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The protein encoded by this gene is membrane-associated and contains five ankyrin repeats, a protein phosphatase-1-interacting domain, and a carboxy-terminal CAAX box domain. Synthesis of the encoded protein is inhibited by transforming growth factor beta-1. The protein may bind to the membrane through its CAAX box domain and may act as a signaling molecule through interaction ... See more...
Aliases for PPP1R16B Gene
Aliases for PPP1R16B Gene
External Ids for PPP1R16B Gene
- HGNC: 15850
- Entrez Gene: 26051
- Ensembl: ENSG00000101445
- OMIM: 613275
- UniProtKB: Q96T49
Previous GeneCards Identifiers for PPP1R16B Gene
- GC20P037162
- GC20P038072
- GC20P038119
- GC20P036867
- GC20P037434
- GC20P034171
Summaries for PPP1R16B Gene
-
The protein encoded by this gene is membrane-associated and contains five ankyrin repeats, a protein phosphatase-1-interacting domain, and a carboxy-terminal CAAX box domain. Synthesis of the encoded protein is inhibited by transforming growth factor beta-1. The protein may bind to the membrane through its CAAX box domain and may act as a signaling molecule through interaction with protein phosphatase-1. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar processing to generate mature protein. [provided by RefSeq, Sep 2015]
GeneCards Summary for PPP1R16B Gene
PPP1R16B (Protein Phosphatase 1 Regulatory Subunit 16B) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include protein phosphatase binding. An important paralog of this gene is PPP1R16A.
UniProtKB/Swiss-Prot Summary for PPP1R16B Gene
-
Regulator of protein phosphatase 1 (PP1) that acts as a positive regulator of pulmonary endothelial cell (EC) barrier function (PubMed:18586956). Involved in the regulation of the PI3K/AKT signaling pathway, angiogenesis and endothelial cell proliferation (PubMed:25007873). Regulates angiogenesis and endothelial cell proliferation through the control of ECE1 dephosphorylation, trafficking and activity (By similarity). Protects the endothelial barrier from lipopolysaccharide (LPS)-induced vascular leakage (By similarity). Involved in the regulation of endothelial cell filopodia extension (By similarity). May be a downstream target for TGF-beta1 signaling cascade in endothelial cells (PubMed:16263087, PubMed:18586956). Involved in PKA-mediated moesin dephosphorylation which is important in EC barrier protection against thrombin stimulation (PubMed:18586956). Promotes the interaction of PPP1CA with RPSA/LAMR1 and in turn facilitates the dephosphorylation of RPSA/LAMR1 (PubMed:16263087). Involved in the dephosphorylation of EEF1A1 (PubMed:26497934).
Additional gene information for PPP1R16B Gene
- HGNC(15850)
- Entrez Gene(26051)
- Ensembl(ENSG00000101445)
- OMIM(613275)
- UniProtKB(Q96T49)
- Open Targets Platform(ENSG00000101445)
- Monarch Initiative
- Search for PPP1R16B at DataMed
- Search for PPP1R16B at HumanCyc
No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PPP1R16B Gene
Genomics for PPP1R16B Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for PPP1R16B Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around PPP1R16B on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for PPP1R16B
- Top Transcription factor binding sites by QIAGEN in the PPP1R16B gene promoter:
-
- AREB6
- Brachyury
- E47
- Olf-1
- Pax-5
- STAT3
- Tal-1beta
- XBP-1
Genomic Locations for PPP1R16B Gene
Genomic Locations for PPP1R16B Gene
- chr20:38,805,694-38,923,024
- (GRCh38/hg38)
- Size:
- 117,331 bases
- Orientation:
- Plus strand
- chr20:37,434,348-37,551,667
- (GRCh37/hg19)
- Size:
- 117,320 bases
- Orientation:
- Plus strand
Genomic View for PPP1R16B Gene
Genes around PPP1R16B on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 20q11.23 by HGNC
- 20q11.23 by Entrez Gene
- 20q11.23 by Ensembl
PPP1R16B Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for PPP1R16B Gene
Proteins for PPP1R16B Gene
-
Protein details for PPP1R16B Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q96T49-PP16B_HUMAN
- Recommended name:
- Protein phosphatase 1 regulatory inhibitor subunit 16B
- Protein Accession:
- Q96T49
- A2RRR6
- E9PFS8
- O94912
- Q5W9G4
- Q9NQG4
Protein attributes for PPP1R16B Gene
- Size:
- 567 amino acids
- Molecular mass:
- 63551 Da
- Quaternary structure:
-
- Interacts with PPP1CA, PPP1CB and MSN. Interacts (via its fourth ankyrin repeat) with the mature dimeric form of RPSA/LAMR1 (PubMed:16263087, PubMed:18586956). Interacts with EEF1A1 (PubMed:26497934). Interacts with PTEN (PubMed:25007873). Interacts with ECE1 (By similarity).
