The protein encoded by this gene belongs to the protein phosphatase family, PP1 subfamily. PP1 is an ubiquitous serine/threonine phosphatase that regulates many cellular processes, including cell division. It is expressed in mammalian cells as three closely related isoforms, alpha, beta/delta and gamma, which have distinct localization patterns. This gene encodes the gamma isoz... See more...

Aliases for PPP1CC Gene

Aliases for PPP1CC Gene

  • Protein Phosphatase 1 Catalytic Subunit Gamma 2 3 5
  • Serine/Threonine-Protein Phosphatase PP1-Gamma Catalytic Subunit 3 4
  • Protein Phosphatase 1, Catalytic Subunit, Gamma Isoform 2 3
  • Protein Phosphatase 1, Catalytic Subunit, Gamma Isozyme 2 3
  • Protein Phosphatase 1C Catalytic Subunit 3 4
  • EC 3.1.3.16 4 51
  • PP-1G 3 4
  • PP1C 2 3
  • Serine/Threonine Phosphatase 1 Gamma 3
  • PP1gamma 2
  • PPP1CC 5
  • PPP1G 3

External Ids for PPP1CC Gene

Previous GeneCards Identifiers for PPP1CC Gene

  • GC12M116400
  • GC12M9F0150
  • GC12M109620
  • GC12M111157
  • GC12M108174

Summaries for PPP1CC Gene

Entrez Gene Summary for PPP1CC Gene

  • The protein encoded by this gene belongs to the protein phosphatase family, PP1 subfamily. PP1 is an ubiquitous serine/threonine phosphatase that regulates many cellular processes, including cell division. It is expressed in mammalian cells as three closely related isoforms, alpha, beta/delta and gamma, which have distinct localization patterns. This gene encodes the gamma isozyme. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

GeneCards Summary for PPP1CC Gene

PPP1CC (Protein Phosphatase 1 Catalytic Subunit Gamma) is a Protein Coding gene. Diseases associated with PPP1CC include Leukodystrophy, Hypomyelinating, 12 and Rheumatoid Arthritis. Among its related pathways are Signaling by GPCR and Focal Adhesion. Gene Ontology (GO) annotations related to this gene include hydrolase activity. An important paralog of this gene is PPP1CA.

UniProtKB/Swiss-Prot Summary for PPP1CC Gene

  • Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase 1 (PP1) is essential for cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Dephosphorylates RPS6KB1. Involved in regulation of ionic conductances and long-term synaptic plasticity. May play an important role in dephosphorylating substrates such as the postsynaptic density-associated Ca(2+)/calmodulin dependent protein kinase II. Component of the PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase. In balance with CSNK1D and CSNK1E, determines the circadian period length, through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation. May dephosphorylate CSNK1D and CSNK1E. Dephosphorylates the 'Ser-418' residue of FOXP3 in regulatory T-cells (Treg) from patients with rheumatoid arthritis, thereby inactivating FOXP3 and rendering Treg cells functionally defective (PubMed:23396208).

Tocris Summary for PPP1CC Gene

  • Protein Ser/Thr phosphatases are a group of enzymes that catalyze the removal of phosphate groups from serine and/or threonine residues by hydrolysis of phosphoric acid monoesters. They oppose the action of kinases and phosphorylases and are involved in signal transduction.

Gene Wiki entry for PPP1CC Gene

No data available for CIViC Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PPP1CC Gene

