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The protein encoded by this gene belongs to the protein phosphatase 1 (PP1) inhibitor family. This protein is an inhibitor of smooth muscle myosin phosphatase, and has higher inhibitory activity when phosphorylated. Inhibition of myosin phosphatase leads to increased myosin phosphorylation and enhanced smooth muscle contraction. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Sep 2011]
PPP1R14A (Protein Phosphatase 1 Regulatory Inhibitor Subunit 14A) is a Protein Coding gene. Diseases associated with PPP1R14A include Israeli Tick Typhus and Japanese Spotted Fever. Among its related pathways are Signaling by GPCR and Activation of cAMP-Dependent PKA. Gene Ontology (GO) annotations related to this gene include protein phosphatase inhibitor activity. An important paralog of this gene is PPP1R14C.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0004864 | protein phosphatase inhibitor activity | IEA | -- |
GO:0004865 | protein serine/threonine phosphatase inhibitor activity | IBA | 21873635 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005737 | cytoplasm | IEA | -- |
GO:0005829 | cytosol | TAS | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Activation of cAMP-Dependent PKA |
Activation of cAMP-Dependent PKA
.77
cAMP Pathway
.77
|
Activation of PKA through GPCR
.71
PKA Signaling
.56
|
2 | Beta-Adrenergic Signaling |
Beta-Adrenergic Signaling
.37
Erythropoietin Pathway
.37
|
CDK5 Pathway
.37
Insulin Receptor Pathway
.37
|
3 | Signaling by Rho GTPases | ||
4 | Oxytocin signaling pathway | ||
5 | CREB Pathway |
Activation of PKC through GPCR
.63
|
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0032515 | negative regulation of phosphoprotein phosphatase activity | IEA | -- |
GO:0035690 | cellular response to drug | IEA | -- |
GO:0042325 | regulation of phosphorylation | IEA | -- |
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Cow (Bos Taurus) |
Mammalia | PPP1R14A 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | PPP1R14A 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Ppp1r14a 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Ppp1r14a 30 |
|
||
Oppossum (Monodelphis domestica) |
Mammalia | PPP1R14A 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | PPP1R14A 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | ppp1r14a 30 |
|
||
Str.5879 30 |
|
||||
African clawed frog (Xenopus laevis) |
Amphibia | Xl.4651 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | ppp1r14aa 31 |
|
OneToMany | |
Dr.14203 30 |
|
Disorder | Aliases | PubMed IDs |
---|---|---|
israeli tick typhus |
|
|
japanese spotted fever |
|
|
epidemic typhus |
|
|
cat-scratch disease |
|
|
indian tick typhus |
|
|