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Aliases for PPP1R16A Gene

Aliases for PPP1R16A Gene

  • Protein Phosphatase 1 Regulatory Subunit 16A 2 3 5
  • Protein Phosphatase 1, Regulatory (Inhibitor) Subunit 16A 2 3
  • Myosin Phosphatase-Targeting Subunit 3 3 4
  • MYPT3 3 4
  • Protein Phosphatase 1, Regulatory Subunit 16A 2

External Ids for PPP1R16A Gene

Previous GeneCards Identifiers for PPP1R16A Gene

  • GC08P143416
  • GC08P145753
  • GC08P145308
  • GC08P145726
  • GC08P145692
  • GC08P145686
  • GC08P140835
  • GC08P145703

Summaries for PPP1R16A Gene

Entrez Gene Summary for PPP1R16A Gene

  • Myosin light chain kinase and phosphatase (MLCP) complexes control the phosphorylation states of regulatory myosin light chains, which is crucial for muscle and intracellular movement. MLCPs typically contain a catalytic protein phosphatase 1 (PP1c) subunit, a myosin phosphatase targeting (MYPT) subunit, and another smaller subunit. The protein encoded by this gene represents an MYPT subunit, which is responsible for directing PP1c to its intended targets. However, while other MYPTs result in PP1c activation after becoming phosphorylated, the encoded protein is phosphorylated by protein kinase A and then inhibits the catalytic activity of PP1c. [provided by RefSeq, Jul 2016]

GeneCards Summary for PPP1R16A Gene

PPP1R16A (Protein Phosphatase 1 Regulatory Subunit 16A) is a Protein Coding gene. Among its related pathways are Beta-Adrenergic Signaling and Activation of cAMP-Dependent PKA. Gene Ontology (GO) annotations related to this gene include actin binding. An important paralog of this gene is PPP1R16B.

UniProtKB/Swiss-Prot for PPP1R16A Gene

  • Inhibits protein phosphatase 1 activity toward phosphorylase, myosin light chain and myosin substrates.

Additional gene information for PPP1R16A Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PPP1R16A Gene

Genomics for PPP1R16A Gene

GeneHancer (GH) Regulatory Elements for PPP1R16A Gene

Promoters and enhancers for PPP1R16A Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH08I144494 Promoter/Enhancer 1.1 EPDnew ENCODE 571.2 +18.4 18413 2.9 KLF1 SP2 ZNF76 ZIC2 GLIS2 ZNF341 GLIS1 ZNF143 ZBTB33 CHD2 PPP1R16A LOC105375803 GC08M144502 GC08M144501 GC08P144481 PIR60433 GC08P144288
GH08I144471 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 30 -2.1 -2115 8 HDGF PKNOX1 ARID4B SIN3A DMAP1 IRF4 YY1 POLR2B ZNF207 ZNF143 FOXH1 PPP1R16A CPSF1 ZNF707 VPS28 ZNF7 ZNF623 ADCK5 SLC52A2 ZNF16
GH08I144461 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 27.3 -13.1 -13126 7 PKNOX1 MLX ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 SLC30A9 CBX5 ENSG00000254578 KIFC2 CYHR1 CPSF1 PPP1R16A ZNF707 ZNF7 SHARPIN ZNF16 VPS28
GH08I144500 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 25 +24.7 24747 4.5 MLX ARID4B DMAP1 ZNF48 ETS1 YY1 GLIS2 PAF1 RXRA SP5 GPT GC08M144502 GC08M144501 PPP1R16A RECQL4 LOC105375803
GH08I144506 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 20.2 +31.0 31000 4 HDGF PKNOX1 CLOCK ARNT ARID4B SIN3A DMAP1 ZNF2 ZBTB7B IRF4 MFSD3 ZNF7 CPSF1 VPS28 ZNF250 ZNF623 ZNF251 ENSG00000254533 LRRC14 ZNF707
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around PPP1R16A on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the PPP1R16A gene promoter:

Genomic Locations for PPP1R16A Gene

Genomic Locations for PPP1R16A Gene
24,153 bases
Plus strand

Genomic View for PPP1R16A Gene

Genes around PPP1R16A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PPP1R16A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PPP1R16A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PPP1R16A Gene

Proteins for PPP1R16A Gene

  • Protein details for PPP1R16A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein phosphatase 1 regulatory subunit 16A
    Protein Accession:
    Secondary Accessions:
    • D3DWM5

    Protein attributes for PPP1R16A Gene

    528 amino acids
    Molecular mass:
    57811 Da
    Quaternary structure:
    • Binds PP1.
    • Sequence=BAC03452.1; Type=Miscellaneous discrepancy; Note=Cloning artifact.; Evidence={ECO:0000305};

neXtProt entry for PPP1R16A Gene

Post-translational modifications for PPP1R16A Gene

No Post-translational modifications

No data available for DME Specific Peptides for PPP1R16A Gene

Domains & Families for PPP1R16A Gene

Gene Families for PPP1R16A Gene

Suggested Antigen Peptide Sequences for PPP1R16A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with PPP1R16A: view

No data available for UniProtKB/Swiss-Prot for PPP1R16A Gene

Function for PPP1R16A Gene

Molecular function for PPP1R16A Gene

UniProtKB/Swiss-Prot Function:
Inhibits protein phosphatase 1 activity toward phosphorylase, myosin light chain and myosin substrates.