Genomics for PPP1CC Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for PPP1CC Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12J110740 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas 600.7 +0.6 558 7 ZNF221 BRCA1 SP1 HNRNPL GATAD2A PRDM10 ZNF629 IKZF1 ZNF692 POLR2A PPP1CC lnc-HVCN1-3 ATXN2 IFT81 TCTN1 FAM216A ENSG00000279925 MN309506 HVCN1
GH12J110466 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE CraniofacialAtlas 10 +274.6 274618 3.8 ZNF221 BRCA1 RNF2 SP1 CREB1 GATAD2A CTCF HNRNPL TEAD4 PRDM10 GPN3 FAM216A lnc-GPN3-1 ARPC3 IFT81 RNU4-32P HSPA8P14 PPP1CC RPL31P49
GH12J110928 Enhancer 1.4 VISTA Ensembl ENCODE dbSUPER 10 -187.7 -187721 3.9 ARHGAP35 CREB1 CTCF KDM1A TARDBP PRDM1 ZSCAN4 REST ZNF239 ZNF311 IFT81 LINC01405 MAPKAPK5 C12orf76 RPS2P41 ATXN2 PPP1CC MYL2 CUX2
GH12J110766 Enhancer 0.5 Ensembl 12.1 -23.6 -23562 0.2 TAL1 CEBPB CBFA2T2 CBFA2T3 ARID1B SP7 RF00017-1268 PPP1CC MYL2 TCTN1 HSALNG0094012 CCDC63
GH12J110760 Enhancer 1 Ensembl ENCODE 0.4 -17.6 -17562 1 GATAD2A LEF1 JUND PKNOX1 ZNF24 DPF2 HDAC1 SOX6 CEBPA EP300 HSALNG0094012 GPN3 PHETA1 FAM216A RF00017-1268 PPP1CC CCDC63
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PPP1CC on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for PPP1CC

Top Transcription factor binding sites by QIAGEN in the PPP1CC gene promoter:
  • AP-4
  • c-Myb
  • E2F-5
  • FAC1
  • GATA-2
  • Hlf
  • HSF2
  • Spz1
  • STAT5B

Genomic Locations for PPP1CC Gene

Genomic Locations for PPP1CC Gene
chr12:110,708,369-110,742,939
(GRCh38/hg38)
Size:
34,571 bases
Orientation:
Minus strand
chr12:111,157,485-111,180,783
(GRCh37/hg19)
Size:
23,299 bases
Orientation:
Minus strand

Genomic View for PPP1CC Gene

Genes around PPP1CC on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PPP1CC Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PPP1CC Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PPP1CC Gene

Proteins for PPP1CC Gene

  • Protein details for PPP1CC Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P36873-PP1G_HUMAN
    Recommended name:
    Serine/threonine-protein phosphatase PP1-gamma catalytic subunit
    Protein Accession:
    P36873

    Protein attributes for PPP1CC Gene

    Size:
    323 amino acids
    Molecular mass:
    36984 Da
    Cofactor:
    Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
    Quaternary structure:
    • PP1 comprises a catalytic subunit, PPP1CA, PPP1CB or PPP1CC, which is folded into its native form by inhibitor 2 and glycogen synthetase kinase 3, and then complexed to one or several targeting or regulatory subunits. PPP1R12A, PPP1R12B and PPP1R12C mediate binding to myosin. PPP1R3A (in skeletal muscle), PPP1R3B (in liver), PPP1R3C, PPP1R3D and PPP1R3F (in brain) mediate binding to glycogen. Interacts with cyanobacterial toxin microcystin; disulfide-linked. Interacts with PPP1R3B and PPP1R7. Isoform 2 interacts with SPZ1 (By similarity). Interacts with CDCA2. PPP1R15A and PPP1R15B mediate binding to EIF2S1. Part of a complex containing PPP1R15B, PP1 and NCK1/2. Interacts with IKFZ1; the interaction targets PPP1CC to pericentromeric heterochromatin, dephosphorylates IKAROS, stabilizes it and prevents it from degradation. Interacts with PPP1R42; the interaction is direct (By similarity). Interacts with NOM1 and PPP1R8. Component of the PTW/PP1 phosphatase complex, composed of PPP1R10/PNUTS, TOX4, WDR82, and PPP1CA or PPP1CB or PPP1CC. Interacts with PPP1R8. Interacts with isoform 1 and isoform 4 NEK2. Interacts with URI1; the interaction is phosphorylation-dependent and occurs in a growth factor-dependent manner. Interacts with FOXP3. Interacts with TMEM225 (via RVxF motif) (By similarity). Interacts with MKI67 (PubMed:24867636). Interacts with RRP1B; this targets PPP1CC to the nucleolus (PubMed:20926688). Interacts with PPP1R2B (PubMed:23506001). Found in a complex with PPP1CA, PPP1CC, SHC1 and PEAK1 (PubMed:23846654).
    Miscellaneous:
    • Microcystin toxin is bound to Cys-273 through a thioether bond.

