Aliases for PPP1R32 Gene

Aliases for PPP1R32 Gene

  • Protein Phosphatase 1 Regulatory Subunit 32 2 3 4 5
  • C11orf66 3 4
  • IIIG9 2 3
  • Protein Phosphatase 1, Regulatory Subunit 32 2
  • Chromosome 11 Open Reading Frame 66 2
  • FLJ32771 2
  • PPP1R32 5

External Ids for PPP1R32 Gene

Previous HGNC Symbols for PPP1R32 Gene

  • C11orf66

Previous GeneCards Identifiers for PPP1R32 Gene

  • GC11P061249

Summaries for PPP1R32 Gene

GeneCards Summary for PPP1R32 Gene

PPP1R32 (Protein Phosphatase 1 Regulatory Subunit 32) is a Protein Coding gene. Diseases associated with PPP1R32 include Nanophthalmos. Gene Ontology (GO) annotations related to this gene include phosphatase binding.

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PPP1R32 Gene

Genomics for PPP1R32 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for PPP1R32 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J061480 Promoter/Enhancer 1.3 EPDnew Ensembl ENCODE CraniofacialAtlas 250.7 +0.6 581 2.6 NFIC CTCF SIN3A MYNN MAZ NRF1 RAD21 RFX1 ZNF143 CSDE1 PPP1R32 TMEM216 HSALNG0084535 LRRC10B ENSG00000256591
GH11J061485 Promoter/Enhancer 0.8 EPDnew Ensembl 250.7 +3.7 3680 3.2 SPI1 EGR2 ESRRA CREB1 ZFHX2 EGR1 HSALNG0084535 PPP1R32 TMEM216 LRRC10B ENSG00000256591
GH11J061020 Enhancer 1 FANTOM5 ENCODE dbSUPER 4.9 -458.7 -458728 3.8 POLR2A ZIC2 EBF1 PKNOX1 MAZ GLIS1 ZNF768 ZMYM3 GABPB1 ZFP3 CD6 CD5 PPP1R32 SDHAF2 lnc-SLC15A3-2 RF00017-839 lnc-VPS37C-3
GH11J061327 Enhancer 0.6 Ensembl ENCODE 4.3 -152.2 -152238 3.4 ATF3 FOS ESRRA RBFOX2 piR-35674-072 TMEM216 CYB561A3 PPP1R32 TKFC lnc-TMEM138-9 DDB1 VWCE
GH11J061487 Promoter/Enhancer 1.7 Ensembl ENCODE CraniofacialAtlas dbSUPER 0.4 +7.8 7840 3.7 SSRP1 ZIC2 YY1 MXD4 CHD2 ZFP64 ZBTB7B ZNF217 THAP11 ELF1 FADS1 SLC15A3 HSALNG0084535 ENSG00000255931 PPP1R32 LRRC10B
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PPP1R32 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for PPP1R32

Genomic Locations for PPP1R32 Gene

Latest Assembly
chr11:61,481,120-61,490,931
(GRCh38/hg38)
Size:
9,812 bases
Orientation:
Plus strand

Previous Assembly
chr11:61,248,592-61,258,400
(GRCh37/hg19 by Entrez Gene)
Size:
9,809 bases
Orientation:
Plus strand

chr11:61,248,592-61,258,403
(GRCh37/hg19 by Ensembl)
Size:
9,812 bases
Orientation:
Plus strand

Genomic View for PPP1R32 Gene

Genes around PPP1R32 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PPP1R32 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PPP1R32 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PPP1R32 Gene

Proteins for PPP1R32 Gene

  • Protein details for PPP1R32 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7Z5V6-PPR32_HUMAN
    Recommended name:
    Protein phosphatase 1 regulatory subunit 32
    Protein Accession:
    Q7Z5V6
    Secondary Accessions:
    • Q4G0P4
    • Q96M77

    Protein attributes for PPP1R32 Gene

    Size:
    425 amino acids
    Molecular mass:
    47295 Da
    Quaternary structure:
    • Interacts with PPP1CA.

    Alternative splice isoforms for PPP1R32 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PPP1R32 Gene

Post-translational modifications for PPP1R32 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PPP1R32 Gene

No data available for DME Specific Peptides for PPP1R32 Gene

Domains & Families for PPP1R32 Gene

Gene Families for PPP1R32 Gene

Protein Domains for PPP1R32 Gene

InterPro:
genes like me logo Genes that share domains with PPP1R32: view

No data available for Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for PPP1R32 Gene

Function for PPP1R32 Gene

Phenotypes From GWAS Catalog for PPP1R32 Gene

Gene Ontology (GO) - Molecular Function for PPP1R32 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 19389623
GO:0019902 phosphatase binding IBA,IDA 19389623
genes like me logo Genes that share ontologies with PPP1R32: view
genes like me logo Genes that share phenotypes with PPP1R32: view

Animal Models for PPP1R32 Gene

MGI Knock Outs for PPP1R32:

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PPP1R32

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for PPP1R32 Gene

Localization for PPP1R32 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PPP1R32 gene
Compartment Confidence
cytoskeleton 4
nucleus 2
plasma membrane 1
cytosol 1
mitochondrion 0

