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This gene is a member of a group of genes whose transcript levels are increased following stressful growth arrest conditions and treatment with DNA-damaging agents. The induction of this gene by ionizing radiation occurs in certain cell lines regardless of p53 status, and its protein response is correlated with apoptosis following ionizing radiation. [provided by RefSeq, Jul 20... See more...
Aliases for PPP1R15A Gene
Aliases for PPP1R15A Gene
- Protein Phosphatase 1 Regulatory Subunit 15A 2 3 4 5
- GADD34 2 3 4
- Myeloid Differentiation Primary Response Protein MyD116 Homolog 3 4
- Protein Phosphatase 1, Regulatory (Inhibitor) Subunit 15A 2 3
- Growth Arrest And DNA Damage-Inducible Protein GADD34 3 4
- Growth Arrest And DNA-Damage-Inducible 34 2 3
- Protein Phosphatase 1, Regulatory Subunit 15A 2
- PPP1R15A 5
External Ids for PPP1R15A Gene
- HGNC: 14375
- Entrez Gene: 23645
- Ensembl: ENSG00000087074
- OMIM: 611048
- UniProtKB: O75807
Previous GeneCards Identifiers for PPP1R15A Gene
- GC19P050033
- GC19P049743
- GC19P054051
- GC19P054067
- GC19P049375
- GC19P045752
Summaries for PPP1R15A Gene
-
This gene is a member of a group of genes whose transcript levels are increased following stressful growth arrest conditions and treatment with DNA-damaging agents. The induction of this gene by ionizing radiation occurs in certain cell lines regardless of p53 status, and its protein response is correlated with apoptosis following ionizing radiation. [provided by RefSeq, Jul 2008]
GeneCards Summary for PPP1R15A Gene
PPP1R15A (Protein Phosphatase 1 Regulatory Subunit 15A) is a Protein Coding gene. Diseases associated with PPP1R15A include Epiphyseal Dysplasia, Multiple, With Early-Onset Diabetes Mellitus and Malignant Pleural Mesothelioma. Among its related pathways are Signaling by GPCR and Activation of cAMP-Dependent PKA. Gene Ontology (GO) annotations related to this gene include protein kinase binding. An important paralog of this gene is PPP1R15B.
UniProtKB/Swiss-Prot Summary for PPP1R15A Gene
-
Recruits the serine/threonine-protein phosphatase PP1 to dephosphorylate the translation initiation factor eIF-2A/EIF2S1, thereby reversing the shut-off of protein synthesis initiated by stress-inducible kinases and facilitating recovery of cells from stress. Down-regulates the TGF-beta signaling pathway by promoting dephosphorylation of TGFB1 by PP1. May promote apoptosis by inducing TP53 phosphorylation on 'Ser-15'.
Additional gene information for PPP1R15A Gene
- HGNC(14375)
- Entrez Gene(23645)
- Ensembl(ENSG00000087074)
- OMIM(611048)
- UniProtKB(O75807)
- Open Targets Platform(ENSG00000087074)
- Search for PPP1R15A at DataMed
- Search for PPP1R15A at HumanCyc
No data available for Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PPP1R15A Gene
Genomics for PPP1R15A Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for PPP1R15A Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around PPP1R15A on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for PPP1R15A
- Top Transcription factor binding sites by QIAGEN in the PPP1R15A gene promoter:
-
- AP-1
- ATF-2
- ATF6
- c-Jun
- CREB
- deltaCREB
- IRF-1
- IRF-7A
- Sp1
Genomic Locations for PPP1R15A Gene
Genomic Locations for PPP1R15A Gene
- chr19:48,872,392-48,876,062
- (GRCh38/hg38)
- Size:
- 3,671 bases
- Orientation:
- Plus strand
- chr19:49,375,649-49,379,319
- (GRCh37/hg19)
- Size:
- 3,671 bases
- Orientation:
- Plus strand
Genomic View for PPP1R15A Gene
Genes around PPP1R15A on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 19q13.2 by HGNC
- 19q13.33 by Entrez Gene
- 19q13.33 by Ensembl
PPP1R15A Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for PPP1R15A Gene
Proteins for PPP1R15A Gene
-
Protein details for PPP1R15A Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- O75807-PR15A_HUMAN
- Recommended name:
- Protein phosphatase 1 regulatory subunit 15A
- Protein Accession:
- O75807
- B4DKQ3
- Q6IA96
- Q9NVU6
Protein attributes for PPP1R15A Gene
- Size:
- 674 amino acids
- Molecular mass:
- 73478 Da
- Quaternary structure:
-
- Interacts with PCNA (By similarity). Interacts with LYN and KMT2A/MLL1. Interacts with PP1, PPP1R1A and SMARCB1. Interacts with SMAD7. Interacts with BAG1.