    Three dimensional structures from OCA and Proteopedia for PPP1CC Gene

    Alternative splice isoforms for PPP1CC Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PPP1CC Gene

Selected DME Specific Peptides for PPP1CC Gene

P36873:
  • KIKYPENFF
  • PGKNVQL
  • RPTDVPD
  • VVEDGYEFF
  • CSFQILK
  • RLLEVRGS
  • DLLWSDP
  • YGFYDEC
  • FSAPNYCGEFDN
  • IFCCHGGLSP
  • ETICLLLAYK
  • RPVTPPR
  • CKRRYNI
  • NFFLLRGNHE
  • DLICRAH
  • GWGENDRGVS
  • CGDIHGQ
  • DLLRLFEYGGFPP
  • GDYVDRG
  • GLLCDLLW
  • FTDCFNCLP
  • GEFDNAGAMM
  • LLELEAP

Post-translational modifications for PPP1CC Gene

Domains & Families for PPP1CC Gene

Gene Families for PPP1CC Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for PPP1CC Gene

InterPro:
Blocks:
  • Serine/threonine-specific protein phosphatase and bis(5-nucleosyl)-tetraphosphatase
ProtoNet:

Suggested Antigen Peptide Sequences for PPP1CC Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ60729, highly similar to Serine/threonine-protein phosphatase PP1-gammacatalytic subunit (EC 3.1.3.16) (B4DNE3_HUMAN)
  • Protein phosphatase 1C catalytic subunit (PP1G_HUMAN)
  • Serine/threonine-protein phosphatase (Q9UPN1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P36873

UniProtKB/Swiss-Prot:

PP1G_HUMAN :
  • Belongs to the PPP phosphatase family. PP-1 subfamily.
Family:
  • Belongs to the PPP phosphatase family. PP-1 subfamily.
genes like me logo Genes that share domains with PPP1CC: view

Function for PPP1CC Gene

Molecular function for PPP1CC Gene

UniProtKB/Swiss-Prot Function:
Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase 1 (PP1) is essential for cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Dephosphorylates RPS6KB1. Involved in regulation of ionic conductances and long-term synaptic plasticity. May play an important role in dephosphorylating substrates such as the postsynaptic density-associated Ca(2+)/calmodulin dependent protein kinase II. Component of the PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase. In balance with CSNK1D and CSNK1E, determines the circadian period length, through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation. May dephosphorylate CSNK1D and CSNK1E. Dephosphorylates the 'Ser-418' residue of FOXP3 in regulatory T-cells (Treg) from patients with rheumatoid arthritis, thereby inactivating FOXP3 and rendering Treg cells functionally defective (PubMed:23396208).
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=H2O + O-phospho-L-seryl-[protein] = L-seryl-[protein] + phosphate; Xref=Rhea:RHEA:20629, Rhea:RHEA-COMP:9863, Rhea:RHEA-COMP:11604, ChEBI:CHEBI:15377, ChEBI:CHEBI:29999, ChEBI:CHEBI:43474, ChEBI:CHEBI:83421; EC=3.1.3.16; Evidence={ECO:0000269|PubMed:15280359};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate; Xref=Rhea:RHEA:47004, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15377, ChEBI:CHEBI:30013, ChEBI:CHEBI:43474, ChEBI:CHEBI:61977; EC=3.1.3.16; Evidence={ECO:0000269|PubMed:15280359};.
UniProtKB/Swiss-Prot Induction:
Up-regulated in synovial fluid mononuclear cells and peripheral blood mononuclear cells from patients with rheumatoid arthritis.
UniProtKB/Swiss-Prot EnzymeRegulation:
Inactivated by binding to URI1. The phosphatase activity of the PPP1R15A-PP1 complex toward EIF2S1 is specifically inhibited by Salubrinal, a drug that protects cells from endoplasmic reticulum stress.
GENATLAS Biochemistry:
serine/threonine protein phosphatase 1,catalytic subunit,gamma,involved in cell division and glycogen metabolism,expressed in skeletal muscle

Enzyme Numbers (IUBMB) for PPP1CC Gene

Phenotypes From GWAS Catalog for PPP1CC Gene

Gene Ontology (GO) - Molecular Function for PPP1CC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding HDA 22681889
GO:0004721 phosphoprotein phosphatase activity IEA,TAS --
GO:0004722 protein serine/threonine phosphatase activity IEA,IMP 10880350
GO:0005515 protein binding IPI 10807923
GO:0005521 lamin binding IEA --
genes like me logo Genes that share ontologies with PPP1CC: view
genes like me logo Genes that share phenotypes with PPP1CC: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PPP1CC

