Aliases for PPP1R2C Gene

Aliases for PPP1R2C Gene

  • PPP1R2C Family Member C 2 3 5
  • Protein Phosphatase 1 Regulatory Inhibitor Subunit 2 Pseudogene 9 2 3
  • Protein Phosphatase Inhibitor 2 Family Member C 3 4
  • Type-1 Protein Phosphatase Inhibitor 4 3 4
  • PPP1R2 Family Member B 3 4
  • PPP1R2P9 3 4
  • I-4 3 4
  • Protein Phosphatase 1, Regulatory (Inhibitor) Subunit 2 Pseudogene 9 2
  • Protein Phosphatase 1 Regulatory Inhibitor Subunit 2-Like 9 3
  • Protein Phosphatase 1, Regulatory Subunit 2 Pseudogene 9 4
  • Putative Type-1 Protein Phosphatase Inhibitor 4 3
  • Type 1 Protein Phosphatase Inhibitor 3

External Ids for PPP1R2C Gene

Previous HGNC Symbols for PPP1R2C Gene

  • PPP1R2P9

Summaries for PPP1R2C Gene

GeneCards Summary for PPP1R2C Gene

PPP1R2C (PPP1R2C Family Member C) is a Protein Coding gene. An important paralog of this gene is PPP1R2.

UniProtKB/Swiss-Prot Summary for PPP1R2C Gene

  • Functions as a protein phosphatase inhibitor. It inhibits activity of the catalytic subunit of PP1 and weakly inhibits the activity of myosin-associated phosphates.

Additional gene information for PPP1R2C Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PPP1R2C Gene

Genomics for PPP1R2C Gene

GeneHancer (GH) Regulatory Elements for PPP1R2C Gene

Promoters and enhancers for PPP1R2C Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH0XJ042776 Enhancer 0.7 Ensembl ENCODE 500.7 +1.9 1880 0.7 FOS JUN JUND EP300 USF2 GATA2 MYC GATA1 POLR2A PPP1R2C RF00017-8341
GH0XJ042779 Enhancer 0.2 ENCODE 0.7 -2.5 -2482 1.5 PPP1R2C piR-56580-055
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PPP1R2C on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for PPP1R2C

Genomic Locations for PPP1R2C Gene

Genomic Locations for PPP1R2C Gene
chrX:42,777,366-42,778,235
(GRCh38/hg38)
Size:
870 bases
Orientation:
Minus strand
chrX:42,636,617-42,637,486
(GRCh37/hg19)
Size:
870 bases
Orientation:
Minus strand

Genomic View for PPP1R2C Gene

Genes around PPP1R2C on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PPP1R2C Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PPP1R2C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PPP1R2C Gene

Proteins for PPP1R2C Gene

  • Protein details for PPP1R2C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O14990-IPP2C_HUMAN
    Recommended name:
    Protein phosphatase inhibitor 2 family member C
    Protein Accession:
    O14990
    Secondary Accessions:
    • Q5H958

    Protein attributes for PPP1R2C Gene

    Size:
    202 amino acids
    Molecular mass:
    22660 Da
    Quaternary structure:
    No Data Available

neXtProt entry for PPP1R2C Gene

Post-translational modifications for PPP1R2C Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PPP1R2C Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for PPP1R2C Gene

Domains & Families for PPP1R2C Gene

Gene Families for PPP1R2C Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for PPP1R2C Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for PPP1R2C Gene

GenScript: Design optimal peptide antigens:
  • Protein phosphatase 1, regulatory subunit 2 pseudogene 9 (IPP4_HUMAN)

Graphical View of Domain Structure for InterPro Entry

O14990

UniProtKB/Swiss-Prot:

IPP2C_HUMAN :
  • Belongs to the protein phosphatase inhibitor 2 family.
Family:
  • Belongs to the protein phosphatase inhibitor 2 family.
genes like me logo Genes that share domains with PPP1R2C: view

Function for PPP1R2C Gene

Molecular function for PPP1R2C Gene

UniProtKB/Swiss-Prot Function:
Functions as a protein phosphatase inhibitor. It inhibits activity of the catalytic subunit of PP1 and weakly inhibits the activity of myosin-associated phosphates.