- Miscellaneous:
-
- The phosphatase activity of the PPP1R15A-PP1 complex toward EIF2S1 is specifically inhibited by Salubrinal, a drug that protects cells from endoplasmic reticulum stress.
Protein Expression for PPP1R15A Gene
Post-translational modifications for PPP1R15A Gene
- Phosphorylated at multiple Ser/Thr residues. Phosphorylated on tyrosine by LYN; which impairs its antiproliferative activity. Phosphorylation at Tyr-262 enhances proteasomal degradation, this position is dephosphorylated by PTPN2.
- Polyubiquitinated. Exhibits a rapid proteasomal degradation with a half-life under 1 hour, ubiquitination depends on endoplasmic reticulum association.
- Modification sites at PhosphoSitePlus
- Modification sites at neXtProt
Other Protein References for PPP1R15A Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- G Biosciences Immunotag™ GADD34 Antibody
- GeneTex Anti-GADD34 antibody [N1N3]
- Novus Biologicals Antibodies for PPP1R15A
-
Abcam antibodies for PPP1R15A
- Invitrogen Antibodies for PPP1R15A (AFLGC-PPP1R15A)
-
Boster Bio Antibodies for PPP1R15A
-
Santa Cruz Biotechnology (SCBT) Antibodies for PPP1R15A
Protein Products
- Search Origene for MassSpec and Protein Over-expression Lysates for PPP1R15A
- Origene Custom Protein Services for PPP1R15A
-
Signalway Proteins for PPP1R15A
-
Abcam proteins for PPP1R15A
Assay Products
- antibodies-online: Show 9 available PPP1R15A Elisa Kits ranked by validation data
- Compare Top PPP1R15A Elisa Kits
-
Quality Products:
No data available for DME Specific Peptides for PPP1R15A Gene
Domains & Families for PPP1R15A Gene
Gene Families for PPP1R15A Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Predicted intracellular proteins
Protein Domains for PPP1R15A Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for PPP1R15A Gene
- GenScript: Design optimal peptide antigens:
-
- cDNA FLJ51898, highly similar to Homo sapiens protein phosphatase 1, regulatory (inhibitor) subunit 15A (PPP1R15A), mRNA (B4DMT2_HUMAN)
- Myeloid differentiation primary response protein MyD116 homolog (PR15A_HUMAN)
Graphical View of Domain Structure for InterPro Entry
O75807- Family:
-
- Belongs to the PPP1R15 family.
Function for PPP1R15A Gene
Molecular function for PPP1R15A Gene
- UniProtKB/Swiss-Prot Function:
- Recruits the serine/threonine-protein phosphatase PP1 to dephosphorylate the translation initiation factor eIF-2A/EIF2S1, thereby reversing the shut-off of protein synthesis initiated by stress-inducible kinases and facilitating recovery of cells from stress. Down-regulates the TGF-beta signaling pathway by promoting dephosphorylation of TGFB1 by PP1. May promote apoptosis by inducing TP53 phosphorylation on 'Ser-15'.
- UniProtKB/Swiss-Prot Induction:
- Specifically produced in response to stress: in absence of stress, some upstream open reading frame (uORF) of this transcript is translated, thereby preventing its translation (PubMed:19131336). By methyl methanesulfonate and ionizing irradiation (PubMed:9153226). By IL24/interleukin-24 in melanoma cells; which induces apoptosis (PubMed:10490642, PubMed:12114539).
