Aliases for PPP1R11 Gene
External Ids for PPP1R11 Gene
Previous HGNC Symbols for PPP1R11 Gene
Previous GeneCards Identifiers for PPP1R11 Gene
This gene encodes a specific inhibitor of protein phosphatase-1 (PP1) with a differential sensitivity toward the metal-independent and metal-dependent forms of PP1. The gene is located within the major histocompatibility complex class I region on chromosome 6. [provided by RefSeq, Jul 2008]
GeneCards Summary for PPP1R11 Gene
PPP1R11 (Protein Phosphatase 1 Regulatory Inhibitor Subunit 11) is a Protein Coding gene. Among its related pathways are Beta-Adrenergic Signaling and Apoptotic Pathways in Synovial Fibroblasts. Gene Ontology (GO) annotations related to this gene include protein phosphatase inhibitor activity.
UniProtKB/Swiss-Prot Summary for PPP1R11 Gene
Atypical E3 ubiquitin-protein ligase which ubiquitinates TLR2 at 'Lys-754' leading to its degradation by the proteasome. Plays a role in regulating inflammatory cytokine release and gram-positive bacterial clearance by functioning, in part, through the ubiquitination and degradation of TLR2 (PubMed:27805901). Inhibitor of protein phosphatase 1 (PubMed:9843442).