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Aliases for PPP1CC Gene

Aliases for PPP1CC Gene

  • Protein Phosphatase 1 Catalytic Subunit Gamma 2 3 5
  • Protein Phosphatase 1, Catalytic Subunit, Gamma Isoform 2 3
  • Protein Phosphatase 1, Catalytic Subunit, Gamma Isozyme 2 3
  • Protein Phosphatase 1C Catalytic Subunit 3 4
  • PP-1G 3 4
  • Serine/Threonine-Protein Phosphatase PP1-Gamma Catalytic Subunit 3
  • Serine/Threonine Phosphatase 1 Gamma 3
  • EC 3.1.3.16 4
  • PPP1G 3
  • PP1C 3

External Ids for PPP1CC Gene

Previous GeneCards Identifiers for PPP1CC Gene

  • GC12M116400
  • GC12M9F0150
  • GC12M109620
  • GC12M111157
  • GC12M108174

Summaries for PPP1CC Gene

Entrez Gene Summary for PPP1CC Gene

  • The protein encoded by this gene belongs to the protein phosphatase family, PP1 subfamily. PP1 is an ubiquitous serine/threonine phosphatase that regulates many cellular processes, including cell division. It is expressed in mammalian cells as three closely related isoforms, alpha, beta/delta and gamma, which have distinct localization patterns. This gene encodes the gamma isozyme. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

GeneCards Summary for PPP1CC Gene

PPP1CC (Protein Phosphatase 1 Catalytic Subunit Gamma) is a Protein Coding gene. Among its related pathways are Cell Cycle, Mitotic and Neurophysiological process Glutamate regulation of Dopamine D1A receptor signaling. Gene Ontology (GO) annotations related to this gene include hydrolase activity. An important paralog of this gene is PPP1CA.

UniProtKB/Swiss-Prot for PPP1CC Gene

  • Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase 1 (PP1) is essential for cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Dephosphorylates RPS6KB1. Involved in regulation of ionic conductances and long-term synaptic plasticity. May play an important role in dephosphorylating substrates such as the postsynaptic density-associated Ca(2+)/calmodulin dependent protein kinase II. Component of the PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase. In balance with CSNK1D and CSNK1E, determines the circadian period length, through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation. May dephosphorylate CSNK1D and CSNK1E. Dephosphorylates the Ser-418 residue of FOXP3 in regulatory T-cells (Treg) from patients with rheumatoid arthritis, thereby inactivating FOXP3 and rendering Treg cells functionally defective (PubMed:23396208).

Tocris Summary for PPP1CC Gene

  • Protein Ser/Thr phosphatases are a group of enzymes that catalyze the removal of phosphate groups from serine and/or threonine residues by hydrolysis of phosphoric acid monoesters. They oppose the action of kinases and phosphorylases and are involved in signal transduction.

Gene Wiki entry for PPP1CC Gene

Additional gene information for PPP1CC Gene

No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PPP1CC Gene

Genomics for PPP1CC Gene

GeneHancer (GH) Regulatory Elements for PPP1CC Gene

Promoters and enhancers for PPP1CC Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12J110739 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE 650.7 +0.2 189 6.2 HDGF PKNOX1 FOXA2 SMAD1 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 ENSG00000279925 PPP1CC ATXN2 IFT81 TCTN1 FAM216A GC12P110720
GH12J109878 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 10.1 +862.4 862449 3.4 HDGF ARNT SIN3A ZNF2 ZBTB7B ZNF213 ZNF143 FOS NFYC ZHX2 GLTP ENSG00000249094 TCHP LINC01486 ENSG00000257268 RNU4-32P KCTD10 IFT81 ANKRD13A PPP1CC
GH12J110466 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 10 +274.7 274660 3.8 CLOCK ZFP64 DMAP1 YBX1 IRF4 YY1 E2F8 ZNF143 SP3 NFYC GPN3 FAM216A ARPC3 RNU4-32P IFT81 HSPA8P14 ENSG00000257268 UBE3B PPP1CC RPL31P49
GH12J110928 Enhancer 1.3 VISTA ENCODE dbSUPER 10 -187.6 -187589 3.7 BCOR HDGF CTCF ZNF777 SUZ12 ZSCAN4 TSC22D4 ZMYM3 CDC5L MCM2 IFT81 LINC01405 MAPKAPK5 C12orf76 RPS2P41 ATXN2 PPP1CC MYL2 GC12P110917
GH12J110740 Enhancer 0.8 Ensembl ENCODE 0.7 +4.2 4175 0.4 ATF1 OSR2 HIC1 SCRT2 ZNF629 GLIS1 CREM PRDM4 ZXDB SP7 TCTN1 FAM216A PPP1CC GC12P110720
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PPP1CC on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the PPP1CC gene promoter:
  • STAT5B
  • HSF2
  • FAC1
  • Spz1
  • c-Myb
  • Hlf
  • AP-4
  • GATA-2
  • E2F-5