Gene Ontology (GO) - Cellular Components for PPP1R32 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0036064 ciliary basal body IDA 29257953
genes like me logo Genes that share ontologies with PPP1R32: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for PPP1R32 Gene

Pathways & Interactions for PPP1R32 Gene

PathCards logo

SuperPathways for PPP1R32 Gene

No Data Available

Gene Ontology (GO) - Biological Process for PPP1R32 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for PPP1R32 Gene

Drugs & Compounds for PPP1R32 Gene

No Compound Related Data Available

Transcripts for PPP1R32 Gene

mRNA/cDNA for PPP1R32 Gene

2 REFSEQ mRNAs :
6 NCBI additional mRNA sequence :
6 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PPP1R32

Alternative Splicing Database (ASD) splice patterns (SP) for PPP1R32 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b
SP1: - -
SP2: - - -
SP3:
SP4: - -
SP5:

Relevant External Links for PPP1R32 Gene

GeneLoc Exon Structure for
PPP1R32

Expression for PPP1R32 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PPP1R32 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PPP1R32 Gene

This gene is overexpressed in Testis (x11.1).

Protein differential expression in normal tissues from HIPED for PPP1R32 Gene

This gene is overexpressed in Testis (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for PPP1R32 Gene



Protein tissue co-expression partners for PPP1R32 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for PPP1R32

SOURCE GeneReport for Unigene cluster for PPP1R32 Gene:

Hs.729003

Evidence on tissue expression from TISSUES for PPP1R32 Gene

  • Nervous system(4.3)
genes like me logo Genes that share expression patterns with PPP1R32: view

Primer products for research

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PPP1R32 Gene

Orthologs for PPP1R32 Gene

This gene was present in the common ancestor of chordates.

Orthologs for PPP1R32 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia PPP1R32 30
  • 99 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia PPP1R32 29 30
  • 83.61 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia PPP1R32 29 30
  • 83.22 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Ppp1r32 29
  • 80 (n)
Mouse
(Mus musculus)
Mammalia Ppp1r32 29 16 30
  • 78.82 (n)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 30
  • 64 (a)
OneToMany
-- 30
  • 56 (a)
OneToMany
Oppossum
(Monodelphis domestica)
Mammalia PPP1R32 30
  • 54 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia PPP1R32 30
  • 53 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia ppp1r32 29
  • 50.78 (n)
Zebrafish
(Danio rerio)
Actinopterygii LOC571714 29
  • 45.86 (n)
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 30
  • 28 (a)
OneToMany
-- 30
  • 24 (a)
OneToMany
Species where no ortholog for PPP1R32 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for PPP1R32 Gene

ENSEMBL:
Gene Tree for PPP1R32 (if available)
TreeFam:
Gene Tree for PPP1R32 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for PPP1R32: view image
Alliance of Genome Resources:
Additional Orthologs for PPP1R32

Paralogs for PPP1R32 Gene

(1) SIMAP similar genes for PPP1R32 Gene using alignment to 5 proteins:

  • PPR32_HUMAN
  • F5GZJ9_HUMAN
  • F5H272_HUMAN
  • H0YF82_HUMAN
  • H0YFZ1_HUMAN
genes like me logo Genes that share paralogs with PPP1R32: view

No data available for Paralogs for PPP1R32 Gene

Variants for PPP1R32 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for PPP1R32 Gene

SNP ID Clinical significance and condition Chr 11 pos Variation AA Info Type
rs146231065 Benign: not provided 61,484,728(+) A/G
NM_145017.3(PPP1R32):c.422A>G (p.Gln141Arg)
MISSENSE
rs11230707 -- p.Thr238Asn
rs12787061 -- p.Ser382Thr

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for PPP1R32 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for PPP1R32 Gene

Variant ID Type Subtype PubMed ID
nsv518592 CNV loss 19592680
nsv555167 CNV loss 21841781
nsv818837 CNV gain 17921354
nsv832178 CNV gain+loss 17160897

Variation tolerance for PPP1R32 Gene

Residual Variation Intolerance Score: 95.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.39; 71.11% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PPP1R32 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PPP1R32
Leiden Open Variation Database (LOVD)
PPP1R32

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PPP1R32 Gene

Disorders for PPP1R32 Gene

MalaCards: The human disease database

(1) MalaCards diseases for PPP1R32 Gene - From: COP

Disorder Aliases PubMed IDs
nanophthalmos
  • nanophthalmia
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for PPP1R32

genes like me logo Genes that share disorders with PPP1R32: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PPP1R32 Gene

Publications for PPP1R32 Gene

  1. Expression of a Novel Ciliary Protein, IIIG9, During the Differentiation and Maturation of Ependymal Cells. (PMID: 28194645) Cifuentes M … Salazar K (Molecular neurobiology 2018) 2 3
  2. Docking motif-guided mapping of the interactome of protein phosphatase-1. (PMID: 19389623) Hendrickx A … Bollen M (Chemistry & biology 2009) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  5. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3

Products for PPP1R32 Gene

Sources for PPP1R32 Gene