- SequenceCaution:
-
- Sequence=BAA74846.2; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
Protein Expression for PPP1R16B Gene
Post-translational modifications for PPP1R16B Gene
- Phosphorylated by PKA and, after PKA priming, by GSK3B. Phosphorylation by GSK3B reduces its association with PP1C and enhances PP1C activity. Dephosphorylation by its associated PP1C results in enhanced association with PP1C, but reduced PP1C activity (By similarity).
- Modification sites at PhosphoSitePlus
- Modification sites at neXtProt
Other Protein References for PPP1R16B Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- G Biosciences Immunotag™ PPP1R16B Antibody
-
Custom Antibody ServicesOriGene Antibodies for PPP1R16B
- Novus Biologicals Antibodies for PPP1R16B
-
Abcam antibodies for PPP1R16B
- Invitrogen Antibodies for PPP1R16B (AFLGC-PPP1R16B)
Protein Products
-
OriGene Purified Proteins for PPP1R16B
- Search Origene for MassSpec and Protein Over-expression Lysates for PPP1R16B
- Origene Custom Protein Services for PPP1R16B
- antibodies-online: Show 4 available PPP1R16B Proteins ranked by validation data
- Compare Top PPP1R16B Proteins
-
Quality Products:
-
Abcam proteins for PPP1R16B
No data available for DME Specific Peptides for PPP1R16B Gene
Domains & Families for PPP1R16B Gene
Gene Families for PPP1R16B Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Protein Domains for PPP1R16B Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for PPP1R16B Gene
- GenScript: Design optimal peptide antigens:
-
- TGF-beta-inhibited membrane-associated protein (PP16B_HUMAN)
- Protein phosphatase 1, regulatory (Inhibitor) subunit 16B (Q5W9G4_HUMAN)
No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for PPP1R16B Gene
Function for PPP1R16B Gene
Molecular function for PPP1R16B Gene
- UniProtKB/Swiss-Prot Function:
- Regulator of protein phosphatase 1 (PP1) that acts as a positive regulator of pulmonary endothelial cell (EC) barrier function (PubMed:18586956). Involved in the regulation of the PI3K/AKT signaling pathway, angiogenesis and endothelial cell proliferation (PubMed:25007873). Regulates angiogenesis and endothelial cell proliferation through the control of ECE1 dephosphorylation, trafficking and activity (By similarity). Protects the endothelial barrier from lipopolysaccharide (LPS)-induced vascular leakage (By similarity). Involved in the regulation of endothelial cell filopodia extension (By similarity). May be a downstream target for TGF-beta1 signaling cascade in endothelial cells (PubMed:16263087, PubMed:18586956). Involved in PKA-mediated moesin dephosphorylation which is important in EC barrier protection against thrombin stimulation (PubMed:18586956). Promotes the interaction of PPP1CA with RPSA/LAMR1 and in turn facilitates the dephosphorylation of RPSA/LAMR1 (PubMed:16263087). Involved in the dephosphorylation of EEF1A1 (PubMed:26497934).
- UniProtKB/Swiss-Prot Induction:
- Inhibited by TGFB1 (Probable). Down-regulated by LPS (PubMed:21907835).
