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Aliases for PPP1R2 Gene

Aliases for PPP1R2 Gene

  • Protein Phosphatase 1 Regulatory Inhibitor Subunit 2 2 3 5
  • IPP-2 3 4
  • IPP2 3 4
  • Protein Phosphatase 1, Regulatory (Inhibitor) Subunit 2 2
  • Protein Phosphatase Inhibitor 2 3
  • Phosphoprotein Phosphatase 3
  • PPP1R2A 3

External Ids for PPP1R2 Gene

Previous GeneCards Identifiers for PPP1R2 Gene

  • GC03M194496
  • GC03M198627
  • GC03M196641
  • GC03M196560
  • GC03M196722
  • GC03M195241

Summaries for PPP1R2 Gene

Entrez Gene Summary for PPP1R2 Gene

  • Protein phosphatase-1 (PP1) is one of the main eukaryotic serine/threonine phosphatases. The protein encoded by this gene binds to the catalytic subunit of PP1, strongly inhibiting its activity. Ten related pseudogenes have been found throughout the human genome. Several splice variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2015]

GeneCards Summary for PPP1R2 Gene

PPP1R2 (Protein Phosphatase 1 Regulatory Inhibitor Subunit 2) is a Protein Coding gene. Diseases associated with PPP1R2 include Cataract 11, Multiple Types and Epileptic Encephalopathy, Early Infantile, 6. Among its related pathways are Activation of cAMP-Dependent PKA and PEDF Induced Signaling. Gene Ontology (GO) annotations related to this gene include protein phosphatase inhibitor activity and protein serine/threonine phosphatase inhibitor activity. An important paralog of this gene is PPP1R2B.

UniProtKB/Swiss-Prot for PPP1R2 Gene

  • Inhibitor of protein-phosphatase 1.

Gene Wiki entry for PPP1R2 Gene

Additional gene information for PPP1R2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PPP1R2 Gene

Genomics for PPP1R2 Gene

GeneHancer (GH) Regulatory Elements for PPP1R2 Gene

Promoters and enhancers for PPP1R2 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03J195538 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE dbSUPER 672.3 +1.2 1244 6.4 PKNOX1 ARID4B NEUROD1 SIN3A FEZF1 DMAP1 ZNF2 ZBTB7B YY1 POLR2B ENSG00000223711 PPP1R2 LSG1 UBXN7 SDHAP1 ACAP2 APOD MUC20-OT1 RNF168 RPL24P6
GH03J195547 Enhancer 1.3 Ensembl ENCODE dbSUPER 30.2 -6.8 -6765 4.7 HDGF FOXA2 MLX DMAP1 SLC30A9 ATF7 RUNX3 NFKBIZ SP5 PPARG ENSG00000223711 PPP1R2 MUC4 APOD RPL24P6 ENSG00000271662 RN7SL73P
GH03J195545 Enhancer 1.2 Ensembl ENCODE dbSUPER 32 -3.0 -2964 1.5 HDAC1 FEZF1 BATF RFX5 ZNF335 TCF12 ELK1 ZFP91 RCOR1 FOS ENSG00000223711 PPP1R2 RN7SL73P
GH03J195537 Enhancer 1.3 FANTOM5 Ensembl ENCODE dbSUPER 28.2 +5.2 5153 1 EBF1 IRF4 RELA EED ATF7 IKZF2 RUNX3 CREM SRF NR2F1 PPP1R2 ENSG00000223711 ACAP2 APOD RPL24P6 TNK2 RNU6ATAC24P
GH03J195557 Enhancer 0.9 Ensembl ENCODE 26.3 -14.9 -14932 2.6 SCRT1 SMARCA5 ELF3 MEIS2 CTCF ZNF654 TRIM22 REST EBF1 RAD21 PPP1R2 APOD ENSG00000223711 MUC4 GC03P195555 ENSG00000236425
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PPP1R2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the PPP1R2 gene promoter:
  • PPAR-gamma2
  • PPAR-gamma1
  • C/EBPbeta
  • Max
  • c-Myc
  • E2F-1
  • E2F
  • HTF
  • SRF
  • SRF (504 AA)

Genomic Locations for PPP1R2 Gene

Genomic Locations for PPP1R2 Gene
28,980 bases
Minus strand
29,004 bases
Minus strand

