Protein phosphatase-1 (PP1; see MIM 176875) is a major cellular phosphatase that reverses serine/threonine protein phosphorylation. PPP1R14D is a PP1 inhibitor that itself is regulated by phosphorylation (Liu et al., 2004 [PubMed 12974676]).[supplied by OMIM, Feb 2010] See more...

Aliases for PPP1R14D Gene

Aliases for PPP1R14D Gene

  • Protein Phosphatase 1 Regulatory Inhibitor Subunit 14D 2 3 5
  • GBPI-1 2 3 4
  • Gastrointestinal And Brain-Specific PP1-Inhibitory Protein 1 3 4
  • Protein Phosphatase 1 Regulatory Subunit 14D 3 4
  • Gut And Brain Phosphatase Inhibitor 1 2 3
  • PKC-Dependent PP1 Inhibitory Protein 2 3
  • CPI17-Like 2 3
  • Protein Phosphatase 1, Regulatory (Inhibitor) Subunit 14D 2
  • MGC119014 2
  • MGC119016 2
  • PPP1R14D 5
  • FLJ20251 2
  • GBPI1 3
  • GBPI 4

External Ids for PPP1R14D Gene

Previous GeneCards Identifiers for PPP1R14D Gene

  • GC15M036475
  • GC15M034003
  • GC15M038686
  • GC15M038823
  • GC15M038894
  • GC15M041107
  • GC15M017956

Summaries for PPP1R14D Gene

Entrez Gene Summary for PPP1R14D Gene

  • Protein phosphatase-1 (PP1; see MIM 176875) is a major cellular phosphatase that reverses serine/threonine protein phosphorylation. PPP1R14D is a PP1 inhibitor that itself is regulated by phosphorylation (Liu et al., 2004 [PubMed 12974676]).[supplied by OMIM, Feb 2010]

GeneCards Summary for PPP1R14D Gene

PPP1R14D (Protein Phosphatase 1 Regulatory Inhibitor Subunit 14D) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include protein phosphatase inhibitor activity. An important paralog of this gene is PPP1R14A.

UniProtKB/Swiss-Prot Summary for PPP1R14D Gene

  • Inhibitor of PPP1CA. Has inhibitory activity only when phosphorylated, creating a molecular switch for regulating the phosphorylation status of PPP1CA substrates and smooth muscle contraction.

Additional gene information for PPP1R14D Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PPP1R14D Gene

Genomics for PPP1R14D Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for PPP1R14D Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PPP1R14D on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for PPP1R14D

Top Transcription factor binding sites by QIAGEN in the PPP1R14D gene promoter:
  • PPAR-gamma2
  • STAT1
  • STAT1alpha
  • STAT1beta
  • STAT2
  • STAT3
  • STAT4
  • STAT5A
  • STAT5B
  • STAT6

Genomic Locations for PPP1R14D Gene

Genomic Locations for PPP1R14D Gene
chr15:40,815,451-40,828,793
(GRCh38/hg38)
Size:
13,343 bases
Orientation:
Minus strand
chr15:41,107,643-41,120,907
(GRCh37/hg19)
Size:
13,265 bases
Orientation:
Minus strand

Genomic View for PPP1R14D Gene

Genes around PPP1R14D on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PPP1R14D Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PPP1R14D Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PPP1R14D Gene

Proteins for PPP1R14D Gene

  • Protein details for PPP1R14D Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NXH3-PP14D_HUMAN
    Recommended name:
    Protein phosphatase 1 regulatory subunit 14D
    Protein Accession:
    Q9NXH3
    Secondary Accessions:
    • Q4V773

    Protein attributes for PPP1R14D Gene

    Size:
    145 amino acids
    Molecular mass:
    16508 Da
    Quaternary structure:
    No Data Available

neXtProt entry for PPP1R14D Gene

Post-translational modifications for PPP1R14D Gene

Other Protein References for PPP1R14D Gene

No data available for DME Specific Peptides for PPP1R14D Gene

Domains & Families for PPP1R14D Gene

Gene Families for PPP1R14D Gene

Protein Domains for PPP1R14D Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for PPP1R14D Gene

GenScript: Design optimal peptide antigens:
  • Gastrointestinal and brain-specific PP1-inhibitory protein 1 (PP14D_HUMAN)
  • PPP1R14D protein (Q4V755_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9NXH3

UniProtKB/Swiss-Prot:

PP14D_HUMAN :
  • Belongs to the PP1 inhibitor family.
Family:
  • Belongs to the PP1 inhibitor family.
genes like me logo Genes that share domains with PPP1R14D: view

Function for PPP1R14D Gene

Molecular function for PPP1R14D Gene

UniProtKB/Swiss-Prot Function:
Inhibitor of PPP1CA. Has inhibitory activity only when phosphorylated, creating a molecular switch for regulating the phosphorylation status of PPP1CA substrates and smooth muscle contraction.

