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This gene encodes a protein phosphatase 1 binding protein. The encoded protein plays a role in many cellular processes including cell cycle progression, DNA repair and apoptosis by regulating the activity of protein phosphatase 1. This gene lies within the major histocompatibility complex class I region on chromosome 6, and alternatively spliced transcript variants have been ob... See more...
Aliases for PPP1R10 Gene
Aliases for PPP1R10 Gene
External Ids for PPP1R10 Gene
- HGNC: 9284
- NCBI Entrez Gene: 5514
- Ensembl: ENSG00000204569
- OMIM®: 603771
- UniProtKB/Swiss-Prot: Q96QC0
Previous GeneCards Identifiers for PPP1R10 Gene
- GC06M030623
- GC06M030338
- GC06M030674
- GC06M030677
- GC06M030568
Summaries for PPP1R10 Gene
-
This gene encodes a protein phosphatase 1 binding protein. The encoded protein plays a role in many cellular processes including cell cycle progression, DNA repair and apoptosis by regulating the activity of protein phosphatase 1. This gene lies within the major histocompatibility complex class I region on chromosome 6, and alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Jul 2012]
GeneCards Summary for PPP1R10 Gene
PPP1R10 (Protein Phosphatase 1 Regulatory Subunit 10) is a Protein Coding gene. Diseases associated with PPP1R10 include Adrenal Gland Pheochromocytoma and Hypermethioninemia Due To Adenosine Kinase Deficiency. Among its related pathways are Beta-Adrenergic Signaling and Apoptotic Pathways in Synovial Fibroblasts. Gene Ontology (GO) annotations related to this gene include protein phosphatase inhibitor activity. An important paralog of this gene is ZC3H18.
UniProtKB/Swiss-Prot Summary for PPP1R10 Gene
-
Scaffold protein which mediates the formation of the PTW/PP1 phosphatase complex by providing a binding platform to each component of the complex. The PTW/PP1 phosphatase complex plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase. Mediates interaction of WDR82 and PPP1CA. Inhibitor of PPP1CA and PPP1CC phosphatase activities. Has inhibitory activity on PPP1CA only when phosphorylated. Binds to mRNA, single-stranded DNA (ssDNA), poly(A) and poly(G) homopolymers (By similarity).
Additional gene information for PPP1R10 Gene
- HGNC (9284)
- NCBI Entrez Gene (5514)
- Ensembl (ENSG00000204569)
- OMIM® (603771)
- UniProtKB/Swiss-Prot (Q96QC0)
- Open Targets Platform(ENSG00000204569)
- Alliance of Genome Resources
- Search for PPP1R10 at DataMed
- Search for PPP1R10 at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PPP1R10 Gene
Genomics for PPP1R10 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for PPP1R10 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around PPP1R10 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for PPP1R10
- Top Transcription factor binding sites by QIAGEN in the PPP1R10 gene promoter:
-
- aMEF-2
- CREB
- deltaCREB
- FOXJ2
- FOXJ2 (long isoform)
- HNF-3beta
- HOXA5
- MEF-2
- MEF-2A
- MRF-2
Genomic Locations for PPP1R10 Gene
Latest Assembly
- chr6:30,600,400-30,618,612
- (GRCh38/hg38)
- Size:
- 18,213 bases
- Orientation:
- Minus strand
Previous Assembly
- chr6:30,568,190-30,585,020
- (GRCh37/hg19 by Entrez Gene)
- Size:
- 16,831 bases
- Orientation:
- Minus strand
Alternative Locations (GRCh38/hg38)
- chr6(ALT_REF_LOCI_2):2,080,137-2,096,967 (-)
- chr6(ALT_REF_LOCI_3):1,856,243-1,873,073 (-)
- chr6(ALT_REF_LOCI_4):1,910,642-1,927,472 (-)
- chr6(ALT_REF_LOCI_5):1,944,460-1,961,291 (-)
- chr6(ALT_REF_LOCI_6):1,855,502-1,872,331 (-)
- chr6(ALT_REF_LOCI_7):1,901,171-1,918,001 (-)
Genomic View for PPP1R10 Gene
Genes around PPP1R10 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 6p21.33 by HGNC
- 6p21.33 by Entrez Gene
- 6p21.33 by Ensembl
PPP1R10 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for PPP1R10 Gene
Proteins for PPP1R10 Gene
-
Protein details for PPP1R10 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q96QC0-PP1RA_HUMAN
- Recommended name:
- Serine/threonine-protein phosphatase 1 regulatory subunit 10
- Protein Accession:
- Q96QC0
- O00405
Protein attributes for PPP1R10 Gene
- Size:
- 940 amino acids
- Molecular mass:
- 99058 Da
- Quaternary structure:
-
- Component of the PTW/PP1 phosphatase complex, composed of PPP1R10/PNUTS, TOX4, WDR82, and PPP1CA or PPP1CB or PPP1CC. Interacts with PPP1CC. Interacts with PPP1CA, WDR82 and TOX4 (By similarity).