Phenotypes From GWAS Catalog for PPP1R16B Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005515 | protein binding | IPI | 16263087 |
| GO:0008157 | protein phosphatase 1 binding | IBA | 21873635 |
| GO:0017020 | myosin phosphatase regulator activity | IBA | 21873635 |
| GO:0019888 | protein phosphatase regulator activity | IDA | 16263087 |
Phenotypes for PPP1R16B Gene
- MGI mutant phenotypes for PPP1R16B:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for PPP1R16B:
-
- Increased vaccinia virus (VACV) infection
- no effect
- Decreased vaccinia virus (VACV) infection
- Decreased shRNA abundance (Z-score < -2)
- Increased apoptosis
- Decreased focal adhesion (FA) area, decreased FA length, decreased FA mean intensity, increased number of small and round FAs, increased cell elongation
- Increased shRNA abundance (Z-score > 2)
- Wnt reporter downregulated
- Downregulation of NF-kappaB pathway after LMP1 stimulation
- Downregulation of NF-kappaB pathway after IL-1beta stimulation
Animal Models for PPP1R16B Gene
- MGI Knock Outs for PPP1R16B:
-
- Ppp1r16b Ppp1r16b<tm1Ccb>
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for PPP1R16B - Select products 50% OFF >
- * PPP1R16B CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for PPP1R16B
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for PPP1R16B
-
Santa Cruz Biotechnology (SCBT) CRISPR for PPP1R16B
miRNA for PPP1R16B Gene
- miRTarBase miRNAs that target PPP1R16B
-
- mmu-miR-34b-5p (MIRT012697)
- hsa-let-7b-5p (MIRT052173)
- hsa-miR-4747-5p (MIRT470390)
- hsa-miR-5196-5p (MIRT470391)
- hsa-miR-3934-3p (MIRT470392)
- hsa-miR-6719-3p (MIRT470393)
- hsa-miR-3670 (MIRT470394)
- hsa-miR-4526 (MIRT470395)
- hsa-miR-6730-3p (MIRT470396)
- hsa-miR-3660 (MIRT470397)
- hsa-miR-3664-3p (MIRT470398)
- hsa-miR-3200-5p (MIRT470399)
- hsa-miR-6854-5p (MIRT470400)
- hsa-miR-2392 (MIRT470401)
- hsa-miR-7855-5p (MIRT569954)
- hsa-miR-6807-5p (MIRT569955)
- hsa-miR-4792 (MIRT569956)
- hsa-miR-4710 (MIRT569957)
- hsa-miR-1251-3p (MIRT569958)
- hsa-miR-107 (MIRT569959)
- hsa-miR-103a-3p (MIRT569960)
- hsa-miR-6804-3p (MIRT569961)
- hsa-miR-8069 (MIRT569962)
- hsa-miR-3065-3p (MIRT569963)
- hsa-miR-1322 (MIRT569964)
- hsa-miR-1272 (MIRT569965)
- mmu-miR-1966-5p (MIRT581684)
- mmu-miR-1943-5p (MIRT581685)
- mmu-miR-466i-5p (MIRT581686)
- mmu-miR-466k (MIRT581687)
- mmu-miR-466d-5p (MIRT581688)
- mmu-miR-466l-5p (MIRT581689)
- mmu-miR-1194 (MIRT605546)
- mmu-miR-3471 (MIRT605547)
- mmu-miR-5102 (MIRT605548)
- mmu-miR-3077-3p (MIRT605549)
- mmu-miR-5114 (MIRT605550)
- mmu-miR-5133 (MIRT605551)
- mmu-miR-3475-3p (MIRT605552)
- mmu-miR-122-5p (MIRT605553)
- hsa-miR-6513-5p (MIRT648338)
- hsa-miR-887-5p (MIRT648339)
- hsa-miR-3913-5p (MIRT648340)
- hsa-miR-3122 (MIRT648341)
- hsa-miR-450a-1-3p (MIRT648342)
- hsa-miR-627-5p (MIRT648343)
- hsa-miR-6716-5p (MIRT648344)
- hsa-miR-924 (MIRT648345)
- hsa-miR-4682 (MIRT648346)
- hsa-miR-4653-5p (MIRT648347)
- hsa-miR-3921 (MIRT648348)
- hsa-miR-501-5p (MIRT648349)
- hsa-miR-574-5p (MIRT707506)
- hsa-miR-4455 (MIRT707507)
- hsa-miR-147a (MIRT707508)
- hsa-miR-6818-5p (MIRT707509)
- hsa-miR-3152-3p (MIRT707510)
- hsa-miR-6867-5p (MIRT707511)
- hsa-miR-223-5p (MIRT707512)
- hsa-miR-581 (MIRT707513)
- hsa-miR-511-3p (MIRT707514)
- hsa-miR-5089-5p (MIRT711112)
- hsa-miR-6506-5p (MIRT711113)
- hsa-miR-7977 (MIRT711114)
- hsa-miR-6849-3p (MIRT711115)
- hsa-miR-619-5p (MIRT711116)
- hsa-miR-1207-3p (MIRT711117)
- hsa-miR-3614-3p (MIRT711118)
- hsa-miR-34a-3p (MIRT711119)
- hsa-miR-1302 (MIRT762401)
- hsa-miR-4298 (MIRT768479)
- hsa-miR-4648 (MIRT770608)
- hsa-miR-6165 (MIRT776000)
- hsa-miR-6828-5p (MIRT779958)
- hsa-miR-873-5p (MIRT782493)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for PPP1R16B
- Browse OriGene Inhibitory RNA Products For PPP1R16B
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PPP1R16B
Clone Products
- Applied Biological Materials (abm): Clones for PPP1R16B - Select products 50% OFF >
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- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
- MG208959
- MG219271
- MR208959
- MR208959L3
- MR208959L4
- MR219271
- MR219271L3
- MR219271L4
- RC218476
- RC218476L1
- RC218476L2
- RC218476L3
- RC218476L4
- RC230229
- RC230229L3
- RC230229L4
- RG218476
- RG230229
- RR216926
- MR208959L3V
- MR208959L4V
- MR219271L3V
- MR219271L4V
- RC218476L1V
- RC218476L2V
- RC218476L3V
- RC218476L4V
