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Aliases for PPP1R12B Gene

Aliases for PPP1R12B Gene

  • Protein Phosphatase 1 Regulatory Subunit 12B 2 3 3 5
  • Protein Phosphatase 1, Regulatory (Inhibitor) Subunit 12B 2 3
  • Myosin Phosphatase-Targeting Subunit 2 3 4
  • Myosin Phosphatase Target Subunit 2 3 4
  • MYPT2 3 4
  • Protein Phosphatase 1, Regulatory Subunit 12B 2
  • Myosin Phosphatase Regulatory Subunit 2
  • Myosin Phosphatase, Target Subunit 2 2
  • PP1bp55 3

External Ids for PPP1R12B Gene

Previous HGNC Symbols for PPP1R12B Gene

  • MYPT2

Previous GeneCards Identifiers for PPP1R12B Gene

  • GC01P200001
  • GC01P197751
  • GC01P198784
  • GC01P199606
  • GC01P199049
  • GC01P200584
  • GC01P202317
  • GC01P173483

Summaries for PPP1R12B Gene

Entrez Gene Summary for PPP1R12B Gene

  • Myosin phosphatase is a protein complex comprised of three subunits: a catalytic subunit (PP1c-delta, protein phosphatase 1, catalytic subunit delta), a large regulatory subunit (MYPT, myosin phosphatase target) and small regulatory subunit (sm-M20). Two isoforms of MYPT have been isolated--MYPT1 and MYPT2, the first of which is widely expressed, and the second of which may be specific to heart, skeletal muscle, and brain. Each of the MYPT isoforms functions to bind PP1c-delta and increase phosphatase activity. This locus encodes both MYTP2 and M20. Alternatively spliced transcript variants encoding different isoforms have been identified. Related pseudogenes have been defined on the Y chromosome. [provided by RefSeq, Oct 2011]

GeneCards Summary for PPP1R12B Gene

PPP1R12B (Protein Phosphatase 1 Regulatory Subunit 12B) is a Protein Coding gene. Among its related pathways are Cell Cycle, Mitotic and Apoptotic Pathways in Synovial Fibroblasts. Gene Ontology (GO) annotations related to this gene include enzyme activator activity and phosphatase regulator activity. An important paralog of this gene is PPP1R12A.

UniProtKB/Swiss-Prot for PPP1R12B Gene

  • Regulates myosin phosphatase activity. Augments Ca(2+) sensitivity of the contractile apparatus.

Gene Wiki entry for PPP1R12B Gene

Additional gene information for PPP1R12B Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PPP1R12B Gene

Genomics for PPP1R12B Gene

GeneHancer (GH) Regulatory Elements for PPP1R12B Gene

Promoters and enhancers for PPP1R12B Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J202347 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 650.7 +0.4 393 2.2 HDGF PKNOX1 CLOCK ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 ZBTB7B PPP1R12B RNPEP ENSG00000273478 HNRNPA1P59 LGR6 PTPRVP KDM5B ELF3-AS1 CYCSP4
GH01J202462 Promoter/Enhancer 1.3 EPDnew ENCODE 650.1 +113.9 113946 0.8 HDAC1 PKNOX1 ATF1 TCF12 SCRT2 SIRT6 ATF7 ZBTB2 YY2 ZEB2 PPP1R12B ENSG00000226862 ELF3-AS1 RPS27P8 ENSG00000232626
GH01J202103 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 2.7 -241.8 -241752 6.6 HDGF FOXA2 PKNOX1 CLOCK NEUROD1 ZBTB7B YY1 FOS DEK SP3 ELF3-AS1 ELF3 RNPEP ENSG00000273478 HNRNPA1P59 ENSG00000249007 RPS27P8 TIMM17A GPR37L1 PTPRVP
GH01J202074 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 2 -272.0 -271998 3.9 HDGF PKNOX1 SMAD1 FOXA2 ARNT ZNF766 FOS SP5 REST MEF2D ELF3-AS1 RNPEP ENSG00000273478 HNRNPA1P59 KDM5B RPS27P8 TIMM17A PPP1R12B ELF3 ENSG00000212512
GH01J202042 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 1.6 -302.9 -302866 7.5 HDGF PKNOX1 CLOCK FOXA2 MLX ARID4B NEUROD1 SIN3A ZBTB7B ZNF48 ELF3-AS1 RNPEP ENSG00000273478 ELF3 HNRNPA1P59 ENSG00000249007 RPS27P8 LMOD1 LGR6 PPP1R12B
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PPP1R12B on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the PPP1R12B gene promoter:
  • FOXL1
  • FOXJ2 (long isoform)
  • FOXJ2
  • Pax-6
  • Meis-1b
  • HSF2
  • SEF-1 (1)
  • Meis-1
  • Meis-1a

