3001 ENSG00000267044 NKPD1 MARK4
GH19J045144 Promoter 0.3 EPDnew 600.2 +53.5 53513 0.1 PPP1R37 RF00017-3001 ENSG00000267044 NKPD1 MARK4
GH19J045477 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 13.8 +386.7 386704 3 CREB1 GATAD2A CTCF TEAD4 PRDM10 REST ZNF629 TFE3 ZNF512 RFX1 ERCC1 TRU-TCA1-1-001 lnc-ERCC1-1 piR-35407 ZNF180 CCDC61 POLR1G IRF2BP1 CLASRP PPP1R37
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PPP1R37 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for PPP1R37

Genomic Locations for PPP1R37 Gene

Genomic Locations for PPP1R37 Gene
56,682 bases
Plus strand
56,682 bases
Plus strand

Genomic View for PPP1R37 Gene

Genes around PPP1R37 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PPP1R37 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PPP1R37 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PPP1R37 Gene

Proteins for PPP1R37 Gene

  • Protein details for PPP1R37 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein phosphatase 1 regulatory subunit 37
    Protein Accession:
    Secondary Accessions:
    • B5MDA4
    • Q8IWK3
    • Q8TF16

    Protein attributes for PPP1R37 Gene

    691 amino acids
    Molecular mass:
    74767 Da
    Quaternary structure:
    • Interacts with PPP1CA.
    • Sequence=AAC62258.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=BAB85572.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
    • [Isoform 2]: Due to an intron retention.

    Alternative splice isoforms for PPP1R37 Gene


neXtProt entry for PPP1R37 Gene

Post-translational modifications for PPP1R37 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PPP1R37 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for PPP1R37 Gene

Domains & Families for PPP1R37 Gene

Gene Families for PPP1R37 Gene

Protein Domains for PPP1R37 Gene

  • Leucine-rich repeat signature

Suggested Antigen Peptide Sequences for PPP1R37 Gene

GenScript: Design optimal peptide antigens:
  • Leucine-rich repeat-containing protein 68 (LRC68_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the PPP1R37 family.
  • Belongs to the PPP1R37 family.
genes like me logo Genes that share domains with PPP1R37: view

Function for PPP1R37 Gene

Molecular function for PPP1R37 Gene

UniProtKB/Swiss-Prot Function:
Inhibits phosphatase activity of protein phosphatase 1 (PP1) complexes.

Phenotypes From GWAS Catalog for PPP1R37 Gene

Gene Ontology (GO) - Molecular Function for PPP1R37 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004864 protein phosphatase inhibitor activity IEA --
GO:0005515 protein binding IPI 15231748
genes like me logo Genes that share ontologies with PPP1R37: view
genes like me logo Genes that share phenotypes with PPP1R37: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PPP1R37

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PPP1R37 Gene

Localization for PPP1R37 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PPP1R37 gene
Compartment Confidence
cytosol 3
nucleus 2

Subcellular locations from the

Human Protein Atlas (HPA)

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for PPP1R37 Gene

Pathways & Interactions for PPP1R37 Gene

PathCards logo

SuperPathways for PPP1R37 Gene

No Data Available

Gene Ontology (GO) - Biological Process for PPP1R37 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010923 negative regulation of phosphatase activity IDA 19389623
GO:0032515 negative regulation of phosphoprotein phosphatase activity IEA --
genes like me logo Genes that share ontologies with PPP1R37: view

No data available for Pathways by source and SIGNOR curated interactions for PPP1R37 Gene

Drugs & Compounds for PPP1R37 Gene

No Compound Related Data Available

Transcripts for PPP1R37 Gene

mRNA/cDNA for PPP1R37 Gene

3 NCBI additional mRNA sequence :
9 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PPP1R37

Alternative Splicing Database (ASD) splice patterns (SP) for PPP1R37 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12
SP1: -
SP3: - - -

