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This gene encodes a protein phosphatase 1 binding protein. The encoded protein plays a role in many cellular processes including cell cycle progression, DNA repair and apoptosis by regulating the activity of protein phosphatase 1. This gene lies within the major histocompatibility complex class I region on chromosome 6, and alternatively spliced transcript variants have been ob... See more...
Aliases for PPP1R10 Gene
Aliases for PPP1R10 Gene
- Protein Phosphatase 1 Regulatory Subunit 10 2 3 5
- Phosphatase 1 Nuclear Targeting Subunit 2 3 4
- Serine/Threonine-Protein Phosphatase 1 Regulatory Subunit 10 3 4
- Protein Phosphatase 1, Regulatory (Inhibitor) Subunit 10 2 3
- MHC Class I Region Proline-Rich Protein CAT53 3 4
- HLA-C Associated Transcript 53 2 3
- PP1-Binding Protein Of 114 KDa 3 4
- CAT53 3 4
External Ids for PPP1R10 Gene
- HGNC: 9284
- Entrez Gene: 5514
- Ensembl: ENSG00000204569
- OMIM: 603771
- UniProtKB: Q96QC0
Previous GeneCards Identifiers for PPP1R10 Gene
- GC06M030623
- GC06M030338
- GC06M030674
- GC06M030677
- GC06M030568
Summaries for PPP1R10 Gene
-
This gene encodes a protein phosphatase 1 binding protein. The encoded protein plays a role in many cellular processes including cell cycle progression, DNA repair and apoptosis by regulating the activity of protein phosphatase 1. This gene lies within the major histocompatibility complex class I region on chromosome 6, and alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Jul 2012]
GeneCards Summary for PPP1R10 Gene
PPP1R10 (Protein Phosphatase 1 Regulatory Subunit 10) is a Protein Coding gene. Diseases associated with PPP1R10 include Melanoma, Cutaneous Malignant 1. Among its related pathways are p70S6K Signaling and Activation of cAMP-Dependent PKA. Gene Ontology (GO) annotations related to this gene include protein phosphatase inhibitor activity. An important paralog of this gene is ZC3H18.
UniProtKB/Swiss-Prot Summary for PPP1R10 Gene
-
Scaffold protein which mediates the formation of the PTW/PP1 phosphatase complex by providing a binding platform to each component of the complex. The PTW/PP1 phosphatase complex plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase. Mediates interaction of WDR82 and PPP1CA. Inhibitor of PPP1CA and PPP1CC phosphatase activities. Has inhibitory activity on PPP1CA only when phosphorylated. Binds to mRNA, single-stranded DNA (ssDNA), poly(A) and poly(G) homopolymers (By similarity).
Additional gene information for PPP1R10 Gene
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PPP1R10 Gene
Genomics for PPP1R10 Gene
GeneHancer (GH) Regulatory Elements for PPP1R10 Gene
Promoters and enhancers for PPP1R10 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around PPP1R10 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the PPP1R10 gene promoter:
-
- aMEF-2
- CREB
- deltaCREB
- FOXJ2
- FOXJ2 (long isoform)
- HNF-3beta
- HOXA5
- MEF-2
- MEF-2A
- MRF-2
Genomic Locations for PPP1R10 Gene
Genomic Locations for PPP1R10 Gene
- chr6:30,600,400-30,618,612
- (GRCh38/hg38)
- Size:
- 18,213 bases
- Orientation:
- Minus strand
- chr6:30,568,177-30,586,389
- (GRCh37/hg19)
- Size:
- 18,213 bases
- Orientation:
- Minus strand
Genomic View for PPP1R10 Gene
Genes around PPP1R10 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 6p21.33 by HGNC
- 6p21.33 by Entrez Gene
- 6p21.33 by Ensembl
PPP1R10 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for PPP1R10 Gene
Proteins for PPP1R10 Gene
-
Protein details for PPP1R10 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q96QC0-PP1RA_HUMAN
- Recommended name:
- Serine/threonine-protein phosphatase 1 regulatory subunit 10
- Protein Accession:
- Q96QC0
- O00405
Protein attributes for PPP1R10 Gene
- Size:
- 940 amino acids
- Molecular mass:
- 99058 Da
- Quaternary structure:
-
- Component of the PTW/PP1 phosphatase complex, composed of PPP1R10/PNUTS, TOX4, WDR82, and PPP1CA or PPP1CB or PPP1CC. Interacts with PPP1CC. Interacts with PPP1CA, WDR82 and TOX4 (By similarity).
