PPP1R14A Gene (Protein Coding)

Protein Phosphatase 1 Regulatory Inhibitor Subunit 14A

GC19M038251
GIFtS:
41
The protein encoded by this gene belongs to the protein phosphatase 1 (PP1) inhibitor family. This protein is an inhibitor of smooth muscle myosin phosphatase, and has higher inhibitory activity when phosphorylated. Inhibition of myosin phosphatase leads to increased myosin phosphorylation and enhanced smooth muscle contraction. Alternatively spliced transcript variants encodin... See more...

Aliases for PPP1R14A Gene

Aliases for PPP1R14A Gene

  • Protein Phosphatase 1 Regulatory Inhibitor Subunit 14A 2 3 5
  • CPI-17 2 3 4
  • Protein Kinase C-Potentiated Inhibitor Protein Of 17 KDa 3 4
  • 17 KDa PKC-Potentiated Inhibitory Protein Of PP1 3 4
  • Protein Phosphatase 1 Regulatory Subunit 14A 3 4
  • PKC-Potentiated Inhibitory Protein Of PP1 2 3
  • 17-KDa Protein 2 3
  • PPP1INL 3 4
  • CPI17 3 4
  • Protein Phosphatase 1, Regulatory (Inhibitor) Subunit 14A 2
  • 17-KDa PKC-Potentiated Inhibitory Protein Of PP1 2
  • PPP1R14A 5

External Ids for PPP1R14A Gene

Previous HGNC Symbols for PPP1R14A Gene

  • PPP1INL

Previous GeneCards Identifiers for PPP1R14A Gene

  • GC19M039356
  • GC19M039133
  • GC19M043417
  • GC19M043433
  • GC19M038741
  • GC19M035189

Summaries for PPP1R14A Gene

Entrez Gene Summary for PPP1R14A Gene

  • The protein encoded by this gene belongs to the protein phosphatase 1 (PP1) inhibitor family. This protein is an inhibitor of smooth muscle myosin phosphatase, and has higher inhibitory activity when phosphorylated. Inhibition of myosin phosphatase leads to increased myosin phosphorylation and enhanced smooth muscle contraction. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Sep 2011]

GeneCards Summary for PPP1R14A Gene

PPP1R14A (Protein Phosphatase 1 Regulatory Inhibitor Subunit 14A) is a Protein Coding gene. Diseases associated with PPP1R14A include Dracunculiasis and Israeli Tick Typhus. Among its related pathways are Beta-Adrenergic Signaling and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include protein phosphatase inhibitor activity. An important paralog of this gene is PPP1R14B.

UniProtKB/Swiss-Prot Summary for PPP1R14A Gene

  • Inhibitor of PPP1CA. Has over 1000-fold higher inhibitory activity when phosphorylated, creating a molecular switch for regulating the phosphorylation status of PPP1CA substrates and smooth muscle contraction.

Gene Wiki entry for PPP1R14A Gene

Additional gene information for PPP1R14A Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PPP1R14A Gene

Genomics for PPP1R14A Gene

GeneHancer (GH) Regulatory Elements Pubs

Download GeneHancer 2017 data
Promoters and enhancers for PPP1R14A Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PPP1R14A on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for PPP1R14A

Top Transcription factor binding sites by QIAGEN in the PPP1R14A gene promoter:
  • AP-1
  • ATF-2
  • c-Fos
  • c-Jun
  • CREB
  • deltaCREB
  • Max1

Genomic Locations for PPP1R14A Gene

Latest Assembly
chr19:38,251,237-38,256,532
(GRCh38/hg38)
Size:
5,296 bases
Orientation:
Minus strand

Previous Assembly
chr19:38,741,877-38,747,014
(GRCh37/hg19 by Entrez Gene)
Size:
5,138 bases
Orientation:
Minus strand

chr19:38,741,877-38,747,231
(GRCh37/hg19 by Ensembl)
Size:
5,355 bases
Orientation:
Minus strand

Genomic View for PPP1R14A Gene

Genes around PPP1R14A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PPP1R14A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PPP1R14A Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for PPP1R14A Gene

Proteins for PPP1R14A Gene

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  • Protein details for PPP1R14A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96A00-PP14A_HUMAN
    Recommended name:
    Protein phosphatase 1 regulatory subunit 14A
    Protein Accession:
    Q96A00
    Secondary Accessions:
    • Q7Z4X7
    • Q96S54

    Protein attributes for PPP1R14A Gene

    Size:
    147 amino acids
    Molecular mass:
    16693 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for PPP1R14A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PPP1R14A Gene

Protein Expression for PPP1R14A Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for PPP1R14A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PPP1R14A Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for PPP1R14A Gene

Domains & Families for PPP1R14A Gene

Gene Families for PPP1R14A Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for PPP1R14A Gene

InterPro:

Suggested Antigen Peptide Sequences for PPP1R14A Gene

GenScript: Design optimal peptide antigens:
  • Protein kinase C-potentiated inhibitor protein of 17 kDa (PP14A_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q96A00

UniProtKB/Swiss-Prot:

PP14A_HUMAN :
  • Belongs to the PP1 inhibitor family.
Family:
  • Belongs to the PP1 inhibitor family.
genes like me logo Genes that share domains with PPP1R14A: view

Function for PPP1R14A Gene

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Molecular function for PPP1R14A Gene

UniProtKB/Swiss-Prot Function:
Inhibitor of PPP1CA. Has over 1000-fold higher inhibitory activity when phosphorylated, creating a molecular switch for regulating the phosphorylation status of PPP1CA substrates and smooth muscle contraction.

Phenotypes From GWAS Catalog for PPP1R14A Gene

Gene Ontology (GO) - Molecular Function for PPP1R14A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004864 protein phosphatase inhibitor activity IEA --
GO:0004865 protein serine/threonine phosphatase inhibitor activity IBA 21873635
genes like me logo Genes that share ontologies with PPP1R14A: view
genes like me logo Genes that share phenotypes with PPP1R14A: view

Animal Models for research

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PPP1R14A

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PPP1R14A Gene

Localization for PPP1R14A Gene

Subcellular locations from UniProtKB/Swiss-Prot for PPP1R14A Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PPP1R14A gene
Compartment Confidence
nucleus 4
cytosol 4
mitochondrion 3
plasma membrane 2
extracellular 2
cytoskeleton 2
endoplasmic reticulum 2
peroxisome 1
endosome 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (3)
  • Nuclear bodies (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for PPP1R14A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with PPP1R14A: view

Pathways & Interactions for PPP1R14A Gene

PathCards logo

SuperPathways for PPP1R14A Gene

SuperPathway Contained pathways
1 Activation of cAMP-Dependent PKA
Activation of cAMP-Dependent PKA
.77
cAMP Pathway
.77
Activation of PKA through GPCR
.71
PKA Signaling
.56
2 Beta-Adrenergic Signaling
Beta-Adrenergic Signaling
.37
Erythropoietin Pathway
.37
Insulin Receptor Pathway
.37
CDK5 Pathway
.36
3 Signaling by Rho GTPases
RHO GTPase Effectors
.69
Signaling by Rho GTPases
.69
4 Oxytocin signaling pathway
Vascular smooth muscle contraction
.32
5 CREB Pathway
Activation of PKC through GPCR
.63
genes like me logo Genes that share pathways with PPP1R14A: view

Pathways by source for PPP1R14A Gene

1 KEGG pathway for PPP1R14A Gene
1 GeneGo (Thomson Reuters) pathway for PPP1R14A Gene
  • Signal transduction Activation of PKC via G-Protein coupled receptor
16 Qiagen pathways for PPP1R14A Gene
  • Activation of cAMP-Dependent PKA
  • Activation of PKA through GPCR
  • Activation of PKC through GPCR
  • Beta-Adrenergic Signaling
  • Breast Cancer Regulation by Stathmin1

SIGNOR curated interactions for PPP1R14A Gene

Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for PPP1R14A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0032515 negative regulation of phosphoprotein phosphatase activity IEA --
GO:0042325 regulation of phosphorylation IEA --
genes like me logo Genes that share ontologies with PPP1R14A: view

Drugs & Compounds for PPP1R14A Gene

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(7) Drugs for PPP1R14A Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(2) Additional Compounds for PPP1R14A Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with PPP1R14A: view

Transcripts for PPP1R14A Gene

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mRNA/cDNA for PPP1R14A Gene

2 REFSEQ mRNAs :
6 NCBI additional mRNA sequence :
5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PPP1R14A

Alternative Splicing Database (ASD) splice patterns (SP) for PPP1R14A Gene

No ASD Table

Relevant External Links for PPP1R14A Gene

GeneLoc Exon Structure for
PPP1R14A

Expression for PPP1R14A Gene

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mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PPP1R14A Gene

mRNA expression in normal human tissues for PPP1R14A Gene
mRNA expression by GTEx for PPP1R14A GenemRNA expression by BioGPS for PPP1R14A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PPP1R14A Gene

This gene is overexpressed in Artery - Aorta (x6.7), Artery - Coronary (x5.9), and Artery - Tibial (x5.4).

Protein differential expression in normal tissues from HIPED for PPP1R14A Gene

This gene is overexpressed in Peripheral blood mononuclear cells (12.3), Urinary Bladder (10.1), and Rectum (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for PPP1R14A Gene



Protein tissue co-expression partners for PPP1R14A Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for PPP1R14A

SOURCE GeneReport for Unigene cluster for PPP1R14A Gene:

Hs.631569

mRNA Expression by UniProt/SwissProt for PPP1R14A Gene:

Q96A00-PP14A_HUMAN
Tissue specificity: Isoform 1 is detected in aorta and testis. Isoform 2 is detected in aorta.

