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Aliases for PPP1R14B Gene
Aliases for PPP1R14B Gene
External Ids for PPP1R14B Gene
- HGNC: 9057
- Entrez Gene: 26472
- Ensembl: ENSG00000173457
- OMIM: 601140
- UniProtKB: Q96C90
Previous HGNC Symbols for PPP1R14B Gene
- PLCB3N
Previous GeneCards Identifiers for PPP1R14B Gene
- GC11M066527
- GC11M065693
- GC11M064262
- GC11M063787
- GC11M063768
- GC11M064011
- GC11M060339
Summaries for PPP1R14B Gene
GeneCards Summary for PPP1R14B Gene
PPP1R14B (Protein Phosphatase 1 Regulatory Inhibitor Subunit 14B) is a Protein Coding gene. Diseases associated with PPP1R14B include Cerebral Falx Meningioma. Among its related pathways are Activation of cAMP-Dependent PKA and Beta-Adrenergic Signaling. Gene Ontology (GO) annotations related to this gene include protein phosphatase inhibitor activity. An important paralog of this gene is PPP1R14C.
UniProtKB/Swiss-Prot Summary for PPP1R14B Gene
-
Inhibitor of PPP1CA. Has over 50-fold higher inhibitory activity when phosphorylated (By similarity).
Additional gene information for PPP1R14B Gene
- HGNC(9057)
- Entrez Gene(26472)
- Ensembl(ENSG00000173457)
- OMIM(601140)
- UniProtKB(Q96C90)
- Open Targets Platform(ENSG00000173457)
- Search for PPP1R14B at DataMed
- Search for PPP1R14B at HumanCyc
No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PPP1R14B Gene
Genomics for PPP1R14B Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for PPP1R14B Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around PPP1R14B on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for PPP1R14B
- Top Transcription factor binding sites by QIAGEN in the PPP1R14B gene promoter:
-
- E2F
- E2F-1
- E2F-2
- E2F-3a
- E2F-4
- E2F-5
- NF-kappaB1
- Pax-5
- Zic3
Genomic Locations for PPP1R14B Gene
Genomic Locations for PPP1R14B Gene
- chr11:64,244,479-64,246,943
- (GRCh38/hg38)
- Size:
- 2,465 bases
- Orientation:
- Minus strand
- chr11:64,011,951-64,014,413
- (GRCh37/hg19)
- Size:
- 2,463 bases
- Orientation:
- Minus strand
Genomic View for PPP1R14B Gene
Genes around PPP1R14B on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 11q13.1 by HGNC
- 11q13.1 by Entrez Gene
- 11q13.1 by Ensembl
PPP1R14B Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for PPP1R14B Gene
Proteins for PPP1R14B Gene
-
Protein details for PPP1R14B Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q96C90-PP14B_HUMAN
- Recommended name:
- Protein phosphatase 1 regulatory subunit 14B
- Protein Accession:
- Q96C90
- Q504S7
- Q7KZD7
Protein attributes for PPP1R14B Gene
- Size:
- 147 amino acids
- Molecular mass:
- 15911 Da
- Quaternary structure:
- No Data Available
Protein Expression for PPP1R14B Gene
Post-translational modifications for PPP1R14B Gene
- Phosphorylated primarily on Thr-57 by PKC (in vitro). An unknown Ser is also phosphorylated by PKC (in vitro) (By similarity).
- Modification sites at PhosphoSitePlus
- Modification sites at neXtProt
Other Protein References for PPP1R14B Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- G Biosciences Immunotag™ PPP1R14B Antibody
- Novus Biologicals Antibodies for PPP1R14B
- Invitrogen Antibodies for PPP1R14B (AFLGC-PPP1R14B)
-
Santa Cruz Biotechnology (SCBT) Antibodies for PPP1R14B
Protein Products
- Search Origene for MassSpec and Protein Over-expression Lysates for PPP1R14B
- Origene Custom Protein Services for PPP1R14B
- antibodies-online: Show 7 available PPP1R14B Proteins ranked by validation data
- Compare Top PPP1R14B Proteins
-
Quality Products:
-
Signalway Proteins for PPP1R14B
-
Abcam proteins for PPP1R14B
Assay Products
- antibodies-online: Show 9 available PPP1R14B Elisa Kits ranked by validation data
- Compare Top PPP1R14B Elisa Kits
-
Quality Products:
-
Signalway ELISA kits for PPP1R14B
No data available for DME Specific Peptides for PPP1R14B Gene
Domains & Families for PPP1R14B Gene
Gene Families for PPP1R14B Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Plasma proteins
- Predicted intracellular proteins
Suggested Antigen Peptide Sequences for PPP1R14B Gene
- GenScript: Design optimal peptide antigens:
-
- Phospholipase C-beta-3 neighbouring gene protein (PP14B_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q96C90- Family:
-
- Belongs to the PP1 inhibitor family.
