Aliases for PPP1R14B Gene
Aliases for PPP1R14B Gene
- Protein Phosphatase 1 Regulatory Inhibitor Subunit 14B 2 3 5
- Phospholipase C-Beta-3 Neighbouring Gene Protein 3 4
- PLCB3N 3 4
- PNG 3 4
- Protein Phosphatase 1, Regulatory (Inhibitor) Subunit 14B 2
- Phospholipase C Beta-3 Neighboring Gene Protein 3
- Protein Phosphatase 1 Regulatory Subunit 14B 3
- SOM172 3
- PHI-1 3
External Ids for PPP1R14B Gene
- HGNC: 9057
- Entrez Gene: 26472
- Ensembl: ENSG00000173457
- OMIM: 601140
- UniProtKB: Q96C90
Previous HGNC Symbols for PPP1R14B Gene
- PLCB3N
Previous GeneCards Identifiers for PPP1R14B Gene
- GC11M066527
- GC11M065693
- GC11M064262
- GC11M063787
- GC11M063768
- GC11M064011
- GC11M060339
Summaries for PPP1R14B Gene
GeneCards Summary for PPP1R14B Gene
PPP1R14B (Protein Phosphatase 1 Regulatory Inhibitor Subunit 14B) is a Protein Coding gene. Among its related pathways are ERK Signaling and Activation of cAMP-Dependent PKA. Gene Ontology (GO) annotations related to this gene include protein phosphatase inhibitor activity. An important paralog of this gene is PPP1R14C.
UniProtKB/Swiss-Prot for PPP1R14B Gene
-
Inhibitor of PPP1CA. Has over 50-fold higher inhibitory activity when phosphorylated (By similarity).
Additional gene information for PPP1R14B Gene
No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PPP1R14B Gene
Genomics for PPP1R14B Gene
GeneHancer (GH) Regulatory Elements for PPP1R14B Gene
Promoters and enhancers for PPP1R14B Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)
GeneHancers around PPP1R14B on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the PPP1R14B gene promoter:
-
- NF-kappaB1
- E2F-1
- E2F
- E2F-2
- E2F-3a
- E2F-4
- E2F-5
- Pax-5
- Zic3
Regulatory Element Products
Genomic Locations for PPP1R14B Gene
Genomic Locations for PPP1R14B Gene
- chr11:64,244,479-64,246,941
- (GRCh38/hg38)
- Size:
- 2,463 bases
- Orientation:
- Minus strand
- chr11:64,011,951-64,014,413
- (GRCh37/hg19)
- Size:
- 2,463 bases
- Orientation:
- Minus strand
Genomic View for PPP1R14B Gene
Genes around PPP1R14B on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 11q13.1 by Entrez Gene
- 11q13.1 by HGNC
- 11q13.1 by Ensembl
PPP1R14B Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for PPP1R14B Gene
Proteins for PPP1R14B Gene
-
Protein details for PPP1R14B Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q96C90-PP14B_HUMAN
- Recommended name:
- Protein phosphatase 1 regulatory subunit 14B
- Protein Accession:
- Q96C90
- Q504S7
- Q7KZD7
Protein attributes for PPP1R14B Gene
- Size:
- 147 amino acids
- Molecular mass:
- 15911 Da
- Quaternary structure:
- No Data Available
Protein Expression for PPP1R14B Gene
Post-translational modifications for PPP1R14B Gene
- Phosphorylated primarily on Thr-57 by PKC (in vitro). An unknown Ser is also phosphorylated by PKC (in vitro) (By similarity).
- Modification sites at PhosphoSitePlus
- Modification sites at neXtProt
Other Protein References for PPP1R14B Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for PPP1R14B
- Invitrogen Antibodies for PPP1R14B (AFLGC-PPP1R14B)
- Search GeneTex for Antibodies for PPP1R14B
-
Santa Cruz Biotechnology (SCBT) Antibodies for PPP1R14B
Protein Products
-
OriGene Purified Proteins for PPP1R14B
- Search Origene for MassSpec and Protein Over-expression Lysates for PPP1R14B
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- antibodies-online: Search results for 7 available PPP1R14B Proteins ranked by validation data
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-
Quality Products:
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-
Abcam proteins for PPP1R14B
Assay Products
- antibodies-online: Search results for 7 available PPP1R14B Elisa Kits ranked by validation data
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-
Quality Products:
No data available for DME Specific Peptides for PPP1R14B Gene
Domains & Families for PPP1R14B Gene
Gene Families for PPP1R14B Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Plasma proteins
- Predicted intracellular proteins
Suggested Antigen Peptide Sequences for PPP1R14B Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q96C90- Family:
-
- Belongs to the PP1 inhibitor family.
Function for PPP1R14B Gene
Molecular function for PPP1R14B Gene
- UniProtKB/Swiss-Prot Function:
- Inhibitor of PPP1CA. Has over 50-fold higher inhibitory activity when phosphorylated (By similarity).
