Aliases for PPP1R13B Gene
External Ids for PPP1R13B Gene
Previous GeneCards Identifiers for PPP1R13B Gene
This gene encodes a member of the ASPP (apoptosis-stimulating protein of p53) family of p53 interacting proteins. The protein contains four ankyrin repeats and an SH3 domain involved in protein-protein interactions. ASPP proteins are required for the induction of apoptosis by p53-family proteins. They promote DNA binding and transactivation of p53-family proteins on the promoters of proapoptotic genes. Expression of this gene is regulated by the E2F transcription factor. [provided by RefSeq, Jul 2008]
GeneCards Summary for PPP1R13B Gene
PPP1R13B (Protein Phosphatase 1 Regulatory Subunit 13B) is a Protein Coding gene. Diseases associated with PPP1R13B include Schizophrenia. Among its related pathways are Beta-Adrenergic Signaling and Regulation of TP53 Activity. Gene Ontology (GO) annotations related to this gene include transcription factor binding. An important paralog of this gene is TP53BP2.
UniProtKB/Swiss-Prot Summary for PPP1R13B Gene
Regulator that plays a central role in regulation of apoptosis via its interaction with p53/TP53 (PubMed:11684014, PubMed:12524540). Regulates TP53 by enhancing the DNA binding and transactivation function of TP53 on the promoters of proapoptotic genes in vivo.