- RC230229L3V
- RC230229L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for PPP1R16B
- Addgene plasmids for PPP1R16B
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for PPP1R16B
Cell Line Products
-
Horizon Cell Lines for PPP1R16B
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PPP1R16B Gene
Localization for PPP1R16B Gene
Subcellular locations from UniProtKB/Swiss-Prot for PPP1R16B Gene
- Cell membrane. Cell membrane. Lipid-anchor. Nucleus. Cell projection. Note=Colocalizes with RPSA/LAMR1 in the cell membrane (PubMed:16263087). Localizes to the perinuclear region (By similarity). Colocalizes with PTEN at the tip of EC projections (PubMed:25007873). {ECO:0000250 UniProtKB:Q95N27, ECO:0000269 PubMed:16263087, ECO:0000269 PubMed:25007873}.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| nucleus | 5 |
| extracellular | 1 |
| cytoskeleton | 1 |
| cytosol | 1 |
- Nuclear speckles (3)
- Plasma membrane (3)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IEA,IDA | 12055102 |
| GO:0005886 | plasma membrane | IEA,IDA | 12055102 |
| GO:0016020 | membrane | IEA | -- |
| GO:0016607 | nuclear speck | IDA | -- |
| GO:0042995 | cell projection | IDA | 25007873 |
Pathways & Interactions for PPP1R16B Gene
Interacting Proteins for PPP1R16B Gene
Selected Interacting proteins:
Q96T49-PP16B_HUMAN
ENSP00000299824
for PPP1R16B Gene via
UniProtKB
STRING
IID
GPS-Prot Interaction Network for PPP1R16B
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001938 | positive regulation of endothelial cell proliferation | IMP | 25007873 |
| GO:0014066 | regulation of phosphatidylinositol 3-kinase signaling | IMP | 25007873 |
| GO:0035304 | regulation of protein dephosphorylation | IMP | 26497934 |
| GO:0035307 | positive regulation of protein dephosphorylation | IDA | 16263087 |
| GO:0035308 | negative regulation of protein dephosphorylation | IDA | 21466834 |
No data available for Pathways by source and SIGNOR curated interactions for PPP1R16B Gene
Transcripts for PPP1R16B Gene
mRNA/cDNA for PPP1R16B Gene
- 2 REFSEQ mRNAs :
- 9 NCBI additional mRNA sequence :
- 4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000299824 6259 nts (view in UCSC)
- ENST00000373331 6106 nts (view in UCSC)
- ENST00000463749 268 nts (view in UCSC)
- ENST00000468265 299 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for PPP1R16B - Select products 50% OFF >
- * PPP1R16B CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for PPP1R16B
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for PPP1R16B
-
Santa Cruz Biotechnology (SCBT) CRISPR for PPP1R16B
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for PPP1R16B
- Browse OriGene Inhibitory RNA Products For PPP1R16B
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PPP1R16B
Clone Products
- Applied Biological Materials (abm): Clones for PPP1R16B - Select products 50% OFF >
- * PPP1R16B as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
- MG208959
- MG219271
- MR208959
- MR208959L3
- MR208959L4
- MR219271
- MR219271L3
- MR219271L4
- RC218476
- RC218476L1
- RC218476L2
- RC218476L3
- RC218476L4
- RC230229
- RC230229L3
- RC230229L4
- RG218476
- RG230229
- RR216926
- MR208959L3V
- MR208959L4V
- MR219271L3V
- MR219271L4V
- RC218476L1V
- RC218476L2V
- RC218476L3V
- RC218476L4V
- RC230229L3V
- RC230229L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for PPP1R16B
- Addgene plasmids for PPP1R16B
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for PPP1R16B
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | ||||||||||||||||||||||||||||
| SP2: | - | ||||||||||||||||||||||||||||||
| SP3: | - | ||||||||||||||||||||||||||||||
| SP4: | - |
Relevant External Links for PPP1R16B Gene
- GeneLoc Exon Structure for
- PPP1R16B
Expression for PPP1R16B Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Blood (Cardiovascular System)
-
Thymus (Hematopoietic System)
- Double Positive Thymocytes Thymus
- Thymus
- Brain (Nervous System)
- Gut Tube (Gastrointestinal Tract)
-
Testis (Reproductive System)
- Pre-Sertoli Cells Testis Cord
- Kidney (Urinary System)
- Glial Cells (Uncategorized)
- Spinal Cord (Nervous System)
-
Spleen (Hematopoietic System)
mRNA differential expression in normal tissues according to GTEx for PPP1R16B Gene
This gene is overexpressed in Brain - Cortex (x4.8), Brain - Nucleus accumbens (basal ganglia) (x4.8), Brain - Putamen (basal ganglia) (x4.6), and Brain - Caudate (basal ganglia) (x4.2).
