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Aliases for PPP1R35 Gene

Aliases for PPP1R35 Gene

  • Protein Phosphatase 1 Regulatory Subunit 35 2 3 5
  • C7orf47 3 4
  • Protein Phosphatase 1, Regulatory Subunit 35 2
  • Chromosome 7 Open Reading Frame 47 2
  • UPF0683 Protein C7orf47 3

External Ids for PPP1R35 Gene

Previous HGNC Symbols for PPP1R35 Gene

  • C7orf47

Previous GeneCards Identifiers for PPP1R35 Gene

  • GC07M100034

Summaries for PPP1R35 Gene

GeneCards Summary for PPP1R35 Gene

PPP1R35 (Protein Phosphatase 1 Regulatory Subunit 35) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include phosphatase binding and protein phosphatase inhibitor activity.

UniProtKB/Swiss-Prot for PPP1R35 Gene

  • Inhibits PPP1CA phosphatase activity.

Additional gene information for PPP1R35 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PPP1R35 Gene

Genomics for PPP1R35 Gene

GeneHancer (GH) Regulatory Elements for PPP1R35 Gene

Promoters and enhancers for PPP1R35 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH07I100427 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE dbSUPER 594.9 +3.4 3416 10.8 CLOCK ZFP64 FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 PPP1R35 MEPCE PIR54054 ZCWPW1 ZSCAN25 TRIM4 SRRT GIGYF1 ZNF3 PILRA
GH07I100475 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 54.4 -41.1 -41140 4.4 HDGF PKNOX1 FOXA2 SMAD1 ARNT ZFP64 ARID4B SIN3A FEZF1 ZNF2 TSC22D4 ZSCAN25 SRRT TRIM4 ZNF655 GIGYF1 ZNF3 ENSG00000242798 STAG3L5P PILRA
GH07I100538 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 42 -108.0 -107998 12.6 CLOCK MLX DMAP1 YY1 SLC30A9 E2F8 ZNF143 SP3 NFYC SSRP1 AGFG2 SAP25 PPP1R35 SRRT ZSCAN25 LRCH4 GIGYF1 AP4M1 MEPCE FBXO24
GH07I099471 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 55.5 +964.0 964011 3 HDGF PKNOX1 CLOCK FOXA2 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF789 ZSCAN25 PPP1R35 PTCD1 MEPCE TRRAP STAG3L5P TRIM4 LOC101927550 AP4M1
GH07I100672 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 42.8 -240.4 -240377 8.6 CLOCK MLX ZFP64 FEZF1 DMAP1 YY1 ZNF213 E2F8 ZNF143 ZNF548 GNB2 GC07P100676 TRIM4 ZNF3 GIGYF1 SRRT PCOLCE STAG3L5P PPP1R35 ENSG00000242798
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around PPP1R35 on UCSC Golden Path with GeneCards custom track

Genomic Locations for PPP1R35 Gene

Genomic Locations for PPP1R35 Gene
1,339 bases
Minus strand

Genomic View for PPP1R35 Gene

Genes around PPP1R35 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PPP1R35 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PPP1R35 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PPP1R35 Gene

Proteins for PPP1R35 Gene

  • Protein details for PPP1R35 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein phosphatase 1 regulatory subunit 35
    Protein Accession:
    Secondary Accessions:
    • A4D2C5

    Protein attributes for PPP1R35 Gene

    253 amino acids
    Molecular mass:
    27953 Da
    Quaternary structure:
    • Interacts with PPP1CA.

neXtProt entry for PPP1R35 Gene

Post-translational modifications for PPP1R35 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PPP1R35 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for PPP1R35 Gene

Domains & Families for PPP1R35 Gene

Gene Families for PPP1R35 Gene

Protein Domains for PPP1R35 Gene


Suggested Antigen Peptide Sequences for PPP1R35 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the PPP1R35 family.
  • Belongs to the PPP1R35 family.
genes like me logo Genes that share domains with PPP1R35: view

Function for PPP1R35 Gene

Molecular function for PPP1R35 Gene

UniProtKB/Swiss-Prot Function:
Inhibits PPP1CA phosphatase activity.