Genomic Locations for PPP1CC Gene

Genomic Locations for PPP1CC Gene
chr12:110,708,970-110,742,978
(GRCh38/hg38)
Size:
34,009 bases
Orientation:
Minus strand
chr12:111,157,485-111,180,783
(GRCh37/hg19)
Size:
23,299 bases
Orientation:
Minus strand

Genomic View for PPP1CC Gene

Genes around PPP1CC on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PPP1CC Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PPP1CC Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PPP1CC Gene

Proteins for PPP1CC Gene

  • Protein details for PPP1CC Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P36873-PP1G_HUMAN
    Recommended name:
    Serine/threonine-protein phosphatase PP1-gamma catalytic subunit
    Protein Accession:
    P36873

    Protein attributes for PPP1CC Gene

    Size:
    323 amino acids
    Molecular mass:
    36984 Da
    Cofactor:
    Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
    Quaternary structure:
    • PP1 comprises a catalytic subunit, PPP1CA, PPP1CB or PPP1CC, which is folded into its native form by inhibitor 2 and glycogen synthetase kinase 3, and then complexed to one or several targeting or regulatory subunits. PPP1R12A, PPP1R12B and PPP1R12C mediate binding to myosin. PPP1R3A (in skeletal muscle), PPP1R3B (in liver), PPP1R3C, PPP1R3D and PPP1R3F (in brain) mediate binding to glycogen. Interacts with cyanobacterial toxin microcystin; disulfide-linked. Interacts with PPP1R3B and PPP1R7. Isoform 2 interacts with SPZ1 (By similarity). Interacts with CDCA2. PPP1R15A and PPP1R15B mediate binding to EIF2S1. Part of a complex containing PPP1R15B, PP1 and NCK1/2. Interacts with IKFZ1; the interaction targets PPP1CC to pericentromeric heterochromatin, dephosphorylates IKAROS, stabilizes it and prevents it from degradation. Interacts with PPP1R42; the interaction is direct (By similarity). Interacts with NOM1 and PPP1R8. Component of the PTW/PP1 phosphatase complex, composed of PPP1R10/PNUTS, TOX4, WDR82, and PPP1CA or PPP1CB or PPP1CC. Interacts with PPP1R8. Interacts with isoform 1 and isoform 4 NEK2. Interacts with URI1; the interaction is phosphorylation-dependent and occurs in a growth factor-dependent manner. Interacts with FOXP3. Interacts with TMEM225 (via RVxF motif) (By similarity). Interacts with MKI67 (PubMed:24867636). Interacts with RRP1B; this targets PPP1CC to the nucleolus (PubMed:20926688). Interacts with PPP1R2B (PubMed:23506001).
    Miscellaneous:
    • Microcystin toxin is bound to Cys-273 through a thioether bond.

    Three dimensional structures from OCA and Proteopedia for PPP1CC Gene

    Alternative splice isoforms for PPP1CC Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PPP1CC Gene

Post-translational modifications for PPP1CC Gene

No data available for DME Specific Peptides for PPP1CC Gene

Domains & Families for PPP1CC Gene

Gene Families for PPP1CC Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Plasma proteins
  • Predicted intracellular proteins

Graphical View of Domain Structure for InterPro Entry

P36873

UniProtKB/Swiss-Prot:

PP1G_HUMAN :
  • Belongs to the PPP phosphatase family. PP-1 subfamily.
Family:
  • Belongs to the PPP phosphatase family. PP-1 subfamily.
genes like me logo Genes that share domains with PPP1CC: view

