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Aliases for PPP1R14B Gene

Aliases for PPP1R14B Gene

  • Protein Phosphatase 1 Regulatory Inhibitor Subunit 14B 2 3 5
  • Phospholipase C-Beta-3 Neighbouring Gene Protein 3 4
  • PLCB3N 3 4
  • PNG 3 4
  • Protein Phosphatase 1, Regulatory (Inhibitor) Subunit 14B 2
  • Phospholipase C Beta-3 Neighboring Gene Protein 3
  • Protein Phosphatase 1 Regulatory Subunit 14B 3
  • SOM172 3
  • PHI-1 3

External Ids for PPP1R14B Gene

Previous HGNC Symbols for PPP1R14B Gene

  • PLCB3N

Previous GeneCards Identifiers for PPP1R14B Gene

  • GC11M066527
  • GC11M065693
  • GC11M064262
  • GC11M063787
  • GC11M063768
  • GC11M064011
  • GC11M060339

Summaries for PPP1R14B Gene

GeneCards Summary for PPP1R14B Gene

PPP1R14B (Protein Phosphatase 1 Regulatory Inhibitor Subunit 14B) is a Protein Coding gene. Among its related pathways are Beta-Adrenergic Signaling and ERK Signaling. Gene Ontology (GO) annotations related to this gene include protein phosphatase inhibitor activity. An important paralog of this gene is PPP1R14C.

UniProtKB/Swiss-Prot for PPP1R14B Gene

  • Inhibitor of PPP1CA. Has over 50-fold higher inhibitory activity when phosphorylated (By similarity).

Gene Wiki entry for PPP1R14B Gene

Additional gene information for PPP1R14B Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PPP1R14B Gene

Genomics for PPP1R14B Gene

GeneHancer (GH) Regulatory Elements for PPP1R14B Gene

Promoters and enhancers for PPP1R14B Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11I064237 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 572.7 +1.6 1622 16.6 CLOCK MLX FEZF1 DMAP1 IRF4 YY1 E2F8 ZNF143 SP3 NFYC PPP1R14B FKBP2 LOC105369340 PLCB3 TRPT1 LOC102723878 VEGFB TRMT112 FERMT3 GPR137
GH11I064331 Enhancer 1.5 Ensembl ENCODE dbSUPER 11.4 -85.0 -84952 1.7 HDGF PKNOX1 SMAD1 ARNT ARID4B SIN3A YBX1 IRF4 POLR2B ZNF207 GC11P064330 GC11P064331 POLA2 SF1 PLCB3 ZFPL1 ENSG00000257086 FAU ATG2A ZNHIT2
GH11I064405 Enhancer 1 Ensembl ENCODE 11.3 -160.0 -159987 2.2 NCOA3 MEIS2 USF1 ZSCAN4 MAX TSC22D4 YBX1 CDC5L MCM2 ZKSCAN1 GC11P064406 POLA2 PLCB3 SF1 ZFPL1 FAU FRMD8 NAALADL1 RPS6KA4 ENSG00000231680
GH11I064874 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 4.9 -630.8 -630838 7.1 HDGF PKNOX1 CLOCK SMAD1 ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 EHD1 ZFPL1 PCNX3 TRMT112 SF1 FRMD8 PLCB3 KAT5 FAU POLA2
GH11I064354 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 3.7 -111.0 -111033 6.6 HDGF PKNOX1 CLOCK SMAD1 MLX ARNT ARID4B SIN3A ZBTB7B YY1 RPS6KA4 LOC102723878 PLCB3 ENSG00000231680 TRPT1 MARK2 PPP1R14B ESRRA PRDX5 TRMT112
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around PPP1R14B on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the PPP1R14B gene promoter:

Genomic Locations for PPP1R14B Gene

Genomic Locations for PPP1R14B Gene
chr11:64,244,479-64,246,941
(GRCh38/hg38)
Size:
2,463 bases
Orientation:
Minus strand
chr11:64,011,951-64,014,413
(GRCh37/hg19)

Genomic View for PPP1R14B Gene

Genes around PPP1R14B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PPP1R14B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PPP1R14B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PPP1R14B Gene

Proteins for PPP1R14B Gene

  • Protein details for PPP1R14B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96C90-PP14B_HUMAN
    Recommended name:
    Protein phosphatase 1 regulatory subunit 14B
    Protein Accession:
    Q96C90
    Secondary Accessions:
    • Q504S7
    • Q7KZD7

    Protein attributes for PPP1R14B Gene

    Size:
    147 amino acids
    Molecular mass:
    15911 Da
    Quaternary structure:
    No Data Available

neXtProt entry for PPP1R14B Gene

Post-translational modifications for PPP1R14B Gene

  • Phosphorylated primarily on Thr-57 by PKC (in vitro). An unknown Ser is also phosphorylated by PKC (in vitro) (By similarity).

Other Protein References for PPP1R14B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for PPP1R14B Gene

Domains & Families for PPP1R14B Gene

Gene Families for PPP1R14B Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for PPP1R14B Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for PPP1R14B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96C90

UniProtKB/Swiss-Prot:

PP14B_HUMAN :
  • Belongs to the PP1 inhibitor family.
Family:
  • Belongs to the PP1 inhibitor family.
genes like me logo Genes that share domains with PPP1R14B: view

Function for PPP1R14B Gene

Molecular function for PPP1R14B Gene

UniProtKB/Swiss-Prot Function:
Inhibitor of PPP1CA. Has over 50-fold higher inhibitory activity when phosphorylated (By similarity).

