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PPP1R14B (Protein Phosphatase 1 Regulatory Inhibitor Subunit 14B) is a Protein Coding gene. Among its related pathways are Beta-Adrenergic Signaling and ERK Signaling. Gene Ontology (GO) annotations related to this gene include protein phosphatase inhibitor activity. An important paralog of this gene is PPP1R14C.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0004864 | protein phosphatase inhibitor activity | IEA | -- |
GO:0004865 | protein serine/threonine phosphatase inhibitor activity | IBA | 21873635 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005737 | cytoplasm | IEA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Activation of cAMP-Dependent PKA |
Activation of cAMP-Dependent PKA
.77
cAMP Pathway
.77
|
Activation of PKA through GPCR
.71
PKA Signaling
.56
|
2 | Beta-Adrenergic Signaling |
Beta-Adrenergic Signaling
.37
Erythropoietin Pathway
.37
|
Insulin Receptor Pathway
.37
CDK5 Pathway
.36
|
3 | ERK Signaling |
ERK Signaling
.61
|
ILK Signaling
.49
|
4 | GPCR Pathway |
Breast Cancer Regulation by Stathmin1
.58
|
|
5 | Dopamine-DARPP32 Feedback onto cAMP Pathway |
Dopamine-DARPP32 Feedback onto cAMP Pathway
-
|
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0032515 | negative regulation of phosphoprotein phosphatase activity | IEA | -- |
GO:0042325 | regulation of phosphorylation | IEA | -- |
GO:0045087 | innate immune response | IBA | 21873635 |
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | PPP1R14B 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | PPP1R14B 30 |
|
||
-- 31 |
|
OneToMany | |||
Rat (Rattus norvegicus) |
Mammalia | Ppp1r14b 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Ppp1r14b 30 17 |
|
||
4933415F23Rik 31 |
|
OneToOne | |||
Cow (Bos Taurus) |
Mammalia | PPP1R14B 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | ppp1r14b 30 |
|
||
Str.7221 30 |
|
||||
African clawed frog (Xenopus laevis) |
Amphibia | Xl.23861 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | ppp1r14bb 30 31 |
|
OneToMany | |
ppp1r14ba 31 |
|
OneToMany | |||
ppp1r14b 30 |
|
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
dgv1963n54 | CNV | loss | 21841781 |
esv24861 | CNV | gain | 19812545 |
nsv1159904 | CNV | deletion | 26073780 |
nsv469961 | CNV | loss | 18288195 |
nsv555184 | CNV | loss | 21841781 |
nsv555187 | CNV | loss | 21841781 |
nsv832186 | CNV | loss | 17160897 |
nsv951010 | CNV | deletion | 24416366 |
nsv983032 | CNV | duplication | 23825009 |
No disorders were found for PPP1R14B Gene.