This gene encodes a bifunctional signal transduction molecule. Dopaminergic and glutamatergic receptor stimulation regulates its phosphorylation and function as a kinase or phosphatase inhibitor. As a target for dopamine, this gene may serve as a therapeutic target for neurologic and psychiatric disorders. Multiple transcript variants encoding different isoforms have been found... See more...

Aliases for PPP1R1B Gene

Aliases for PPP1R1B Gene

  • Protein Phosphatase 1 Regulatory Inhibitor Subunit 1B 2 3 5
  • DARPP-32 2 3 4
  • Protein Phosphatase 1 Regulatory Subunit 1B 3 4
  • DARPP32 3 4
  • Protein Phosphatase 1, Regulatory (Inhibitor) Subunit 1B 2
  • Dopamine And CAMP-Regulated Neuronal Phosphoprotein 32 3
  • Dopamine- And CAMP-Regulated Neuronal Phosphoprotein 4
  • Dopamine And CAMP Regulated Phosphoprotein 2
  • FLJ20940 2
  • PPP1R1B 5

External Ids for PPP1R1B Gene

Previous GeneCards Identifiers for PPP1R1B Gene

  • GC17P037283
  • GC17P039780
  • GC17P037693
  • GC17P038158
  • GC17P035036
  • GC17P037783
  • GC17P033576

Summaries for PPP1R1B Gene

Entrez Gene Summary for PPP1R1B Gene

  • This gene encodes a bifunctional signal transduction molecule. Dopaminergic and glutamatergic receptor stimulation regulates its phosphorylation and function as a kinase or phosphatase inhibitor. As a target for dopamine, this gene may serve as a therapeutic target for neurologic and psychiatric disorders. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

GeneCards Summary for PPP1R1B Gene

PPP1R1B (Protein Phosphatase 1 Regulatory Inhibitor Subunit 1B) is a Protein Coding gene. Diseases associated with PPP1R1B include Heart Disease and Schizophrenia. Among its related pathways are Beta-Adrenergic Signaling and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include protein phosphatase inhibitor activity. An important paralog of this gene is PPP1R1A.

UniProtKB/Swiss-Prot Summary for PPP1R1B Gene

Gene Wiki entry for PPP1R1B Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PPP1R1B Gene

Genomics for PPP1R1B Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for PPP1R1B Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17J039626 Promoter/Enhancer 1.6 EPDnew Ensembl ENCODE dbSUPER 261.8 +1.4 1373 3.7 ZIC2 FOXA1 SAP130 POLR2A HDAC2 HNF4A SCRT1 EGR1 ZNF48 ZSCAN29 PPP1R1B HSALNG0116260 STARD3 PGAP3 RAPGEFL1 PNMT
GH17J039635 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 11.4 +10.5 10485 3.2 BCLAF1 ZNF207 MYC ZNF600 SIX5 ZNF580 ZNF592 KLF9 POLR2A ZNF10 STARD3 lnc-NEUROD2-4 MED24 PPP1R1B PGAP3 SNORD124 ORMDL3 HSALNG0116262 TCAP
GH17J038876 Promoter/Enhancer 1.4 Ensembl ENCODE dbSUPER 5.7 -744.6 -744586 11.1 MYC ZNF600 ZNF580 ZMYM3 ZSCAN16 POLR2A NFIC ZIC2 CHD4 YY1 RPL23 SNORA21 ENSG00000244086 SNORA21B C17orf98 CWC25 PSMB3 LASP1 PCGF2 PPP1R1B
GH17J039537 Enhancer 0.7 Ensembl 6.3 -87.1 -87134 4 ZNF654 ZNF580 ZNF623 ZNF433 MYC MAX POLR2A REST ZNF664 TEAD4 MED1 SNORA21 CDK12 STARD3 LOC105371762 RPL23 MSL1 PGAP3 RPL19 MED24
GH17J040061 Promoter/Enhancer 2.8 VISTA EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 1.5 +442.6 442560 14.8 BCLAF1 MYC IKZF1 NCOR1 ZNF600 ZNF580 ZNF592 ZMYM3 KLF9 CEBPA THRA MED24 MSL1 MED1 SMARCE1 GSDMA CDK12 RAPGEFL1 PSMD3 RPL19
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PPP1R1B on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for PPP1R1B

