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Aliases for PPP1R14C Gene

Aliases for PPP1R14C Gene

  • Protein Phosphatase 1 Regulatory Inhibitor Subunit 14C 2 3 5
  • Serologically Defined Breast Cancer Antigen NY-BR-81 3 4
  • PKC-Potentiated PP1 Inhibitory Protein 3 4
  • Kinase C-Enhanced PP1 Inhibitor 2 3
  • Kinase-Enhanced PP1 Inhibitor 3 4
  • KEPI 3 4
  • Protein Phosphatase 1, Regulatory (Inhibitor) Subunit 14C 2
  • Protein Phosphatase 1 Regulatory Subunit 14C 3
  • CPI17-Like 3
  • NY-BR-81 3

External Ids for PPP1R14C Gene

Previous GeneCards Identifiers for PPP1R14C Gene

  • GC06P150025
  • GC06P150359
  • GC06P150495
  • GC06P150556
  • GC06P150505
  • GC06P150464
  • GC06P148029

Summaries for PPP1R14C Gene

Entrez Gene Summary for PPP1R14C Gene

  • The degree of protein phosphorylation is regulated by a balance of protein kinase and phosphatase activities. Protein phosphatase-1 (PP1; see MIM 176875) is a signal-transducing phosphatase that influences neuronal activity, protein synthesis, metabolism, muscle contraction, and cell division. PPP1R14C is an inhibitor of PP1 (Liu et al., 2002 [PubMed 11812771]).[supplied by OMIM, Feb 2010]

GeneCards Summary for PPP1R14C Gene

PPP1R14C (Protein Phosphatase 1 Regulatory Inhibitor Subunit 14C) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include protein serine/threonine phosphatase inhibitor activity. An important paralog of this gene is PPP1R14B.

UniProtKB/Swiss-Prot for PPP1R14C Gene

  • Inhibitor of the PP1 regulatory subunit PPP1CA.

Gene Wiki entry for PPP1R14C Gene

Additional gene information for PPP1R14C Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PPP1R14C Gene

Genomics for PPP1R14C Gene

GeneHancer (GH) Regulatory Elements for PPP1R14C Gene

Promoters and enhancers for PPP1R14C Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH06I150142 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE dbSUPER 550.8 +1.3 1288 4.6 PKNOX1 ARNT FEZF1 GLI4 ZNF2 GLIS2 ZNF213 KLF7 ZNF263 SP3 PPP1R14C NUP43 PPIL4 ENSG00000231760 KATNA1 LATS1 ENSG00000238594
GH06I150200 Enhancer 0.9 ENCODE dbSUPER 20.8 +58.8 58830 2.8 BCOR ESRRA PKNOX1 ZMYM3 FOSL2 FOS SMARCA5 L3MBTL2 BHLHE40 MNT PPP1R14C ENSG00000238594 RNU4-7P IYD LOC105378054 GC06M150158
GH06I150250 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 10.8 +111.4 111356 8 ATF1 PKNOX1 ARNT FEZF1 ZNF2 TCF12 ZNF766 ZNF213 GATA2 KLF7 ENSG00000268592 NUP43 ENSG00000216906 PPIL4 ENSG00000231760 KATNA1 LRP11 LATS1 ENSG00000238594 PPP1R14C
GH06I150266 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 9.1 +127.3 127317 8.3 HDGF PKNOX1 SMAD1 ARNT FEZF1 ZNF2 ZNF766 CBX5 ZNF416 FOS LOC105378054 LATS1 NUP43 PPIL4 ENSG00000231760 KATNA1 RNU4-7P ENSG00000238594 ENSG00000233330 PPP1R14C
GH06I150176 Enhancer 1.5 VISTA FANTOM5 ENCODE dbSUPER 7.9 +34.0 33954 2.9 SRF RFX1 ZNF189 KLF17 EBF1 ZIC2 GLIS1 SCRT2 ZSCAN5C HMBOX1 PPP1R14C ENSG00000238594 LOC105378054 GC06M150158
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around PPP1R14C on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the PPP1R14C gene promoter:

Genomic Locations for PPP1R14C Gene

Genomic Locations for PPP1R14C Gene
107,341 bases
Plus strand

Genomic View for PPP1R14C Gene

Genes around PPP1R14C on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PPP1R14C Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PPP1R14C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PPP1R14C Gene