Genomic Locations for PPP1R12B Gene

Genomic Locations for PPP1R12B Gene
chr1:202,348,699-202,592,706
(GRCh38/hg38)
Size:
244,008 bases
Orientation:
Plus strand
chr1:202,317,827-202,561,834
(GRCh37/hg19)
Size:
244,008 bases
Orientation:
Plus strand

Genomic View for PPP1R12B Gene

Genes around PPP1R12B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PPP1R12B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PPP1R12B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PPP1R12B Gene

Proteins for PPP1R12B Gene

  • Protein details for PPP1R12B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O60237-MYPT2_HUMAN
    Recommended name:
    Protein phosphatase 1 regulatory subunit 12B
    Protein Accession:
    O60237
    Secondary Accessions:
    • A0A0A0MS24
    • A8MYF5
    • B7ZMN6
    • Q2TAI8
    • Q5T506
    • Q5VUK2
    • Q8N179
    • Q9HCB7
    • Q9HCB8

    Protein attributes for PPP1R12B Gene

    Size:
    982 amino acids
    Molecular mass:
    110404 Da
    Quaternary structure:
    • PP1 comprises a catalytic subunit, PPP1CA, PPP1CB or PPP1CC, and one or several targeting or regulatory subunits. PPP1R12B mediates binding to myosin. Isoform 3 and isoform 4 bind PPP1R12A, but not isoform 1 of PPP1R12B itself. Binds IL16.

    Alternative splice isoforms for PPP1R12B Gene

neXtProt entry for PPP1R12B Gene

Post-translational modifications for PPP1R12B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for PPP1R12B Gene

Domains & Families for PPP1R12B Gene

Gene Families for PPP1R12B Gene

Suggested Antigen Peptide Sequences for PPP1R12B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with PPP1R12B: view

No data available for UniProtKB/Swiss-Prot for PPP1R12B Gene

Function for PPP1R12B Gene

Molecular function for PPP1R12B Gene

UniProtKB/Swiss-Prot Function:
Regulates myosin phosphatase activity. Augments Ca(2+) sensitivity of the contractile apparatus.

Phenotypes From GWAS Catalog for PPP1R12B Gene

Gene Ontology (GO) - Molecular Function for PPP1R12B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004857 enzyme inhibitor activity IBA --
GO:0005515 protein binding IPI 11067852
GO:0008047 enzyme activator activity TAS 9570949
GO:0019208 phosphatase regulator activity IEA --
GO:0019901 protein kinase binding IEA --
genes like me logo Genes that share ontologies with PPP1R12B: view
genes like me logo Genes that share phenotypes with PPP1R12B: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PPP1R12B

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PPP1R12B Gene

Localization for PPP1R12B Gene

Subcellular locations from UniProtKB/Swiss-Prot for PPP1R12B Gene

Cytoplasm. Note=Along actomyosin filaments and stress fibers.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PPP1R12B gene
Compartment Confidence
nucleus 5
cytosol 5
cytoskeleton 3
plasma membrane 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Actin filaments (3)
  • Plasma membrane (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for PPP1R12B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IBA,IEA --
GO:0005829 cytosol TAS --
GO:0030018 Z disc ISS --
GO:0031672 A band ISS --
genes like me logo Genes that share ontologies with PPP1R12B: view