Top Transcription factor binding sites by QIAGEN in the PPP1R1B gene promoter:
  • CREB
  • deltaCREB
  • Sp1

Genomic Locations for PPP1R1B Gene

Latest Assembly
chr17:39,626,735-39,636,626
(GRCh38/hg38)
Size:
9,892 bases
Orientation:
Plus strand

Previous Assembly
chr17:37,783,205-37,792,877
(GRCh37/hg19 by Entrez Gene)
Size:
9,673 bases
Orientation:
Plus strand

chr17:37,782,993-37,792,879
(GRCh37/hg19 by Ensembl)
Size:
9,887 bases
Orientation:
Plus strand

Genomic View for PPP1R1B Gene

Genes around PPP1R1B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PPP1R1B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PPP1R1B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PPP1R1B Gene

Proteins for PPP1R1B Gene

  • Protein details for PPP1R1B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UD71-PPR1B_HUMAN
    Recommended name:
    Protein phosphatase 1 regulatory subunit 1B
    Protein Accession:
    Q9UD71
    Secondary Accessions:
    • Q547V9
    • Q547W0
    • Q9H7G1

    Protein attributes for PPP1R1B Gene

    Size:
    204 amino acids
    Molecular mass:
    22963 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for PPP1R1B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PPP1R1B Gene

Post-translational modifications for PPP1R1B Gene

Antibodies for research

  • Abcam antibodies for PPP1R1B

No data available for DME Specific Peptides for PPP1R1B Gene

Domains & Families for PPP1R1B Gene

Gene Families for PPP1R1B Gene

Protein Domains for PPP1R1B Gene

InterPro:
Blocks:
  • Protein phosphatase inhibitor, 1DARPP-32

Suggested Antigen Peptide Sequences for PPP1R1B Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ45635 fis, clone COLON2001829, highly similar to Dopamine- and cAMP-regulated neuronal phosphoprotein (B3KVQ9_HUMAN)
  • Dopamine- and cAMP-regulated neuronal phosphoprotein (PPR1B_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9UD71

UniProtKB/Swiss-Prot:

PPR1B_HUMAN :
  • Belongs to the protein phosphatase inhibitor 1 family.
Family:
  • Belongs to the protein phosphatase inhibitor 1 family.
genes like me logo Genes that share domains with PPP1R1B: view

Function for PPP1R1B Gene

Molecular function for PPP1R1B Gene

UniProtKB/Swiss-Prot Function:
Inhibitor of protein-phosphatase 1.

Phenotypes From GWAS Catalog for PPP1R1B Gene

Gene Ontology (GO) - Molecular Function for PPP1R1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004860 protein kinase inhibitor activity TAS 10604473
GO:0004864 protein phosphatase inhibitor activity IDA,TAS 10604473
GO:0005515 protein binding IPI 25416956
GO:0019888 protein phosphatase regulator activity TAS --
GO:0031748 D1 dopamine receptor binding IEA --
genes like me logo Genes that share ontologies with PPP1R1B: view
genes like me logo Genes that share phenotypes with PPP1R1B: view

Animal Models for PPP1R1B Gene

MGI Knock Outs for PPP1R1B:

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PPP1R1B

Clone products for research

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for PPP1R1B Gene

Localization for PPP1R1B Gene

Subcellular locations from UniProtKB/Swiss-Prot for PPP1R1B Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PPP1R1B gene
Compartment Confidence
cytosol 5
nucleus 4
plasma membrane 2
extracellular 2
cytoskeleton 2
mitochondrion 2
endoplasmic reticulum 2
endosome 1
lysosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for PPP1R1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IBA 21873635
GO:0005829 cytosol TAS --
GO:0043025 neuronal cell body IEA --
GO:0044326 dendritic spine neck IEA --
genes like me logo Genes that share ontologies with PPP1R1B: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for PPP1R1B Gene

