Protein phosphatase-1 (PP1) is one of the main eukaryotic serine/threonine phosphatases. The protein encoded by this gene binds to the catalytic subunit of PP1, strongly inhibiting its activity. Ten related pseudogenes have been found throughout the human genome. Several splice variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2015] See more...

Aliases for PPP1R2 Gene

Aliases for PPP1R2 Gene

  • Protein Phosphatase 1 Regulatory Inhibitor Subunit 2 2 3 5
  • IPP2 2 3 4
  • Protein Phosphatase Inhibitor 2 3 4
  • PPP1R2A 2 3
  • IPP-2 3 4
  • Protein Phosphatase 1, Regulatory (Inhibitor) Subunit 2 2
  • Phosphoprotein Phosphatase 3
  • PPP1R2 5

External Ids for PPP1R2 Gene

Previous GeneCards Identifiers for PPP1R2 Gene

  • GC03M194496
  • GC03M198627
  • GC03M196641
  • GC03M196560
  • GC03M196722
  • GC03M195241

Summaries for PPP1R2 Gene

Entrez Gene Summary for PPP1R2 Gene

  • Protein phosphatase-1 (PP1) is one of the main eukaryotic serine/threonine phosphatases. The protein encoded by this gene binds to the catalytic subunit of PP1, strongly inhibiting its activity. Ten related pseudogenes have been found throughout the human genome. Several splice variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2015]

GeneCards Summary for PPP1R2 Gene

PPP1R2 (Protein Phosphatase 1 Regulatory Inhibitor Subunit 2) is a Protein Coding gene. Diseases associated with PPP1R2 include Pneumoconiosis Due To Talc and Cataract 11, Multiple Types. Among its related pathways are Beta-Adrenergic Signaling and Apoptotic Pathways in Synovial Fibroblasts. Gene Ontology (GO) annotations related to this gene include protein phosphatase inhibitor activity and protein serine/threonine phosphatase inhibitor activity. An important paralog of this gene is PPP1R2B.

UniProtKB/Swiss-Prot Summary for PPP1R2 Gene

Gene Wiki entry for PPP1R2 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PPP1R2 Gene

Genomics for PPP1R2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for PPP1R2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PPP1R2 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for PPP1R2

Top Transcription factor binding sites by QIAGEN in the PPP1R2 gene promoter:
  • c-Myc
  • C/EBPbeta
  • E2F
  • E2F-1
  • HTF
  • Max
  • PPAR-gamma1
  • PPAR-gamma2
  • SRF
  • SRF (504 AA)

Genomic Locations for PPP1R2 Gene

Latest Assembly
chr3:195,514,428-195,543,386
(GRCh38/hg38)
Size:
28,959 bases
Orientation:
Minus strand

Previous Assembly
chr3:195,241,224-195,270,148
(GRCh37/hg19 by Entrez Gene)
Size:
28,925 bases
Orientation:
Minus strand

chr3:195,241,221-195,270,209
(GRCh37/hg19 by Ensembl)
Size:
28,989 bases
Orientation:
Minus strand

Genomic View for PPP1R2 Gene

Genes around PPP1R2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PPP1R2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PPP1R2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PPP1R2 Gene

Proteins for PPP1R2 Gene

  • Protein details for PPP1R2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P41236-IPP2_HUMAN
    Recommended name:
    Protein phosphatase inhibitor 2
    Protein Accession:
    P41236

    Protein attributes for PPP1R2 Gene

    Size:
    205 amino acids
    Molecular mass:
    23015 Da
    Quaternary structure:
    • Heterodimer with PP1.

neXtProt entry for PPP1R2 Gene

Post-translational modifications for PPP1R2 Gene

  • Phosphorylation on Thr-73 by GSK3 activates PP1 by dissociating the PP1-PPP1R2 complex (By similarity). Phosphorylation on Ser-44 by ATM activates PP1 by dissociating the PP1-PPP1R2 complex.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for PPP1R2 Gene

Domains & Families for PPP1R2 Gene

Gene Families for PPP1R2 Gene

Protein Domains for PPP1R2 Gene

InterPro:
Blocks:
  • Protein phosphatase inhibitor 2 (IPP-2)