Pathways & Interactions for PPP1R12B Gene

genes like me logo Genes that share pathways with PPP1R12B: view

Interacting Proteins for PPP1R12B Gene

SIGNOR curated interactions for PPP1R12B Gene

Is inactivated by:

Gene Ontology (GO) - Biological Process for PPP1R12B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000086 G2/M transition of mitotic cell cycle TAS --
GO:0006937 regulation of muscle contraction TAS 9570949
GO:0007165 signal transduction IEA,TAS --
GO:0010923 negative regulation of phosphatase activity IBA --
GO:0043085 positive regulation of catalytic activity IEA --
genes like me logo Genes that share ontologies with PPP1R12B: view

Drugs & Compounds for PPP1R12B Gene

No Compound Related Data Available

Transcripts for PPP1R12B Gene

mRNA/cDNA for PPP1R12B Gene

Unigene Clusters for PPP1R12B Gene

Protein phosphatase 1, regulatory subunit 12B:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PPP1R12B

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for PPP1R12B Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b ^ 17a · 17b ^ 18 ^ 19 ^ 20a · 20b · 20c ^ 21 ^
SP1: - -
SP2: - -
SP3: - -
SP4:
SP5: - -
SP6: -
SP7:
SP8:
SP9:
SP10:

ExUns: 22 ^ 23 ^ 24
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:

Relevant External Links for PPP1R12B Gene

GeneLoc Exon Structure for
PPP1R12B
ECgene alternative splicing isoforms for
PPP1R12B

Expression for PPP1R12B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PPP1R12B Gene

mRNA differential expression in normal tissues according to GTEx for PPP1R12B Gene

This gene is overexpressed in Artery - Tibial (x4.2), Heart - Left Ventricle (x4.1), and Colon - Sigmoid (x4.1).

Protein differential expression in normal tissues from HIPED for PPP1R12B Gene

This gene is overexpressed in Seminal vesicle (10.8), Uterus (8.0), Colon (7.4), and Heart (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for PPP1R12B Gene



Protein tissue co-expression partners for PPP1R12B Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of PPP1R12B Gene:

PPP1R12B

SOURCE GeneReport for Unigene cluster for PPP1R12B Gene:

Hs.444403

mRNA Expression by UniProt/SwissProt for PPP1R12B Gene:

O60237-MYPT2_HUMAN
Tissue specificity: Detected in skeletal muscle, fetal and adult heart, brain, placenta, kidney, spleen, thymus, pancreas and lung. Isoform 3 and isoform 4 are heart specific.

Evidence on tissue expression from TISSUES for PPP1R12B Gene

  • Nervous system(4.8)
  • Heart(4.6)
  • Muscle(3.1)
genes like me logo Genes that share expression patterns with PPP1R12B: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for PPP1R12B Gene

Orthologs for PPP1R12B Gene

This gene was present in the common ancestor of animals.

Orthologs for PPP1R12B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PPP1R12B 34 33
  • 99.59 (n)
OneToOne
dog
(Canis familiaris)
Mammalia PPP1R12B 34 33
  • 87.36 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Ppp1r12b 34
  • 87 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PPP1R12B 34
  • 79 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PPP1R12B 34
  • 74 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PPP1R12B 34
  • 58 (a)
OneToOne
chicken
(Gallus gallus)
Aves LOC101749340 33
  • 70.53 (n)
PPP1R12B 34
  • 69 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PPP1R12B 34
  • 66 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii PPP1R12B 34
  • 59 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Mbs 34
  • 26 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 35 (a)
ManyToMany
Species where no ortholog for PPP1R12B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PPP1R12B Gene