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004864 | protein phosphatase inhibitor activity | IEA | -- |
| GO:0004865 | protein serine/threonine phosphatase inhibitor activity | IBA | -- |
| GO:0019212 | phosphatase inhibitor activity | IEA | -- |
| GO:0019888 | protein phosphatase regulator activity | IEA | -- |
Phenotypes for PPP1R14B Gene
- GenomeRNAi human phenotypes for PPP1R14B:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for PPP1R14B
-
CRISPR Products
-
OriGene CRISPR knockouts for PPP1R14B
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- Applied Biological Materials CRISPR for PPP1R14B
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for PPP1R14B
- GenScript: Design CRISPR guide RNA sequences for PPP1R14B
miRNA for PPP1R14B Gene
- miRTarBase miRNAs that target PPP1R14B
-
- hsa-mir-26b-5p (MIRT029319)
- hsa-mir-615-3p (MIRT040374)
- hsa-mir-137 (MIRT737526)
- hsa-mir-1911-3p (MIRT738480)
- hsa-mir-33b-5p (MIRT741376)
- hsa-mir-367-5p (MIRT742144)
- hsa-mir-4650-5p (MIRT746522)
- hsa-mir-4733-3p (MIRT747969)
- hsa-mir-5089-3p (MIRT749649)
- hsa-mir-5681b (MIRT751163)
- hsa-mir-593-5p (MIRT751597)
- hsa-mir-6840-5p (MIRT757333)
- hsa-mir-6886-5p (MIRT758561)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for PPP1R14B
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- genomics-online: shRNA clones - Search results for available PPP1R14B gene related products
Clone Products
- Sino Biological Human cDNA Clone for PPP1R14B
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for PPP1R14B
- genomics-online: cdna clones - Search results for available PPP1R14B gene related products
- orf clones - Search results for available PPP1R14B gene related products
- Applied Biological Materials Clones for PPP1R14B
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for PPP1R14B
No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PPP1R14B Gene
Localization for PPP1R14B Gene
Subcellular locations from UniProtKB/Swiss-Prot for PPP1R14B Gene
- Cytoplasm.
| Compartment | Confidence |
|---|---|
| nucleus | 2 |
| cytosol | 2 |
| extracellular | 1 |
| mitochondrion | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005737 | cytoplasm | IEA | -- |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for PPP1R14B Gene
Pathways & Interactions for PPP1R14B Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Activation of cAMP-Dependent PKA |
.77
|
.56
|
| 2 | Beta-Adrenergic Signaling |
.36
|
|
| 3 | ERK Signaling |
.61
|
.49
|
| 4 | GPCR Pathway | ||
| 5 | Dopamine-DARPP32 Feedback onto cAMP Pathway | ||
Pathways by source for PPP1R14B Gene
15 Qiagen pathways for PPP1R14B Gene
Interacting Proteins for PPP1R14B Gene
Selected Interacting proteins:
ENSP00000310117
Q96C90-PP14B_HUMAN
for PPP1R14B Gene via
STRING
IID
MINT
| Symbol | External ID(s) | Details |
|---|---|---|
| PPP1CC | ||
| ROCK2 | ||
| IGBP1 | ||
| NUBP2 | ||
| PTGES3L-AARSD1 |
GPS-Prot Interaction Network for PPP1R14B
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0032515 | negative regulation of phosphoprotein phosphatase activity | IEA | -- |
| GO:0035304 | regulation of protein dephosphorylation | IBA | -- |
| GO:0042325 | regulation of phosphorylation | IEA | -- |
| GO:0045087 | innate immune response | IBA | -- |
No data available for SIGNOR curated interactions for PPP1R14B Gene
Transcripts for PPP1R14B Gene
mRNA/cDNA for PPP1R14B Gene
- (1) REFSEQ mRNAs :
- (5) Additional mRNA sequences :
- (404) Selected AceView cDNA sequences:
- (3) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000392210 600 bps (uc058cvp.1)
- ENST00000309318 982 bps (uc001nza.4)
- ENST00000542235 920 bps (uc058cvq.1)
Unigene Clusters for PPP1R14B Gene
- Protein phosphatase 1, regulatory (inhibitor) subunit 14B:
- Representative Sequences:
CRISPR Products
-
OriGene CRISPR knockouts for PPP1R14B
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for PPP1R14B
- genomics-online: gRNA clones - Search results for available PPP1R14B gene related products
- Applied Biological Materials CRISPR for PPP1R14B
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for PPP1R14B
- GenScript: Design CRISPR guide RNA sequences for PPP1R14B
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for PPP1R14B
- Browse OriGene Inhibitory RNA Products For PPP1R14B
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- genomics-online: shRNA clones - Search results for available PPP1R14B gene related products
Clone Products
- Sino Biological Human cDNA Clone for PPP1R14B
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for PPP1R14B
- genomics-online: cdna clones - Search results for available PPP1R14B gene related products
- orf clones - Search results for available PPP1R14B gene related products
- Applied Biological Materials Clones for PPP1R14B
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Expression for PPP1R14B Gene
This gene is overexpressed in Heart (16.2) and Amniocyte (9.2).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for PPP1R14B Gene
NURSA nuclear receptor signaling pathways regulating expression of PPP1R14B Gene:
PPP1R14BSOURCE GeneReport for Unigene cluster for PPP1R14B Gene:
Hs.523760mRNA Expression by UniProt/SwissProt for PPP1R14B Gene:
Q96C90-PP14B_HUMAN
Tissue specificity:
Ubiquitous. Expressed at low levels.