Genomic View for PPP1R2 Gene

Genes around PPP1R2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PPP1R2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PPP1R2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PPP1R2 Gene

Proteins for PPP1R2 Gene

  • Protein details for PPP1R2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein phosphatase inhibitor 2
    Protein Accession:

    Protein attributes for PPP1R2 Gene

    205 amino acids
    Molecular mass:
    23015 Da
    Quaternary structure:
    • Heterodimer with PP1.

neXtProt entry for PPP1R2 Gene

Post-translational modifications for PPP1R2 Gene

  • Phosphorylation on Thr-73 by GSK3 activates PP1 by dissociating the PP1-PPP1R2 complex (By similarity). Phosphorylation on Ser-44 by ATM activates PP1 by dissociating the PP1-PPP1R2 complex.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for PPP1R2 Gene

Domains & Families for PPP1R2 Gene

Gene Families for PPP1R2 Gene

Protein Domains for PPP1R2 Gene

Suggested Antigen Peptide Sequences for PPP1R2 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the protein phosphatase inhibitor 2 family.
  • Belongs to the protein phosphatase inhibitor 2 family.
genes like me logo Genes that share domains with PPP1R2: view

Function for PPP1R2 Gene

Molecular function for PPP1R2 Gene

UniProtKB/Swiss-Prot Function:
Inhibitor of protein-phosphatase 1.
GENATLAS Biochemistry:
protein phosphatase 1,regulatory (inhibitor) subunit 2,IPP-2 related sequence

Phenotypes From GWAS Catalog for PPP1R2 Gene

Gene Ontology (GO) - Molecular Function for PPP1R2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004864 protein phosphatase inhibitor activity IEA,IBA --
GO:0004865 protein serine/threonine phosphatase inhibitor activity TAS 8119416
GO:0005515 protein binding IPI 10807923
genes like me logo Genes that share ontologies with PPP1R2: view
genes like me logo Genes that share phenotypes with PPP1R2: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PPP1R2 Gene

Localization for PPP1R2 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PPP1R2 gene
Compartment Confidence
nucleus 5
cytosol 5
mitochondrion 1
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for PPP1R2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000164 protein phosphatase type 1 complex IBA --
genes like me logo Genes that share ontologies with PPP1R2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for PPP1R2 Gene

Pathways & Interactions for PPP1R2 Gene

genes like me logo Genes that share pathways with PPP1R2: view

Pathways by source for PPP1R2 Gene

SIGNOR curated interactions for PPP1R2 Gene

Is activated by:
Is inactivated by:
Other effect:

Gene Ontology (GO) - Biological Process for PPP1R2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005975 carbohydrate metabolic process IEA --
GO:0005977 glycogen metabolic process IEA --
GO:0006091 generation of precursor metabolites and energy TAS 9126490
GO:0009966 regulation of signal transduction IEA --
GO:0032515 negative regulation of phosphoprotein phosphatase activity IEA --
genes like me logo Genes that share ontologies with PPP1R2: view

Drugs & Compounds for PPP1R2 Gene

No Compound Related Data Available

Transcripts for PPP1R2 Gene

Unigene Clusters for PPP1R2 Gene

Protein phosphatase 1, regulatory (inhibitor) subunit 2:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for PPP1R2 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b · 5c
SP2: -
SP3: -

Relevant External Links for PPP1R2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PPP1R2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PPP1R2 Gene

Protein differential expression in normal tissues from HIPED for PPP1R2 Gene

This gene is overexpressed in Lymph node (11.0) and Uterus (8.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for PPP1R2 Gene

NURSA nuclear receptor signaling pathways regulating expression of PPP1R2 Gene:


SOURCE GeneReport for Unigene cluster for PPP1R2 Gene:


Evidence on tissue expression from TISSUES for PPP1R2 Gene

  • Heart(4.2)
  • Skin(4.2)
  • Nervous system(4.2)
  • Blood(4.1)
  • Muscle(2.5)
  • Lung(2.2)
genes like me logo Genes that share expression patterns with PPP1R2: view

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PPP1R2 Gene

Orthologs for PPP1R2 Gene

This gene was present in the common ancestor of animals.