Pathways & Interactions for PPP1R1B Gene

PathCards logo

SuperPathways for PPP1R1B Gene

SuperPathway Contained pathways
1 Activation of cAMP-Dependent PKA
.77
.77
.71
.56
2 Beta-Adrenergic Signaling
.37
.37
.37
.36
3 Amphetamine addiction
4 Nicotine Pathway (Dopaminergic Neuron), Pharmacodynamics
5 Neurophysiological process Glutamate regulation of Dopamine D1A receptor signaling
.32
genes like me logo Genes that share pathways with PPP1R1B: view

Pathways by source for PPP1R1B Gene

1 BioSystems pathway for PPP1R1B Gene
1 PharmGKB pathway for PPP1R1B Gene
2 GeneGo (Thomson Reuters) pathways for PPP1R1B Gene
  • Neurophysiological process Glutamate regulation of Dopamine D1A receptor signaling
  • Signal transduction_PKA signaling
1 Tocris pathway for PPP1R1B Gene
14 Qiagen pathways for PPP1R1B Gene
  • Activation of cAMP-Dependent PKA
  • Activation of PKA through GPCR
  • Beta-Adrenergic Signaling
  • Breast Cancer Regulation by Stathmin1
  • cAMP Pathway
2 Cell Signaling Technology pathways for PPP1R1B Gene

SIGNOR curated interactions for PPP1R1B Gene

Is activated by:

Gene Ontology (GO) - Biological Process for PPP1R1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001975 response to amphetamine IEA --
GO:0006351 transcription, DNA-templated IEA --
GO:0006469 negative regulation of protein kinase activity IEA --
GO:0007165 signal transduction TAS 10604473
GO:0007613 memory IEA --
genes like me logo Genes that share ontologies with PPP1R1B: view

Drugs & Compounds for PPP1R1B Gene

(14) Drugs for PPP1R1B Gene - From: DGIdb and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
ITI-007 Pharma 0

(2) Additional Compounds for PPP1R1B Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with PPP1R1B: view

Transcripts for PPP1R1B Gene

mRNA/cDNA for PPP1R1B Gene

3 REFSEQ mRNAs :
17 NCBI additional mRNA sequence :
10 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PPP1R1B

Clone products for research

Alternative Splicing Database (ASD) splice patterns (SP) for PPP1R1B Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10
SP1: - - -
SP2: -
SP3:
SP4:
SP5: - - -
SP6: - -

Relevant External Links for PPP1R1B Gene

GeneLoc Exon Structure for
PPP1R1B

Expression for PPP1R1B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PPP1R1B Gene

mRNA differential expression in normal tissues according to GTEx for PPP1R1B Gene

This gene is overexpressed in Brain - Putamen (basal ganglia) (x13.4), Brain - Caudate (basal ganglia) (x11.5), and Brain - Nucleus accumbens (basal ganglia) (x9.5).

Protein differential expression in normal tissues from HIPED for PPP1R1B Gene

This gene is overexpressed in Skin (24.0), Brain (15.5), and Pancreas (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for PPP1R1B Gene



Protein tissue co-expression partners for PPP1R1B Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for PPP1R1B

SOURCE GeneReport for Unigene cluster for PPP1R1B Gene:

Hs.286192

Evidence on tissue expression from TISSUES for PPP1R1B Gene

  • Nervous system(4.9)
  • Intestine(4.7)
  • Stomach(2.4)
  • Adrenal gland(2.3)
  • Eye(2.2)
  • Skin(2.1)
genes like me logo Genes that share expression patterns with PPP1R1B: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PPP1R1B Gene

Orthologs for PPP1R1B Gene

This gene was present in the common ancestor of chordates.