ENSEMBL:
Gene Tree for PPP1R12B (if available)
TreeFam:
Gene Tree for PPP1R12B (if available)
Aminode:
Evolutionary constrained regions (ECRs) for PPP1R12B: view image

Paralogs for PPP1R12B Gene

(18) SIMAP similar genes for PPP1R12B Gene using alignment to 4 proteins:

  • MYPT2_HUMAN
  • F8W8M3_HUMAN
  • H7C4R6_HUMAN
  • Q6GQY8_HUMAN

Pseudogenes.org Pseudogenes for PPP1R12B Gene

genes like me logo Genes that share paralogs with PPP1R12B: view

Variants for PPP1R12B Gene

Sequence variations from dbSNP and Humsavar for PPP1R12B Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000032005 -- 202,380,848(+) A/G genic_upstream_transcript_variant, intron_variant
rs1000076988 -- 202,524,784(+) G/C genic_downstream_transcript_variant, genic_upstream_transcript_variant, intron_variant
rs1000112881 -- 202,504,733(+) A/G downstream_transcript_variant, genic_downstream_transcript_variant, genic_upstream_transcript_variant, intron_variant, non_coding_transcript_variant
rs1000133777 -- 202,396,623(+) T/A genic_upstream_transcript_variant, intron_variant
rs1000139814 -- 202,435,323(+) G/T genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for PPP1R12B Gene

Variant ID Type Subtype PubMed ID
dgv96n67 CNV loss 20364138
dgv97n67 CNV loss 20364138
esv1006468 CNV deletion 20482838
esv1009152 CNV gain 20482838
esv2027802 CNV deletion 18987734
esv2379385 CNV deletion 18987734
esv24486 CNV loss 19812545
esv2673485 CNV deletion 23128226
esv2721584 CNV deletion 23290073
esv2721595 CNV deletion 23290073
esv2721606 CNV deletion 23290073
esv29503 CNV loss 19812545
esv3588582 CNV gain 21293372
esv3588583 CNV loss 21293372
esv3891070 CNV loss 25118596
esv8498 CNV loss 19470904
nsv1068420 CNV deletion 25765185
nsv159751 CNV deletion 16902084
nsv433192 CNV loss 18776910
nsv471538 CNV gain 19718026
nsv473451 CNV novel sequence insertion 20440878
nsv514037 CNV gain 21397061
nsv514038 CNV gain 21397061
nsv516501 CNV gain 19592680
nsv832337 CNV loss 17160897
nsv946578 CNV duplication 23825009
nsv946579 CNV duplication 23825009
nsv946581 CNV duplication 23825009
nsv946582 CNV duplication 23825009
nsv946583 CNV duplication 23825009
nsv946584 CNV duplication 23825009
nsv958065 CNV deletion 24416366

Variation tolerance for PPP1R12B Gene

Residual Variation Intolerance Score: 44% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.16; 51.71% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PPP1R12B Gene

Human Gene Mutation Database (HGMD)
PPP1R12B
SNPedia medical, phenotypic, and genealogical associations of SNPs for
PPP1R12B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PPP1R12B Gene

Disorders for PPP1R12B Gene

Additional Disease Information for PPP1R12B

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for PPP1R12B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PPP1R12B Gene

Publications for PPP1R12B Gene

  1. A new isoform of human myosin phosphatase targeting/regulatory subunit (MYPT2): cDNA cloning, tissue expression, and chromosomal mapping. (PMID: 9570949) Fujioka M … Ito M (Genomics 1998) 2 3 4 58
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  3. Assessment of a polymorphism of SDK1 with hypertension in Japanese Individuals. (PMID: 19851296) Oguri M … Yamada Y (American journal of hypertension 2010) 3 44 58
  4. Association of genetic variants with hemorrhagic stroke in Japanese individuals. (PMID: 20198315) Yoshida T … Yamada Y (International journal of molecular medicine 2010) 3 44 58
  5. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4 58

Products for PPP1R12B Gene

Sources for PPP1R12B Gene

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