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Aliases for PPP1R21 Gene

Aliases for PPP1R21 Gene

  • Protein Phosphatase 1 Regulatory Subunit 21 2 3 5
  • Coiled-Coil Domain-Containing Protein 128 3 4
  • Coiled-Coil Domain Containing 128 2 3
  • KLRAQ Motif-Containing Protein 1 3 4
  • KLRAQ Motif Containing 1 2 3
  • CCDC128 3 4
  • KLRAQ1 3 4
  • Protein Phosphatase 1, Regulatory Subunit 21 2

External Ids for PPP1R21 Gene

Previous HGNC Symbols for PPP1R21 Gene

  • CCDC128
  • KLRAQ1

Previous GeneCards Identifiers for PPP1R21 Gene

  • GC02P048670

Summaries for PPP1R21 Gene

GeneCards Summary for PPP1R21 Gene

PPP1R21 (Protein Phosphatase 1 Regulatory Subunit 21) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include phosphatase binding.

Additional gene information for PPP1R21 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PPP1R21 Gene

Genomics for PPP1R21 Gene

GeneHancer (GH) Regulatory Elements for PPP1R21 Gene

Promoters and enhancers for PPP1R21 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02I048439 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 570.9 +0.2 215 2.2 HDGF PKNOX1 ARNT ARID4B SIN3A DMAP1 YY1 POLR2B ZNF766 E2F8 PPP1R21 ENSG00000272663 GC02M048441 MSH6 RPL36AP15 RNU6-282P GTF2A1L PIR50991 GC02M048449 GC02P048370
GH02I048529 Promoter/Enhancer 2 EPDnew Ensembl ENCODE dbSUPER 32.1 +90.0 90012 3.2 INSM2 FEZF1 ZBTB40 ZNF48 ZNF335 GLIS2 ZNF302 EGR1 RCOR1 ZNF263 STON1 STON1-GTF2A1L PPP1R21 FOXN2 GTF2A1L GC02P048542
GH02I048311 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 24.1 -125.8 -125842 6.2 MLX ZFP64 DMAP1 YY1 SLC30A9 E2F8 ZNF143 SP3 NFYC GLIS1 FOXN2 LOC105374593 PPP1R21 STON1-GTF2A1L GTF2A1L GC02P048318
GH02I048507 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 33.6 +68.9 68854 3.3 PKNOX1 ATF1 FOXA2 ARID4B ETS1 TCF12 ZNF766 CBX5 REST ZNF592 PPP1R21 STON1-GTF2A1L MSH6 STON1 RNU6-282P GC02M048502
GH02I048419 Enhancer 1.4 Ensembl ENCODE dbSUPER 33.1 -19.9 -19929 1.6 FOXA2 ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 IRF4 SLC30A9 ZNF143 PPP1R21 FOXN2 STON1-GTF2A1L GTF2A1L ENSG00000272663 GC02M048388 GC02P048370
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around PPP1R21 on UCSC Golden Path with GeneCards custom track

Genomic Locations for PPP1R21 Gene

Genomic Locations for PPP1R21 Gene
74,795 bases
Plus strand

Genomic View for PPP1R21 Gene

Genes around PPP1R21 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PPP1R21 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PPP1R21 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PPP1R21 Gene

Proteins for PPP1R21 Gene

  • Protein details for PPP1R21 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein phosphatase 1 regulatory subunit 21
    Protein Accession:
    Secondary Accessions:
    • B7ZKY5
    • B7ZKY7
    • E1B6W7
    • Q2TA78
    • Q6ZMI6
    • Q8IW83
    • Q8J029
    • Q96ES8

    Protein attributes for PPP1R21 Gene

    780 amino acids
    Molecular mass:
    88314 Da
    Quaternary structure:
    • Interacts with PPP1CA.
    • Sequence=AAH11978.2; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAD18739.1; Type=Frameshift; Positions=115; Evidence={ECO:0000305};

    Alternative splice isoforms for PPP1R21 Gene


neXtProt entry for PPP1R21 Gene

Post-translational modifications for PPP1R21 Gene

No Post-translational modifications

No data available for DME Specific Peptides for PPP1R21 Gene

Domains & Families for PPP1R21 Gene

Gene Families for PPP1R21 Gene

Protein Domains for PPP1R21 Gene

Suggested Antigen Peptide Sequences for PPP1R21 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with PPP1R21: view

No data available for UniProtKB/Swiss-Prot for PPP1R21 Gene

Function for PPP1R21 Gene

Phenotypes From GWAS Catalog for PPP1R21 Gene

Gene Ontology (GO) - Molecular Function for PPP1R21 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0019902 phosphatase binding IDA --
genes like me logo Genes that share ontologies with PPP1R21: view

Phenotypes for PPP1R21 Gene

genes like me logo Genes that share phenotypes with PPP1R21: view

Animal Model Products

CRISPR Products

miRNA for PPP1R21 Gene

Inhibitory RNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PPP1R21 Gene

Localization for PPP1R21 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PPP1R21 gene
Compartment Confidence
nucleus 3
cytosol 3
mitochondrion 2