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PPP1CC Gene

Localization for PPP1CC Gene

Subcellular locations from UniProtKB/Swiss-Prot for PPP1CC Gene

Cytoplasm. Nucleus. Nucleus, nucleolus. Nucleus, nucleoplasm. Nucleus speckle. Chromosome, centromere, kinetochore. Cleavage furrow. Midbody. Mitochondrion. Note=Colocalizes with SPZ1 in the nucleus (By similarity). Colocalizes with URI1 at mitochondrion (PubMed:17936702). Rapidly exchanges between the nucleolar, nucleoplasmic and cytoplasmic compartments (PubMed:11739654). Highly mobile in cells and can be relocalized through interaction with targeting subunits (PubMed:17965019). In the presence of PPP1R8 relocalizes from the nucleolus to nuclear speckles (PubMed:11739654). Shows a dynamic targeting to specific sites throughout the cell cycle (PubMed:12529430). Highly concentrated in nucleoli of interphase cells and localizes at kinetochores early in mitosis (PubMed:12529430). Relocalization to chromosome-containing regions occurs at the transition from early to late anaphase (PubMed:12529430). Also accumulates at the cleavage furrow and midbody by telophase (PubMed:12529430). {ECO:0000250 UniProtKB:P63087, ECO:0000269 PubMed:11739654, ECO:0000269 PubMed:12529430, ECO:0000269 PubMed:17936702, ECO:0000269 PubMed:17965019}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PPP1CC gene
Compartment Confidence
mitochondrion 5
nucleus 5
cytosol 5
plasma membrane 4
extracellular 2
cytoskeleton 2
endoplasmic reticulum 2
peroxisome 1
endosome 1
lysosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for PPP1CC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000164 protein phosphatase type 1 complex IEA --
GO:0000775 chromosome, centromeric region IEA --
GO:0000776 kinetochore IEA --
GO:0000777 condensed chromosome kinetochore IEA --
GO:0000784 colocalizes_with nuclear chromosome, telomeric region IDA 24270157
genes like me logo Genes that share ontologies with PPP1CC: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for PPP1CC Gene

Pathways & Interactions for PPP1CC Gene

PathCards logo

SuperPathways for PPP1CC Gene

genes like me logo Genes that share pathways with PPP1CC: view

Pathways by source for PPP1CC Gene

6 GeneGo (Thomson Reuters) pathways for PPP1CC Gene
  • Neurophysiological process Glutamate regulation of Dopamine D1A receptor signaling
  • Regulation of lipid metabolism Insulin signaling-generic cascades
  • Signal transduction Calcium signaling
  • Transcription CREB pathway
  • Translation Regulation of EIF2 activity
1 Tocris pathway for PPP1CC Gene

SIGNOR curated interactions for PPP1CC Gene

Activates:
Inactivates:
Is activated by:
Is inactivated by:
Other effect:

Gene Ontology (GO) - Biological Process for PPP1CC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005975 carbohydrate metabolic process IEA --
GO:0005977 glycogen metabolic process IEA --
GO:0006470 protein dephosphorylation IEA,ISS --
GO:0007049 cell cycle IEA --
GO:0030182 neuron differentiation IEA --
genes like me logo Genes that share ontologies with PPP1CC: view

Drugs & Compounds for PPP1CC Gene

(11) Drugs for PPP1CC Gene - From: DrugBank, HMDB, and Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Iron Approved, Experimental Pharma 1560
Phosphoric acid Approved Pharma 0
Water Approved Pharma 0
Manganese Approved Nutra 56
Cyclosporin A Approved, Investigational, Vet_approved Pharma Antagonist, Inhibitor, Inhibition Immunosuppressive agent, Calcineurin inhibitor 0

(3) Additional Compounds for PPP1CC Gene - From: HMDB and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Glycogen
  • Animal starch
  • Liver starch
  • Lyoglycogen
  • Phytoglycogen
9005-79-2
Phosphate
  • [po(OH)3]
  • Acide phosphorique
  • Acidum phosphoricum
  • H3PO4
  • Orthophosphoric acid
14066-19-4, 14265-44-2
FK 506
104987-11-3