Proteins for PPP1R14C Gene

  • Protein details for PPP1R14C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein phosphatase 1 regulatory subunit 14C
    Protein Accession:
    Secondary Accessions:
    • Q5VY83
    • Q96BB1
    • Q9H277

    Protein attributes for PPP1R14C Gene

    165 amino acids
    Molecular mass:
    17843 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAG48264.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for PPP1R14C Gene

Post-translational modifications for PPP1R14C Gene

  • Has over 600-fold higher inhibitory activity when phosphorylated, creating a molecular switch for regulating the phosphorylation status of PPP1CA substrates and smooth muscle contraction (By similarity). The main inhibitory site appears to be Thr-73.

Other Protein References for PPP1R14C Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for PPP1R14C Gene

Domains & Families for PPP1R14C Gene

Gene Families for PPP1R14C Gene

Protein Domains for PPP1R14C Gene


Suggested Antigen Peptide Sequences for PPP1R14C Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the PP1 inhibitor family.
  • Belongs to the PP1 inhibitor family.
genes like me logo Genes that share domains with PPP1R14C: view

Function for PPP1R14C Gene

Molecular function for PPP1R14C Gene

UniProtKB/Swiss-Prot Function:
Inhibitor of the PP1 regulatory subunit PPP1CA.

Phenotypes From GWAS Catalog for PPP1R14C Gene

Gene Ontology (GO) - Molecular Function for PPP1R14C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004865 protein serine/threonine phosphatase inhibitor activity IEA --
genes like me logo Genes that share ontologies with PPP1R14C: view
genes like me logo Genes that share phenotypes with PPP1R14C: view

Animal Models for PPP1R14C Gene

MGI Knock Outs for PPP1R14C:

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PPP1R14C Gene

Localization for PPP1R14C Gene

Subcellular locations from UniProtKB/Swiss-Prot for PPP1R14C Gene

Cytoplasm. Membrane; Peripheral membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PPP1R14C gene
Compartment Confidence
nucleus 2
cytosol 2
extracellular 1

Gene Ontology (GO) - Cellular Components for PPP1R14C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with PPP1R14C: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for PPP1R14C Gene

Pathways & Interactions for PPP1R14C Gene

SuperPathways for PPP1R14C Gene

No Data Available

SIGNOR curated interactions for PPP1R14C Gene

Is inactivated by:

Gene Ontology (GO) - Biological Process for PPP1R14C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0032515 negative regulation of phosphoprotein phosphatase activity IEA --
GO:0042325 regulation of phosphorylation IEA --
GO:0043086 negative regulation of catalytic activity IEA --
genes like me logo Genes that share ontologies with PPP1R14C: view

No data available for Pathways by source for PPP1R14C Gene

Drugs & Compounds for PPP1R14C Gene

(1) Drugs for PPP1R14C Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with PPP1R14C: view

Transcripts for PPP1R14C Gene

mRNA/cDNA for PPP1R14C Gene

(2) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(85) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for PPP1R14C Gene

Protein phosphatase 1, regulatory (inhibitor) subunit 14C:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for PPP1R14C Gene

No ASD Table

Relevant External Links for PPP1R14C Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PPP1R14C Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PPP1R14C Gene

mRNA differential expression in normal tissues according to GTEx for PPP1R14C Gene

This gene is overexpressed in Skin - Sun Exposed (Lower leg) (x7.4), Skin - Not Sun Exposed (Suprapubic) (x7.2), Heart - Left Ventricle (x6.5), and Heart - Atrial Appendage (x6.3).

Protein differential expression in normal tissues from HIPED for PPP1R14C Gene

This gene is overexpressed in Adipocyte (37.9), Fetal heart (14.2), and Heart (8.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for PPP1R14C Gene

Protein tissue co-expression partners for PPP1R14C Gene

NURSA nuclear receptor signaling pathways regulating expression of PPP1R14C Gene:


SOURCE GeneReport for Unigene cluster for PPP1R14C Gene:


mRNA Expression by UniProt/SwissProt for PPP1R14C Gene:

Tissue specificity: Detected in breast cancer.

Evidence on tissue expression from TISSUES for PPP1R14C Gene

  • Skin(4.3)
genes like me logo Genes that share expression patterns with PPP1R14C: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for PPP1R14C Gene

Orthologs for PPP1R14C Gene

This gene was present in the common ancestor of chordates.

