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Aliases for PPP1R10 Gene

Aliases for PPP1R10 Gene

  • Protein Phosphatase 1 Regulatory Subunit 10 2 3 5
  • Phosphatase 1 Nuclear Targeting Subunit 2 3 4
  • Protein Phosphatase 1, Regulatory (Inhibitor) Subunit 10 2 3
  • MHC Class I Region Proline-Rich Protein CAT53 3 4
  • HLA-C Associated Transcript 53 2 3
  • PP1-Binding Protein Of 114 KDa 3 4
  • CAT53 3 4
  • PNUTS 3 4
  • FB19 3 4
  • P99 3 4
  • Serine/Threonine-Protein Phosphatase 1 Regulatory Subunit 10 3
  • Protein Phosphatase 1, Regulatory Subunit 10 2
  • Testis Tissue Sperm-Binding Protein Li 67n 3
  • Protein FB19 4
  • PP1R10 3
  • R111 3

External Ids for PPP1R10 Gene

Previous GeneCards Identifiers for PPP1R10 Gene

  • GC06M030623
  • GC06M030338
  • GC06M030674
  • GC06M030677

Summaries for PPP1R10 Gene

Entrez Gene Summary for PPP1R10 Gene

  • This gene encodes a protein phosphatase 1 binding protein. The encoded protein plays a role in many cellular processes including cell cycle progression, DNA repair and apoptosis by regulating the activity of protein phosphatase 1. This gene lies within the major histocompatibility complex class I region on chromosome 6, and alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Jul 2012]

GeneCards Summary for PPP1R10 Gene

PPP1R10 (Protein Phosphatase 1 Regulatory Subunit 10) is a Protein Coding gene. Diseases associated with PPP1R10 include Melanoma, Cutaneous Malignant 1. Among its related pathways are Activation of cAMP-Dependent PKA and PEDF Induced Signaling. Gene Ontology (GO) annotations related to this gene include protein phosphatase inhibitor activity. An important paralog of this gene is PRR3.

UniProtKB/Swiss-Prot for PPP1R10 Gene

  • Scaffold protein which mediates the formation of the PTW/PP1 phosphatase complex by providing a binding platform to each component of the complex. The PTW/PP1 phosphatase complex plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase. Mediates interaction of WDR82 and PPP1CA. Inhibitor of PPP1CA and PPP1CC phosphatase activities. Has inhibitory activity on PPP1CA only when phosphorylated. Binds to mRNA, single-stranded DNA (ssDNA), poly(A) and poly(G) homopolymers (By similarity).

Gene Wiki entry for PPP1R10 Gene

Additional gene information for PPP1R10 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PPP1R10 Gene

Genomics for PPP1R10 Gene

GeneHancer (GH) Regulatory Elements for PPP1R10 Gene

Promoters and enhancers for PPP1R10 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH06J030611 Promoter/Enhancer 2.6 EPDnew Ensembl ENCODE dbSUPER 742.3 +3.1 3060 8.7 CLOCK MLX ZFP64 DMAP1 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 PPP1R10 MRPS18B MDC1 DDX39B TRIM39 NRM DHX16 ZNRD1 ABCF1 TRIM26
GH06J030645 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 650.3 -28.7 -28680 2.6 HDGF PKNOX1 FOXA2 MLX ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 C6orf136 PPP1R10 HCG18 PRR3 RPL7P4 HLA-L TMPOP1 UBQLN1P1 SNORA38 ENSG00000233902
GH06J031538 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 104.9 -922.5 -922527 4.9 MLX ZFP64 FEZF1 DMAP1 IRF4 YY1 ZNF213 E2F8 ZNF143 ZNF263 DDX39B DDX39B-AS1 GC06M031542 GC06M031543 GC06M031550 GC06M031555 GC06M031573 GC06M032007 GC06M032013 GC06M032015
GH06J030907 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 94.1 -289.8 -289845 2.2 CLOCK DMAP1 YBX1 IRF4 YY1 ZNF213 E2F8 ZNF416 ZNF143 ZNF548 GTF2H4 VARS2 GC06P032276 MDC1 DDX39B LY6G5B LSM2 TRIM39 DHX16 PPP1R10
GH06J030715 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE dbSUPER 75.1 -100.9 -100914 7.7 CLOCK MLX ZFP64 FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 MDC1 TUBB DDX39B LY6G5B TRIM39 DHX16 PPP1R10 ZNRD1 PAIP1P1 NRM
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PPP1R10 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the PPP1R10 gene promoter:
  • CREB
  • HOXA5
  • deltaCREB
  • aMEF-2
  • MEF-2
  • MEF-2A
  • HNF-3beta
  • FOXJ2
  • FOXJ2 (long isoform)
  • MRF-2

Genomic Locations for PPP1R10 Gene

Genomic Locations for PPP1R10 Gene
chr6:30,600,400-30,618,612
(GRCh38/hg38)
Size:
18,213 bases
Orientation:
Minus strand
chr6:30,568,177-30,586,389
(GRCh37/hg19)
Size:
18,213 bases
Orientation:
Minus strand