Gene Ontology (GO) - Molecular Function for PPP1R14B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004864 protein phosphatase inhibitor activity IEA --
genes like me logo Genes that share ontologies with PPP1R14B: view
genes like me logo Genes that share phenotypes with PPP1R14B: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PPP1R14B Gene

Localization for PPP1R14B Gene

Subcellular locations from UniProtKB/Swiss-Prot for PPP1R14B Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PPP1R14B gene
Compartment Confidence
nucleus 2
cytosol 2
extracellular 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for PPP1R14B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with PPP1R14B: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for PPP1R14B Gene

Pathways & Interactions for PPP1R14B Gene

genes like me logo Genes that share pathways with PPP1R14B: view

Gene Ontology (GO) - Biological Process for PPP1R14B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0032515 negative regulation of phosphoprotein phosphatase activity IEA --
GO:0042325 regulation of phosphorylation IEA --
GO:0043086 negative regulation of catalytic activity IEA --
GO:0045087 innate immune response IBA --
genes like me logo Genes that share ontologies with PPP1R14B: view

No data available for SIGNOR curated interactions for PPP1R14B Gene

Drugs & Compounds for PPP1R14B Gene

No Compound Related Data Available

Transcripts for PPP1R14B Gene

mRNA/cDNA for PPP1R14B Gene

Unigene Clusters for PPP1R14B Gene

Protein phosphatase 1, regulatory (inhibitor) subunit 14B:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for PPP1R14B Gene

No ASD Table

Relevant External Links for PPP1R14B Gene

GeneLoc Exon Structure for
PPP1R14B
ECgene alternative splicing isoforms for
PPP1R14B

Expression for PPP1R14B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PPP1R14B Gene

Protein differential expression in normal tissues from HIPED for PPP1R14B Gene

This gene is overexpressed in Heart (16.2) and Amniocyte (9.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for PPP1R14B Gene



Protein tissue co-expression partners for PPP1R14B Gene

NURSA nuclear receptor signaling pathways regulating expression of PPP1R14B Gene:

PPP1R14B

SOURCE GeneReport for Unigene cluster for PPP1R14B Gene:

Hs.523760

mRNA Expression by UniProt/SwissProt for PPP1R14B Gene:

Q96C90-PP14B_HUMAN
Tissue specificity: Ubiquitous. Expressed at low levels.

Evidence on tissue expression from TISSUES for PPP1R14B Gene

  • Skin(4.2)
  • Muscle(2.7)
  • Liver(2)
genes like me logo Genes that share expression patterns with PPP1R14B: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for PPP1R14B Gene

Orthologs for PPP1R14B Gene

This gene was present in the common ancestor of chordates.

Orthologs for PPP1R14B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PPP1R14B 33 34
  • 100 (n)
dog
(Canis familiaris)
Mammalia PPP1R14B 33
  • 92.56 (n)
-- 34
  • 86 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Ppp1r14b 33
  • 89.8 (n)
mouse
(Mus musculus)
Mammalia Ppp1r14b 33 16
  • 89.34 (n)
4933415F23Rik 34
  • 73 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PPP1R14B 34
  • 71 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ppp1r14b 33
  • 74.63 (n)
Str.7221 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.23861 33
zebrafish
(Danio rerio)
Actinopterygii ppp1r14bb 33 34
  • 71.88 (n)
ppp1r14ba 34
  • 67 (a)
OneToMany
ppp1r14b 33
Species where no ortholog for PPP1R14B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PPP1R14B Gene

ENSEMBL:
Gene Tree for PPP1R14B (if available)
TreeFam:
Gene Tree for PPP1R14B (if available)

Paralogs for PPP1R14B Gene

Paralogs for PPP1R14B Gene

(4) SIMAP similar genes for PPP1R14B Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for PPP1R14B Gene

genes like me logo Genes that share paralogs with PPP1R14B: view

Variants for PPP1R14B Gene

Sequence variations from dbSNP and Humsavar for PPP1R14B Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1000379419 -- 64,246,632(-) G/A coding_sequence_variant, synonymous_variant
rs1000981937 -- 64,244,972(-) G/A intron_variant
rs1001294271 -- 64,248,222(-) CC/CCC upstream_transcript_variant
rs1001341927 -- 64,244,465(-) A/C downstream_transcript_variant
rs1001394854 -- 64,247,238(-) T/C upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for PPP1R14B Gene

Variant ID Type Subtype PubMed ID
nsv983032 CNV duplication 23825009
nsv951010 CNV deletion 24416366
nsv832186 CNV loss 17160897
nsv555187 CNV loss 21841781
nsv555184 CNV loss 21841781
nsv469961 CNV loss 18288195
nsv1159904 CNV deletion 26073780
esv24861 CNV gain 19812545
dgv1963n54 CNV loss 21841781

Variation tolerance for PPP1R14B Gene

Residual Variation Intolerance Score: 56.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.08; 1.81% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PPP1R14B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PPP1R14B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PPP1R14B Gene

Disorders for PPP1R14B Gene

Additional Disease Information for PPP1R14B

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for PPP1R14B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PPP1R14B Gene

Publications for PPP1R14B Gene

  1. Isolation and characterization of a novel gene close to the human phosphoinositide-specific phospholipase C beta 3 gene on chromosomal region 11q13. (PMID: 8838322) Lagercrantz J … Weber G (Genomics 1996) 2 3 4 58
  2. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 44 58
  3. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PMID: 16964243) Beausoleil SA … Gygi SP (Nature biotechnology 2006) 3 4 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. Migration and retraction of endothelial and epithelial cells require PHI-1, a specific protein-phosphatase-1 inhibitor protein. (PMID: 15522888) Tountas NA … Brautigan DL (Journal of cell science 2004) 3 22 58

Products for PPP1R14B Gene

Sources for PPP1R14B Gene

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