The degree of protein phosphorylation is regulated by a balance of protein kinase and phosphatase activities. Protein phosphatase-1 (PP1; see MIM 176875) is a signal-transducing phosphatase that influences neuronal activity, protein synthesis, metabolism, muscle contraction, and cell division. PPP1R14C is an inhibitor of PP1 (Liu et al., 2002 [PubMed 11812771]).[supplied by OMI... See more...

Aliases for PPP1R14C Gene

Aliases for PPP1R14C Gene

  • Protein Phosphatase 1 Regulatory Inhibitor Subunit 14C 2 3 5
  • KEPI 2 3 4
  • Serologically Defined Breast Cancer Antigen NY-BR-81 3 4
  • Protein Phosphatase 1 Regulatory Subunit 14C 3 4
  • PKC-Potentiated PP1 Inhibitory Protein 3 4
  • Kinase C-Enhanced PP1 Inhibitor 2 3
  • Kinase-Enhanced PP1 Inhibitor 3 4
  • CPI17-Like 2 3
  • NY-BR-81 2 3
  • Protein Phosphatase 1, Regulatory (Inhibitor) Subunit 14C 2
  • PPP1R14C 5

External Ids for PPP1R14C Gene

Previous GeneCards Identifiers for PPP1R14C Gene

  • GC06P150025
  • GC06P150359
  • GC06P150495
  • GC06P150556
  • GC06P150505
  • GC06P150464
  • GC06P148029

Summaries for PPP1R14C Gene

Entrez Gene Summary for PPP1R14C Gene

  • The degree of protein phosphorylation is regulated by a balance of protein kinase and phosphatase activities. Protein phosphatase-1 (PP1; see MIM 176875) is a signal-transducing phosphatase that influences neuronal activity, protein synthesis, metabolism, muscle contraction, and cell division. PPP1R14C is an inhibitor of PP1 (Liu et al., 2002 [PubMed 11812771]).[supplied by OMIM, Feb 2010]

GeneCards Summary for PPP1R14C Gene

PPP1R14C (Protein Phosphatase 1 Regulatory Inhibitor Subunit 14C) is a Protein Coding gene. Diseases associated with PPP1R14C include Ophthalmomyiasis and Pseudobulbar Palsy. Gene Ontology (GO) annotations related to this gene include protein serine/threonine phosphatase inhibitor activity. An important paralog of this gene is PPP1R14B.

UniProtKB/Swiss-Prot Summary for PPP1R14C Gene

Gene Wiki entry for PPP1R14C Gene

Additional gene information for PPP1R14C Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PPP1R14C Gene

Genomics for PPP1R14C Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for PPP1R14C Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PPP1R14C on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for PPP1R14C

Top Transcription factor binding sites by QIAGEN in the PPP1R14C gene promoter:
  • AML1a
  • E47
  • FOXO4
  • LCR-F1
  • NF-kappaB
  • NF-kappaB1
  • NF-kappaB2
  • Nkx6-1
  • RORalpha2
  • Tal-1beta

Genomic Locations for PPP1R14C Gene

Genomic Locations for PPP1R14C Gene
chr6:150,143,044-150,250,392
(GRCh38/hg38)
Size:
107,349 bases
Orientation:
Plus strand
chr6:150,464,188-150,571,528
(GRCh37/hg19)
Size:
107,341 bases
Orientation:
Plus strand

Genomic View for PPP1R14C Gene

Genes around PPP1R14C on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PPP1R14C Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PPP1R14C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PPP1R14C Gene

Proteins for PPP1R14C Gene

  • Protein details for PPP1R14C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TAE6-PP14C_HUMAN
    Recommended name:
    Protein phosphatase 1 regulatory subunit 14C
    Protein Accession:
    Q8TAE6
    Secondary Accessions:
    • Q5VY83
    • Q96BB1
    • Q9H277

    Protein attributes for PPP1R14C Gene

    Size:
    165 amino acids
    Molecular mass:
    17843 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAG48264.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for PPP1R14C Gene

Post-translational modifications for PPP1R14C Gene

  • Has over 600-fold higher inhibitory activity when phosphorylated, creating a molecular switch for regulating the phosphorylation status of PPP1CA substrates and smooth muscle contraction (By similarity). The main inhibitory site appears to be Thr-73.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PPP1R14C Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for PPP1R14C Gene