Genomic View for PPP1R10 Gene

Genes around PPP1R10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PPP1R10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PPP1R10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

Proteins for PPP1R10 Gene

  • Protein details for PPP1R10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96QC0-PP1RA_HUMAN
    Recommended name:
    Serine/threonine-protein phosphatase 1 regulatory subunit 10
    Protein Accession:
    Q96QC0
    Secondary Accessions:
    • O00405

    Protein attributes for PPP1R10 Gene

    Size:
    940 amino acids
    Molecular mass:
    99058 Da
    Quaternary structure:
    • Component of the PTW/PP1 phosphatase complex, composed of PPP1R10/PNUTS, TOX4, WDR82, and PPP1CA or PPP1CB or PPP1CC. Interacts with PPP1CC. Interacts with PPP1CA, WDR82 and TOX4 (By similarity).

neXtProt entry for PPP1R10 Gene

Post-translational modifications for PPP1R10 Gene

  • Phosphorylated on Ser-398 by PKA within the region necessary for interaction with PPP1CA.
  • Ubiquitination at Lys33 and posLast=1313
  • Modification sites at PhosphoSitePlus

Other Protein References for PPP1R10 Gene

Antibody Products

  • Abcam antibodies for PPP1R10
  • Boster Bio Antibodies for PPP1R10

No data available for DME Specific Peptides for PPP1R10 Gene

Domains & Families for PPP1R10 Gene

Gene Families for PPP1R10 Gene

Protein Domains for PPP1R10 Gene

Suggested Antigen Peptide Sequences for PPP1R10 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with PPP1R10: view

No data available for UniProtKB/Swiss-Prot for PPP1R10 Gene

Function for PPP1R10 Gene

Molecular function for PPP1R10 Gene

UniProtKB/Swiss-Prot Function:
Scaffold protein which mediates the formation of the PTW/PP1 phosphatase complex by providing a binding platform to each component of the complex. The PTW/PP1 phosphatase complex plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase. Mediates interaction of WDR82 and PPP1CA. Inhibitor of PPP1CA and PPP1CC phosphatase activities. Has inhibitory activity on PPP1CA only when phosphorylated. Binds to mRNA, single-stranded DNA (ssDNA), poly(A) and poly(G) homopolymers (By similarity).

Phenotypes From GWAS Catalog for PPP1R10 Gene

Gene Ontology (GO) - Molecular Function for PPP1R10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003723 RNA binding HDA,IEA 22681889
GO:0004864 protein phosphatase inhibitor activity IEA --
GO:0005515 protein binding IPI 15231748
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with PPP1R10: view
genes like me logo Genes that share phenotypes with PPP1R10: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PPP1R10

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PPP1R10 Gene

Localization for PPP1R10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PPP1R10 Gene

Nucleus. Note=Found in discrete nucleoplasmic bodies and within nucleoli. Associates with chromatin during interphase, excluded from condensed chromosomes during early mitosis and is reloaded onto chromosomes at the late telophase (By similarity). {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PPP1R10 gene
Compartment Confidence
nucleus 5

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear bodies (4)
  • Nucleoplasm (4)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for PPP1R10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000784 colocalizes_with nuclear chromosome, telomeric region IDA 24270157
GO:0000785 chromatin IEA,ISS --
GO:0005634 nucleus TAS 9461602
GO:0005654 nucleoplasm IDA --
GO:0016604 nuclear body IDA --
genes like me logo Genes that share ontologies with PPP1R10: view

Pathways & Interactions for PPP1R10 Gene

genes like me logo Genes that share pathways with PPP1R10: view

Pathways by source for PPP1R10 Gene

1 Cell Signaling Technology pathway for PPP1R10 Gene

Gene Ontology (GO) - Biological Process for PPP1R10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006606 protein import into nucleus TAS 9461602
GO:0010667 negative regulation of cardiac muscle cell apoptotic process IDA 23426265
GO:0032206 positive regulation of telomere maintenance IMP 23426265
GO:0032515 negative regulation of phosphoprotein phosphatase activity IEA --
GO:1904290 negative regulation of mitotic DNA damage checkpoint IGI 23426265
genes like me logo Genes that share ontologies with PPP1R10: view

No data available for SIGNOR curated interactions for PPP1R10 Gene

Drugs & Compounds for PPP1R10 Gene

(2) Drugs for PPP1R10 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with PPP1R10: view

Transcripts for PPP1R10 Gene

mRNA/cDNA for PPP1R10 Gene

Unigene Clusters for PPP1R10 Gene

Protein phosphatase 1, regulatory subunit 10:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PPP1R10

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for PPP1R10 Gene

No ASD Table

Relevant External Links for PPP1R10 Gene

GeneLoc Exon Structure for
PPP1R10
ECgene alternative splicing isoforms for
PPP1R10

Expression for PPP1R10 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PPP1R10 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for PPP1R10 Gene

This gene is overexpressed in Cervix (21.4), Peripheral blood mononuclear cells (11.0), and Breast (9.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for PPP1R10 Gene



Protein tissue co-expression partners for PPP1R10 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of PPP1R10 Gene:

PPP1R10

SOURCE GeneReport for Unigene cluster for PPP1R10 Gene:

Hs.106019

mRNA Expression by UniProt/SwissProt for PPP1R10 Gene:

Q96QC0-PP1RA_HUMAN
Tissue specificity: Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.