Protein Expression for PPP1R10 Gene
Post-translational modifications for PPP1R10 Gene
- Phosphorylated on Ser-398 by PKA within the region necessary for interaction with PPP1CA.
-
Ubiquitination at Lys13 and Lys33
- NX_Q96QC0 (NX_Q96QC0-1)
- Modification sites at PhosphoSitePlus
Other Protein References for PPP1R10 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- G Biosciences Immunotag™ PPP1R10 Antibody
- Atlas Antibodies Anti-PPP1R10 Antibody (HPA047248) and Anti-PPP1R10 Antibody (HPA056756)
-
Custom Antibody ServicesOriGene Antibodies for PPP1R10
- Novus Biologicals Antibodies for PPP1R10
-
Abcam antibodies for PPP1R10
- Invitrogen Antibodies for PPP1R10 (AFLGC-PPP1R10)
-
Biorbyt antibodies for PPP1R10
-
Santa Cruz Biotechnology (SCBT) Antibodies for PPP1R10
Protein Products
- Atlas Antibodies PrEST Antigen PPP1R10 (APrEST87486) and PrEST Antigen PPP1R10 (APrEST87769)
- Creative Diagnostics Human PPP1R10 peptide
- Creative Biomart Recombinant Human PPP1R10 Protein, His-tagged
-
OriGene Purified Proteins for PPP1R10
- Search Origene for MassSpec and Protein Over-expression Lysates for PPP1R10
- Origene Custom Protein Services for PPP1R10
-
Abcam proteins for PPP1R10
No data available for DME Specific Peptides for PPP1R10 Gene
Domains & Families for PPP1R10 Gene
Gene Families for PPP1R10 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Protein Domains for PPP1R10 Gene
- Blocks:
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for PPP1R10 Gene
- GenScript: Design optimal peptide antigens:
-
- p99 (PP1RA_HUMAN)
- Protein phosphatase 1, regulatory subunit 10 (Q2L6I0_HUMAN)
- PPP1R10 protein (Q58F28_HUMAN)
No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for PPP1R10 Gene
Function for PPP1R10 Gene
Molecular function for PPP1R10 Gene
- UniProtKB/Swiss-Prot Function:
- Scaffold protein which mediates the formation of the PTW/PP1 phosphatase complex by providing a binding platform to each component of the complex. The PTW/PP1 phosphatase complex plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase. Mediates interaction of WDR82 and PPP1CA. Inhibitor of PPP1CA and PPP1CC phosphatase activities. Has inhibitory activity on PPP1CA only when phosphorylated. Binds to mRNA, single-stranded DNA (ssDNA), poly(A) and poly(G) homopolymers (By similarity).
Phenotypes From GWAS Catalog for PPP1R10 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003677 | DNA binding | IEA | -- |
| GO:0003723 | RNA binding | IEA,HDA | 22681889 |
| GO:0004864 | protein phosphatase inhibitor activity | IEA | -- |
| GO:0005515 | protein binding | IPI | 15231748 |
| GO:0046872 | metal ion binding | IEA | -- |
Phenotypes for PPP1R10 Gene
- MGI mutant phenotypes for PPP1R10:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for PPP1R10:
-
- Decreased viability ratio
- Decreased viability
- Decreased shRNA abundance (Z-score < -2)
- Decreased DCP1a protein expression and assembly in processing bodies after arsenite stimulation
- Increased shRNA abundance (Z-score > 2)
- Increased cell death HMECs cells
- Reduced mammosphere formation
- Decreased viability in esophageal squamous lineage
- Decreased Salmonella enterica Typhimurium invasion
- Decreased Salmonella-containing vacuole maturation
- Decreased Salmonella enterica Typhimurium membrane closure
- no effect
- Increased vaccinia virus (VACV) infection
- Decreased interferon-beta reporter expression
- Decreased viability with paclitaxel
- Mildly decreased CFP-tsO45G cell surface transport
- Decreased NF-kappaB reporter expression
- Decreased IL-8 secretion
- Increased transferrin (TF) endocytosis
- Synthetic lethal with MLN4924 (a NAE inhibitor)
- Increased viability with MLN4924 (a NAE inhibitor)
- Synthetic lethal with vaccinia virus (VACV) infection
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