Phenotypes From GWAS Catalog for PPP1R15A Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005515 | protein binding | IPI | 11564868 |
| GO:0008157 | protein phosphatase 1 binding | IPI | 12556489 |
| GO:0019888 | protein phosphatase regulator activity | IC | 11564868 |
| GO:0019901 | protein kinase binding | IPI | 11517336 |
| GO:0072542 | protein phosphatase activator activity | IC | 21518769 |
Phenotypes for PPP1R15A Gene
- MGI mutant phenotypes for PPP1R15A:
- inferred from 3 alleles
- GenomeRNAi human phenotypes for PPP1R15A:
Animal Models for PPP1R15A Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for PPP1R15A - Select products 50% OFF >
- * PPP1R15A CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
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-
OriGene CRISPR knockouts for PPP1R15A
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for PPP1R15A
-
Santa Cruz Biotechnology (SCBT) CRISPR for PPP1R15A
miRNA for PPP1R15A Gene
- miRTarBase miRNAs that target PPP1R15A
-
- mmu-miR-124-3p (MIRT015964)
- hsa-miR-17-5p (MIRT050807)
- hsa-miR-3180-5p (MIRT650872)
- hsa-miR-4303 (MIRT650873)
- hsa-miR-891a-3p (MIRT650874)
- hsa-miR-4483 (MIRT650875)
- hsa-miR-1293 (MIRT650876)
- hsa-miR-6766-5p (MIRT650877)
- hsa-miR-6756-5p (MIRT650878)
- hsa-miR-6745 (MIRT650879)
- hsa-miR-363-5p (MIRT650880)
- hsa-miR-593-5p (MIRT650881)
- hsa-miR-539-5p (MIRT650882)
- hsa-miR-6761-5p (MIRT650883)
- hsa-miR-4329 (MIRT650884)
- hsa-miR-4251 (MIRT650885)
- hsa-miR-136-5p (MIRT650886)
- hsa-miR-4277 (MIRT650887)
- hsa-miR-6874-3p (MIRT650888)
- hsa-miR-148b-5p (MIRT650889)
- hsa-miR-140-3p (MIRT650890)
- hsa-miR-1827 (MIRT763092)
- hsa-miR-1910-3p (MIRT763325)
- hsa-miR-2467-3p (MIRT764120)
- hsa-miR-3192-5p (MIRT765447)
- hsa-miR-34b-3p (MIRT765789)
- hsa-miR-3612 (MIRT765937)
- hsa-miR-3614-5p (MIRT766053)
- hsa-miR-3929 (MIRT767792)
- hsa-miR-4257 (MIRT768157)
- hsa-miR-4419b (MIRT768788)
- hsa-miR-4478 (MIRT769539)
- hsa-miR-4722-5p (MIRT771574)
- hsa-miR-485-5p (MIRT772632)
- hsa-miR-490-3p (MIRT772732)
- hsa-miR-6165 (MIRT775999)
- hsa-miR-6500-3p (MIRT776458)
- hsa-miR-650 (MIRT776695)
- hsa-miR-6511a-5p (MIRT776824)
- hsa-miR-6884-5p (MIRT781020)
- hsa-miR-7851-3p (MIRT782223)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for PPP1R15A
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Clone Products
- Applied Biological Materials (abm): Clones for PPP1R15A - Select products 50% OFF >
- * PPP1R15A as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for PPP1R15A
- Addgene plasmids for PPP1R15A
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for PPP1R15A
Cell Line Products
-
Horizon Cell Lines for PPP1R15A
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PPP1R15A Gene
Localization for PPP1R15A Gene
Subcellular locations from UniProtKB/Swiss-Prot for PPP1R15A Gene
- Endoplasmic reticulum membrane. Peripheral membrane protein. Cytoplasmic side. Mitochondrion outer membrane. Peripheral membrane protein. Cytoplasmic side. Note=Associates with membranes via an N-terminal amphipathic intramembrane region. {ECO:0000269 PubMed:21518769}.
