Myosin light chain kinase and phosphatase (MLCP) complexes control the phosphorylation states of regulatory myosin light chains, which is crucial for muscle and intracellular movement. MLCPs typically contain a catalytic protein phosphatase 1 (PP1c) subunit, a myosin phosphatase targeting (MYPT) subunit, and another smaller subunit. The protein encoded by this gene represents a... See more...

Aliases for PPP1R16A Gene

Aliases for PPP1R16A Gene

  • Protein Phosphatase 1 Regulatory Subunit 16A 2 3 4 5
  • Protein Phosphatase 1, Regulatory (Inhibitor) Subunit 16A 2 3
  • Myosin Phosphatase-Targeting Subunit 3 3 4
  • MYPT3 3 4
  • Protein Phosphatase 1, Regulatory Subunit 16A 2

External Ids for PPP1R16A Gene

Previous GeneCards Identifiers for PPP1R16A Gene

  • GC08P143416
  • GC08P145753
  • GC08P145308
  • GC08P145726
  • GC08P145692
  • GC08P145686
  • GC08P140835
  • GC08P145703

Summaries for PPP1R16A Gene

Entrez Gene Summary for PPP1R16A Gene

  • Myosin light chain kinase and phosphatase (MLCP) complexes control the phosphorylation states of regulatory myosin light chains, which is crucial for muscle and intracellular movement. MLCPs typically contain a catalytic protein phosphatase 1 (PP1c) subunit, a myosin phosphatase targeting (MYPT) subunit, and another smaller subunit. The protein encoded by this gene represents an MYPT subunit, which is responsible for directing PP1c to its intended targets. However, while other MYPTs result in PP1c activation after becoming phosphorylated, the encoded protein is phosphorylated by protein kinase A and then inhibits the catalytic activity of PP1c. [provided by RefSeq, Jul 2016]

GeneCards Summary for PPP1R16A Gene

PPP1R16A (Protein Phosphatase 1 Regulatory Subunit 16A) is a Protein Coding gene. Among its related pathways are ERK Signaling and Beta-Adrenergic Signaling. Gene Ontology (GO) annotations related to this gene include actin binding. An important paralog of this gene is PPP1R16B.

UniProtKB/Swiss-Prot Summary for PPP1R16A Gene

  • Inhibits protein phosphatase 1 activity toward phosphorylase, myosin light chain and myosin substrates.

Additional gene information for PPP1R16A Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PPP1R16A Gene

Genomics for PPP1R16A Gene

GeneHancer (GH) Regulatory Elements for PPP1R16A Gene

Promoters and enhancers for PPP1R16A Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PPP1R16A on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for PPP1R16A

Top Transcription factor binding sites by QIAGEN in the PPP1R16A gene promoter:
  • COUP
  • COUP-TF
  • COUP-TF1
  • E47
  • HNF-4alpha2
  • Nkx2-5
  • p53
  • Sp1

Genomic Locations for PPP1R16A Gene

Genomic Locations for PPP1R16A Gene
chr8:144,477,969-144,502,121
(GRCh38/hg38)
Size:
24,153 bases
Orientation:
Plus strand
chr8:145,703,352-145,727,504
(GRCh37/hg19)
Size:
24,153 bases
Orientation:
Plus strand

Genomic View for PPP1R16A Gene

Genes around PPP1R16A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PPP1R16A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PPP1R16A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PPP1R16A Gene

Proteins for PPP1R16A Gene

  • Protein details for PPP1R16A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96I34-PP16A_HUMAN
    Recommended name:
    Protein phosphatase 1 regulatory subunit 16A
    Protein Accession:
    Q96I34
    Secondary Accessions:
    • D3DWM5

    Protein attributes for PPP1R16A Gene

    Size:
    528 amino acids
    Molecular mass:
    57811 Da
    Quaternary structure:
    • Binds PP1.
    SequenceCaution:
    • Sequence=BAC03452.1; Type=Miscellaneous discrepancy; Note=Cloning artifact.; Evidence={ECO:0000305};

neXtProt entry for PPP1R16A Gene

Post-translational modifications for PPP1R16A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • Boster Bio Antibodies for PPP1R16A
  • Santa Cruz Biotechnology (SCBT) Antibodies for PPP1R16A

No data available for DME Specific Peptides for PPP1R16A Gene

Domains & Families for PPP1R16A Gene

Protein Domains for PPP1R16A Gene

Blocks:
  • Ankyrin repeat signature
  • Regulator of chromosome condensation, RCC1
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for PPP1R16A Gene

GenScript: Design optimal peptide antigens:
  • Myosin phosphatase-targeting subunit 3 (PP16A_HUMAN)
genes like me logo Genes that share domains with PPP1R16A: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for PPP1R16A Gene

Function for PPP1R16A Gene

Molecular function for PPP1R16A Gene

UniProtKB/Swiss-Prot Function:
Inhibits protein phosphatase 1 activity toward phosphorylase, myosin light chain and myosin substrates.