Evidence on tissue expression from TISSUES for PPP1R14A Gene

  • Muscle(4.5)
  • Blood(4.4)
  • Liver(4.4)
  • Pancreas(4.3)
  • Nervous system(3.1)
  • Heart(2.7)
  • Intestine(2.7)
  • Lung(2.6)
  • Spleen(2.5)
  • Kidney(2)
genes like me logo Genes that share expression patterns with PPP1R14A: view

Primer products for research

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for PPP1R14A Gene

Orthologs for PPP1R14A Gene

This gene was present in the common ancestor of chordates.

Orthologs for PPP1R14A Gene

Organism Taxonomy Gene Similarity Type Details
Cow
(Bos Taurus)
 Mammalia PPP1R14A 29 30
  • 90.93 (n)
 OneToOne
Dog
(Canis familiaris)
 Mammalia PPP1R14A 29 30
  • 84.85 (n)
 OneToOne
Mouse
(Mus musculus)
 Mammalia Ppp1r14a 29 16 30
  • 84.81 (n)
 OneToOne
Rat
(Rattus norvegicus)
 Mammalia Ppp1r14a 29
  • 83.67 (n)
Oppossum
(Monodelphis domestica)
 Mammalia PPP1R14A 30
  • 71 (a)
 OneToOne
Lizard
(Anolis carolinensis)
 Reptilia PPP1R14A 30
  • 50 (a)
 OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
 Amphibia ppp1r14a 29
  • 64.06 (n)
Str.5879 29
African clawed frog
(Xenopus laevis)
 Amphibia Xl.4651 29
Zebrafish
(Danio rerio)
 Actinopterygii ppp1r14aa 30
  • 42 (a)
 OneToMany
Dr.14203 29
Species where no ortholog for PPP1R14A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for PPP1R14A Gene

ENSEMBL:
Gene Tree for PPP1R14A (if available)
TreeFam:
Gene Tree for PPP1R14A (if available)
Aminode:
Evolutionary constrained regions (ECRs) for PPP1R14A: view image
Alliance of Genome Resources:
Additional Orthologs for PPP1R14A

Paralogs for PPP1R14A Gene

Paralogs for PPP1R14A Gene

(4) SIMAP similar genes for PPP1R14A Gene using alignment to 3 proteins:

  • PP14A_HUMAN
  • K7EJB8_HUMAN
  • K7EMN0_HUMAN
genes like me logo Genes that share paralogs with PPP1R14A: view

Variants for PPP1R14A Gene

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dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for PPP1R14A Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for PPP1R14A Gene

Variant ID Type Subtype PubMed ID
nsv476367 CNV novel sequence insertion 20440878
nsv833821 CNV loss 17160897

Variation tolerance for PPP1R14A Gene

Residual Variation Intolerance Score: 68.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.28; 25.59% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PPP1R14A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PPP1R14A
Leiden Open Variation Database (LOVD)
PPP1R14A

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for PPP1R14A Gene

Disorders for PPP1R14A Gene

MalaCards: The human disease database

(18) MalaCards diseases for PPP1R14A Gene - From: COP

Disorder Aliases PubMed IDs
dracunculiasis
  • dracontiasis
israeli tick typhus
  • israeli spotted fever
epidemic typhus
  • sylvatic typhus
indian tick typhus
ophthalmia nodosa
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for PPP1R14A

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with PPP1R14A: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PPP1R14A Gene

Publications for PPP1R14A Gene

  1. Identification of human CPI-17, an inhibitory phosphoprotein for myosin phosphatase. (PMID: 11467857) Yamawaki K … Nakano T (Biochemical and biophysical research communications 2001) 2 3 4 22
  2. Association of CPI-17 with protein kinase C and casein kinase I. (PMID: 15003508) Zemlickova E … Dubois T (Biochemical and biophysical research communications 2004) 3 4 22
  3. Functional inactivation of NF2/merlin in human mesothelioma. (PMID: 18835652) Thurneysen C … Felley-Bosco E (Lung cancer (Amsterdam, Netherlands) 2009) 3 22
  4. CPI-17 silencing-reduced responsiveness in control and TNF-alpha-treated human bronchi. (PMID: 18757304) Morin C … Rousseau E (American journal of respiratory cell and molecular biology 2008) 3 22
  5. Up-regulation of myometrial RHO effector proteins (PKN1 and DIAPH1) and CPI-17 (PPP1R14A) phosphorylation in human pregnancy is associated with increased GTP-RHOA in spontaneous preterm labor. (PMID: 17301291) Lartey J … López Bernal A (Biology of reproduction 2007) 3 22

ExternalLinks

View latest publications for PPP1R14A gene in Mastermind

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