Protein Expression for PPP1R10 Gene
Post-translational modifications for PPP1R10 Gene
- Phosphorylated on Ser-398 by PKA within the region necessary for interaction with PPP1CA.
-
Ubiquitination at Lys13 and Lys33
- NX_Q96QC0 (NX_Q96QC0-1)
- Modification sites at PhosphoSitePlus
Other Protein References for PPP1R10 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibodies for research
- LifeSpan BioSciences PPP1R10 / PNUTS Antibody (LS-B7130) and PPP1R10 / PNUTS Antibody (LS-B11298)
- G Biosciences Immunotag™ PPP1R10 Antibody
-
Custom Antibody ServicesOriGene Antibodies for PPP1R10
- Novus Biologicals Antibodies for PPP1R10
-
Abcam antibodies for PPP1R10
- Invitrogen Antibodies for PPP1R10 (AFLGC-PPP1R10)
-
Biorbyt antibodies for PPP1R10
-
Boster Bio Antibodies for PPP1R10
-
Custom Antibody ServicesProSci Antibodies for PPP1R10
-
Santa Cruz Biotechnology (SCBT) Antibodies for PPP1R10
Protein products for research
-
OriGene Purified Proteins for PPP1R10
- Search Origene for MassSpec and Protein Over-expression Lysates for PPP1R10
- Origene Custom Protein Services for PPP1R10
-
Abcam proteins for PPP1R10
Assay products for research
No data available for DME Specific Peptides for PPP1R10 Gene
Domains & Families for PPP1R10 Gene
Gene Families for PPP1R10 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Protein Domains for PPP1R10 Gene
- InterPro:
- Blocks:
-
- Zn-finger, C-x8-C-x5-C-x3-H type
Suggested Antigen Peptide Sequences for PPP1R10 Gene
- GenScript: Design optimal peptide antigens:
-
- p99 (PP1RA_HUMAN)
- Protein phosphatase 1, regulatory subunit 10 (Q2L6I0_HUMAN)
- PPP1R10 protein (Q58F28_HUMAN)
No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for PPP1R10 Gene
Function for PPP1R10 Gene
Molecular function for PPP1R10 Gene
- UniProtKB/Swiss-Prot Function:
- Scaffold protein which mediates the formation of the PTW/PP1 phosphatase complex by providing a binding platform to each component of the complex. The PTW/PP1 phosphatase complex plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase. Mediates interaction of WDR82 and PPP1CA. Inhibitor of PPP1CA and PPP1CC phosphatase activities. Has inhibitory activity on PPP1CA only when phosphorylated. Binds to mRNA, single-stranded DNA (ssDNA), poly(A) and poly(G) homopolymers (By similarity).