(4) Tocris Compounds for PPP1CC Gene

Compound Action Cas Number
Calcineurin Autoinhibitory Peptide Selective calcineurin inhibitor 148067-21-4
Cyclosporin A Calcineurin inhibitor 59865-13-3
FK 506 Potent calcineurin inhibitor; immunosuppressant 104987-11-3
INCA-6 Inhibitor of calcineurin-substrate association 3519-82-2
genes like me logo Genes that share compounds with PPP1CC: view

Transcripts for PPP1CC Gene

mRNA/cDNA for PPP1CC Gene

2 REFSEQ mRNAs :
9 NCBI additional mRNA sequence :
11 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PPP1CC

Alternative Splicing Database (ASD) splice patterns (SP) for PPP1CC Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b · 7c ^ 8a · 8b · 8c ^ 9a · 9b
SP1: - - - -
SP2: -
SP3: - - - -
SP4: -
SP5: -
SP6: -

Relevant External Links for PPP1CC Gene

GeneLoc Exon Structure for
PPP1CC

Expression for PPP1CC Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PPP1CC Gene

Protein differential expression in normal tissues from HIPED for PPP1CC Gene

This gene is overexpressed in Saliva (7.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for PPP1CC Gene



Protein tissue co-expression partners for PPP1CC Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for PPP1CC

SOURCE GeneReport for Unigene cluster for PPP1CC Gene:

Hs.79081

Evidence on tissue expression from TISSUES for PPP1CC Gene

  • Nervous system(4.8)
  • Muscle(4.6)
  • Liver(4.5)
  • Skin(3.5)
  • Kidney(3.4)
  • Lung(3.2)
  • Intestine(3.2)
  • Heart(3)
  • Blood(2.6)
  • Eye(2.5)
  • Lymph node(2.5)
  • Spleen(2.4)
  • Stomach(2.3)
  • Thyroid gland(2.3)
  • Pancreas(2.3)
  • Bone marrow(2.3)
  • Adrenal gland(2.3)
genes like me logo Genes that share expression patterns with PPP1CC: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PPP1CC Gene

Orthologs for PPP1CC Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PPP1CC Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia PPP1CC 30 31
  • 99.79 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia PPP1CC 31
  • 99 (a)
OneToOne
Mouse
(Mus musculus)
Mammalia Ppp1cc 31
  • 97 (a)
OneToOne
Gm5601 30
  • 91.72 (n)
Ppp1ccb 17
Dog
(Canis familiaris)
Mammalia PPP1CC 30 31
  • 96.59 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia PPP1CC 30 31
  • 96.28 (n)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia PPP1CC 31
  • 93 (a)
OneToOne
Chicken
(Gallus gallus)
Aves PPP1CC 30 31
  • 87.72 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia PPP1CC 31
  • 97 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia ppp1cc 30
  • 82.46 (n)
Zebrafish
(Danio rerio)
Actinopterygii ppp1cc 30 31
  • 79.15 (n)
OneToOne
Dr.3477 30
Fruit Fly
(Drosophila melanogaster)
Insecta Pp1-13C 31 32
  • 91 (a)
ManyToMany
Pp1alpha-96A 31 32
  • 87 (a)
ManyToMany
flw 32
  • 82 (a)
Pp1-Y2 32
  • 74 (a)
Pp1-87B 30 31 32
  • 72.24 (n)
ManyToMany
PpN58A 32
  • 63 (a)
PpY-55A 32
  • 63 (a)
PpD5 32
  • 62 (a)
PpD6 32
  • 60 (a)
Pp1rY1 32
  • 58 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011166 30
  • 69.88 (n)
Worm
(Caenorhabditis elegans)
Secernentea gsp-2 31
  • 88 (a)
OneToMany
F25B3.4 32
  • 55 (a)
F52H3.6 32
  • 55 (a)
C25A6.1 32
  • 54 (a)
T03F1.5 32
  • 54 (a)
W09C3.6 32
  • 54 (a)
F23B12.1 32
  • 53 (a)
ZK354.9 32
  • 53 (a)
C34D4.2 32
  • 52 (a)
C47A4.3 32
  • 51 (a)
C06A1.3 32
  • 48 (a)
C09H5.7 32
  • 48 (a)
C24H11.1 32
  • 48 (a)
C24H11.2 32
  • 48 (a)
C23G10.1a 32
  • 45 (a)
C23G10.1b 32
  • 45 (a)
W03D8.2 32
  • 44 (a)
F58G1.3 32
  • 42 (a)
R13A5.11 32
  • 42 (a)
T25B9.2 32
  • 41 (a)
C27B7.6 32
  • 40 (a)
F22D6.9 32
  • 40 (a)
Y40H4A.2 32
  • 40 (a)
Y69E1A.4 32
  • 39 (a)
R08A2.2 32
  • 38 (a)
F49E11.7 32
  • 37 (a)
F42G8.8 32
  • 34 (a)
C30A5.4 32
  • 33 (a)
ZC477.2 32
  • 33 (a)
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes GLC7 31
  • 84 (a)
OneToMany
PPZ1 33
Thale Cress
(Arabidopsis thaliana)
eudicotyledons TOPP4 30
  • 68.45 (n)
Rice
(Oryza sativa)
Liliopsida Os03g0268000 30
  • 69.57 (n)
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.7187 31
  • 91 (a)
OneToMany
Fission Yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes sds21 30
  • 67.23 (n)
Species where no ortholog for PPP1CC was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for PPP1CC Gene