Suggested Antigen Peptide Sequences for PPP1R2 Gene

GenScript: Design optimal peptide antigens:
  • Protein phosphatase inhibitor 2 (IPP2_HUMAN)
  • PPP1R2 protein (Q6NXS2_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P41236

UniProtKB/Swiss-Prot:

IPP2_HUMAN :
  • Belongs to the protein phosphatase inhibitor 2 family.
Family:
  • Belongs to the protein phosphatase inhibitor 2 family.
genes like me logo Genes that share domains with PPP1R2: view

Function for PPP1R2 Gene

Molecular function for PPP1R2 Gene

UniProtKB/Swiss-Prot Function:
Inhibitor of protein-phosphatase 1.
GENATLAS Biochemistry:
protein phosphatase 1,regulatory (inhibitor) subunit 2,IPP-2 related sequence

Phenotypes From GWAS Catalog for PPP1R2 Gene

Gene Ontology (GO) - Molecular Function for PPP1R2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004864 protein phosphatase inhibitor activity IEA,IBA 21873635
GO:0004865 protein serine/threonine phosphatase inhibitor activity TAS 8119416
GO:0005515 protein binding IPI 10807923
genes like me logo Genes that share ontologies with PPP1R2: view
genes like me logo Genes that share phenotypes with PPP1R2: view

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PPP1R2

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PPP1R2 Gene

Localization for PPP1R2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PPP1R2 gene
Compartment Confidence
nucleus 3
cytosol 3
mitochondrion 2
plasma membrane 1
extracellular 1
cytoskeleton 1
peroxisome 0

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoplasm (2)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for PPP1R2 Gene

Pathways & Interactions for PPP1R2 Gene

PathCards logo

SuperPathways for PPP1R2 Gene

SuperPathway Contained pathways
1 Activation of cAMP-Dependent PKA
.77
.77
.71
.56
2 Beta-Adrenergic Signaling
.37
.37
.37
.36
3 mTOR Pathway
4 GPCR Pathway
.58
5 Dopamine-DARPP32 Feedback onto cAMP Pathway
-
genes like me logo Genes that share pathways with PPP1R2: view

Pathways by source for PPP1R2 Gene

1 Tocris pathway for PPP1R2 Gene
14 Qiagen pathways for PPP1R2 Gene
  • Activation of cAMP-Dependent PKA
  • Activation of PKA through GPCR
  • Beta-Adrenergic Signaling
  • Breast Cancer Regulation by Stathmin1
  • cAMP Pathway

SIGNOR curated interactions for PPP1R2 Gene

Inactivates:
Is activated by:
Is inactivated by:
Other effect:

Gene Ontology (GO) - Biological Process for PPP1R2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005975 carbohydrate metabolic process IEA --
GO:0005977 glycogen metabolic process IEA --
GO:0006091 generation of precursor metabolites and energy TAS 9126490
GO:0009966 regulation of signal transduction IEA --
GO:0032515 negative regulation of phosphoprotein phosphatase activity IEA --
genes like me logo Genes that share ontologies with PPP1R2: view

Drugs & Compounds for PPP1R2 Gene

No Compound Related Data Available

Transcripts for PPP1R2 Gene

mRNA/cDNA for PPP1R2 Gene

4 REFSEQ mRNAs :
11 NCBI additional mRNA sequence :
7 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PPP1R2

Alternative Splicing Database (ASD) splice patterns (SP) for PPP1R2 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b · 5c
SP1:
SP2: -
SP3: -

Relevant External Links for PPP1R2 Gene

GeneLoc Exon Structure for
PPP1R2

Expression for PPP1R2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PPP1R2 Gene

Protein differential expression in normal tissues from HIPED for PPP1R2 Gene

This gene is overexpressed in Lymph node (11.0) and Uterus (8.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for PPP1R2 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for PPP1R2

SOURCE GeneReport for Unigene cluster for PPP1R2 Gene:

Hs.535731

Evidence on tissue expression from TISSUES for PPP1R2 Gene

  • Heart(4.3)
  • Nervous system(4.3)
  • Skin(4.3)
  • Blood(4.3)
  • Muscle(2.4)
  • Lung(2.2)
  • Kidney(2.2)
genes like me logo Genes that share expression patterns with PPP1R2: view

Primer products for research

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PPP1R2 Gene

Orthologs for PPP1R2 Gene

This gene was present in the common ancestor of animals.