Domains & Families for PPP1R14C Gene

Gene Families for PPP1R14C Gene

Protein Domains for PPP1R14C Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for PPP1R14C Gene

GenScript: Design optimal peptide antigens:
  • Serologically defined breast cancer antigen NY-BR-81 (PP14C_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8TAE6

UniProtKB/Swiss-Prot:

PP14C_HUMAN :
  • Belongs to the PP1 inhibitor family.
Family:
  • Belongs to the PP1 inhibitor family.
genes like me logo Genes that share domains with PPP1R14C: view

Function for PPP1R14C Gene

Molecular function for PPP1R14C Gene

UniProtKB/Swiss-Prot Function:
Inhibitor of the PP1 regulatory subunit PPP1CA.

Phenotypes From GWAS Catalog for PPP1R14C Gene

Gene Ontology (GO) - Molecular Function for PPP1R14C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004864 protein phosphatase inhibitor activity IEA --
GO:0004865 protein serine/threonine phosphatase inhibitor activity IEA,IBA 21873635
genes like me logo Genes that share ontologies with PPP1R14C: view
genes like me logo Genes that share phenotypes with PPP1R14C: view

Animal Models for PPP1R14C Gene

MGI Knock Outs for PPP1R14C:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PPP1R14C

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PPP1R14C Gene

Localization for PPP1R14C Gene

Subcellular locations from UniProtKB/Swiss-Prot for PPP1R14C Gene

Cytoplasm. Membrane. Peripheral membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PPP1R14C gene
Compartment Confidence
nucleus 2
cytosol 2
plasma membrane 1
extracellular 1
cytoskeleton 1
mitochondrion 1
endoplasmic reticulum 1
lysosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for PPP1R14C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with PPP1R14C: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for PPP1R14C Gene

Pathways & Interactions for PPP1R14C Gene

PathCards logo

SuperPathways for PPP1R14C Gene

No Data Available

SIGNOR curated interactions for PPP1R14C Gene

Is activated by:

Gene Ontology (GO) - Biological Process for PPP1R14C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0032515 negative regulation of phosphoprotein phosphatase activity IEA --
GO:0042325 regulation of phosphorylation IEA --
genes like me logo Genes that share ontologies with PPP1R14C: view

No data available for Pathways by source for PPP1R14C Gene

Drugs & Compounds for PPP1R14C Gene

(1) Drugs for PPP1R14C Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with PPP1R14C: view

Transcripts for PPP1R14C Gene

mRNA/cDNA for PPP1R14C Gene

1 REFSEQ mRNAs :
7 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PPP1R14C

Alternative Splicing Database (ASD) splice patterns (SP) for PPP1R14C Gene

No ASD Table

Relevant External Links for PPP1R14C Gene

GeneLoc Exon Structure for
PPP1R14C

Expression for PPP1R14C Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PPP1R14C Gene

mRNA differential expression in normal tissues according to GTEx for PPP1R14C Gene

This gene is overexpressed in Skin - Sun Exposed (Lower leg) (x7.4), Skin - Not Sun Exposed (Suprapubic) (x7.2), Heart - Left Ventricle (x6.5), and Heart - Atrial Appendage (x6.3).

Protein differential expression in normal tissues from HIPED for PPP1R14C Gene

This gene is overexpressed in Adipocyte (37.9), Fetal heart (14.2), and Heart (8.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for PPP1R14C Gene



Protein tissue co-expression partners for PPP1R14C Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for PPP1R14C

SOURCE GeneReport for Unigene cluster for PPP1R14C Gene:

Hs.486798

mRNA Expression by UniProt/SwissProt for PPP1R14C Gene:

Q8TAE6-PP14C_HUMAN
Tissue specificity: Detected in breast cancer.

Evidence on tissue expression from TISSUES for PPP1R14C Gene

  • Skin(4.5)
  • Heart(2.4)
  • Muscle(2.3)
genes like me logo Genes that share expression patterns with PPP1R14C: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for PPP1R14C Gene

Orthologs for PPP1R14C Gene

This gene was present in the common ancestor of chordates.