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for PPP1R21 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane HDA 19946888
genes like me logo Genes that share ontologies with PPP1R21: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for PPP1R21 Gene

Pathways & Interactions for PPP1R21 Gene

SuperPathways for PPP1R21 Gene

No Data Available

Gene Ontology (GO) - Biological Process for PPP1R21 Gene


No data available for Pathways by source and SIGNOR curated interactions for PPP1R21 Gene

Drugs & Compounds for PPP1R21 Gene

No Compound Related Data Available

Transcripts for PPP1R21 Gene

Unigene Clusters for PPP1R21 Gene

Protein phosphatase 1, regulatory subunit 21:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for PPP1R21 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a · 17b ^ 18 ^ 19a · 19b ^ 20 ^
SP1: - - -
SP2: - - - -
SP3: - -
SP5: -
SP7: -

ExUns: 21a · 21b ^ 22 ^ 23a · 23b ^ 24
SP1: -
SP2: -
SP7: -

Relevant External Links for PPP1R21 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PPP1R21 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PPP1R21 Gene

Protein differential expression in normal tissues from HIPED for PPP1R21 Gene

This gene is overexpressed in Lymph node (12.7) and Peripheral blood mononuclear cells (8.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for PPP1R21 Gene

Protein tissue co-expression partners for PPP1R21 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of PPP1R21 Gene:


SOURCE GeneReport for Unigene cluster for PPP1R21 Gene:


Evidence on tissue expression from TISSUES for PPP1R21 Gene

  • Nervous system(4.3)
  • Intestine(4.2)
genes like me logo Genes that share expression patterns with PPP1R21: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PPP1R21 Gene

Orthologs for PPP1R21 Gene

This gene was present in the common ancestor of animals.

Orthologs for PPP1R21 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia KLRAQ1 33 34
  • 99.74 (n)
(Bos Taurus)
Mammalia KLRAQ1 34
  • 95 (a)
PPP1R21 33
  • 91.58 (n)
(Canis familiaris)
Mammalia PPP1R21 33 34
  • 92.56 (n)
(Monodelphis domestica)
Mammalia PPP1R21 34
  • 89 (a)
(Rattus norvegicus)
Mammalia Ppp1r21 33
  • 87.56 (n)
(Mus musculus)
Mammalia Ppp1r21 33 16 34
  • 86.97 (n)
(Ornithorhynchus anatinus)
Mammalia PPP1R21 34
  • 60 (a)
(Gallus gallus)
Aves PPP1R21 33 34
  • 78.41 (n)
(Anolis carolinensis)
Reptilia PPP1R21 34
  • 80 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia ppp1r21 33
  • 71.56 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.14159 33
(Danio rerio)
Actinopterygii ppp1r21 33 34
  • 60.59 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG6607 34
  • 32 (a)
(Caenorhabditis elegans)
Secernentea F33E11.3 34
  • 25 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 43 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.7865 33
Species where no ortholog for PPP1R21 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PPP1R21 Gene

Gene Tree for PPP1R21 (if available)
Gene Tree for PPP1R21 (if available)

Paralogs for PPP1R21 Gene

No data available for Paralogs for PPP1R21 Gene

Variants for PPP1R21 Gene

Sequence variations from dbSNP and Humsavar for PPP1R21 Gene

SNP ID Clin Chr 02 pos Variation AA Info Type
rs1000011858 -- 48,515,073(+) A/G 3_prime_UTR_variant, non_coding_transcript_variant
rs1000047171 -- 48,501,288(+) T/G intron_variant
rs1000067848 -- 48,471,327(+) A/G coding_sequence_variant, missense_variant, non_coding_transcript_variant
rs1000075352 -- 48,503,299(+) T/G intron_variant
rs1000097345 -- 48,454,034(+) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for PPP1R21 Gene

Variant ID Type Subtype PubMed ID
nsv833981 CNV loss 17160897
nsv581775 CNV loss 21841781
esv3583787 CNV loss 25503493
esv2762252 CNV gain 21179565
esv2656842 CNV deletion 23128226
esv2548827 CNV deletion 19546169
esv1932167 CNV deletion 18987734
dgv1120e212 CNV loss 25503493

Variation tolerance for PPP1R21 Gene

Residual Variation Intolerance Score: 12.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.99; 49.76% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PPP1R21 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PPP1R21 Gene

Disorders for PPP1R21 Gene

Additional Disease Information for PPP1R21

No disorders were found for PPP1R21 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PPP1R21 Gene

Publications for PPP1R21 Gene

  1. Docking motif-guided mapping of the interactome of protein phosphatase-1. (PMID: 19389623) Hendrickx A … Bollen M (Chemistry & biology 2009) 3 4 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 58
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  5. Phospho-tyrosine dependent protein-protein interaction network. (PMID: 25814554) Grossmann A … Stelzl U (Molecular systems biology 2015) 3 58

Products for PPP1R21 Gene

Sources for PPP1R21 Gene

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