This gene is overexpressed in Frontal cortex (36.7) and Blymphocyte (23.2).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for PPP1R16B Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for PPP1R16B
SOURCE GeneReport for Unigene cluster for PPP1R16B Gene:
Hs.45719Evidence on tissue expression from TISSUES for PPP1R16B Gene
- Nervous system(4.9)
Primer Products
-
OriGene qPCR primer pairs for PPP1R16B
Gene Expression Assay Products
No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PPP1R16B Gene
Orthologs for PPP1R16B Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | PPP1R16B 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | PPP1R16B 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | PPP1R16B 30 31 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Ppp1r16b 30 17 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Ppp1r16b 30 |
|
||
| Oppossum (Monodelphis domestica) |
Mammalia | PPP1R16B 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | PPP1R16B 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | PPP1R16B 30 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | PPP1R16B 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | ppp1r16b 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | LOC799771 30 |
|
||
| PPP1R16B 31 |
|
OneToOne | |||
| Fruit Fly (Drosophila melanogaster) |
Insecta | CG6896 32 |
|
|
|
| MYPT-75D 31 |
|
OneToMany | |||
| Worm (Caenorhabditis elegans) |
Secernentea | gfi-2 31 32 |
|
OneToMany | |
| Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.1404 31 |
|
OneToMany |
- Species where no ortholog for PPP1R16B was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
Evolution for PPP1R16B Gene
- ENSEMBL:
- Gene Tree for PPP1R16B (if available)
- TreeFam:
- Gene Tree for PPP1R16B (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for PPP1R16B: view image
Paralogs for PPP1R16B Gene
Variants for PPP1R16B Gene
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv2674770 | CNV | deletion | 23128226 |
| esv2722402 | CNV | deletion | 23290073 |
| esv2722403 | CNV | deletion | 23290073 |
| esv3645791 | CNV | loss | 21293372 |
| esv3645792 | CNV | gain | 21293372 |
| esv3645793 | CNV | gain | 21293372 |
| nsv1058457 | CNV | loss | 25217958 |
| nsv1121579 | CNV | deletion | 24896259 |
| nsv1153233 | CNV | insertion | 26484159 |
| nsv3373 | CNV | insertion | 18451855 |
| nsv3374 | CNV | deletion | 18451855 |
Residual Variation Intolerance Score:
11.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.30;
25.82% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for PPP1R16B Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- PPP1R16B
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for PPP1R16B Gene
Disorders for PPP1R16B Gene
Additional Disease Information for PPP1R16B
- Genetic Association Database
- (GAD)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No disorders were found for PPP1R16B Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PPP1R16B Gene
Publications for PPP1R16B Gene
- TIMAP is a positive regulator of pulmonary endothelial barrier function. (PMID: 18586956) Csortos C … Verin AD (American journal of physiology. Lung cellular and molecular physiology 2008) 3 4 23
- TIMAP, a novel CAAX box protein regulated by TGF-beta1 and expressed in endothelial cells. (PMID: 12055102) Cao W … Ballermann BJ (American journal of physiology. Cell physiology 2002) 2 3 4
- Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10048485) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 1998) 2 3 4
- Elongation factor-1A1 is a novel substrate of the protein phosphatase 1-TIMAP complex. (PMID: 26497934) Boratkó A … Csortos C (The international journal of biochemistry & cell biology 2015) 3 4
- TIMAP promotes angiogenesis by suppressing PTEN-mediated Akt inhibition in human glomerular endothelial cells. (PMID: 25007873) Obeidat M … Ballermann BJ (American journal of physiology. Renal physiology 2014) 3 4
ExternalLinks
Products for PPP1R16B Gene
- Custom Antibody ServicesOriGene Antibodies for PPP1R16B
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Sources for PPP1R16B Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) Genetics Home Reference
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNACentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Signalway Antibody
- (175) Open Targets Platform
- (176) 5SRRNADB
- (177) snoDB
- (178) MirGeneDB