Function for PPP1CC Gene

Molecular function for PPP1CC Gene

UniProtKB/Swiss-Prot Function:
Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase 1 (PP1) is essential for cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Dephosphorylates RPS6KB1. Involved in regulation of ionic conductances and long-term synaptic plasticity. May play an important role in dephosphorylating substrates such as the postsynaptic density-associated Ca(2+)/calmodulin dependent protein kinase II. Component of the PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase. In balance with CSNK1D and CSNK1E, determines the circadian period length, through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation. May dephosphorylate CSNK1D and CSNK1E. Dephosphorylates the Ser-418 residue of FOXP3 in regulatory T-cells (Treg) from patients with rheumatoid arthritis, thereby inactivating FOXP3 and rendering Treg cells functionally defective (PubMed:23396208).
UniProtKB/Swiss-Prot CatalyticActivity:
[a protein]-serine/threonine phosphate + H(2)O = [a protein]-serine/threonine + phosphate.
UniProtKB/Swiss-Prot EnzymeRegulation:
Inactivated by binding to URI1. The phosphatase activity of the PPP1R15A-PP1 complex toward EIF2S1 is specifically inhibited by Salubrinal, a drug that protects cells from endoplasmic reticulum stress.
UniProtKB/Swiss-Prot Induction:
Up-regulated in synovial fluid mononuclear cells and peripheral blood mononuclear cells from patients with rheumatoid arthritis.
GENATLAS Biochemistry:
serine/threonine protein phosphatase 1,catalytic subunit,gamma,involved in cell division and glycogen metabolism,expressed in skeletal muscle

Enzyme Numbers (IUBMB) for PPP1CC Gene

Phenotypes From GWAS Catalog for PPP1CC Gene

Gene Ontology (GO) - Molecular Function for PPP1CC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding HDA 22681889
GO:0004721 phosphoprotein phosphatase activity TAS,IEA --
GO:0004722 protein serine/threonine phosphatase activity IEA,IMP 10880350
GO:0005515 protein binding IPI 10807923
GO:0005521 lamin binding IEA --
genes like me logo Genes that share ontologies with PPP1CC: view
genes like me logo Genes that share phenotypes with PPP1CC: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PPP1CC

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PPP1CC Gene

Localization for PPP1CC Gene

Subcellular locations from UniProtKB/Swiss-Prot for PPP1CC Gene

Cytoplasm. Nucleus. Nucleus, nucleolus. Nucleus, nucleoplasm. Nucleus speckle. Chromosome, centromere, kinetochore. Cleavage furrow. Midbody. Mitochondrion. Note=Colocalizes with SPZ1 in the nucleus (By similarity). Colocalizes with URI1 at mitochondrion (PubMed:17936702). Rapidly exchanges between the nucleolar, nucleoplasmic and cytoplasmic compartments (PubMed:11739654). Highly mobile in cells and can be relocalized through interaction with targeting subunits (PubMed:17965019). In the presence of PPP1R8 relocalizes from the nucleolus to nuclear speckles (PubMed:11739654). Shows a dynamic targeting to specific sites throughout the cell cycle (PubMed:12529430). Highly concentrated in nucleoli of interphase cells and localizes at kinetochores early in mitosis (PubMed:12529430). Relocalization to chromosome-containing regions occurs at the transition from early to late anaphase (PubMed:12529430). Also accumulates at the cleavage furrow and midbody by telophase (PubMed:12529430). {ECO:0000250 UniProtKB:P63087, ECO:0000269 PubMed:11739654, ECO:0000269 PubMed:12529430, ECO:0000269 PubMed:17936702, ECO:0000269 PubMed:17965019}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PPP1CC gene
Compartment Confidence
mitochondrion 5
nucleus 5
cytosol 5
cytoskeleton 2
plasma membrane 1
extracellular 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for PPP1CC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000164 protein phosphatase type 1 complex IEA --
GO:0000775 chromosome, centromeric region IEA --
GO:0000776 kinetochore IEA --
GO:0000777 condensed chromosome kinetochore IEA --
GO:0000784 colocalizes_with nuclear chromosome, telomeric region IDA 24270157
genes like me logo Genes that share ontologies with PPP1CC: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for PPP1CC Gene

Pathways & Interactions for PPP1CC Gene

genes like me logo Genes that share pathways with PPP1CC: view

SIGNOR curated interactions for PPP1CC Gene

Activates:
Inactivates:
Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for PPP1CC Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005975 carbohydrate metabolic process IEA --
GO:0005977 glycogen metabolic process IEA --
GO:0006470 protein dephosphorylation IEA,ISS --
GO:0007049 cell cycle IEA --
GO:0007062 sister chromatid cohesion TAS --
genes like me logo Genes that share ontologies with PPP1CC: view

Drugs & Compounds for PPP1CC Gene

(10) Drugs for PPP1CC Gene - From: DrugBank, HMDB, and Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phosphoric acid Approved Pharma 0
Water Approved Pharma 0
calcium Approved Nutra 0
Manganese Approved Nutra 37
Cyclosporin A Approved, Investigational, Vet_approved Pharma Antagonist, Inhibition, Inhibitor Immunosuppressant drug, Immunosuppressive agent, Calcineurin inhibitor 0

