Protein phosphatase-1 (PP1) is a major serine/threonine phosphatase that regulates a variety of cellular functions. PP1 consists of a catalytic subunit (see PPP1CA; MIM 176875) and regulatory subunits that determine the subcellular localization of PP1 or regulate its function. PPP1R1C belongs to a group of PP1 inhibitory subunits that are themselves regulated by phosphorylation... See more...

Aliases for PPP1R1C Gene

Aliases for PPP1R1C Gene

  • Protein Phosphatase 1 Regulatory Inhibitor Subunit 1C 2 3 5
  • Protein Phosphatase 1 Regulatory Subunit 1C 3 4
  • Inhibitor-5 Of Protein Phosphatase 1 3 4
  • IPP5 3 4
  • Protein Phosphatase 1, Regulatory (Inhibitor) Subunit 1C 2
  • Protein Phosphatase 1 Regulatory Subunit 1A 3
  • PP1 Inhibitor Protein 5 3
  • Inhibitor-1-Like 2
  • PPP1R1C 5

External Ids for PPP1R1C Gene

Previous GeneCards Identifiers for PPP1R1C Gene

  • GC00U991021
  • GC02P182676
  • GC02P182558
  • GC02P182818
  • GC02P174706

Summaries for PPP1R1C Gene

Entrez Gene Summary for PPP1R1C Gene

  • Protein phosphatase-1 (PP1) is a major serine/threonine phosphatase that regulates a variety of cellular functions. PP1 consists of a catalytic subunit (see PPP1CA; MIM 176875) and regulatory subunits that determine the subcellular localization of PP1 or regulate its function. PPP1R1C belongs to a group of PP1 inhibitory subunits that are themselves regulated by phosphorylation (Wang et al., 2008 [PubMed 18310074]).[supplied by OMIM, Feb 2010]

GeneCards Summary for PPP1R1C Gene

PPP1R1C (Protein Phosphatase 1 Regulatory Inhibitor Subunit 1C) is a Protein Coding gene. Diseases associated with PPP1R1C include Conduct Disorder. Among its related pathways are mTOR Pathway. Gene Ontology (GO) annotations related to this gene include protein phosphatase inhibitor activity and protein serine/threonine phosphatase inhibitor activity. An important paralog of this gene is PPP1R1A.

UniProtKB/Swiss-Prot Summary for PPP1R1C Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PPP1R1C Gene

Genomics for PPP1R1C Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for PPP1R1C Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02J181952 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 250.7 -0.1 -141 3.4 JUND YY1 CTCF TRIM22 EP300 ZNF623 NBN CUX1 SMC3 STAT3 PPP1R1C DNAJC10 lnc-PPP1R1C-2 ITPRID2
GH02J181985 Promoter 0.7 EPDnew Ensembl 261.7 +31.9 31859 0.6 PPP1R1C KRT18P29 piR-61532-158 PDE1A
GH02J181889 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 10.7 -58.6 -58612 11.7 BCLAF1 ZNF207 MYC ZNF592 CEBPA ZSCAN16 ZIC2 YY1 MXD4 NONO ITPRID2 PPP1R1C ENSG00000260742 lnc-PPP1R1C-2
GH02J182066 Enhancer 0.9 Ensembl ENCODE 21.6 +113.7 113660 3.4 JUND CEBPB ZEB1 ZNF217 EP300 CTBP1 MAFF ZNF316 MAFK GATA3 PPP1R1C HSALNG0020810 HSALNG0020811 PDE1A
GH02J182077 Enhancer 1 Ensembl ENCODE 15.7 +123.3 123283 1.4 ZNF654 ATF3 BRCA1 YY1 REST CEBPB FEZF1 CTCF ZNF217 EP300 PPP1R1C RNU6ATAC19P HSALNG0020810 HSALNG0020811 PDE1A
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PPP1R1C on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for PPP1R1C

Top Transcription factor binding sites by QIAGEN in the PPP1R1C gene promoter:
  • Bach2
  • C/EBPalpha
  • FOXD3
  • Pax-4a
  • Pbx1a
  • POU2F1
  • POU2F1a
  • POU2F1b
  • ZID

Genomic Locations for PPP1R1C Gene

Latest Assembly
chr2:181,954,241-182,131,398
(GRCh38/hg38)
Size:
177,158 bases
Orientation:
Plus strand

Previous Assembly
chr2:182,819,207-182,996,112
(GRCh37/hg19 by Entrez Gene)
Size:
176,906 bases
Orientation:
Plus strand

chr2:182,818,968-182,996,125
(GRCh37/hg19 by Ensembl)
Size:
177,158 bases
Orientation:
Plus strand