Phenotypes From GWAS Catalog for PPP1R10 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003677 | DNA binding | IEA | -- |
| GO:0003723 | RNA binding | IEA,HDA | 22681889 |
| GO:0004864 | protein phosphatase inhibitor activity | IEA | -- |
| GO:0005515 | protein binding | IPI | 15231748 |
| GO:0046872 | metal ion binding | IEA | -- |
Phenotypes for PPP1R10 Gene
- MGI mutant phenotypes for PPP1R10:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for PPP1R10:
-
- Increased vaccinia virus (VACV) infection
- Decreased NF-kappaB reporter expression
- Mildly decreased CFP-tsO45G cell surface transport
- Reduced mammosphere formation
- no effect
- Decreased viability ratio
- Synthetic lethal with MLN4924 (a NAE inhibitor)
- Decreased interferon-beta reporter expression
- Increased IL-8 secretion
- Increased shRNA abundance (Z-score > 2)
- Decreased viability in esophageal squamous lineage
- Decreased viability with paclitaxel
- Decreased shRNA abundance (Z-score < -2)
- Synthetic lethal with vaccinia virus (VACV) infection
- Decreased G3BP1 protein expression and assembly in stress granules after arsenite stimulation
- Increased endosome-nucleus distance (endosomes dispersed in the cell periphery)
- Decreased Salmonella enterica Typhimurium invasion
- Decreased Salmonella-containing vacuole maturation
- Decreased Salmonella enterica Typhimurium membrane closure
- Increased cell death in HCC-1954 cells
- Decreased viability
Animal Models for research
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for PPP1R10 - Starting at $85 >
- * PPP1R10 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for PPP1R10
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for PPP1R10
-
Santa Cruz Biotechnology (SCBT) CRISPR for PPP1R10
miRNA for PPP1R10 Gene
- miRTarBase miRNAs that target PPP1R10
-
- hsa-miR-34a-5p (MIRT007193)
- hsa-miR-335-5p (MIRT017879)
- hsa-miR-30a-5p (MIRT028486)
- hsa-miR-1914-3p (MIRT035778)
- hsa-miR-615-3p (MIRT040376)
- hsa-miR-324-3p (MIRT042999)
- hsa-let-7e-5p (MIRT051563)
- mmu-miR-34a-5p (MIRT054729)
- hsa-miR-383-5p (MIRT438194)
- hsa-miR-4291 (MIRT528124)
- hsa-miR-98-3p (MIRT528126)
- hsa-let-7f-1-3p (MIRT528127)
- hsa-let-7b-3p (MIRT528128)
- hsa-let-7a-3p (MIRT528129)
- hsa-miR-4769-5p (MIRT528130)
- hsa-miR-4654 (MIRT528131)
- hsa-miR-194-3p (MIRT528132)
- hsa-miR-7157-5p (MIRT528133)
- hsa-miR-4310 (MIRT528134)
- hsa-miR-4666a-3p (MIRT528135)
- hsa-miR-381-3p (MIRT528136)
- hsa-miR-300 (MIRT528137)
- hsa-miR-5195-5p (MIRT528138)
- hsa-miR-338-5p (MIRT528139)
- hsa-miR-592 (MIRT700662)
- hsa-miR-6796-5p (MIRT700663)
- hsa-miR-6810-5p (MIRT700664)
- hsa-miR-4666b (MIRT700665)
- hsa-miR-597-5p (MIRT700666)
- hsa-miR-6742-5p (MIRT700667)
- hsa-miR-4472 (MIRT700668)
- hsa-miR-4447 (MIRT700669)
- hsa-miR-3151-5p (MIRT700670)
- hsa-miR-491-5p (MIRT700671)
- hsa-miR-4652-5p (MIRT700672)
- hsa-miR-3191-3p (MIRT700673)
- hsa-miR-3144-5p (MIRT700674)
- hsa-miR-1914-5p (MIRT700675)
- hsa-miR-759 (MIRT700676)
- hsa-miR-299-3p (MIRT700677)
- hsa-miR-6874-3p (MIRT700678)
- hsa-miR-148b-5p (MIRT700679)
- hsa-miR-3154 (MIRT700680)
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for PPP1R10
- Browse OriGene Inhibitory RNA Products For PPP1R10
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PPP1R10
Clone products for research
- Applied Biological Materials (abm): Clones for PPP1R10 - Starting at $45 >
- * PPP1R10 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
- Sino Biological Human cDNA Clone for PPP1R10
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for PPP1R10
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PPP1R10 Gene
Localization for PPP1R10 Gene
Subcellular locations from UniProtKB/Swiss-Prot for PPP1R10 Gene
- Nucleus. Note=Found in discrete nucleoplasmic bodies and within nucleoli. Associates with chromatin during interphase, excluded from condensed chromosomes during early mitosis and is reloaded onto chromosomes at the late telophase (By similarity). {ECO:0000250}.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| plasma membrane | 1 |
