Free for academic non-profit institutions. Other users need a Commercial license

Aliases for PPP1R27 Gene

Aliases for PPP1R27 Gene

  • Protein Phosphatase 1 Regulatory Subunit 27 2 3 3 5
  • Dysferlin-Interacting Protein 1 (Toonin) 2 3
  • Dysferlin Interacting Protein 1 2 3
  • DYSFIP1 3 4
  • Toonin 3 4
  • Protein Phosphatase 1, Regulatory Subunit 27 2
  • Dysferlin Interacting Protein 1 (Toonin) 2
  • Dysferlin-Interacting Protein 1 4

External Ids for PPP1R27 Gene

Previous HGNC Symbols for PPP1R27 Gene


Previous GeneCards Identifiers for PPP1R27 Gene

  • GC17M079793

Summaries for PPP1R27 Gene

GeneCards Summary for PPP1R27 Gene

PPP1R27 (Protein Phosphatase 1 Regulatory Subunit 27) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include phosphatase binding and protein phosphatase inhibitor activity. An important paralog of this gene is PPP1R12C.

UniProtKB/Swiss-Prot for PPP1R27 Gene

  • Inhibits phosphatase activity of protein phosphatase 1 (PP1) complexes.

Additional gene information for PPP1R27 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PPP1R27 Gene

Genomics for PPP1R27 Gene

GeneHancer (GH) Regulatory Elements for PPP1R27 Gene

Promoters and enhancers for PPP1R27 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17J081831 Promoter/Enhancer 2.5 EPDnew Ensembl ENCODE dbSUPER 650.7 +1.6 1614 4.2 HDGF PKNOX1 CLOCK SMAD1 MLX ZFP64 ARID4B SIN3A YBX1 DMAP1 MCRIP1 PPP1R27 TBCD OGFOD3 ENSG00000263321 P4HB NPLOC4 RFNG FAAP100 HEXDC
GH17J081700 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 11.9 +132.3 132260 4.2 HDGF CLOCK MLX ARID4B SIN3A DMAP1 ZBTB7B IRF4 YY1 POLR2B ENSG00000262049 ENSG00000262660 MRPL12 ARL16 HGS FAAP100 CEP131 ENSG00000260563 TEPSIN NARF-IT1
GH17J081682 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 11.7 +150.9 150896 3.5 PKNOX1 SMAD1 ARNT ARID4B SIN3A DMAP1 ZNF2 SLC30A9 POLR2B ZNF213 ARL16 HGS ALYREF FOXK2 LOC105371942 CCDC137 PDE6G NPLOC4 TSPAN10 P4HB
GH17J081558 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE dbSUPER 11.2 +270.7 270688 11.1 PKNOX1 FOXA2 NFIB ZSCAN4 SIN3A FEZF1 BATF RAD21 ZNF366 ATF7 NPLOC4 TSPAN10 ARL16 OXLD1 ENSG00000229848 FSCN2 ENSG00000262877 PDE6G CCDC137 GCGR
GH17J081384 Promoter/Enhancer 2.4 FANTOM5 Ensembl ENCODE dbSUPER 4.6 +438.9 438946 22.4 CLOCK MLX ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF213 E2F8 ZNF263 BAHCC1 ENSG00000279692 ENSG00000262877 CEP131 HGS FAAP100 ENSG00000265678 CCDC57 ARL16 RFNG
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PPP1R27 on UCSC Golden Path with GeneCards custom track

Genomic Locations for PPP1R27 Gene

Genomic Locations for PPP1R27 Gene
1,559 bases
Minus strand
1,559 bases
Minus strand

Genomic View for PPP1R27 Gene

Genes around PPP1R27 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PPP1R27 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PPP1R27 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PPP1R27 Gene

Proteins for PPP1R27 Gene

  • Protein details for PPP1R27 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein phosphatase 1 regulatory subunit 27
    Protein Accession:

    Protein attributes for PPP1R27 Gene

    154 amino acids
    Molecular mass:
    17438 Da
    Quaternary structure:
    • Interacts with DYSF and PPP1CA.

neXtProt entry for PPP1R27 Gene

Post-translational modifications for PPP1R27 Gene

  • Ubiquitination at Lys85
  • Modification sites at PhosphoSitePlus

Other Protein References for PPP1R27 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for PPP1R27 Gene

Domains & Families for PPP1R27 Gene

Gene Families for PPP1R27 Gene

Protein Domains for PPP1R27 Gene

Suggested Antigen Peptide Sequences for PPP1R27 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with PPP1R27: view

No data available for UniProtKB/Swiss-Prot for PPP1R27 Gene

Function for PPP1R27 Gene

Molecular function for PPP1R27 Gene

UniProtKB/Swiss-Prot Function:
Inhibits phosphatase activity of protein phosphatase 1 (PP1) complexes.