(4) Additional Compounds for PPP1CC Gene - From: HMDB and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Fe2+
  • FE (II) ion
  • Fe(II)
  • Fe(2+)
  • Ferrous ion
  • Iron ion(2+)
15438-31-0
Glycogen
  • Animal starch
  • Liver starch
  • Lyoglycogen
  • Phytoglycogen
9005-79-2
Phosphate
  • [po(OH)3]
  • Acide phosphorique
  • Acidum phosphoricum
  • H3PO4
  • Orthophosphoric acid
14265-44-2
FK 506
104987-11-3

(4) Tocris Compounds for PPP1CC Gene

Compound Action Cas Number
Calcineurin Autoinhibitory Peptide Selective calcineurin inhibitor 148067-21-4
Cyclosporin A Calcineurin inhibitor 59865-13-3
FK 506 Potent calcineurin inhibitor; immunosuppressant 104987-11-3
INCA-6 Inhibitor of calcineurin-substrate association 3519-82-2
genes like me logo Genes that share compounds with PPP1CC: view

Transcripts for PPP1CC Gene

mRNA/cDNA for PPP1CC Gene

Unigene Clusters for PPP1CC Gene

Protein phosphatase 1, catalytic subunit, gamma isozyme:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PPP1CC

Alternative Splicing Database (ASD) splice patterns (SP) for PPP1CC Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b · 7c ^ 8a · 8b · 8c ^ 9a · 9b
SP1: - - - -
SP2: -
SP3: - - - -
SP4: -
SP5: -
SP6: -

Relevant External Links for PPP1CC Gene

GeneLoc Exon Structure for
PPP1CC
ECgene alternative splicing isoforms for
PPP1CC

Expression for PPP1CC Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PPP1CC Gene

Protein differential expression in normal tissues from HIPED for PPP1CC Gene

This gene is overexpressed in Saliva (7.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for PPP1CC Gene



Protein tissue co-expression partners for PPP1CC Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of PPP1CC Gene:

PPP1CC

SOURCE GeneReport for Unigene cluster for PPP1CC Gene:

Hs.79081

Evidence on tissue expression from TISSUES for PPP1CC Gene

  • Nervous system(4.7)
  • Muscle(4.6)
  • Liver(4.4)
  • Kidney(3)
  • Skin(2.7)
  • Heart(2.6)
  • Lung(2.6)
  • Intestine(2.4)
  • Eye(2.2)
  • Lymph node(2)
genes like me logo Genes that share expression patterns with PPP1CC: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PPP1CC Gene

Orthologs for PPP1CC Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PPP1CC Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PPP1CC 34 33
  • 99.79 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PPP1CC 34
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ppp1cc 34
  • 97 (a)
OneToOne
Gm5601 33
  • 91.72 (n)
Ppp1ccb 16
dog
(Canis familiaris)
Mammalia PPP1CC 34 33
  • 96.59 (n)
OneToOne
cow
(Bos Taurus)
Mammalia PPP1CC 34 33
  • 96.28 (n)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PPP1CC 34
  • 93 (a)
OneToOne
chicken
(Gallus gallus)
Aves PPP1CC 34 33
  • 87.72 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PPP1CC 34
  • 97 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ppp1cc 33
  • 82.46 (n)
zebrafish
(Danio rerio)
Actinopterygii ppp1cc 34 33
  • 79.15 (n)
OneToOne
Dr.3477 33
fruit fly
(Drosophila melanogaster)
Insecta Pp1-13C 34 35
  • 91 (a)
ManyToMany
Pp1alpha-96A 34 35
  • 87 (a)
ManyToMany
flw 35
  • 82 (a)
Pp1-Y2 35
  • 74 (a)
Pp1-87B 34 35 33
  • 72.24 (n)
ManyToMany
PpN58A 35
  • 63 (a)
PpY-55A 35
  • 63 (a)
PpD5 35
  • 62 (a)
PpD6 35
  • 60 (a)
Pp1rY1 35
  • 58 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011166 33
  • 69.88 (n)
worm
(Caenorhabditis elegans)
Secernentea gsp-2 34
  • 88 (a)
OneToMany
F25B3.4 35
  • 55 (a)
F52H3.6 35
  • 55 (a)
T03F1.5 35
  • 54 (a)
C25A6.1 35
  • 54 (a)
W09C3.6 35
  • 54 (a)
ZK354.9 35
  • 53 (a)
F23B12.1 35
  • 53 (a)
C34D4.2 35
  • 52 (a)
C47A4.3 35
  • 51 (a)
C24H11.1 35
  • 48 (a)
C06A1.3 35
  • 48 (a)
C09H5.7 35
  • 48 (a)
C24H11.2 35
  • 48 (a)
C23G10.1b 35
  • 45 (a)
C23G10.1a 35
  • 45 (a)
W03D8.2 35
  • 44 (a)
R13A5.11 35
  • 42 (a)
F58G1.3 35
  • 42 (a)
T25B9.2 35
  • 41 (a)
C27B7.6 35
  • 40 (a)
F22D6.9 35
  • 40 (a)
Y40H4A.2 35
  • 40 (a)
Y69E1A.4 35
  • 39 (a)
R08A2.2 35
  • 38 (a)
F49E11.7 35
  • 37 (a)
F42G8.8 35
  • 34 (a)
C30A5.4 35
  • 33 (a)
ZC477.2 35
  • 33 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes GLC7 34
  • 84 (a)
OneToMany
PPZ2 36
thale cress
(Arabidopsis thaliana)
eudicotyledons TOPP4 33
  • 68.45 (n)
rice
(Oryza sativa)
Liliopsida Os03g0268000 33
  • 69.57 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.7187 34
  • 91 (a)
OneToMany
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes sds21 33
  • 67.23 (n)
Species where no ortholog for PPP1CC was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PPP1CC Gene

