Aliases for PPP1R36 Gene

Aliases for PPP1R36 Gene

  • Protein Phosphatase 1 Regulatory Subunit 36 2 3 4 5
  • C14orf50 3 4
  • Protein Phosphatase 1, Regulatory Subunit 36 2
  • Chromosome 14 Open Reading Frame 50 2
  • PPP1R36 5

External Ids for PPP1R36 Gene

Previous HGNC Symbols for PPP1R36 Gene

  • C14orf50

Previous GeneCards Identifiers for PPP1R36 Gene

  • GC14P065017

Summaries for PPP1R36 Gene

GeneCards Summary for PPP1R36 Gene

PPP1R36 (Protein Phosphatase 1 Regulatory Subunit 36) is a Protein Coding gene. Diseases associated with PPP1R36 include Spermatogenic Failure 9. Gene Ontology (GO) annotations related to this gene include phosphatase binding and protein phosphatase inhibitor activity.

UniProtKB/Swiss-Prot Summary for PPP1R36 Gene

  • Inhibits phosphatase activity of protein phosphatase 1 (PP1) complexes.

Additional gene information for PPP1R36 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PPP1R36 Gene

Genomics for PPP1R36 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for PPP1R36 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PPP1R36 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for PPP1R36

Genomic Locations for PPP1R36 Gene

Latest Assembly
chr14:64,549,896-64,589,386
(GRCh38/hg38)
Size:
39,491 bases
Orientation:
Plus strand

Previous Assembly
chr14:65,016,679-65,056,099
(GRCh37/hg19 by Entrez Gene)
Size:
39,421 bases
Orientation:
Plus strand

chr14:65,016,620-65,056,098
(GRCh37/hg19 by Ensembl)
Size:
39,479 bases
Orientation:
Plus strand

Genomic View for PPP1R36 Gene

Genes around PPP1R36 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PPP1R36 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PPP1R36 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PPP1R36 Gene

Proteins for PPP1R36 Gene

  • Protein details for PPP1R36 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96LQ0-PPR36_HUMAN
    Recommended name:
    Protein phosphatase 1 regulatory subunit 36
    Protein Accession:
    Q96LQ0
    Secondary Accessions:
    • Q6NTH6

    Protein attributes for PPP1R36 Gene

    Size:
    422 amino acids
    Molecular mass:
    49440 Da
    Quaternary structure:
    • Interacts with PPP1CA.

neXtProt entry for PPP1R36 Gene

Post-translational modifications for PPP1R36 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for PPP1R36 Gene

Domains & Families for PPP1R36 Gene

Gene Families for PPP1R36 Gene

Protein Domains for PPP1R36 Gene

InterPro:
ProtoNet:
genes like me logo Genes that share domains with PPP1R36: view

No data available for Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for PPP1R36 Gene

Function for PPP1R36 Gene

Molecular function for PPP1R36 Gene

UniProtKB/Swiss-Prot Function:
Inhibits phosphatase activity of protein phosphatase 1 (PP1) complexes.

Phenotypes From GWAS Catalog for PPP1R36 Gene

Gene Ontology (GO) - Molecular Function for PPP1R36 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004864 protein phosphatase inhibitor activity IEA --
GO:0019902 phosphatase binding IEA --
genes like me logo Genes that share ontologies with PPP1R36: view
genes like me logo Genes that share phenotypes with PPP1R36: view

miRNA for PPP1R36 Gene

miRTarBase miRNAs that target PPP1R36

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PPP1R36

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PPP1R36 Gene

Localization for PPP1R36 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PPP1R36 gene
Compartment Confidence
nucleus 2
cytosol 2
mitochondrion 0

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for PPP1R36 Gene

Pathways & Interactions for PPP1R36 Gene

PathCards logo

SuperPathways for PPP1R36 Gene

No Data Available

Interacting Proteins for PPP1R36 Gene

STRING Interaction Network Preview (showing top 1 STRING interactants - click image to see details)
STRING Interaction Network
Selected Interacting proteins: ENSP00000298705 Q96LQ0-PPR36_HUMAN for PPP1R36 Gene via STRING IID

Gene Ontology (GO) - Biological Process for PPP1R36 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010923 negative regulation of phosphatase activity IEA,IDA 19389623
GO:0032515 negative regulation of phosphoprotein phosphatase activity IEA --
genes like me logo Genes that share ontologies with PPP1R36: view

No data available for Pathways by source and SIGNOR curated interactions for PPP1R36 Gene

Drugs & Compounds for PPP1R36 Gene

No Compound Related Data Available

Transcripts for PPP1R36 Gene

mRNA/cDNA for PPP1R36 Gene

1 REFSEQ mRNAs :
3 NCBI additional mRNA sequence :
6 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PPP1R36

Alternative Splicing Database (ASD) splice patterns (SP) for PPP1R36 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b · 10c ^ 11 ^ 12a · 12b ^ 13
SP1: - - - -
SP2:
SP3: -
SP4:

Relevant External Links for PPP1R36 Gene

GeneLoc Exon Structure for
PPP1R36

Expression for PPP1R36 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PPP1R36 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PPP1R36 Gene

This gene is overexpressed in Testis (x21.4) and Pancreas (x4.5).