Phenotypes From GWAS Catalog for PPP1R35 Gene

Gene Ontology (GO) - Molecular Function for PPP1R35 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004864 protein phosphatase inhibitor activity IEA --
GO:0019902 phosphatase binding IEA,IDA --
genes like me logo Genes that share ontologies with PPP1R35: view
genes like me logo Genes that share phenotypes with PPP1R35: view

Animal Models for PPP1R35 Gene

MGI Knock Outs for PPP1R35:

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for PPP1R35 Gene

Localization for PPP1R35 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PPP1R35 gene
Compartment Confidence
nucleus 3
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for PPP1R35 Gene

Pathways & Interactions for PPP1R35 Gene

SuperPathways for PPP1R35 Gene

No Data Available

Gene Ontology (GO) - Biological Process for PPP1R35 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010923 negative regulation of phosphatase activity IEA,IDA 19389623
GO:0032515 negative regulation of phosphoprotein phosphatase activity IEA --
genes like me logo Genes that share ontologies with PPP1R35: view

No data available for Pathways by source and SIGNOR curated interactions for PPP1R35 Gene

Drugs & Compounds for PPP1R35 Gene

No Compound Related Data Available

Transcripts for PPP1R35 Gene

Unigene Clusters for PPP1R35 Gene

Protein phosphatase 1, regulatory subunit 35:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for PPP1R35 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b
SP1: -

Relevant External Links for PPP1R35 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PPP1R35 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PPP1R35 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for PPP1R35 Gene

This gene is overexpressed in Pancreatic juice (51.0) and Testis (18.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for PPP1R35 Gene

Protein tissue co-expression partners for PPP1R35 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of PPP1R35 Gene:


SOURCE GeneReport for Unigene cluster for PPP1R35 Gene:

genes like me logo Genes that share expression patterns with PPP1R35: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for PPP1R35 Gene

Orthologs for PPP1R35 Gene

This gene was present in the common ancestor of chordates.

Orthologs for PPP1R35 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia PPP1R35 33 34
  • 99.6 (n)
(Canis familiaris)
Mammalia PPP1R35 33 34
  • 85.71 (n)
(Bos Taurus)
Mammalia PPP1R35 33 34
  • 84.52 (n)
(Mus musculus)
Mammalia Ppp1r35 33 16 34
  • 77.64 (n)
(Monodelphis domestica)
Mammalia PPP1R35 34
  • 49 (a)
(Danio rerio)
Actinopterygii PPP1R35 34
  • 32 (a)
Species where no ortholog for PPP1R35 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PPP1R35 Gene

Gene Tree for PPP1R35 (if available)
Gene Tree for PPP1R35 (if available)

Paralogs for PPP1R35 Gene

No data available for Paralogs for PPP1R35 Gene

Variants for PPP1R35 Gene

Sequence variations from dbSNP and Humsavar for PPP1R35 Gene

SNP ID Clin Chr 07 pos Variation AA Info Type
rs1001031038 -- 100,437,751(-) C/T upstream_transcript_variant
rs1001553730 -- 100,435,292(-) A/G 3_prime_UTR_variant
rs1001940656 -- 100,435,441(-) G/A coding_sequence_variant, synonymous_variant
rs1002502362 -- 100,435,000(-) C/T downstream_transcript_variant
rs1003504474 -- 100,436,056(-) G/A coding_sequence_variant, synonymous_variant

Structural Variations from Database of Genomic Variants (DGV) for PPP1R35 Gene

Variant ID Type Subtype PubMed ID
esv2734888 CNV deletion 23290073
nsv527107 CNV loss 19592680
nsv831071 CNV loss 17160897

Variation tolerance for PPP1R35 Gene

Residual Variation Intolerance Score: 52.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.20; 24.14% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PPP1R35 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PPP1R35 Gene

Disorders for PPP1R35 Gene

Additional Disease Information for PPP1R35

No disorders were found for PPP1R35 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PPP1R35 Gene

Publications for PPP1R35 Gene

  1. Docking motif-guided mapping of the interactome of protein phosphatase-1. (PMID: 19389623) Hendrickx A … Bollen M (Chemistry & biology 2009) 3 4 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. Human chromosome 7: DNA sequence and biology. (PMID: 12690205) Scherer SW … Tsui LC (Science (New York, N.Y.) 2003) 3 4 58
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 58
  5. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein MY … Mann M (Cell 2015) 3 58

Products for PPP1R35 Gene

Sources for PPP1R35 Gene

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