ENSEMBL:
Gene Tree for PPP1CC (if available)
TreeFam:
Gene Tree for PPP1CC (if available)
Aminode:
Evolutionary constrained regions (ECRs) for PPP1CC: view image

Paralogs for PPP1CC Gene

Paralogs for PPP1CC Gene

(10) SIMAP similar genes for PPP1CC Gene using alignment to 7 proteins:

  • PP1G_HUMAN
  • F8VR82_HUMAN
  • F8VYE8_HUMAN
  • F8W0V8_HUMAN
  • F8W0W8_HUMAN
  • F8W1A0_HUMAN
  • Q9UPN1_HUMAN
genes like me logo Genes that share paralogs with PPP1CC: view

Variants for PPP1CC Gene

Sequence variations from dbSNP and Humsavar for PPP1CC Gene

SNP ID Clin Chr 12 pos Variation AA Info Type
rs367543175 not-provided, not provided 110,720,185(-) C/T 3_prime_UTR_variant, coding_sequence_variant, intron_variant, synonymous_variant
rs367543176 not-provided, not provided 110,731,881(-) T/C coding_sequence_variant, missense_variant
rs367543177 not-provided, not provided 110,742,702(-) C/A coding_sequence_variant, synonymous_variant
rs1000006111 -- 110,707,912(-) T/A/C downstream_transcript_variant
rs1000128354 -- 110,712,088(-) C/A/T genic_downstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for PPP1CC Gene

Variant ID Type Subtype PubMed ID
esv2657045 CNV deletion 23128226
esv2675965 CNV deletion 23128226
nsv525818 CNV loss 19592680

Variation tolerance for PPP1CC Gene

Residual Variation Intolerance Score: 33.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.17; 3.94% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PPP1CC Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PPP1CC

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PPP1CC Gene

Disorders for PPP1CC Gene

Additional Disease Information for PPP1CC

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for PPP1CC Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PPP1CC Gene

Publications for PPP1CC Gene

  1. Sequence of human protein serine/threonine phosphatase 1 gamma and localization of the gene (PPP1CC) encoding it to chromosome bands 12q24.1-q24.2. (PMID: 8394140) Barker HM … Cohen PT (Biochimica et biophysica acta 1993) 3 4 22 58
  2. Protein phosphatase 1 (PP1) is a post-translational regulator of the mammalian circadian clock. (PMID: 21712997) Schmutz I … Albrecht U (PloS one 2011) 3 4 58
  3. Identification and characterization of a novel human PP1 phosphatase complex. (PMID: 20516061) Lee JH … Skalnik DG (The Journal of biological chemistry 2010) 3 4 58
  4. RRP1B targets PP1 to mammalian cell nucleoli and is associated with Pre-60S ribosomal subunits. (PMID: 20926688) Chamousset D … Trinkle-Mulcahy L (Molecular biology of the cell 2010) 3 4 58
  5. Identification of potentially damaging amino acid substitutions leading to human male infertility. (PMID: 19369647) Kuzmin A … Varmuza S (Biology of reproduction 2009) 3 44 58

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