Orthologs for PPP1R1B Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia PPP1R1B 29 30
  • 98.03 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia PPP1R1B 29 30
  • 90.26 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia PPP1R1B 29 30
  • 89.38 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Ppp1r1b 29 16 30
  • 86.63 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Ppp1r1b 29
  • 86.6 (n)
Oppossum
(Monodelphis domestica)
Mammalia PPP1R1B 30
  • 74 (a)
OneToOne
Chicken
(Gallus gallus)
Aves PPP1R1B 30
  • 48 (a)
OneToOne
Zebrafish
(Danio rerio)
Actinopterygii ppp1r1b 30
  • 34 (a)
OneToOne
Species where no ortholog for PPP1R1B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for PPP1R1B Gene

ENSEMBL:
Gene Tree for PPP1R1B (if available)
TreeFam:
Gene Tree for PPP1R1B (if available)
Aminode:
Evolutionary constrained regions (ECRs) for PPP1R1B: view image
Alliance of Genome Resources:
Additional Orthologs for PPP1R1B

Paralogs for PPP1R1B Gene

Paralogs for PPP1R1B Gene

(3) SIMAP similar genes for PPP1R1B Gene using alignment to 4 proteins:

  • PPR1B_HUMAN
  • B3KVQ9_HUMAN
  • J3KSJ8_HUMAN
  • J3KT77_HUMAN
genes like me logo Genes that share paralogs with PPP1R1B: view

Variants for PPP1R1B Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for PPP1R1B Gene

SNP ID Clinical significance and condition Chr 17 pos Variation AA Info Type
rs34257414 Benign: not provided 39,635,641(+) A/G
NM_032192.4(PPP1R1B):c.480A>G (p.Glu160=)
SYNONYMOUS
rs367543178 Not Provided: not provided 39,627,464(+) G/A
NM_032192.4(PPP1R1B):c.72G>A (p.Gln24=)
SYNONYMOUS
rs367543179 Not Provided: not provided 39,629,174(+) G/A
NM_032192.4(PPP1R1B):c.86G>A (p.Arg29Gln)
MISSENSE_VARIANT,FIVE_PRIME_UTR
rs367543180 Not Provided: not provided 39,634,034(+) G/A
NM_032192.4(PPP1R1B):c.393G>A (p.Glu131=)
SYNONYMOUS
rs367543181 Not Provided: not provided 39,635,654(+) C/A
NM_032192.4(PPP1R1B):c.493C>A (p.Arg165Ser)
MISSENSE

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for PPP1R1B Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for PPP1R1B Gene

Variant ID Type Subtype PubMed ID
dgv40n68 CNV loss 17160897
nsv1146669 OTHER inversion 26484159
nsv2047 CNV insertion 18451855
nsv457738 CNV loss 19166990
nsv516757 CNV loss 19592680
nsv521294 CNV loss 19592680
nsv574991 CNV loss 21841781

Variation tolerance for PPP1R1B Gene

Residual Variation Intolerance Score: 51.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.19; 52.03% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PPP1R1B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PPP1R1B
Leiden Open Variation Database (LOVD)
PPP1R1B

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PPP1R1B Gene

Disorders for PPP1R1B Gene

MalaCards: The human disease database

(15) MalaCards diseases for PPP1R1B Gene - From: LNC, COP, and GCD

- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for PPP1R1B

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with PPP1R1B: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PPP1R1B Gene

Publications for PPP1R1B Gene

  1. Expression of mRNAs encoding ARPP-16/19, ARPP-21, and DARPP-32 in human brain tissue. (PMID: 8120638) Brené S … Persson H (The Journal of neuroscience : the official journal of the Society for Neuroscience 1994) 2 3 4 22
  2. The biological basis of anger: associations with the gene coding for DARPP-32 (PPP1R1B) and with amygdala volume. (PMID: 19463699) Reuter M … Montag C (Behavioural brain research 2009) 3 22 40
  3. Association analysis of the protein phosphatase 1 regulatory subunit 1B (PPP1R1B) gene with nicotine dependence in European- and African-American smokers. (PMID: 17171661) Beuten J … Li MD (American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2007) 3 22 40
  4. An association study between PPP1R1B gene and schizophrenia in the Chinese population. (PMID: 17618027) Hu JX … He L (Progress in neuro-psychopharmacology & biological psychiatry 2007) 3 22 40
  5. Mutation analysis of DARPP-32 as a candidate gene for schizophrenia. (PMID: 16750903) Li CH … Chen CH (Schizophrenia research 2006) 3 22 40

Products for PPP1R1B Gene

Sources for PPP1R1B Gene