Gene Ontology (GO) - Molecular Function for PPP1R2C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004864 protein phosphatase inhibitor activity NAS 11076525
genes like me logo Genes that share ontologies with PPP1R2C: view
genes like me logo Genes that share phenotypes with PPP1R2C: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for PPP1R2C Gene

Localization for PPP1R2C Gene

Gene Ontology (GO) - Cellular Components for PPP1R2C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
genes like me logo Genes that share ontologies with PPP1R2C: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for PPP1R2C Gene

Pathways & Interactions for PPP1R2C Gene

PathCards logo

SuperPathways for PPP1R2C Gene

No Data Available

Interacting Proteins for PPP1R2C Gene

Selected Interacting proteins: O14990-IPP2C_HUMAN for PPP1R2C Gene via IID

;

Gene Ontology (GO) - Biological Process for PPP1R2C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0009966 regulation of signal transduction IEA --
GO:0032515 negative regulation of phosphoprotein phosphatase activity IEA --
GO:0043666 regulation of phosphoprotein phosphatase activity IBA 21873635
genes like me logo Genes that share ontologies with PPP1R2C: view

No data available for Pathways by source and SIGNOR curated interactions for PPP1R2C Gene

Drugs & Compounds for PPP1R2C Gene

No Compound Related Data Available

Transcripts for PPP1R2C Gene

mRNA/cDNA for PPP1R2C Gene

1 REFSEQ mRNAs :
2 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for PPP1R2C Gene

No ASD Table

Relevant External Links for PPP1R2C Gene

GeneLoc Exon Structure for
PPP1R2C

Expression for PPP1R2C Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for PPP1R2C

mRNA Expression by UniProt/SwissProt for PPP1R2C Gene:

O14990-IPP2C_HUMAN
Tissue specificity: Detected in sperm (at protein level).

Primer Products

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for PPP1R2C Gene

Orthologs for PPP1R2C Gene

Evolution for PPP1R2C Gene

ENSEMBL:
Gene Tree for PPP1R2C (if available)
TreeFam:
Gene Tree for PPP1R2C (if available)

No data available for Orthologs for PPP1R2C Gene

Paralogs for PPP1R2C Gene

Paralogs for PPP1R2C Gene

genes like me logo Genes that share paralogs with PPP1R2C: view

Variants for PPP1R2C Gene

Additional dbSNP identifiers (rs#s) for PPP1R2C Gene

Structural Variations from Database of Genomic Variants (DGV) for PPP1R2C Gene

Variant ID Type Subtype PubMed ID
esv33720 CNV loss 17666407
nsv510830 CNV deletion 20534489

Additional Variant Information for PPP1R2C Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PPP1R2C

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for PPP1R2C Gene

Disorders for PPP1R2C Gene

Additional Disease Information for PPP1R2C

No disorders were found for PPP1R2C Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PPP1R2C Gene

Publications for PPP1R2C Gene

  1. Not so pseudo: the evolutionary history of protein phosphatase 1 regulatory subunit 2 and related pseudogenes. (PMID: 24195737) Korrodi-Gregório L … Esteves PJ (BMC evolutionary biology 2013) 2 3 4 54
  2. Identification and characterization of a novel protein inhibitor of type 1 protein phosphatase. (PMID: 11076525) Shirato H … Kikuchi K (Biochemistry 2000) 3 4 23 54
  3. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross MT … Bentley DR (Nature 2005) 3 4 54
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 54
  5. Regulator-driven functional diversification of protein phosphatase-1 in eukaryotic evolution. (PMID: 11948623) Ceulemans H … Bollen M (BioEssays : news and reviews in molecular, cellular and developmental biology 2002) 2 3 54

Products for PPP1R2C Gene

Sources for PPP1R2C Gene