Aliases for PPP1R15B Gene
External Ids for PPP1R15B Gene
Previous GeneCards Identifiers for PPP1R15B Gene
This gene encodes a protein phosphatase I-interacting protein that promotes the dephosphorylation of eukaryotic translation initiation factor 2A to regulate translation under conditions of cellular stress. The transcribed messenger RNA contains two upstream open reading frames (ORFs) that repress translation of the main protein coding ORF under normal conditions, while the protein coding ORF is expressed at high levels in response to stress. Continual translation of the mRNA under conditions of eukaryotic translation initiation factor 2A inactivation is thought to create a feedback loop for reactivation of the gene during recovery from stress. In addition, it has been shown that this protein plays a role in membrane traffic that is independent of translation and that it is required for exocytosis from erythroleukemia cells. Allelic variants of this gene are associated with microcephaly, short stature, and impaired glucose metabolism. [provided by RefSeq, Feb 2016]
GeneCards Summary for PPP1R15B Gene
PPP1R15B (Protein Phosphatase 1 Regulatory Subunit 15B) is a Protein Coding gene. Diseases associated with PPP1R15B include Microcephaly, Short Stature, And Impaired Glucose Metabolism 2 and Primary Microcephaly-Mild Intellectual Disability-Young-Onset Diabetes Syndrome. Gene Ontology (GO) annotations related to this gene include protein serine/threonine phosphatase activity. An important paralog of this gene is PPP1R15A.
UniProtKB/Swiss-Prot Summary for PPP1R15B Gene
Maintains low levels of EIF2S1 phosphorylation in unstressed cells by promoting its dephosphorylation by PP1.