Relevant External Links for PPP1R37 Gene

GeneLoc Exon Structure for

Expression for PPP1R37 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PPP1R37 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for PPP1R37 Gene

This gene is overexpressed in Fetal Brain (23.2), Platelet (15.0), Retina (11.6), and Peripheral blood mononuclear cells (7.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for PPP1R37 Gene

Protein tissue co-expression partners for PPP1R37 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for PPP1R37

SOURCE GeneReport for Unigene cluster for PPP1R37 Gene:


Evidence on tissue expression from TISSUES for PPP1R37 Gene

  • Intestine(4.2)
  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with PPP1R37: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PPP1R37 Gene

Orthologs for PPP1R37 Gene

This gene was present in the common ancestor of animals.

Orthologs for PPP1R37 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia LRRC68 30
  • 99.09 (n)
PPP1R37 31
  • 99 (a)
(Bos Taurus)
Mammalia PPP1R37 30 31
  • 89.77 (n)
(Canis familiaris)
Mammalia PPP1R37 30 31
  • 87.65 (n)
(Rattus norvegicus)
Mammalia Ppp1r37 30
  • 83.7 (n)
(Mus musculus)
Mammalia Ppp1r37 30 17 31
  • 83.65 (n)
(Monodelphis domestica)
Mammalia PPP1R37 31
  • 74 (a)
(Ornithorhynchus anatinus)
Mammalia PPP1R37 31
  • 56 (a)
(Anolis carolinensis)
Reptilia PPP1R37 31
  • 69 (a)
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia ppp1r37 30
  • 67.31 (n)
(Danio rerio)
Actinopterygii ppp1r37 30 31 31
  • 64.71 (n)
PPP1R37 (3 of 3) 31
  • 51 (a)
Dr.20530 30
Fruit Fly
(Drosophila melanogaster)
Insecta CG31635 31
  • 9 (a)
(Caenorhabditis elegans)
Secernentea F28C1.3 31
  • 19 (a)
Species where no ortholog for PPP1R37 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for PPP1R37 Gene

Gene Tree for PPP1R37 (if available)
Gene Tree for PPP1R37 (if available)
Evolutionary constrained regions (ECRs) for PPP1R37: view image

Paralogs for PPP1R37 Gene

Paralogs for PPP1R37 Gene

genes like me logo Genes that share paralogs with PPP1R37: view

Variants for PPP1R37 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for PPP1R37 Gene

SNP ID Clinical significance and condition Chr 19 pos Variation AA Info Type
rs765288398 Benign: not specified 45,145,823(+) T/C SYNONYMOUS_VARIANT

Additional dbSNP identifiers (rs#s) for PPP1R37 Gene

Structural Variations from Database of Genomic Variants (DGV) for PPP1R37 Gene

Variant ID Type Subtype PubMed ID
esv3644499 CNV loss 21293372
nsv522341 CNV loss 19592680
nsv828563 CNV gain 20364138
nsv833842 CNV loss 17160897
nsv833843 CNV loss 17160897
nsv953587 CNV deletion 24416366

Variation tolerance for PPP1R37 Gene

Gene Damage Index Score: 4.19; 61.87% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PPP1R37 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PPP1R37 Gene

Disorders for PPP1R37 Gene

No disorders were found for PPP1R37 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PPP1R37 Gene

Publications for PPP1R37 Gene

  1. Docking motif-guided mapping of the interactome of protein phosphatase-1. (PMID: 19389623) Hendrickx A … Bollen M (Chemistry & biology 2009) 3 4
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3
  3. Prediction of the coding sequences of unidentified human genes. XXII. The complete sequences of 50 new cDNA clones which code for large proteins. (PMID: 11853319) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 2001) 3 4
  4. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3
  5. Systematic identification of cancer cell vulnerabilities to natural killer cell-mediated immune surveillance. (PMID: 31452512) Pech MF … Settleman J (eLife 2019) 3

Products for PPP1R37 Gene

Sources for PPP1R37 Gene