Function for PPP1R14B Gene
Molecular function for PPP1R14B Gene
- UniProtKB/Swiss-Prot Function:
- Inhibitor of PPP1CA. Has over 50-fold higher inhibitory activity when phosphorylated (By similarity).
Phenotypes From GWAS Catalog for PPP1R14B Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004864 | protein phosphatase inhibitor activity | IEA | -- |
| GO:0004865 | protein serine/threonine phosphatase inhibitor activity | IBA | 21873635 |
Phenotypes for PPP1R14B Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for PPP1R14B - Select products 50% OFF >
- * PPP1R14B CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
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-
OriGene CRISPR knockouts for PPP1R14B
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for PPP1R14B
-
Santa Cruz Biotechnology (SCBT) CRISPR for PPP1R14B
miRNA for PPP1R14B Gene
- miRTarBase miRNAs that target PPP1R14B
-
- hsa-miR-26b-5p (MIRT029319)
- hsa-miR-615-3p (MIRT040374)
- hsa-miR-137 (MIRT737526)
- hsa-miR-1911-3p (MIRT738480)
- hsa-miR-33b-5p (MIRT741376)
- hsa-miR-367-5p (MIRT742144)
- hsa-miR-4650-5p (MIRT746522)
- hsa-miR-4733-3p (MIRT747969)
- hsa-miR-5089-3p (MIRT749649)
- hsa-miR-5681b (MIRT751163)
- hsa-miR-593-5p (MIRT751597)
- hsa-miR-6840-5p (MIRT757333)
- hsa-miR-6886-5p (MIRT758561)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for PPP1R14B
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Clone Products
- Applied Biological Materials (abm): Clones for PPP1R14B - Select products 50% OFF >
- * PPP1R14B as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for PPP1R14B
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for PPP1R14B
Cell Line Products
-
Horizon Cell Lines for PPP1R14B
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PPP1R14B Gene
Localization for PPP1R14B Gene
Subcellular locations from UniProtKB/Swiss-Prot for PPP1R14B Gene
- Cytoplasm.
| Compartment | Confidence |
|---|---|
| nucleus | 3 |
| extracellular | 2 |
| cytosol | 2 |
| plasma membrane | 1 |
| cytoskeleton | 1 |
| mitochondrion | 1 |
| endoplasmic reticulum | 1 |
| endosome | 1 |
| golgi apparatus | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005737 | cytoplasm | IEA | -- |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for PPP1R14B Gene
Pathways & Interactions for PPP1R14B Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Activation of cAMP-Dependent PKA |
Activation of cAMP-Dependent PKA
.77
cAMP Pathway
.77
|
Activation of PKA through GPCR
.71
PKA Signaling
.56
|
| 2 | Beta-Adrenergic Signaling |
Beta-Adrenergic Signaling
.37
Erythropoietin Pathway
.37
|
CDK5 Pathway
.37
Insulin Receptor Pathway
.37
|
| 3 | ERK Signaling |
ERK Signaling
.61
|
ILK Signaling
.49
|
| 4 | GPCR Pathway |
Breast Cancer Regulation by Stathmin1
.58
|
|
| 5 | Dopamine-DARPP32 Feedback onto cAMP Pathway |
Dopamine-DARPP32 Feedback onto cAMP Pathway
-
|
|
Pathways by source for PPP1R14B Gene
15 Qiagen pathways for PPP1R14B Gene
- Activation of cAMP-Dependent PKA
- Activation of PKA through GPCR
- Beta-Adrenergic Signaling
- Breast Cancer Regulation by Stathmin1
- cAMP Pathway
Interacting Proteins for PPP1R14B Gene
Selected Interacting proteins:
Q96C90-PP14B_HUMAN
ENSP00000310117
for PPP1R14B Gene via
MINT
STRING
IID
GPS-Prot Interaction Network for PPP1R14B
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0032515 | negative regulation of phosphoprotein phosphatase activity | IEA | -- |
| GO:0042325 | regulation of phosphorylation | IEA | -- |
| GO:0045087 | innate immune response | IBA | 21873635 |
No data available for SIGNOR curated interactions for PPP1R14B Gene
Transcripts for PPP1R14B Gene
mRNA/cDNA for PPP1R14B Gene
- 1 REFSEQ mRNAs :
- 8 NCBI additional mRNA sequence :
- 3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000309318 989 nts (view in UCSC)
- ENST00000392210 600 nts (view in UCSC)
- ENST00000542235 920 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for PPP1R14B - Select products 50% OFF >
- * PPP1R14B CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for PPP1R14B
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for PPP1R14B
-
Santa Cruz Biotechnology (SCBT) CRISPR for PPP1R14B
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for PPP1R14B
- Browse OriGene Inhibitory RNA Products For PPP1R14B
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PPP1R14B
Clone Products
- Applied Biological Materials (abm): Clones for PPP1R14B - Select products 50% OFF >
- * PPP1R14B as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for PPP1R14B
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for PPP1R14B
Relevant External Links for PPP1R14B Gene
- GeneLoc Exon Structure for
- PPP1R14B
Expression for PPP1R14B Gene
This gene is overexpressed in Heart (16.2) and Amniocyte (9.2).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for PPP1R14B Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for PPP1R14B
SOURCE GeneReport for Unigene cluster for PPP1R14B Gene:
Hs.523760mRNA Expression by UniProt/SwissProt for PPP1R14B Gene:
Q96C90-PP14B_HUMAN
Tissue specificity:
Ubiquitous. Expressed at low levels.