ENSEMBL:
Gene Tree for PPP1CC (if available)
TreeFam:
Gene Tree for PPP1CC (if available)
Aminode:
Evolutionary constrained regions (ECRs) for PPP1CC: view image

Paralogs for PPP1CC Gene

(10) SIMAP similar genes for PPP1CC Gene using alignment to 7 proteins:

  • PP1G_HUMAN
  • F8VR82_HUMAN
  • F8VYE8_HUMAN
  • F8W0V8_HUMAN
  • F8W0W8_HUMAN
  • F8W1A0_HUMAN
  • Q9UPN1_HUMAN
genes like me logo Genes that share paralogs with PPP1CC: view

Variants for PPP1CC Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for PPP1CC Gene

SNP ID Clinical significance and condition Chr 12 pos Variation AA Info Type
rs367543175 Not Provided: not provided 110,720,185(-) C/T SYNONYMOUS_VARIANT,THREE_PRIME_UTR_VARIANT
rs367543176 Not Provided: not provided 110,731,881(-) T/C MISSENSE_VARIANT
rs367543177 Not Provided: not provided 110,742,702(-) C/A SYNONYMOUS_VARIANT
rs11558237 - p.Phe152Ser

Additional dbSNP identifiers (rs#s) for PPP1CC Gene

Structural Variations from Database of Genomic Variants (DGV) for PPP1CC Gene

Variant ID Type Subtype PubMed ID
esv2657045 CNV deletion 23128226
esv2675965 CNV deletion 23128226
nsv525818 CNV loss 19592680

Variation tolerance for PPP1CC Gene

Residual Variation Intolerance Score: 33.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.17; 3.94% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PPP1CC Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PPP1CC

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PPP1CC Gene

Disorders for PPP1CC Gene

MalaCards: The human disease database

(2) MalaCards diseases for PPP1CC Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
leukodystrophy, hypomyelinating, 12
  • hld12
rheumatoid arthritis
  • ra
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for PPP1CC

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with PPP1CC: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PPP1CC Gene

Publications for PPP1CC Gene

  1. Sequence of human protein serine/threonine phosphatase 1 gamma and localization of the gene (PPP1CC) encoding it to chromosome bands 12q24.1-q24.2. (PMID: 8394140) Barker HM … Cohen PT (Biochimica et biophysica acta 1993) 3 4 23
  2. Protein phosphatase 1 (PP1) is a post-translational regulator of the mammalian circadian clock. (PMID: 21712997) Schmutz I … Albrecht U (PloS one 2011) 3 4
  3. RRP1B targets PP1 to mammalian cell nucleoli and is associated with Pre-60S ribosomal subunits. (PMID: 20926688) Chamousset D … Trinkle-Mulcahy L (Molecular biology of the cell 2010) 3 4
  4. Identification and characterization of a novel human PP1 phosphatase complex. (PMID: 20516061) Lee JH … Skalnik DG (The Journal of biological chemistry 2010) 3 4
  5. Identification of potentially damaging amino acid substitutions leading to human male infertility. (PMID: 19369647) Kuzmin A … Varmuza S (Biology of reproduction 2009) 3 41

Products for PPP1CC Gene

  • Signalway Proteins for PPP1CC

Sources for PPP1CC Gene