Phenotypes From GWAS Catalog for PPP1R14D Gene

Gene Ontology (GO) - Molecular Function for PPP1R14D Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004864 protein phosphatase inhibitor activity IEA --
GO:0004865 protein serine/threonine phosphatase inhibitor activity IDA 12974676
genes like me logo Genes that share ontologies with PPP1R14D: view
genes like me logo Genes that share phenotypes with PPP1R14D: view

Animal Models for PPP1R14D Gene

MGI Knock Outs for PPP1R14D:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PPP1R14D

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for PPP1R14D Gene

Localization for PPP1R14D Gene

Subcellular locations from UniProtKB/Swiss-Prot for PPP1R14D Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PPP1R14D gene
Compartment Confidence
nucleus 3
cytosol 2
extracellular 1
cytoskeleton 1
endoplasmic reticulum 1
endosome 1

Gene Ontology (GO) - Cellular Components for PPP1R14D Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with PPP1R14D: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for PPP1R14D Gene

Pathways & Interactions for PPP1R14D Gene

PathCards logo

SuperPathways for PPP1R14D Gene

No Data Available

Interacting Proteins for PPP1R14D Gene

STRING Interaction Network Preview (showing top 1 STRING interactants - click image to see details)
STRING Interaction Network
Selected Interacting proteins: ENSP00000398342 Q9NXH3-PP14D_HUMAN for PPP1R14D Gene via STRING IID

Gene Ontology (GO) - Biological Process for PPP1R14D Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0042325 regulation of phosphorylation IEA --
GO:1905183 negative regulation of protein serine/threonine phosphatase activity IDA 12974676
GO:1905184 positive regulation of protein serine/threonine phosphatase activity IDA 12974676
genes like me logo Genes that share ontologies with PPP1R14D: view

No data available for Pathways by source and SIGNOR curated interactions for PPP1R14D Gene

Drugs & Compounds for PPP1R14D Gene

No Compound Related Data Available

Transcripts for PPP1R14D Gene

mRNA/cDNA for PPP1R14D Gene

2 REFSEQ mRNAs :
7 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PPP1R14D

Alternative Splicing Database (ASD) splice patterns (SP) for PPP1R14D Gene

ExUns: 1 ^ 2 ^ 3 ^ 4
SP1:
SP2: -

Relevant External Links for PPP1R14D Gene

GeneLoc Exon Structure for
PPP1R14D

Expression for PPP1R14D Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PPP1R14D Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PPP1R14D Gene

This gene is overexpressed in Colon - Transverse (x33.4) and Small Intestine - Terminal Ileum (x13.2).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for PPP1R14D

SOURCE GeneReport for Unigene cluster for PPP1R14D Gene:

Hs.192927

mRNA Expression by UniProt/SwissProt for PPP1R14D Gene:

Q9NXH3-PP14D_HUMAN
Tissue specificity: Detected in colon, intestine, kidney and brain cortex.

Evidence on tissue expression from TISSUES for PPP1R14D Gene

  • Intestine(4.3)
genes like me logo Genes that share expression patterns with PPP1R14D: view

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for PPP1R14D Gene

Orthologs for PPP1R14D Gene

This gene was present in the common ancestor of chordates.

Orthologs for PPP1R14D Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia PPP1R14D 30 31
  • 99.54 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia PPP1R14D 30 31
  • 90.05 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia PPP1R14D 30 31
  • 88.66 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Ppp1r14d 30
  • 83.68 (n)
Mouse
(Mus musculus)
Mammalia Ppp1r14d 30 17 31
  • 83.45 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia PPP1R14D 31
  • 44 (a)
OneToOne
Chicken
(Gallus gallus)
Aves PPP1R14D 30 31
  • 62.72 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia PPP1R14D 31
  • 18 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia ppp1r14d 30
  • 56.67 (n)
Zebrafish
(Danio rerio)
Actinopterygii ppp1r14ab 31
  • 14 (a)
ManyToMany
Species where no ortholog for PPP1R14D was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for PPP1R14D Gene

ENSEMBL:
Gene Tree for PPP1R14D (if available)
TreeFam:
Gene Tree for PPP1R14D (if available)
Aminode:
Evolutionary constrained regions (ECRs) for PPP1R14D: view image

Paralogs for PPP1R14D Gene

Paralogs for PPP1R14D Gene

(4) SIMAP similar genes for PPP1R14D Gene using alignment to 3 proteins:

  • PP14D_HUMAN
  • E9PAT1_HUMAN
  • Q4V755_HUMAN
genes like me logo Genes that share paralogs with PPP1R14D: view

Variants for PPP1R14D Gene

Additional dbSNP identifiers (rs#s) for PPP1R14D Gene

Structural Variations from Database of Genomic Variants (DGV) for PPP1R14D Gene

Variant ID Type Subtype PubMed ID
nsv1054764 CNV gain 25217958
nsv569228 CNV loss 21841781

Variation tolerance for PPP1R14D Gene

Residual Variation Intolerance Score: 55.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.82; 17.28% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PPP1R14D Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PPP1R14D

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for PPP1R14D Gene

Disorders for PPP1R14D Gene

No disorders were found for PPP1R14D Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PPP1R14D Gene

Publications for PPP1R14D Gene

  1. GBPI, a novel gastrointestinal- and brain-specific PP1-inhibitory protein, is activated by PKC and inactivated by PKA. (PMID: 12974676) Liu QR … Uhl GR (The Biochemical journal 2004) 3 4 23
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  4. Regulator-driven functional diversification of protein phosphatase-1 in eukaryotic evolution. (PMID: 11948623) Ceulemans H … Bollen M (BioEssays : news and reviews in molecular, cellular and developmental biology 2002) 2 3
  5. Systematic Analysis of Human Protein Phosphatase Interactions and Dynamics. (PMID: 28330616) Yadav L … Varjosalo M (Cell systems 2017) 3

Products for PPP1R14D Gene

Sources for PPP1R14D Gene