Phenotypes From GWAS Catalog for PPP1R16A Gene

Gene Ontology (GO) - Molecular Function for PPP1R16A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16169070
GO:0019888 protein phosphatase regulator activity IEA --
genes like me logo Genes that share ontologies with PPP1R16A: view
genes like me logo Genes that share phenotypes with PPP1R16A: view

Animal Model Products

CRISPR Products

miRNA for PPP1R16A Gene

miRTarBase miRNAs that target PPP1R16A

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PPP1R16A

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PPP1R16A Gene

Localization for PPP1R16A Gene

Subcellular locations from UniProtKB/Swiss-Prot for PPP1R16A Gene

Cell membrane; Lipid-anchor.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PPP1R16A gene
Compartment Confidence
plasma membrane 4
nucleus 3
cytosol 2
cytoskeleton 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for PPP1R16A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with PPP1R16A: view

Pathways & Interactions for PPP1R16A Gene

PathCards logo

SuperPathways for PPP1R16A Gene

SuperPathway Contained pathways
1 Activation of cAMP-Dependent PKA
.77
.77
.71
.56
2 Beta-Adrenergic Signaling
.37
.37
.37
.36
3 GPCR Pathway
.58
4 Dopamine-DARPP32 Feedback onto cAMP Pathway
-
5 Apoptotic Pathways in Synovial Fibroblasts
.60
genes like me logo Genes that share pathways with PPP1R16A: view

Pathways by source for PPP1R16A Gene

14 Qiagen pathways for PPP1R16A Gene
  • Activation of cAMP-Dependent PKA
  • Activation of PKA through GPCR
  • Beta-Adrenergic Signaling
  • Breast Cancer Regulation by Stathmin1
  • cAMP Pathway

Gene Ontology (GO) - Biological Process for PPP1R16A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0043666 regulation of phosphoprotein phosphatase activity IEA --
genes like me logo Genes that share ontologies with PPP1R16A: view

No data available for SIGNOR curated interactions for PPP1R16A Gene

Drugs & Compounds for PPP1R16A Gene

No Compound Related Data Available

Transcripts for PPP1R16A Gene

mRNA/cDNA for PPP1R16A Gene

5 REFSEQ mRNAs :
13 NCBI additional mRNA sequence :
11 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PPP1R16A

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for PPP1R16A Gene

No ASD Table

Relevant External Links for PPP1R16A Gene

GeneLoc Exon Structure for
PPP1R16A

Expression for PPP1R16A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PPP1R16A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for PPP1R16A Gene

This gene is overexpressed in Testis (19.2), Retina (19.1), Fetal Brain (17.8), and Liver (12.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for PPP1R16A Gene



Protein tissue co-expression partners for PPP1R16A Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for PPP1R16A

SOURCE GeneReport for Unigene cluster for PPP1R16A Gene:

Hs.521937

Evidence on tissue expression from TISSUES for PPP1R16A Gene

  • Lung(4.2)
  • Spleen(4.1)
  • Nervous system(2.5)
genes like me logo Genes that share expression patterns with PPP1R16A: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PPP1R16A Gene

Orthologs for PPP1R16A Gene

This gene was present in the common ancestor of animals.

Orthologs for PPP1R16A Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PPP1R16A 31 30
  • 86.28 (n)
OneToOne
dog
(Canis familiaris)
Mammalia PPP1R16A 31 30
  • 86.01 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Ppp1r16a 17 31 30
  • 82.19 (n)
rat
(Rattus norvegicus)
Mammalia Ppp1r16a 30
  • 82.12 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia PPP1R16A 31
  • 68 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PPP1R16A 31
  • 67 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PPP1R16A 31
  • 68 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ppp1r16a 30
  • 65.97 (n)
zebrafish
(Danio rerio)
Actinopterygii si:dkey-9l5.3 30
  • 57.69 (n)
PPP1R16A 31
  • 53 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG6896 32
  • 42 (a)
MYPT-75D 31
  • 29 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea gfi-2 31 32 30
  • 49.56 (n)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.1404 31
  • 51 (a)
OneToMany
Species where no ortholog for PPP1R16A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PPP1R16A Gene

ENSEMBL:
Gene Tree for PPP1R16A (if available)
TreeFam:
Gene Tree for PPP1R16A (if available)
Aminode:
Evolutionary constrained regions (ECRs) for PPP1R16A: view image

Paralogs for PPP1R16A Gene

Paralogs for PPP1R16A Gene

(1) SIMAP similar genes for PPP1R16A Gene using alignment to 3 proteins:

  • PP16A_HUMAN
  • H0YDB3_HUMAN
  • H0YDU5_HUMAN
genes like me logo Genes that share paralogs with PPP1R16A: view

Variants for PPP1R16A Gene

Additional dbSNP identifiers (rs#s) for PPP1R16A Gene

Structural Variations from Database of Genomic Variants (DGV) for PPP1R16A Gene

Variant ID Type Subtype PubMed ID
dgv1207n67 CNV gain 20364138
dgv12434n54 CNV loss 21841781
dgv12439n54 CNV loss 21841781
dgv12442n54 CNV loss 21841781
dgv907n27 CNV loss 19166990
esv29999 CNV loss 17803354
esv3619130 CNV gain 21293372
nsv428208 CNV gain 18775914
nsv470249 CNV loss 18288195
nsv482126 CNV gain 20164927
nsv515809 CNV gain+loss 19592680
nsv612940 CNV loss 21841781
nsv612951 CNV loss 21841781
nsv612955 CNV loss 21841781
nsv831489 CNV loss 17160897

Variation tolerance for PPP1R16A Gene

Residual Variation Intolerance Score: 59.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.02; 37.24% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PPP1R16A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PPP1R16A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for PPP1R16A Gene

Disorders for PPP1R16A Gene

Additional Disease Information for PPP1R16A

No disorders were found for PPP1R16A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PPP1R16A Gene

Publications for PPP1R16A Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 54
  2. Regulator-driven functional diversification of protein phosphatase-1 in eukaryotic evolution. (PMID: 11948623) Ceulemans H … Bollen M (BioEssays : news and reviews in molecular, cellular and developmental biology 2002) 2 3 54
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 54
  4. Systematic Analysis of Human Protein Phosphatase Interactions and Dynamics. (PMID: 28330616) Yadav L … Varjosalo M (Cell systems 2017) 3 54
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 54

Products for PPP1R16A Gene

Sources for PPP1R16A Gene