| extracellular | 1 |
| cytoskeleton | 1 |
| mitochondrion | 1 |
| endoplasmic reticulum | 1 |
| endosome | 1 |
| cytosol | 1 |
- Nucleoplasm (4)
- Nuclear bodies (3)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000781 | colocalizes_with chromosome, telomeric region | IDA | 24270157 |
| GO:0000785 | chromatin | IEA,ISS | -- |
| GO:0005634 | nucleus | TAS | 9461602 |
| GO:0005654 | nucleoplasm | IDA | -- |
| GO:0016604 | nuclear body | IDA | -- |
Pathways & Interactions for PPP1R10 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Activation of cAMP-Dependent PKA |
Activation of cAMP-Dependent PKA
.77
cAMP Pathway
.77
|
Activation of PKA through GPCR
.71
PKA Signaling
.56
|
| 2 | Beta-Adrenergic Signaling |
Beta-Adrenergic Signaling
.37
Erythropoietin Pathway
.37
|
Insulin Receptor Pathway
.37
CDK5 Pathway
.36
|
| 3 | PI3K / Akt Signaling | ||
| 4 | mTOR Pathway |
.32
|
|
| 5 | GPCR Pathway |
Breast Cancer Regulation by Stathmin1
.58
|
|
Pathways by source for PPP1R10 Gene
1 Tocris pathway for PPP1R10 Gene
14 Qiagen pathways for PPP1R10 Gene
- Activation of cAMP-Dependent PKA
- Activation of PKA through GPCR
- Beta-Adrenergic Signaling
- Breast Cancer Regulation by Stathmin1
- cAMP Pathway
1 Cell Signaling Technology pathway for PPP1R10 Gene
Interacting Proteins for PPP1R10 Gene
Selected Interacting proteins:
Q96QC0-PP1RA_HUMAN
ENSP00000365694
for PPP1R10 Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for PPP1R10
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006606 | protein import into nucleus | TAS | 9461602 |
| GO:0010667 | negative regulation of cardiac muscle cell apoptotic process | IDA | 23426265 |
| GO:0032206 | positive regulation of telomere maintenance | IMP | 23426265 |
| GO:0032515 | negative regulation of phosphoprotein phosphatase activity | IEA | -- |
| GO:1904290 | negative regulation of mitotic DNA damage checkpoint | IGI | 23426265 |
No data available for SIGNOR curated interactions for PPP1R10 Gene
Transcripts for PPP1R10 Gene
mRNA/cDNA for PPP1R10 Gene
- 2 REFSEQ mRNAs :
- 9 NCBI additional mRNA sequence :
- 7 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000376511 4511 nts (view in UCSC)
- ENST00000461593 566 nts (view in UCSC)
- ENST00000468181 333 nts (view in UCSC)
- ENST00000473954 470 nts (view in UCSC)
- ENST00000476704 559 nts (view in UCSC)
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for PPP1R10 - Starting at $85 >
- * PPP1R10 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for PPP1R10
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for PPP1R10
-
Santa Cruz Biotechnology (SCBT) CRISPR for PPP1R10
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for PPP1R10
- Browse OriGene Inhibitory RNA Products For PPP1R10
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PPP1R10
Clone products for research
- Applied Biological Materials (abm): Clones for PPP1R10 - Starting at $45 >
- * PPP1R10 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
- Sino Biological Human cDNA Clone for PPP1R10
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for PPP1R10
Relevant External Links for PPP1R10 Gene
- GeneLoc Exon Structure for
- PPP1R10
Expression for PPP1R10 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Inner Cell Mass (Early Embryonic Tissues)
This gene is overexpressed in Cervix (21.4), Peripheral blood mononuclear cells (11.0), and Breast (9.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for PPP1R10 Gene
- Elite partner
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for PPP1R10
SOURCE GeneReport for Unigene cluster for PPP1R10 Gene:
Hs.106019mRNA Expression by UniProt/SwissProt for PPP1R10 Gene:
Q96QC0-PP1RA_HUMAN
Tissue specificity:
Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.