Genomic View for PPP1R1C Gene

Genes around PPP1R1C on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PPP1R1C Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PPP1R1C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PPP1R1C Gene

Proteins for PPP1R1C Gene

  • Protein details for PPP1R1C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WVI7-PPR1C_HUMAN
    Recommended name:
    Protein phosphatase 1 regulatory subunit 1C
    Protein Accession:
    Q8WVI7
    Secondary Accessions:
    • Q5HYJ5
    • Q8TD54

    Protein attributes for PPP1R1C Gene

    Size:
    109 amino acids
    Molecular mass:
    12346 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for PPP1R1C Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PPP1R1C Gene

Post-translational modifications for PPP1R1C Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PPP1R1C Gene

No data available for DME Specific Peptides for PPP1R1C Gene

Domains & Families for PPP1R1C Gene

Gene Families for PPP1R1C Gene

Protein Domains for PPP1R1C Gene

InterPro:
Blocks:
  • Protein phosphatase inhibitor, 1DARPP-32

Suggested Antigen Peptide Sequences for PPP1R1C Gene

GenScript: Design optimal peptide antigens:
  • Protein phosphatase 1 regulatory subunit 1C (PPR1C_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8WVI7

UniProtKB/Swiss-Prot:

PPR1C_HUMAN :
  • Belongs to the protein phosphatase inhibitor 1 family.
Family:
  • Belongs to the protein phosphatase inhibitor 1 family.
genes like me logo Genes that share domains with PPP1R1C: view

Function for PPP1R1C Gene

Molecular function for PPP1R1C Gene

UniProtKB/Swiss-Prot Function:
May increase cell susceptibility to TNF-induced apoptosis.

Phenotypes From GWAS Catalog for PPP1R1C Gene

Gene Ontology (GO) - Molecular Function for PPP1R1C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004864 protein phosphatase inhibitor activity IEA --
GO:0005515 protein binding IPI 32296183
genes like me logo Genes that share ontologies with PPP1R1C: view
genes like me logo Genes that share phenotypes with PPP1R1C: view

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PPP1R1C

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PPP1R1C Gene

Localization for PPP1R1C Gene

Subcellular locations from UniProtKB/Swiss-Prot for PPP1R1C Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PPP1R1C gene
Compartment Confidence
nucleus 2
cytosol 2
extracellular 1
cytoskeleton 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (2)
  • Nucleoli (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for PPP1R1C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA 21873635
genes like me logo Genes that share ontologies with PPP1R1C: view

Pathways & Interactions for PPP1R1C Gene

PathCards logo

SuperPathways for PPP1R1C Gene

SuperPathway Contained pathways
1 mTOR Pathway
genes like me logo Genes that share pathways with PPP1R1C: view

Pathways by source for PPP1R1C Gene

1 Tocris pathway for PPP1R1C Gene

Interacting Proteins for PPP1R1C Gene

STRING Interaction Network Preview (showing top 2 STRING interactants - click image to see details)
STRING Interaction Network
Selected Interacting proteins: Q8WVI7-PPR1C_HUMAN ENSP00000280295 for PPP1R1C Gene via UniProtKB STRING

Gene Ontology (GO) - Biological Process for PPP1R1C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007049 cell cycle IEA --
GO:0007165 signal transduction IEA --
GO:0032515 negative regulation of phosphoprotein phosphatase activity IEA --
GO:0035556 intracellular signal transduction IBA 21873635
GO:0051301 cell division IEA --
genes like me logo Genes that share ontologies with PPP1R1C: view

No data available for SIGNOR curated interactions for PPP1R1C Gene

Drugs & Compounds for PPP1R1C Gene

No Compound Related Data Available

Transcripts for PPP1R1C Gene

mRNA/cDNA for PPP1R1C Gene

3 REFSEQ mRNAs :
8 NCBI additional mRNA sequence :
12 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PPP1R1C

Alternative Splicing Database (ASD) splice patterns (SP) for PPP1R1C Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6
SP1: - - -
SP2: - -
SP3: - -
SP4:
SP5: - - -

Relevant External Links for PPP1R1C Gene

GeneLoc Exon Structure for
PPP1R1C

Expression for PPP1R1C Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PPP1R1C Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PPP1R1C Gene

This gene is overexpressed in Heart - Left Ventricle (x12.9), Testis (x10.0), and Heart - Atrial Appendage (x4.3).

