Aliases for PPP1R1A Gene
External Ids for PPP1R1A Gene
Previous GeneCards Identifiers for PPP1R1A Gene
GeneCards Summary for PPP1R1A Gene
PPP1R1A (Protein Phosphatase 1 Regulatory Inhibitor Subunit 1A) is a Protein Coding gene. Diseases associated with PPP1R1A include Rosette-Forming Glioneuronal Tumor and Ewing Sarcoma. Among its related pathways are Beta-Adrenergic Signaling and Apoptotic Pathways in Synovial Fibroblasts. Gene Ontology (GO) annotations related to this gene include protein phosphatase inhibitor activity and protein serine/threonine phosphatase inhibitor activity. An important paralog of this gene is PPP1R1B.
UniProtKB/Swiss-Prot Summary for PPP1R1A Gene
Inhibitor of protein-phosphatase 1. This protein may be important in hormonal control of glycogen metabolism. Hormones that elevate intracellular cAMP increase I-1 activity in many tissues. I-1 activation may impose cAMP control over proteins that are not directly phosphorylated by PKA. Following a rise in intracellular calcium, I-1 is inactivated by calcineurin (or PP2B). Does not inhibit type-2 phosphatases.