Phenotypes From GWAS Catalog for PPP1R16A Gene

Gene Ontology (GO) - Molecular Function for PPP1R16A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16169070
GO:0019888 protein phosphatase regulator activity IEA --
genes like me logo Genes that share ontologies with PPP1R16A: view
genes like me logo Genes that share phenotypes with PPP1R16A: view

Animal Model Products

CRISPR Products

miRNA for PPP1R16A Gene

miRTarBase miRNAs that target PPP1R16A

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PPP1R16A Gene

Localization for PPP1R16A Gene

Subcellular locations from UniProtKB/Swiss-Prot for PPP1R16A Gene

Cell membrane; Lipid-anchor.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PPP1R16A gene
Compartment Confidence
plasma membrane 4
nucleus 3
cytosol 2
cytoskeleton 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for PPP1R16A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with PPP1R16A: view

Pathways & Interactions for PPP1R16A Gene

genes like me logo Genes that share pathways with PPP1R16A: view

Gene Ontology (GO) - Biological Process for PPP1R16A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0043666 regulation of phosphoprotein phosphatase activity IEA --
GO:0050790 regulation of catalytic activity IEA --
genes like me logo Genes that share ontologies with PPP1R16A: view

No data available for SIGNOR curated interactions for PPP1R16A Gene

Drugs & Compounds for PPP1R16A Gene

No Compound Related Data Available

Transcripts for PPP1R16A Gene

Unigene Clusters for PPP1R16A Gene

Protein phosphatase 1, regulatory subunit 16A:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for PPP1R16A Gene

No ASD Table

Relevant External Links for PPP1R16A Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PPP1R16A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PPP1R16A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for PPP1R16A Gene

This gene is overexpressed in Testis (19.2), Retina (19.1), Fetal Brain (17.8), and Liver (12.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for PPP1R16A Gene

Protein tissue co-expression partners for PPP1R16A Gene

NURSA nuclear receptor signaling pathways regulating expression of PPP1R16A Gene:


SOURCE GeneReport for Unigene cluster for PPP1R16A Gene:


Evidence on tissue expression from TISSUES for PPP1R16A Gene

  • Lung(4.2)
  • Spleen(4.1)
  • Nervous system(2.5)
genes like me logo Genes that share expression patterns with PPP1R16A: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PPP1R16A Gene

Orthologs for PPP1R16A Gene

This gene was present in the common ancestor of animals.

Orthologs for PPP1R16A Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia PPP1R16A 33 34
  • 86.28 (n)
(Canis familiaris)
Mammalia PPP1R16A 33 34
  • 86.01 (n)
(Mus musculus)
Mammalia Ppp1r16a 33 16 34
  • 82.19 (n)
(Rattus norvegicus)
Mammalia Ppp1r16a 33
  • 82.12 (n)
(Ornithorhynchus anatinus)
Mammalia PPP1R16A 34
  • 68 (a)
(Monodelphis domestica)
Mammalia PPP1R16A 34
  • 67 (a)
(Anolis carolinensis)
Reptilia PPP1R16A 34
  • 68 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia ppp1r16a 33
  • 65.97 (n)
(Danio rerio)
Actinopterygii si:dkey-9l5.3 33
  • 57.69 (n)
PPP1R16A 34
  • 53 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG6896 35
  • 42 (a)
MYPT-75D 34
  • 29 (a)
(Caenorhabditis elegans)
Secernentea gfi-2 35 33 34
  • 49.56 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.1404 34
  • 51 (a)
Species where no ortholog for PPP1R16A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PPP1R16A Gene

Gene Tree for PPP1R16A (if available)
Gene Tree for PPP1R16A (if available)

Paralogs for PPP1R16A Gene

(1) SIMAP similar genes for PPP1R16A Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with PPP1R16A: view

Variants for PPP1R16A Gene

Sequence variations from dbSNP and Humsavar for PPP1R16A Gene

SNP ID Clin Chr 08 pos Variation AA Info Type
rs1023680529 uncertain-significance, Holoprosencephaly 144,476,262(+) C/T upstream_transcript_variant
rs147276162 likely-benign, Holoprosencephaly 144,476,089(+) A/G upstream_transcript_variant
rs750472 benign, Holoprosencephaly 144,476,070(+) A/C upstream_transcript_variant
rs886062757 uncertain-significance, Holoprosencephaly 144,476,036(+) C/T upstream_transcript_variant
rs886062758 uncertain-significance, Holoprosencephaly 144,476,202(+) A/G upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for PPP1R16A Gene

Variant ID Type Subtype PubMed ID
nsv831489 CNV loss 17160897
nsv612955 CNV loss 21841781
nsv612951 CNV loss 21841781
nsv612940 CNV loss 21841781
nsv515809 CNV gain+loss 19592680
nsv482126 CNV gain 20164927
nsv470249 CNV loss 18288195
nsv428208 CNV gain 18775914
esv3619130 CNV gain 21293372
esv29999 CNV loss 17803354
dgv907n27 CNV loss 19166990
dgv12442n54 CNV loss 21841781
dgv12439n54 CNV loss 21841781
dgv12434n54 CNV loss 21841781
dgv1207n67 CNV gain 20364138

Variation tolerance for PPP1R16A Gene

Residual Variation Intolerance Score: 59.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.02; 37.24% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PPP1R16A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PPP1R16A Gene

Disorders for PPP1R16A Gene

Additional Disease Information for PPP1R16A

No disorders were found for PPP1R16A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PPP1R16A Gene

Publications for PPP1R16A Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  2. Regulator-driven functional diversification of protein phosphatase-1 in eukaryotic evolution. (PMID: 11948623) Ceulemans H … Bollen M (BioEssays : news and reviews in molecular, cellular and developmental biology 2002) 2 3 58
  3. Systematic Analysis of Human Protein Phosphatase Interactions and Dynamics. (PMID: 28330616) Yadav L … Varjosalo M (Cell systems 2017) 3 58
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 58

Products for PPP1R16A Gene

Sources for PPP1R16A Gene

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