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This gene encodes a protein phosphatase 1 binding protein. The encoded protein plays a role in many cellular processes including cell cycle progression, DNA repair and apoptosis by regulating the activity of protein phosphatase 1. This gene lies within the major histocompatibility complex class I region on chromosome 6, and alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Jul 2012]
PPP1R10 (Protein Phosphatase 1 Regulatory Subunit 10) is a Protein Coding gene. Diseases associated with PPP1R10 include Melanoma, Cutaneous Malignant 1. Among its related pathways are p70S6K Signaling and Activation of cAMP-Dependent PKA. Gene Ontology (GO) annotations related to this gene include protein phosphatase inhibitor activity. An important paralog of this gene is ZC3H18.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0003677 | DNA binding | IEA | -- |
GO:0003723 | RNA binding | IEA,HDA | 22681889 |
GO:0004864 | protein phosphatase inhibitor activity | IEA | -- |
GO:0005515 | protein binding | IPI | 15231748 |
GO:0046872 | metal ion binding | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000784 | colocalizes_with nuclear chromosome, telomeric region | IDA | 24270157 |
GO:0000785 | chromatin | ISS,IEA | -- |
GO:0005634 | nucleus | TAS | 9461602 |
GO:0005654 | nucleoplasm | IDA | -- |
GO:0016604 | nuclear body | IDA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Activation of cAMP-Dependent PKA |
Activation of cAMP-Dependent PKA
.77
cAMP Pathway
.77
|
Activation of PKA through GPCR
.71
PKA Signaling
.56
|
2 | Beta-Adrenergic Signaling |
Beta-Adrenergic Signaling
.37
Erythropoietin Pathway
.37
|
Insulin Receptor Pathway
.37
CDK5 Pathway
.36
|
3 | PI3K / Akt Signaling | ||
4 | mTOR Pathway |
.32
|
|
5 | GPCR Pathway |
Breast Cancer Regulation by Stathmin1
.58
|
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006606 | protein import into nucleus | TAS | 9461602 |
GO:0010667 | negative regulation of cardiac muscle cell apoptotic process | IDA | 23426265 |
GO:0032206 | positive regulation of telomere maintenance | IMP | 23426265 |
GO:0032515 | negative regulation of phosphoprotein phosphatase activity | IEA | -- |
GO:1904290 | negative regulation of mitotic DNA damage checkpoint | IGI | 23426265 |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
chimpanzee (Pan troglodytes) |
Mammalia | PPP1R10 33 32 |
|
OneToOne | |
dog (Canis familiaris) |
Mammalia | PPP1R10 33 32 |
|
OneToOne | |
oppossum (Monodelphis domestica) |
Mammalia | PPP1R10 33 |
|
OneToOne | |
cow (Bos Taurus) |
Mammalia | PPP1R10 33 32 |
|
OneToOne | |
mouse (Mus musculus) |
Mammalia | Ppp1r10 17 33 32 |
|
||
platypus (Ornithorhynchus anatinus) |
Mammalia | -- 33 |
|
OneToMany | |
-- 33 |
|
OneToMany | |||
rat (Rattus norvegicus) |
Mammalia | Ppp1r10 32 |
|
||
lizard (Anolis carolinensis) |
Reptilia | PPP1R10 33 |
|
OneToOne | |
tropical clawed frog (Silurana tropicalis) |
Amphibia | Str.10280 32 |
|
||
zebrafish (Danio rerio) |
Actinopterygii | ppp1r10 33 32 32 |
|
OneToOne | |
fruit fly (Drosophila melanogaster) |
Insecta | PNUTS 33 |
|
OneToMany | |
sea squirt (Ciona savignyi) |
Ascidiacea | CSA.8858 33 |
|
OneToMany |
SNP ID | Clin | Chr 06 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs1000157407 | -- | 30,614,454(-) | A/C | intron_variant | |
rs1000442325 | -- | 30,616,660(-) | C/T | 5_prime_UTR_variant, non_coding_transcript_variant | |
rs1000473154 | -- | 30,616,508(-) | G/A | 5_prime_UTR_variant, non_coding_transcript_variant | |
rs1000483702 | -- | 30,608,257(-) | G/A | intron_variant | |
rs1000549684 | -- | 30,613,169(-) | C/T | intron_variant |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv2670269 | CNV | deletion | 23128226 |
esv2731791 | CNV | deletion | 23290073 |
esv3411275 | CNV | duplication | 20981092 |
nsv1074389 | CNV | deletion | 25765185 |
nsv1122126 | CNV | deletion | 24896259 |
nsv1144137 | CNV | deletion | 24896259 |
nsv5244 | CNV | deletion | 18451855 |
nsv601264 | CNV | loss | 21841781 |
nsv601481 | CNV | loss | 21841781 |
nsv830626 | CNV | loss | 17160897 |
Disorder | Aliases | PubMed IDs |
---|---|---|
melanoma, cutaneous malignant 1 |
|
|