Evidence on tissue expression from TISSUES for PPP1R10 Gene
- Nervous system(4.8)
- Liver(4.6)
- Muscle(3.1)
- Kidney(3)
- Intestine(2.6)
- Heart(2.5)
- Lung(2.4)
- Spleen(2.2)
Primer products for research
-
OriGene qPCR primer pairs for PPP1R10
Gene Expression Assays for research
No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for PPP1R10 Gene
Orthologs for PPP1R10 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | PPP1R10 29 30 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | PPP1R10 29 30 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | PPP1R10 30 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | PPP1R10 29 30 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Ppp1r10 29 16 30 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | -- 30 |
|
OneToMany | |
| -- 30 |
|
OneToMany | |||
| Rat (Rattus norvegicus) |
Mammalia | Ppp1r10 29 |
|
||
| Lizard (Anolis carolinensis) |
Reptilia | PPP1R10 30 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | Str.10280 29 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | ppp1r10 29 30 |
|
OneToOne | |
| Fruit Fly (Drosophila melanogaster) |
Insecta | PNUTS 30 |
|
OneToMany | |
| Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.8858 30 |
|
OneToMany |
- Species where no ortholog for PPP1R10 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
Evolution for PPP1R10 Gene
- ENSEMBL:
- Gene Tree for PPP1R10 (if available)
- TreeFam:
- Gene Tree for PPP1R10 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for PPP1R10: view image
- Alliance of Genome Resources:
- Additional Orthologs for PPP1R10
Paralogs for PPP1R10 Gene
Variants for PPP1R10 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for PPP1R10 Gene
| SNP ID | Clinical significance and condition | Chr 06 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs138350050 | Benign: not provided | 30,606,246(-) |
G/A NM_002714.4(PPP1R10):c.635-3C>T |
INTRON | |
| rs34208587 | Benign: not provided | 30,608,824(-) |
T/C NM_002714.4(PPP1R10):c.285A>G (p.Leu95=) |
NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS | |
| rs16897725 | -- |
p.Arg173Pro |
All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv2670269 | CNV | deletion | 23128226 |
| esv2731791 | CNV | deletion | 23290073 |
| esv3411275 | CNV | duplication | 20981092 |
| nsv1074389 | CNV | deletion | 25765185 |
| nsv1122126 | CNV | deletion | 24896259 |
| nsv1144137 | CNV | deletion | 24896259 |
| nsv5244 | CNV | deletion | 18451855 |
| nsv601264 | CNV | loss | 21841781 |
| nsv601481 | CNV | loss | 21841781 |
| nsv830626 | CNV | loss | 17160897 |
Residual Variation Intolerance Score:
3.13% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
2.03;
37.29% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for PPP1R10 Gene
SNP Genotyping and Copy Number Assays for research
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PPP1R10 Gene
Disorders for PPP1R10 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| adrenal gland pheochromocytoma |
|
|
| hypermethioninemia due to adenosine kinase deficiency |
|
|
| histiocytoid hemangioma |
|
|
Search PPP1R10 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for PPP1R10
- Human Genome Epidemiology Navigator
- (HuGE)
- Atlas
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for PPP1R10 Gene
Publications for PPP1R10 Gene
- Cloning of a new gene (FB19) within HLA class I region. (PMID: 9784381) Totaro A … Gasparini P (Biochemical and biophysical research communications 1998) 2 3 4
- Purification and characterisation of p99, a nuclear modulator of protein phosphatase 1 activity. (PMID: 9450550) Kreivi JP … Lamond AI (FEBS letters 1997) 3 4 22
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ExternalLinks
Products for PPP1R10 Gene
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Sources for PPP1R10 Gene
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