-
OriGene CRISPR knockouts for PPP1R10
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for PPP1R10
- genomics-online: gRNA clones - Search results for available PPP1R10 gene related products
- Applied Biological Materials (abm): CRISPR Clones for PPP1R10 - Select products 50% OFF >
- * PPP1R10 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * PPP1R10 CRISPR applications: KO, Activation, Repression, and more - Browse All
-
Santa Cruz Biotechnology (SCBT) CRISPR for PPP1R10
miRNA for PPP1R10 Gene
- miRTarBase miRNAs that target PPP1R10
-
- hsa-mir-34a-5p (MIRT007193)
- hsa-mir-335-5p (MIRT017879)
- hsa-mir-30a-5p (MIRT028486)
- hsa-mir-1914-3p (MIRT035778)
- hsa-mir-615-3p (MIRT040376)
- hsa-mir-324-3p (MIRT042999)
- hsa-let-7e-5p (MIRT051563)
- hsa-mir-383-5p (MIRT438194)
- hsa-mir-4291 (MIRT528124)
- hsa-mir-98-3p (MIRT528126)
- hsa-let-7f-1-3p (MIRT528127)
- hsa-let-7b-3p (MIRT528128)
- hsa-let-7a-3p (MIRT528129)
- hsa-mir-4769-5p (MIRT528130)
- hsa-mir-4654 (MIRT528131)
- hsa-mir-194-3p (MIRT528132)
- hsa-mir-7157-5p (MIRT528133)
- hsa-mir-4310 (MIRT528134)
- hsa-mir-4666a-3p (MIRT528135)
- hsa-mir-381-3p (MIRT528136)
- hsa-mir-300 (MIRT528137)
- hsa-mir-5195-5p (MIRT528138)
- hsa-mir-338-5p (MIRT528139)
- hsa-mir-592 (MIRT700662)
- hsa-mir-6796-5p (MIRT700663)
- hsa-mir-6810-5p (MIRT700664)
- hsa-mir-4666b (MIRT700665)
- hsa-mir-597-5p (MIRT700666)
- hsa-mir-6742-5p (MIRT700667)
- hsa-mir-4472 (MIRT700668)
- hsa-mir-4447 (MIRT700669)
- hsa-mir-3151-5p (MIRT700670)
- hsa-mir-491-5p (MIRT700671)
- hsa-mir-4652-5p (MIRT700672)
- hsa-mir-3191-3p (MIRT700673)
- hsa-mir-3144-5p (MIRT700674)
- hsa-mir-1914-5p (MIRT700675)
- hsa-mir-759 (MIRT700676)
- hsa-mir-299-3p (MIRT700677)
- hsa-mir-6874-3p (MIRT700678)
- hsa-mir-148b-5p (MIRT700679)
- hsa-mir-3154 (MIRT700680)
miRNA Products
Inhibitory RNA Products
- Origene sirna, shrna, and RNAi products in human, mouse, rat for PPP1R10
- Browse OriGene Inhibitory RNA Products For PPP1R10
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PPP1R10
- genomics-online: shRNA clones - Search results for available PPP1R10 gene related products
Clone Products
- Sino Biological Human cDNA Clone for PPP1R10
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for PPP1R10
- genomics-online: cdna clones - Search results for available PPP1R10 gene related products
- orf clones - Search results for available PPP1R10 gene related products
- Applied Biological Materials (abm): Clones for PPP1R10 - Select products 50% OFF >
- * PPP1R10 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * PPP1R10 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PPP1R10 Gene
Localization for PPP1R10 Gene
Subcellular locations from UniProtKB/Swiss-Prot for PPP1R10 Gene
- Nucleus. Note=Found in discrete nucleoplasmic bodies and within nucleoli. Associates with chromatin during interphase, excluded from condensed chromosomes during early mitosis and is reloaded onto chromosomes at the late telophase (By similarity). {ECO:0000250}.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
- Nuclear bodies (4)
- Nucleoplasm (4)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000784 | colocalizes_with nuclear chromosome, telomeric region | IDA | 24270157 |
| GO:0000785 | chromatin | ISS,IEA | -- |
| GO:0005634 | nucleus | TAS | 9461602 |
| GO:0005654 | nucleoplasm | IDA | -- |
| GO:0016604 | nuclear body | IDA | -- |
Pathways & Interactions for PPP1R10 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Activation of cAMP-Dependent PKA |
Activation of cAMP-Dependent PKA
.77
cAMP Pathway
.77
|
Activation of PKA through GPCR
.71
PKA Signaling
.56
|
| 2 | Beta-Adrenergic Signaling |
Beta-Adrenergic Signaling
.37
Erythropoietin Pathway
.37
|
Insulin Receptor Pathway
.37
CDK5 Pathway
.36