Orthologs for PPP1R2 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia PPP1R2 29 30
  • 99.51 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia PPP1R2 29 30
  • 88.78 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia PPP1R2 29 30
  • 88.62 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Ppp1r2 29
  • 86.83 (n)
Mouse
(Mus musculus)
Mammalia Ppp1r2 29 16 30
  • 85.69 (n)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia PPP1R2 30
  • 74 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia -- 30
  • 64 (a)
OneToMany
-- 30
  • 64 (a)
OneToMany
Chicken
(Gallus gallus)
Aves PPP1R2 29 30
  • 70.86 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia PPP1R2 30
  • 57 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia ppp1r2 29
  • 66.26 (n)
Zebrafish
(Danio rerio)
Actinopterygii ppp1r2 29 30
  • 62.61 (n)
OneToOne
Dr.19508 29
Rainbow Trout
(Oncorhynchus mykiss)
Actinopterygii Omy.5774 29
Fruit Fly
(Drosophila melanogaster)
Insecta I-2 30
  • 22 (a)
OneToMany
CG6380 30
  • 18 (a)
OneToMany
Worm
(Caenorhabditis elegans)
Secernentea Y32H12A.4 30
  • 35 (a)
OneToOne
Species where no ortholog for PPP1R2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for PPP1R2 Gene

ENSEMBL:
Gene Tree for PPP1R2 (if available)
TreeFam:
Gene Tree for PPP1R2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for PPP1R2: view image
Alliance of Genome Resources:
Additional Orthologs for PPP1R2

Paralogs for PPP1R2 Gene

Paralogs for PPP1R2 Gene

(3) SIMAP similar genes for PPP1R2 Gene using alignment to 5 proteins:

  • IPP2_HUMAN
  • E7EMN6_HUMAN
  • E7EUI7_HUMAN
  • H7C416_HUMAN
  • Q6NXS2_HUMAN
genes like me logo Genes that share paralogs with PPP1R2: view

Variants for PPP1R2 Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for PPP1R2 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for PPP1R2 Gene

Variant ID Type Subtype PubMed ID
dgv5014n100 CNV gain 25217958
dgv5015n100 CNV loss 25217958
esv2759213 CNV gain+loss 17122850
esv2763776 CNV gain+loss 21179565
nsv1001387 CNV gain 25217958
nsv1006229 CNV gain 25217958
nsv428430 CNV gain+loss 18775914
nsv829824 CNV loss 17160897
nsv963395 CNV duplication 23825009

Variation tolerance for PPP1R2 Gene

Residual Variation Intolerance Score: 64% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.89; 18.62% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PPP1R2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PPP1R2
Leiden Open Variation Database (LOVD)
PPP1R2

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for PPP1R2 Gene

Disorders for PPP1R2 Gene

MalaCards: The human disease database

(5) MalaCards diseases for PPP1R2 Gene - From: COP

Disorder Aliases PubMed IDs
pneumoconiosis due to talc
  • talc pneumoconiosis
cataract 11, multiple types
  • ctrct11
pseudobulbar palsy
  • pseudobulbar paralysis
spinal muscular atrophy, type ii
  • sma2
spinal muscular atrophy, type iii
  • sma3
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for PPP1R2

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with PPP1R2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PPP1R2 Gene

Publications for PPP1R2 Gene

  1. Cloning of the complete coding region for human protein phosphatase inhibitor 2 using the two hybrid system and expression of inhibitor 2 in E. coli. (PMID: 8119416) Helps NR … Cohen PT (FEBS letters 1994) 2 3 4 22
  2. Genetic analysis of human type 1 protein phosphatase inhibitor 2 in insulin-resistant Pima Indians. (PMID: 9126490) Permana PA … Mott DM (Genomics 1997) 2 3 4
  3. Identification and characterization of two distinct PPP1R2 isoforms in human spermatozoa. (PMID: 23506001) Korrodi-Gregório L … da Cruz E Silva EF (BMC cell biology 2013) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  5. Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. (PMID: 12665801) Gevaert K … Vandekerckhove J (Nature biotechnology 2003) 3 4

Products for PPP1R2 Gene

Sources for PPP1R2 Gene