| Compartment | Confidence |
|---|---|
| endoplasmic reticulum | 5 |
| cytosol | 5 |
| mitochondrion | 4 |
| golgi apparatus | 4 |
| plasma membrane | 2 |
| extracellular | 2 |
| cytoskeleton | 2 |
| nucleus | 2 |
| lysosome | 2 |
| peroxisome | 1 |
| endosome | 1 |
- Vesicles (1)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000164 | protein phosphatase type 1 complex | IBA,IDA | 11564868 |
| GO:0005737 | cytoplasm | IDA | 21518769 |
| GO:0005739 | mitochondrion | IDA | 21518769 |
| GO:0005741 | mitochondrial outer membrane | IEA | -- |
| GO:0005783 | endoplasmic reticulum | IDA | 12556489 |
Pathways & Interactions for PPP1R15A Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Activation of cAMP-Dependent PKA |
Activation of cAMP-Dependent PKA
.77
cAMP Pathway
.77
|
Activation of PKA through GPCR
.71
PKA Signaling
.56
|
| 2 | Beta-Adrenergic Signaling |
Beta-Adrenergic Signaling
.37
Erythropoietin Pathway
.37
|
CDK5 Pathway
.37
Insulin Receptor Pathway
.37
|
| 3 | TGF-beta receptor signaling activates SMADs | ||
| 4 | Protein processing in endoplasmic reticulum | ||
| 5 | GPCR Pathway |
Breast Cancer Regulation by Stathmin1
.58
|
|
Pathways by source for PPP1R15A Gene
3 BioSystems pathways for PPP1R15A Gene
4 Reactome pathways for PPP1R15A Gene
1 KEGG pathway for PPP1R15A Gene
14 Qiagen pathways for PPP1R15A Gene
- Activation of cAMP-Dependent PKA
- Activation of PKA through GPCR
- Beta-Adrenergic Signaling
- Breast Cancer Regulation by Stathmin1
- cAMP Pathway
Interacting Proteins for PPP1R15A Gene
Selected Interacting proteins:
O75807-PR15A_HUMAN
ENSP00000200453
for PPP1R15A Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for PPP1R15A
SIGNOR curated interactions for PPP1R15A Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006417 | regulation of translation | IEA | -- |
| GO:0006915 | apoptotic process | TAS | 9153226 |
| GO:0006974 | cellular response to DNA damage stimulus | TAS | 9153226 |
| GO:0007050 | cell cycle arrest | TAS | 9153226 |
| GO:0032058 | positive regulation of translational initiation in response to stress | IC | 12556489 |
Drugs & Compounds for PPP1R15A Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Sephin1 | Pharma | Selective PPP1R15A inhibitor | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
|---|
(1) ApexBio Compounds for PPP1R15A Gene
| Compound | Action | Cas Number |
|---|---|---|
| Sephin1 | Selective PPP1R15A inhibitor | 13098-73-2 |
Transcripts for PPP1R15A Gene
mRNA/cDNA for PPP1R15A Gene
- 1 REFSEQ mRNAs :
- 10 NCBI additional mRNA sequence :
- 2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000200453 2350 nts (view in UCSC)
- ENST00000600406 1725 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for PPP1R15A - Select products 50% OFF >
- * PPP1R15A CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for PPP1R15A
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for PPP1R15A
-
Santa Cruz Biotechnology (SCBT) CRISPR for PPP1R15A
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for PPP1R15A
- Browse OriGene Inhibitory RNA Products For PPP1R15A
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PPP1R15A
Clone Products
- Applied Biological Materials (abm): Clones for PPP1R15A - Select products 50% OFF >
- * PPP1R15A as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for PPP1R15A
- Addgene plasmids for PPP1R15A
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for PPP1R15A
Relevant External Links for PPP1R15A Gene
- GeneLoc Exon Structure for
- PPP1R15A
Expression for PPP1R15A Gene
mRNA differential expression in normal tissues according to GTEx for PPP1R15A Gene
This gene is overexpressed in Whole Blood (x5.3).
This gene is overexpressed in Retina (41.0) and Testis (16.9).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for PPP1R15A Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for PPP1R15A
SOURCE GeneReport for Unigene cluster for PPP1R15A Gene:
Hs.631593Evidence on tissue expression from TISSUES for PPP1R15A Gene
- Nervous system(4.9)
- Blood(4.6)
- Lung(4.1)
- Skin(3.3)
- Pancreas(3.2)
- Muscle(3.2)
- Bone marrow(3.1)
- Liver(3.1)
- Heart(3)
- Intestine(3)
- Kidney(2.9)
- Spleen(2.5)
- Adrenal gland(2.5)
- Lymph node(2.4)
- Stomach(2.3)
- Eye(2.2)
- Thyroid gland(2.2)
Primer Products
-
OriGene qPCR primer pairs for PPP1R15A
-
OriGene qPCR primer pairs and template standards for PPP1R15A
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PPP1R15A Gene
Orthologs for PPP1R15A Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | PPP1R15A 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | PPP1R15A 30 31 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Ppp1r15a 30 17 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | PPP1R15A 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | PPP1R15A 31 |
|
OneToOne | |
| Zebrafish (Danio rerio) |
Actinopterygii | ppp1r15a 31 |
|
OneToOne |
- Species where no ortholog for PPP1R15A was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Lizard (Anolis carolinensis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Oppossum (Monodelphis domestica)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rat (Rattus norvegicus)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Tropical Clawed Frog (Silurana tropicalis)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