Evidence on tissue expression from TISSUES for PPP1R14B Gene
- Skin(4.6)
- Muscle(3.3)
- Liver(2.8)
- Nervous system(2.6)
- Intestine(2.6)
- Heart(2.5)
- Kidney(2.4)
- Stomach(2.2)
Primer Products
-
OriGene qPCR primer pairs for PPP1R14B
-
OriGene qPCR primer pairs and template standards for PPP1R14B
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for PPP1R14B Gene
Orthologs for PPP1R14B Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | PPP1R14B 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | PPP1R14B 30 |
|
||
| -- 31 |
|
OneToMany | |||
| Rat (Rattus norvegicus) |
Mammalia | Ppp1r14b 30 |
|
||
| Mouse (Mus musculus) |
Mammalia | Ppp1r14b 30 17 |
|
||
| 4933415F23Rik 31 |
|
OneToOne | |||
| Cow (Bos Taurus) |
Mammalia | PPP1R14B 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | ppp1r14b 30 |
|
||
| Str.7221 30 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.23861 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | ppp1r14bb 30 31 |
|
OneToMany | |
| ppp1r14ba 31 |
|
OneToMany | |||
| ppp1r14b 30 |
|
- Species where no ortholog for PPP1R14B was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Lizard (Anolis carolinensis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Oppossum (Monodelphis domestica)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Platypus (Ornithorhynchus anatinus)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
Evolution for PPP1R14B Gene
- ENSEMBL:
- Gene Tree for PPP1R14B (if available)
- TreeFam:
- Gene Tree for PPP1R14B (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for PPP1R14B: view image
Paralogs for PPP1R14B Gene
(4) SIMAP similar genes for PPP1R14B Gene using alignment to 3 proteins:
- PP14B_HUMAN
- F5GXC4_HUMAN
- F5H2U0_HUMAN
Pseudogenes.org Pseudogenes for PPP1R14B Gene
Variants for PPP1R14B Gene
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv1963n54 | CNV | loss | 21841781 |
| esv24861 | CNV | gain | 19812545 |
| nsv1159904 | CNV | deletion | 26073780 |
| nsv469961 | CNV | loss | 18288195 |
| nsv555184 | CNV | loss | 21841781 |
| nsv555187 | CNV | loss | 21841781 |
| nsv832186 | CNV | loss | 17160897 |
| nsv951010 | CNV | deletion | 24416366 |
| nsv983032 | CNV | duplication | 23825009 |
Residual Variation Intolerance Score:
56.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.08;
1.81% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for PPP1R14B Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- PPP1R14B
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for PPP1R14B Gene
Disorders for PPP1R14B Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| cerebral falx meningioma |
|
|
Search PPP1R14B in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for PPP1R14B
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for PPP1R14B Gene
Publications for PPP1R14B Gene
- Isolation and characterization of a novel gene close to the human phosphoinositide-specific phospholipase C beta 3 gene on chromosomal region 11q13. (PMID: 8838322) Lagercrantz J … Weber G (Genomics 1996) 2 3 4
- Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 41
- A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PMID: 16964243) Beausoleil SA … Gygi SP (Nature biotechnology 2006) 3 4
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
- Migration and retraction of endothelial and epithelial cells require PHI-1, a specific protein-phosphatase-1 inhibitor protein. (PMID: 15522888) Tountas NA … Brautigan DL (Journal of cell science 2004) 3 23
ExternalLinks
Products for PPP1R14B Gene
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- Novus Biologicals proteins and lysates for PPP1R14B
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- Invitrogen Antibodies for PPP1R14B (AFLGC-PPP1R14B)
- VectorBuilder Custom and pre-made DNA vectors for PPP1R14B (ie. gene expression, shRNA knockdown, CRISPR)
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- antibodies-online: Show 4 available PPP1R14B Antibodies ranked by validation data
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- antibodies-online: Show 7 available PPP1R14B Proteins ranked by validation data
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- Quality Products:
- Santa Cruz Biotechnology (SCBT) Antibodies for PPP1R14B
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- Horizon Cell Lines for PPP1R14B
- Browse GeneCopoeia Cell Lines
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- Search GeneCopoeia for miRNA 3'UTR Target clone products for PPP1R14B
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PPP1R14B
Sources for PPP1R14B Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
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