Orthologs for PPP1R14C Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia PPP1R14C 33 34
  • 99.39 (n)
(Canis familiaris)
Mammalia PPP1R14C 33
  • 94.02 (n)
-- 34
  • 60 (a)
(Bos Taurus)
Mammalia PPP1R14C 34
  • 92 (a)
LOC783497 33
  • 88.28 (n)
(Mus musculus)
Mammalia Ppp1r14c 33 16 34
  • 86.59 (n)
(Rattus norvegicus)
Mammalia Ppp1r14c 33
  • 86.59 (n)
(Ornithorhynchus anatinus)
Mammalia PPP1R14C 34
  • 80 (a)
(Monodelphis domestica)
Mammalia PPP1R14C 34
  • 42 (a)
(Gallus gallus)
Aves PPP1R14C 34
  • 78 (a)
(Anolis carolinensis)
Reptilia PPP1R14C 34
  • 84 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia ppp1r14c 33
  • 82.46 (n)
Str.11 33
(Danio rerio)
Actinopterygii LOC100330870 33
  • 75.89 (n)
ppp1r14c 34 34
  • 69 (a)
Species where no ortholog for PPP1R14C was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PPP1R14C Gene

Gene Tree for PPP1R14C (if available)
Gene Tree for PPP1R14C (if available)

Paralogs for PPP1R14C Gene

Paralogs for PPP1R14C Gene

(4) SIMAP similar genes for PPP1R14C Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with PPP1R14C: view

Variants for PPP1R14C Gene

Sequence variations from dbSNP and Humsavar for PPP1R14C Gene

SNP ID Clin Chr 06 pos Variation AA Info Type
rs1000044510 -- 150,208,790(+) A/C intron_variant
rs1000052024 -- 150,141,118(+) C/G upstream_transcript_variant
rs1000059672 -- 150,158,495(+) G/C genic_upstream_transcript_variant, intron_variant
rs1000059921 -- 150,248,070(+) T/C intron_variant
rs1000123756 -- 150,165,135(+) G/T genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for PPP1R14C Gene

Variant ID Type Subtype PubMed ID
nsv830843 CNV gain+loss 17160897
nsv604848 CNV gain 21841781
nsv5537 CNV insertion 18451855
nsv5536 CNV insertion 18451855
nsv477214 CNV novel sequence insertion 20440878
nsv1151745 CNV insertion 26484159
nsv1148196 CNV insertion 26484159
nsv1141828 CNV insertion 24896259
nsv1140712 CNV deletion 24896259
nsv1026690 CNV gain 25217958
esv3890963 CNV loss 25118596
esv3611228 CNV loss 21293372
esv3576235 CNV gain 25503493
esv3571462 CNV loss 25503493
esv3571450 CNV loss 25503493
esv3303044 CNV tandem duplication 20981092
esv26363 CNV gain 19812545
esv2434869 CNV insertion 19546169
esv1003519 CNV insertion 20482838
dgv1840e212 CNV loss 25503493
dgv1839e212 CNV loss 25503493

Variation tolerance for PPP1R14C Gene

Residual Variation Intolerance Score: 61.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.64; 13.62% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PPP1R14C Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PPP1R14C Gene

Disorders for PPP1R14C Gene

Additional Disease Information for PPP1R14C

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for PPP1R14C Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PPP1R14C Gene

Publications for PPP1R14C Gene

  1. KEPI, a PKC-dependent protein phosphatase 1 inhibitor regulated by morphine. (PMID: 11812771) Liu QR … Uhl GR (The Journal of biological chemistry 2002) 3 4 22 58
  2. Genome-wide association and large-scale follow up identifies 16 new loci influencing lung function. (PMID: 21946350) Soler Artigas M … Tobin MD (Nature genetics 2011) 3 44 58
  3. SNCA variants are associated with increased risk for multiple system atrophy. (PMID: 19475667) Scholz SW … Gasser T (Annals of neurology 2009) 3 44 58
  4. A genome-wide association study identifies novel and functionally related susceptibility Loci for Kawasaki disease. (PMID: 19132087) Burgner D … International Kawasaki Disease Genetics Consortium (PLoS genetics 2009) 3 44 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58

Products for PPP1R14C Gene

Sources for PPP1R14C Gene

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