Evolution for PPP1R15A Gene
- ENSEMBL:
- Gene Tree for PPP1R15A (if available)
- TreeFam:
- Gene Tree for PPP1R15A (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for PPP1R15A: view image
Paralogs for PPP1R15A Gene
Variants for PPP1R15A Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for PPP1R15A Gene
| SNP ID | Clinical significance and condition | Chr 19 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 778851 | Benign: not provided | 48,873,785(+) | G/A | SYNONYMOUS_VARIANT | |
| 788621 | Benign: not provided | 48,875,607(+) | C/T | INTRON_VARIANT | |
| rs1050166 | - | p.Ala381Val | |||
| rs11541192 | - | p.Gly312Ser | |||
| rs2270946 | - | p.Arg594Cys |
Residual Variation Intolerance Score:
97.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
17.66;
98.29% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for PPP1R15A Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- PPP1R15A
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PPP1R15A Gene
Disorders for PPP1R15A Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| epiphyseal dysplasia, multiple, with early-onset diabetes mellitus |
|
|
| malignant pleural mesothelioma |
|
|
| charcot-marie-tooth disease, demyelinating, type 1b |
|
|
| leukoencephalopathy with vanishing white matter |
|
|
| charcot-marie-tooth disease |
|
|
Search PPP1R15A in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for PPP1R15A
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for PPP1R15A Gene
Publications for PPP1R15A Gene
- Mammalian GADD34, an apoptosis- and DNA damage-inducible gene. (PMID: 9153226) Hollander MC … Fornace AJ (The Journal of biological chemistry 1997) 2 3 4 23
- An upstream open reading frame regulates translation of GADD34 during cellular stresses that induce eIF2alpha phosphorylation. (PMID: 19131336) Lee YY … Jan E (The Journal of biological chemistry 2009) 3 4 23
- GADD34-PP1c recruited by Smad7 dephosphorylates TGFbeta type I receptor. (PMID: 14718519) Shi W … Cao X (The Journal of cell biology 2004) 3 4 23
- Human BAG-1 proteins bind to the cellular stress response protein GADD34 and interfere with GADD34 functions. (PMID: 12724406) Hung WJ … Wu DY (Molecular and cellular biology 2003) 3 4 23
- Growth arrest and DNA damage-inducible protein GADD34 targets protein phosphatase 1 alpha to the endoplasmic reticulum and promotes dephosphorylation of the alpha subunit of eukaryotic translation initiation factor 2. (PMID: 12556489) Brush MH … Shenolikar S (Molecular and cellular biology 2003) 3 4 23
ExternalLinks
Products for PPP1R15A Gene
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- Origene shrna, sirna, and RNAi products in human, mouse, rat for PPP1R15A
- Browse OriGene Inhibitory RNA Products For PPP1R15A
- OriGene qPCR primer pairs for PPP1R15A
- OriGene qPCR primer pairs and template standards for PPP1R15A
- OriGene CRISPR knockouts for PPP1R15A
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For PPP1R15A
- Sino Biological Human cDNA Clone for PPP1R15A
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- Epitope Tag Antibodies & Reporter Protein Antibodies
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- Novus Biologicals Antibodies for PPP1R15A
- Novus Biologicals proteins and lysates for PPP1R15A
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- Abcam antibodies for PPP1R15A
- Abcam proteins for PPP1R15A
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- Invitrogen Antibodies for PPP1R15A (AFLGC-PPP1R15A)
- ApexBio compounds for PPP1R15A
- VectorBuilder Custom and pre-made DNA vectors for PPP1R15A (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for PPP1R15A (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for PPP1R15A (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for PPP1R15A CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for PPP1R15A
- Addgene plasmids for PPP1R15A
- antibodies-online: Show 15 available PPP1R15A Antibodies ranked by validation data
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- antibodies-online: Show 9 available PPP1R15A Elisa Kits ranked by validation data
- Compare Top PPP1R15A Elisa Kits
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- antibodies-online: Show 7 available PPP1R15A Proteins ranked by validation data
- Compare Top PPP1R15A Proteins
- Santa Cruz Biotechnology (SCBT) Antibodies for PPP1R15A
- Search Santa Cruz Biotechnology (SCBT) for PPP1R15A siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for PPP1R15A
- Horizon Cell Lines for PPP1R15A
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- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for PPP1R15A
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for PPP1R15A
- Search GeneCopoeia for miRNA 3'UTR Target clone products for PPP1R15A
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PPP1R15A
- Boster Bio Antibodies for PPP1R15A
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- Signalway Proteins for PPP1R15A
Sources for PPP1R15A Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) Genetics Home Reference
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNACentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Signalway Antibody
- (175) Open Targets Platform
- (176) 5SRRNADB
- (177) snoDB
- (178) MirGeneDB