Evidence on tissue expression from TISSUES for PPP1R14B Gene
- Skin(4.2)
- Muscle(2.7)
- Liver(2)
Primer Products
-
OriGene qPCR primer pairs for PPP1R14B
-
OriGene qPCR primer pairs and template standards for PPP1R14B
- genomics-online: primer clones - Search results for available PPP1R14B gene related products
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for PPP1R14B Gene
Orthologs for PPP1R14B Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | PPP1R14B 34 33 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | PPP1R14B 33 |
|
||
| -- 34 |
|
OneToMany | |||
| rat (Rattus norvegicus) |
Mammalia | Ppp1r14b 33 |
|
||
| mouse (Mus musculus) |
Mammalia | Ppp1r14b 16 33 |
|
||
| 4933415F23Rik 34 |
|
OneToOne | |||
| cow (Bos Taurus) |
Mammalia | PPP1R14B 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | ppp1r14b 33 |
|
||
| Str.7221 33 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.23861 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | ppp1r14bb 34 33 |
|
OneToMany | |
| ppp1r14ba 34 |
|
OneToMany | |||
| ppp1r14b 33 |
|
- Species where no ortholog for PPP1R14B was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- lizard (Anolis carolinensis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- oppossum (Monodelphis domestica)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Evolution for PPP1R14B Gene
- ENSEMBL:
- Gene Tree for PPP1R14B (if available)
- TreeFam:
- Gene Tree for PPP1R14B (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for PPP1R14B: view image
Paralogs for PPP1R14B Gene
(4) SIMAP similar genes for PPP1R14B Gene using alignment to 3 proteins:
- PP14B_HUMAN
- F5GXC4_HUMAN
- F5H2U0_HUMAN
Pseudogenes.org Pseudogenes for PPP1R14B Gene
Variants for PPP1R14B Gene
| SNP ID | Clin | Chr 11 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000379419 | -- | 64,246,632(-) | G/A | coding_sequence_variant, synonymous_variant | |
| rs1000981937 | -- | 64,244,972(-) | G/A | intron_variant | |
| rs1001294271 | -- | 64,248,222(-) | CC/CCC | upstream_transcript_variant | |
| rs1001341927 | -- | 64,244,465(-) | A/C | downstream_transcript_variant | |
| rs1001394854 | -- | 64,247,238(-) | T/C | upstream_transcript_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv1963n54 | CNV | loss | 21841781 |
| esv24861 | CNV | gain | 19812545 |
| nsv1159904 | CNV | deletion | 26073780 |
| nsv469961 | CNV | loss | 18288195 |
| nsv555184 | CNV | loss | 21841781 |
| nsv555187 | CNV | loss | 21841781 |
| nsv832186 | CNV | loss | 17160897 |
| nsv951010 | CNV | deletion | 24416366 |
| nsv983032 | CNV | duplication | 23825009 |
Residual Variation Intolerance Score:
56.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.08;
1.81% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for PPP1R14B Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- PPP1R14B
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PPP1R14B Gene
Disorders for PPP1R14B Gene
Additional Disease Information for PPP1R14B
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No disorders were found for PPP1R14B Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PPP1R14B Gene
Publications for PPP1R14B Gene
- Isolation and characterization of a novel gene close to the human phosphoinositide-specific phospholipase C beta 3 gene on chromosomal region 11q13. (PMID: 8838322) Lagercrantz J … Weber G (Genomics 1996) 2 3 4 58
- Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 44 58
- A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PMID: 16964243) Beausoleil SA … Gygi SP (Nature biotechnology 2006) 3 4 58
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
- Migration and retraction of endothelial and epithelial cells require PHI-1, a specific protein-phosphatase-1 inhibitor protein. (PMID: 15522888) Tountas NA … Brautigan DL (Journal of cell science 2004) 3 22 58
Products for PPP1R14B Gene
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Sources for PPP1R14B Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
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- (40) DGV
- (41) dbSNP
- (42) GenAtlas
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- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
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- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
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- (112) RVIS
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- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew
- (158) Applied Biosystems
- (159) GlyConnect
- (160) Aminode
- (161) GeneCopoeia
- (162) GPS-Prot
- (163) RNACentral
- (164) LncRNADisease
- (165) LOVD
- (166) miR2Disease
- (167) DiseaseEnhancer
- (168) Boster Bio
- (169) Biorbyt