Protein differential expression in normal tissues from HIPED for PPP1R36 Gene

This gene is overexpressed in Breast (58.8) and Platelet (10.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for PPP1R36 Gene



Protein tissue co-expression partners for PPP1R36 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for PPP1R36

SOURCE GeneReport for Unigene cluster for PPP1R36 Gene:

Hs.144696
genes like me logo Genes that share expression patterns with PPP1R36: view

Primer products for research

No data available for mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for PPP1R36 Gene

Orthologs for PPP1R36 Gene

This gene was present in the common ancestor of chordates.

Orthologs for PPP1R36 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia PPP1R36 30 31
  • 99.37 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia PPP1R36 30 31
  • 89.36 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia PPP1R36 30 31
  • 84.52 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Ppp1r36 30
  • 77.7 (n)
Mouse
(Mus musculus)
Mammalia Ppp1r36 30 17 31
  • 76.79 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia PPP1R36 31
  • 60 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia PPP1R36 31
  • 54 (a)
OneToOne
Chicken
(Gallus gallus)
Aves PPP1R36 30 31
  • 55.44 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia PPP1R36 31
  • 34 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia ppp1r36 30
  • 54.31 (n)
Species where no ortholog for PPP1R36 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for PPP1R36 Gene

ENSEMBL:
Gene Tree for PPP1R36 (if available)
TreeFam:
Gene Tree for PPP1R36 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for PPP1R36: view image

Paralogs for PPP1R36 Gene

Pseudogenes.org Pseudogenes for PPP1R36 Gene

genes like me logo Genes that share paralogs with PPP1R36: view

No data available for Paralogs for PPP1R36 Gene

Variants for PPP1R36 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for PPP1R36 Gene

SNP ID Clinical significance and condition Chr 14 pos Variation AA Info Type
rs116108142 Benign: not provided 64,589,188(+) C/T
NM_172365.3(PPP1R36):c.1119C>T (p.Asn373=)
SYNONYMOUS
rs142499430 Benign: not provided 64,550,943(+) T/A
NM_172365.3(PPP1R36):c.92T>A (p.Met31Lys)
MISSENSE
rs74056311 Benign: not provided 64,564,791(+) G/T
NM_172365.3(PPP1R36):c.223G>T (p.Gly75Cys)
MISSENSE
rs45482504 - p.Phe267Leu
rs6573560 - p.Thr83Ile

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for PPP1R36 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for PPP1R36 Gene

Variant ID Type Subtype PubMed ID
esv25548 CNV gain 19812545
esv2748779 CNV deletion 23290073
esv3581226 CNV loss 25503493
esv3634754 CNV gain 21293372
nsv1049097 CNV gain 25217958
nsv1160195 CNV duplication 26073780
nsv1308 CNV insertion 18451855
nsv442343 CNV gain 18776908
nsv564907 CNV gain 21841781
nsv564908 CNV gain 21841781
nsv564909 CNV gain 21841781

Variation tolerance for PPP1R36 Gene

Residual Variation Intolerance Score: 95.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.77; 73.49% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PPP1R36 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PPP1R36

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PPP1R36 Gene

Disorders for PPP1R36 Gene

MalaCards: The human disease database

(1) MalaCards diseases for PPP1R36 Gene - From: COP

Disorder Aliases PubMed IDs
spermatogenic failure 9
  • spgf9
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for PPP1R36

genes like me logo Genes that share disorders with PPP1R36: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PPP1R36 Gene

Publications for PPP1R36 Gene

  1. Docking motif-guided mapping of the interactome of protein phosphatase-1. (PMID: 19389623) Hendrickx A … Bollen M (Chemistry & biology 2009) 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  4. Histone Interaction Landscapes Visualized by Crosslinking Mass Spectrometry in Intact Cell Nuclei. (PMID: 30021884) Fasci D … Heck AJR (Molecular & cellular proteomics : MCP 2018) 3
  5. Estrogen-regulated feedback loop limits the efficacy of estrogen receptor-targeted breast cancer therapy. (PMID: 29987050) Xiao T … Brown M (Proceedings of the National Academy of Sciences of the United States of America 2018) 3

Products for PPP1R36 Gene

Sources for PPP1R36 Gene