|
| 3 | PI3K / Akt Signaling | ||
| 4 | mTOR Pathway |
.32
|
|
| 5 | GPCR Pathway |
Breast Cancer Regulation by Stathmin1
.58
|
|
Pathways by source for PPP1R10 Gene
1 Tocris pathway for PPP1R10 Gene
14 Qiagen pathways for PPP1R10 Gene
- Activation of cAMP-Dependent PKA
- Activation of PKA through GPCR
- Beta-Adrenergic Signaling
- Breast Cancer Regulation by Stathmin1
- cAMP Pathway
1 Cell Signaling Technology pathway for PPP1R10 Gene
Interacting Proteins for PPP1R10 Gene
Selected Interacting proteins:
Q96QC0-PP1RA_HUMAN
ENSP00000365694
for PPP1R10 Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for PPP1R10
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006606 | protein import into nucleus | TAS | 9461602 |
| GO:0010667 | negative regulation of cardiac muscle cell apoptotic process | IDA | 23426265 |
| GO:0032206 | positive regulation of telomere maintenance | IMP | 23426265 |
| GO:0032515 | negative regulation of phosphoprotein phosphatase activity | IEA | -- |
| GO:1904290 | negative regulation of mitotic DNA damage checkpoint | IGI | 23426265 |
No data available for SIGNOR curated interactions for PPP1R10 Gene
Drugs & Compounds for PPP1R10 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|
Drug Products
- Atlas Antibodies PrEST Antigen PPP1R10 (APrEST87486) and PrEST Antigen PPP1R10 (APrEST87769)
- Creative Diagnostics Human PPP1R10 peptide
- Creative Biomart Recombinant Human PPP1R10 Protein, His-tagged
Transcripts for PPP1R10 Gene
mRNA/cDNA for PPP1R10 Gene
- (1) REFSEQ mRNAs :
- (9) Additional mRNA sequences :
- (26) Selected AceView cDNA sequences:
- (7) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000376511 4511 bps (ENST00000376511.6)
- ENST00000461593 566 bps (ENST00000461593.5)
- ENST00000468181 333 bps (ENST00000468181.1)
- ENST00000473954 470 bps (ENST00000473954.1)
- ENST00000476704 559 bps (ENST00000476704.1)
CRISPR Products
-
OriGene CRISPR knockouts for PPP1R10
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for PPP1R10
- genomics-online: gRNA clones - Search results for available PPP1R10 gene related products
- Applied Biological Materials (abm): CRISPR Clones for PPP1R10 - Select products 50% OFF >
- * PPP1R10 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * PPP1R10 CRISPR applications: KO, Activation, Repression, and more - Browse All
-
Santa Cruz Biotechnology (SCBT) CRISPR for PPP1R10
miRNA Products
Inhibitory RNA Products
- Origene sirna, shrna, and RNAi products in human, mouse, rat for PPP1R10
- Browse OriGene Inhibitory RNA Products For PPP1R10
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PPP1R10
- genomics-online: shRNA clones - Search results for available PPP1R10 gene related products
Clone Products
- Sino Biological Human cDNA Clone for PPP1R10
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for PPP1R10
- genomics-online: cdna clones - Search results for available PPP1R10 gene related products
- orf clones - Search results for available PPP1R10 gene related products
- Applied Biological Materials (abm): Clones for PPP1R10 - Select products 50% OFF >
- * PPP1R10 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * PPP1R10 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All
Expression for PPP1R10 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Inner Cell Mass (Early Embryonic Tissues)
This gene is overexpressed in Cervix (21.4), Peripheral blood mononuclear cells (11.0), and Breast (9.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for PPP1R10 Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of PPP1R10 Gene:
PPP1R10SOURCE GeneReport for Unigene cluster for PPP1R10 Gene:
Hs.106019mRNA Expression by UniProt/SwissProt for PPP1R10 Gene:
Q96QC0-PP1RA_HUMAN
Tissue specificity:
Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.