Orthologs for PPP1R14C Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia PPP1R14C 30 31
  • 99.39 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia PPP1R14C 30
  • 94.02 (n)
-- 31
  • 60 (a)
ManyToMany
Cow
(Bos Taurus)
Mammalia PPP1R14C 31
  • 92 (a)
OneToOne
LOC783497 30
  • 88.28 (n)
Rat
(Rattus norvegicus)
Mammalia Ppp1r14c 30
  • 86.59 (n)
Mouse
(Mus musculus)
Mammalia Ppp1r14c 30 17 31
  • 86.59 (n)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia PPP1R14C 31
  • 80 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia PPP1R14C 31
  • 42 (a)
OneToOne
Chicken
(Gallus gallus)
Aves PPP1R14C 31
  • 78 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia PPP1R14C 31
  • 84 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia ppp1r14c 30
  • 82.46 (n)
Str.11 30
Zebrafish
(Danio rerio)
Actinopterygii ppp1r14c 30 31 31
  • 75.89 (n)
OneToMany
Species where no ortholog for PPP1R14C was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for PPP1R14C Gene

ENSEMBL:
Gene Tree for PPP1R14C (if available)
TreeFam:
Gene Tree for PPP1R14C (if available)
Aminode:
Evolutionary constrained regions (ECRs) for PPP1R14C: view image

Paralogs for PPP1R14C Gene

Paralogs for PPP1R14C Gene

(4) SIMAP similar genes for PPP1R14C Gene using alignment to 2 proteins:

  • PP14C_HUMAN
  • L8EAF9_HUMAN
genes like me logo Genes that share paralogs with PPP1R14C: view

Variants for PPP1R14C Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for PPP1R14C Gene

SNP ID Clinical significance and condition Chr 06 pos Variation AA Info Type
rs2297672 - p.Thr10Ala

Additional dbSNP identifiers (rs#s) for PPP1R14C Gene

Structural Variations from Database of Genomic Variants (DGV) for PPP1R14C Gene

Variant ID Type Subtype PubMed ID
dgv1839e212 CNV loss 25503493
dgv1840e212 CNV loss 25503493
esv1003519 CNV insertion 20482838
esv2434869 CNV insertion 19546169
esv26363 CNV gain 19812545
esv3303044 CNV tandem duplication 20981092
esv3571450 CNV loss 25503493
esv3571462 CNV loss 25503493
esv3576235 CNV gain 25503493
esv3611228 CNV loss 21293372
esv3890963 CNV loss 25118596
nsv1026690 CNV gain 25217958
nsv1140712 CNV deletion 24896259
nsv1141828 CNV insertion 24896259
nsv1148196 CNV insertion 26484159
nsv1151745 CNV insertion 26484159
nsv477214 CNV novel sequence insertion 20440878
nsv5536 CNV insertion 18451855
nsv5537 CNV insertion 18451855
nsv604848 CNV gain 21841781
nsv830843 CNV gain+loss 17160897

Variation tolerance for PPP1R14C Gene

Residual Variation Intolerance Score: 61.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.64; 13.62% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PPP1R14C Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PPP1R14C

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PPP1R14C Gene

Disorders for PPP1R14C Gene

MalaCards: The human disease database

(3) MalaCards diseases for PPP1R14C Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
ophthalmomyiasis
  • ocular myiasis
pseudobulbar palsy
  • pseudobulbar paralysis
breast cancer
  • breast lobular carcinoma
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for PPP1R14C

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with PPP1R14C: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PPP1R14C Gene

Publications for PPP1R14C Gene

  1. KEPI, a PKC-dependent protein phosphatase 1 inhibitor regulated by morphine. (PMID: 11812771) Liu QR … Uhl GR (The Journal of biological chemistry 2002) 3 4 23
  2. Genome-wide association and large-scale follow up identifies 16 new loci influencing lung function. (PMID: 21946350) Soler Artigas M … Tobin MD (Nature genetics 2011) 3 41
  3. A genome-wide association study identifies novel and functionally related susceptibility Loci for Kawasaki disease. (PMID: 19132087) Burgner D … International Kawasaki Disease Genetics Consortium (PLoS genetics 2009) 3 41
  4. SNCA variants are associated with increased risk for multiple system atrophy. (PMID: 19475667) Scholz SW … Gasser T (Annals of neurology 2009) 3 41
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4

Products for PPP1R14C Gene

Sources for PPP1R14C Gene