Evidence on tissue expression from TISSUES for PPP1R10 Gene

  • Nervous system(4.7)
  • Liver(4.4)
  • Stomach(2.8)
  • Kidney(2.3)
  • Muscle(2.3)
  • Intestine(2)
genes like me logo Genes that share expression patterns with PPP1R10: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for PPP1R10 Gene

Orthologs for PPP1R10 Gene

This gene was present in the common ancestor of animals.

Orthologs for PPP1R10 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PPP1R10 34 33
  • 99.5 (n)
OneToOne
dog
(Canis familiaris)
Mammalia PPP1R10 34 33
  • 92.02 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PPP1R10 34
  • 91 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PPP1R10 34 33
  • 88.93 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Ppp1r10 16 34 33
  • 86.11 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 85 (a)
OneToMany
-- 34
  • 29 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Ppp1r10 33
  • 84.98 (n)
lizard
(Anolis carolinensis)
Reptilia PPP1R10 34
  • 70 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.10280 33
zebrafish
(Danio rerio)
Actinopterygii ppp1r10 34 33 33
  • 63.68 (n)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta PNUTS 34
  • 17 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8858 34
  • 25 (a)
OneToMany
Species where no ortholog for PPP1R10 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PPP1R10 Gene

ENSEMBL:
Gene Tree for PPP1R10 (if available)
TreeFam:
Gene Tree for PPP1R10 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for PPP1R10: view image

Paralogs for PPP1R10 Gene

Paralogs for PPP1R10 Gene

Pseudogenes.org Pseudogenes for PPP1R10 Gene

genes like me logo Genes that share paralogs with PPP1R10: view

Variants for PPP1R10 Gene

Sequence variations from dbSNP and Humsavar for PPP1R10 Gene

SNP ID Clin Chr 06 pos Variation AA Info Type
rs1000157407 -- 30,614,454(-) A/C intron_variant
rs1000442325 -- 30,616,660(-) C/T 5_prime_UTR_variant, non_coding_transcript_variant
rs1000473154 -- 30,616,508(-) G/A 5_prime_UTR_variant, non_coding_transcript_variant
rs1000483702 -- 30,608,257(-) G/A intron_variant
rs1000549684 -- 30,613,169(-) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for PPP1R10 Gene

Variant ID Type Subtype PubMed ID
esv2670269 CNV deletion 23128226
esv2731791 CNV deletion 23290073
esv3411275 CNV duplication 20981092
nsv1074389 CNV deletion 25765185
nsv1122126 CNV deletion 24896259
nsv1144137 CNV deletion 24896259
nsv5244 CNV deletion 18451855
nsv601264 CNV loss 21841781
nsv601481 CNV loss 21841781
nsv830626 CNV loss 17160897

Variation tolerance for PPP1R10 Gene

Residual Variation Intolerance Score: 3.13% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.03; 37.29% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PPP1R10 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PPP1R10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PPP1R10 Gene

Disorders for PPP1R10 Gene

MalaCards: The human disease database

(1) MalaCards diseases for PPP1R10 Gene - From: DISEASES

Disorder Aliases PubMed IDs
melanoma, cutaneous malignant 1
  • melanoma, cutaneous malignant, susceptibility to, 1
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for PPP1R10

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with PPP1R10: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PPP1R10 Gene

Publications for PPP1R10 Gene

  1. Cloning of a new gene (FB19) within HLA class I region. (PMID: 9784381) Totaro A … Gasparini P (Biochemical and biophysical research communications 1998) 2 3 4 58
  2. Purification and characterisation of p99, a nuclear modulator of protein phosphatase 1 activity. (PMID: 9450550) Kreivi JP … Lamond AI (FEBS letters 1997) 3 4 22 58
  3. PNUTS knockdown potentiates the apoptotic effect of Roscovitine in breast and colon cancer cells. (PMID: 20372802) De Leon G … Krucher NA (International journal of oncology 2010) 3 22 58
  4. High-density SNP screening of the major histocompatibility complex in systemic lupus erythematosus demonstrates strong evidence for independent susceptibility regions. (PMID: 19851445) Barcellos LF … Criswell LA (PLoS genetics 2009) 3 44 58
  5. CAT53 and HFE alleles in Alzheimer's disease: a putative protective role of the C282Y HFE mutation. (PMID: 19429178) Correia AP … Porto G (Neuroscience letters 2009) 3 44 58

Products for PPP1R10 Gene

Sources for PPP1R10 Gene

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