Protein differential expression in normal tissues from HIPED for PPP1R1C Gene

This gene is overexpressed in Heart (46.3) and Testis (17.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for PPP1R1C Gene



Protein tissue co-expression partners for PPP1R1C Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for PPP1R1C

SOURCE GeneReport for Unigene cluster for PPP1R1C Gene:

Hs.10941

Evidence on tissue expression from TISSUES for PPP1R1C Gene

  • Heart(4.3)
  • Muscle(4.3)
genes like me logo Genes that share expression patterns with PPP1R1C: view

Primer products for research

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PPP1R1C Gene

Orthologs for PPP1R1C Gene

This gene was present in the common ancestor of chordates.

Orthologs for PPP1R1C Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia PPP1R1C 29 30
  • 99.14 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia PPP1R1C 29 30
  • 91.74 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia PPP1R1C 29 30
  • 91.13 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Ppp1r1c 29
  • 89.2 (n)
Mouse
(Mus musculus)
Mammalia Ppp1r1c 29 16 30
  • 88.27 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia PPP1R1C 30
  • 87 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia PPP1R1C 30
  • 81 (a)
OneToOne
Chicken
(Gallus gallus)
Aves PPP1R1C 29 30
  • 77.3 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia PPP1R1C 30
  • 75 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia ppp1r1c 29
  • 73.52 (n)
Zebrafish
(Danio rerio)
Actinopterygii ppp1r1c 29 30
  • 68.78 (n)
OneToOne
Species where no ortholog for PPP1R1C was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for PPP1R1C Gene

ENSEMBL:
Gene Tree for PPP1R1C (if available)
TreeFam:
Gene Tree for PPP1R1C (if available)
Aminode:
Evolutionary constrained regions (ECRs) for PPP1R1C: view image
Alliance of Genome Resources:
Additional Orthologs for PPP1R1C

Paralogs for PPP1R1C Gene

Paralogs for PPP1R1C Gene

(3) SIMAP similar genes for PPP1R1C Gene using alignment to 1 proteins:

  • PPR1C_HUMAN
genes like me logo Genes that share paralogs with PPP1R1C: view

Variants for PPP1R1C Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for PPP1R1C Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for PPP1R1C Gene

Variant ID Type Subtype PubMed ID
dgv2107n106 CNV deletion 24896259
dgv681n67 CNV loss 20364138
esv2404437 CNV deletion 18987734
esv24195 CNV loss 19812545
esv2527716 CNV deletion 19546169
esv2659935 CNV deletion 23128226
esv2721208 CNV deletion 23290073
esv3307449 CNV mobile element insertion 20981092
esv3377895 CNV insertion 20981092
esv3560645 CNV deletion 23714750
esv3593549 CNV loss 21293372
esv3593550 CNV gain 21293372
esv3593555 CNV loss 21293372
esv3593557 CNV loss 21293372
esv3593558 CNV loss 21293372
esv3593559 CNV gain 21293372
esv3893515 CNV gain 25118596
nsv1072469 CNV deletion 25765185
nsv583911 CNV loss 21841781
nsv583912 CNV loss 21841781
nsv819374 CNV loss 19587683
nsv834478 CNV gain 17160897
nsv834479 CNV gain 17160897
nsv954714 CNV deletion 24416366
nsv963753 CNV duplication 23825009

Variation tolerance for PPP1R1C Gene

Residual Variation Intolerance Score: 56.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.70; 14.83% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PPP1R1C Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PPP1R1C
Leiden Open Variation Database (LOVD)
PPP1R1C

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for PPP1R1C Gene

Disorders for PPP1R1C Gene

MalaCards: The human disease database

(1) MalaCards diseases for PPP1R1C Gene - From: COP and GCD

Disorder Aliases PubMed IDs
conduct disorder
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for PPP1R1C

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with PPP1R1C: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PPP1R1C Gene

Publications for PPP1R1C Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 40
  2. Evidence for genes on chromosome 2 contributing to alcohol dependence with conduct disorder and suicide attempts. (PMID: 20468071) Dick DM … Bierut L (American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2010) 3 40
  3. Effect of IPP5, a novel inhibitor of PP1, on apoptosis and the underlying mechanisms involved. (PMID: 19874272) Zeng Q … Zhang H (Biotechnology and applied biochemistry 2009) 3 4
  4. Regulator-driven functional diversification of protein phosphatase-1 in eukaryotic evolution. (PMID: 11948623) Ceulemans H … Bollen M (BioEssays : news and reviews in molecular, cellular and developmental biology 2002) 2 3
  5. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3

Products for PPP1R1C Gene

Sources for PPP1R1C Gene