Evidence on tissue expression from TISSUES for PPP1R10 Gene
- Nervous system(4.7)
- Liver(4.4)
- Stomach(2.8)
- Kidney(2.3)
- Muscle(2.3)
- Intestine(2)
Primer Products
-
OriGene qPCR primer pairs for PPP1R10
- genomics-online: primer clones - Search results for available PPP1R10 gene related products
Gene Expression Assay Products
No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for PPP1R10 Gene
Orthologs for PPP1R10 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | PPP1R10 33 32 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | PPP1R10 33 32 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | PPP1R10 33 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | PPP1R10 33 32 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | Ppp1r10 17 33 32 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | -- 33 |
|
OneToMany | |
| -- 33 |
|
OneToMany | |||
| rat (Rattus norvegicus) |
Mammalia | Ppp1r10 32 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | PPP1R10 33 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | Str.10280 32 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | ppp1r10 33 32 32 |
|
OneToOne | |
| fruit fly (Drosophila melanogaster) |
Insecta | PNUTS 33 |
|
OneToMany | |
| sea squirt (Ciona savignyi) |
Ascidiacea | CSA.8858 33 |
|
OneToMany |
- Species where no ortholog for PPP1R10 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Evolution for PPP1R10 Gene
- ENSEMBL:
- Gene Tree for PPP1R10 (if available)
- TreeFam:
- Gene Tree for PPP1R10 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for PPP1R10: view image
Paralogs for PPP1R10 Gene
Variants for PPP1R10 Gene
| SNP ID | Clin | Chr 06 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000157407 | -- | 30,614,454(-) | A/C | intron_variant | |
| rs1000442325 | -- | 30,616,660(-) | C/T | 5_prime_UTR_variant, non_coding_transcript_variant | |
| rs1000473154 | -- | 30,616,508(-) | G/A | 5_prime_UTR_variant, non_coding_transcript_variant | |
| rs1000483702 | -- | 30,608,257(-) | G/A | intron_variant | |
| rs1000549684 | -- | 30,613,169(-) | C/T | intron_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv2670269 | CNV | deletion | 23128226 |
| esv2731791 | CNV | deletion | 23290073 |
| esv3411275 | CNV | duplication | 20981092 |
| nsv1074389 | CNV | deletion | 25765185 |
| nsv1122126 | CNV | deletion | 24896259 |
| nsv1144137 | CNV | deletion | 24896259 |
| nsv5244 | CNV | deletion | 18451855 |
| nsv601264 | CNV | loss | 21841781 |
| nsv601481 | CNV | loss | 21841781 |
| nsv830626 | CNV | loss | 17160897 |
Residual Variation Intolerance Score:
3.13% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
2.03;
37.29% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for PPP1R10 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- PPP1R10
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PPP1R10 Gene
Disorders for PPP1R10 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| melanoma, cutaneous malignant 1 |
|
|
Search PPP1R10 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for PPP1R10
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for PPP1R10 Gene
Publications for PPP1R10 Gene
- Cloning of a new gene (FB19) within HLA class I region. (PMID: 9784381) Totaro A … Gasparini P (Biochemical and biophysical research communications 1998) 2 3 4 56
- Purification and characterisation of p99, a nuclear modulator of protein phosphatase 1 activity. (PMID: 9450550) Kreivi JP … Lamond AI (FEBS letters 1997) 3 4 23 56
- PNUTS knockdown potentiates the apoptotic effect of Roscovitine in breast and colon cancer cells. (PMID: 20372802) De Leon G … Krucher NA (International journal of oncology 2010) 3 23 56
- High-density SNP screening of the major histocompatibility complex in systemic lupus erythematosus demonstrates strong evidence for independent susceptibility regions. (PMID: 19851445) Barcellos LF … Criswell LA (PLoS genetics 2009) 3 43 56
- CAT53 and HFE alleles in Alzheimer's disease: a putative protective role of the C282Y HFE mutation. (PMID: 19429178) Correia AP … Porto G (Neuroscience letters 2009) 3 43 56
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Products for PPP1R10 Gene
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Sources for PPP1R10 Gene
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