Orthologs for PPP1R2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia PPP1R2 34 33
  • 99.51 (n)
(Bos Taurus)
Mammalia PPP1R2 34 33
  • 88.78 (n)
(Canis familiaris)
Mammalia PPP1R2 34 33
  • 88.62 (n)
(Rattus norvegicus)
Mammalia Ppp1r2 33
  • 86.83 (n)
(Mus musculus)
Mammalia Ppp1r2 16 34 33
  • 85.69 (n)
(Ornithorhynchus anatinus)
Mammalia PPP1R2 34
  • 74 (a)
(Monodelphis domestica)
Mammalia -- 34
  • 64 (a)
-- 34
  • 64 (a)
(Gallus gallus)
Aves PPP1R2 34 33
  • 70.86 (n)
(Anolis carolinensis)
Reptilia PPP1R2 34
  • 57 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia ppp1r2 33
  • 66.26 (n)
(Danio rerio)
Actinopterygii ppp1r2 34 33
  • 62.61 (n)
Dr.19508 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.5774 33
fruit fly
(Drosophila melanogaster)
Insecta I-2 34
  • 22 (a)
CG6380 34
  • 18 (a)
(Caenorhabditis elegans)
Secernentea Y32H12A.4 34
  • 35 (a)
Species where no ortholog for PPP1R2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PPP1R2 Gene

Gene Tree for PPP1R2 (if available)
Gene Tree for PPP1R2 (if available)
Evolutionary constrained regions (ECRs) for PPP1R2: view image

Paralogs for PPP1R2 Gene

Paralogs for PPP1R2 Gene

(3) SIMAP similar genes for PPP1R2 Gene using alignment to 5 proteins:

  • H7C416_HUMAN
genes like me logo Genes that share paralogs with PPP1R2: view

Variants for PPP1R2 Gene

Sequence variations from dbSNP and Humsavar for PPP1R2 Gene

SNP ID Clin Chr 03 pos Variation AA Info Type
rs1000005546 -- 195,534,291(-) G/A intron_variant
rs1000068595 -- 195,537,145(-) T/C intron_variant
rs1000124958 -- 195,534,261(-) C/T intron_variant
rs1000154657 -- 195,540,260(-) C/T intron_variant
rs1000239918 -- 195,517,180(-) T/G genic_downstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for PPP1R2 Gene

Variant ID Type Subtype PubMed ID
dgv5014n100 CNV gain 25217958
dgv5015n100 CNV loss 25217958
esv2759213 CNV gain+loss 17122850
esv2763776 CNV gain+loss 21179565
nsv1001387 CNV gain 25217958
nsv1006229 CNV gain 25217958
nsv428430 CNV gain+loss 18775914
nsv829824 CNV loss 17160897
nsv963395 CNV duplication 23825009

Variation tolerance for PPP1R2 Gene

Residual Variation Intolerance Score: 64% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.89; 18.62% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PPP1R2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PPP1R2 Gene

Disorders for PPP1R2 Gene

MalaCards: The human disease database

(3) MalaCards diseases for PPP1R2 Gene - From: DISEASES

Disorder Aliases PubMed IDs
cataract 11, multiple types
  • ctrct11
epileptic encephalopathy, early infantile, 6
  • ds
congenital stationary night blindness
  • congenital essential nyctalopia
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for PPP1R2

genes like me logo Genes that share disorders with PPP1R2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PPP1R2 Gene

Publications for PPP1R2 Gene

  1. Cloning of the complete coding region for human protein phosphatase inhibitor 2 using the two hybrid system and expression of inhibitor 2 in E. coli. (PMID: 8119416) Helps NR … Cohen PT (FEBS letters 1994) 2 3 4 22 58
  2. Genetic analysis of human type 1 protein phosphatase inhibitor 2 in insulin-resistant Pima Indians. (PMID: 9126490) Permana PA … Mott DM (Genomics 1997) 2 3 4 58
  3. Identification and characterization of two distinct PPP1R2 isoforms in human spermatozoa. (PMID: 23506001) Korrodi-Gregório L … da Cruz E Silva EF (BMC cell biology 2013) 3 4 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. (PMID: 12665801) Gevaert K … Vandekerckhove J (Nature biotechnology 2003) 3 4 58

Products for PPP1R2 Gene

Sources for PPP1R2 Gene

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