Phenotypes From GWAS Catalog for PPP1R27 Gene

Gene Ontology (GO) - Molecular Function for PPP1R27 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004857 enzyme inhibitor activity IBA --
GO:0004864 protein phosphatase inhibitor activity IEA --
GO:0005515 protein binding IPI,IEA 19389623
GO:0019208 phosphatase regulator activity IBA --
GO:0019902 phosphatase binding IDA 19389623
genes like me logo Genes that share ontologies with PPP1R27: view
genes like me logo Genes that share phenotypes with PPP1R27: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for PPP1R27 Gene

Localization for PPP1R27 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PPP1R27 gene
Compartment Confidence
nucleus 3
cytosol 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for PPP1R27 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA --
genes like me logo Genes that share ontologies with PPP1R27: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for PPP1R27 Gene

Pathways & Interactions for PPP1R27 Gene

SuperPathways for PPP1R27 Gene

No Data Available

Gene Ontology (GO) - Biological Process for PPP1R27 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010923 negative regulation of phosphatase activity IDA 19389623
GO:0032515 negative regulation of phosphoprotein phosphatase activity IEA --
genes like me logo Genes that share ontologies with PPP1R27: view

No data available for Pathways by source and SIGNOR curated interactions for PPP1R27 Gene

Drugs & Compounds for PPP1R27 Gene

No Compound Related Data Available

Transcripts for PPP1R27 Gene

mRNA/cDNA for PPP1R27 Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for PPP1R27 Gene

Protein phosphatase 1, regulatory subunit 27:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for PPP1R27 Gene

No ASD Table

Relevant External Links for PPP1R27 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PPP1R27 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PPP1R27 Gene

mRNA differential expression in normal tissues according to GTEx for PPP1R27 Gene

This gene is overexpressed in Muscle - Skeletal (x50.4).

NURSA nuclear receptor signaling pathways regulating expression of PPP1R27 Gene:


SOURCE GeneReport for Unigene cluster for PPP1R27 Gene:


Evidence on tissue expression from TISSUES for PPP1R27 Gene

  • Nervous system(4.1)
  • Muscle(3.7)
genes like me logo Genes that share expression patterns with PPP1R27: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PPP1R27 Gene

Orthologs for PPP1R27 Gene

This gene was present in the common ancestor of chordates.

Orthologs for PPP1R27 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia DYSFIP1 33
  • 99.57 (n)
PPP1R27 34
  • 99 (a)
(Canis familiaris)
Mammalia PPP1R27 34 33
  • 88.31 (n)
(Bos Taurus)
Mammalia PPP1R27 34 33
  • 88.1 (n)
(Mus musculus)
Mammalia Ppp1r27 16 34 33
  • 86.15 (n)
(Rattus norvegicus)
Mammalia Ppp1r27 33
  • 84.85 (n)
(Gallus gallus)
Aves PPP1R27 34 33
  • 73.6 (n)
(Anolis carolinensis)
Reptilia PPP1R27 34
  • 64 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia ppp1r27 33
  • 72.27 (n)
(Danio rerio)
Actinopterygii ppp1r27 34 33
  • 67.47 (n)
PPP1R27 (2 of 2) 34
  • 38 (a)
Species where no ortholog for PPP1R27 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PPP1R27 Gene

Gene Tree for PPP1R27 (if available)
Gene Tree for PPP1R27 (if available)
Evolutionary constrained regions (ECRs) for PPP1R27: view image

Paralogs for PPP1R27 Gene

(13) SIMAP similar genes for PPP1R27 Gene using alignment to 2 proteins:

  • I3L267_HUMAN
genes like me logo Genes that share paralogs with PPP1R27: view

Variants for PPP1R27 Gene

Sequence variations from dbSNP and Humsavar for PPP1R27 Gene

SNP ID Clin Chr 17 pos Variation AA Info Type
rs1000452669 -- 81,834,405(-) G/A intron_variant
rs1000817457 -- 81,835,594(-) C/T upstream_transcript_variant
rs1001078732 -- 81,835,394(-) A/G upstream_transcript_variant
rs1001700528 -- 81,835,645(-) G/A upstream_transcript_variant
rs1002083981 -- 81,833,378(-) C/T downstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for PPP1R27 Gene

Variant ID Type Subtype PubMed ID
esv21913 CNV gain+loss 19812545
nsv428351 CNV gain 18775914
nsv470620 CNV loss 18288195
nsv952390 CNV deletion 24416366

Variation tolerance for PPP1R27 Gene

Residual Variation Intolerance Score: 40% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.74; 15.73% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PPP1R27 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PPP1R27 Gene

Disorders for PPP1R27 Gene

Additional Disease Information for PPP1R27

No disorders were found for PPP1R27 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PPP1R27 Gene

Publications for PPP1R27 Gene

  1. Docking motif-guided mapping of the interactome of protein phosphatase-1. (PMID: 19389623) Hendrickx A … Bollen M (Chemistry & biology 2009) 3 4 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K … Sugano S (Genome research 2006) 3 58
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 58
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 58

Products for PPP1R27 Gene

Sources for PPP1R27 Gene

Loading form....