Free for academic non-profit institutions. Other users need a Commercial license
The protein encoded by this gene is one of the three catalytic subunits of protein phosphatase 1 (PP1). PP1 is a serine/threonine specific protein phosphatase known to be involved in the regulation of a variety of cellular processes, such as cell division, glycogen metabolism, muscle contractility, protein synthesis, and HIV-1 viral transcription. Mouse studies suggest that PP1... See more...
Aliases for PPP1CB Gene
Aliases for PPP1CB Gene
- Protein Phosphatase 1 Catalytic Subunit Beta 2 3 5
- PP-1B 2 3 4
- Serine/Threonine-Protein Phosphatase PP1-Beta Catalytic Subunit 3 4
- Protein Phosphatase 1, Catalytic Subunit, Beta Isoform 2 3
- Protein Phosphatase 1, Catalytic Subunit, Beta Isozyme 2 3
- Myosin Phosphatase 2 3
- EC 3.1.3.16 4 51
- PPP1beta 2 3
- PP1beta 2 3
- PPP1CD 3 4
External Ids for PPP1CB Gene
- HGNC: 9282
- Entrez Gene: 5500
- Ensembl: ENSG00000213639
- OMIM: 600590
- UniProtKB: P62140
Previous GeneCards Identifiers for PPP1CB Gene
- GC02P028895
- GC02P029067
- GC02P028949
- GC02P028886
- GC02P028829
- GC02P028974
- GC02P028716
Summaries for PPP1CB Gene
-
The protein encoded by this gene is one of the three catalytic subunits of protein phosphatase 1 (PP1). PP1 is a serine/threonine specific protein phosphatase known to be involved in the regulation of a variety of cellular processes, such as cell division, glycogen metabolism, muscle contractility, protein synthesis, and HIV-1 viral transcription. Mouse studies suggest that PP1 functions as a suppressor of learning and memory. Two alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]
GeneCards Summary for PPP1CB Gene
PPP1CB (Protein Phosphatase 1 Catalytic Subunit Beta) is a Protein Coding gene. Diseases associated with PPP1CB include Noonan Syndrome-Like Disorder With Loose Anagen Hair 2 and Noonan Syndrome-Like Disorder With Loose Anagen Hair 1. Among its related pathways are Signaling by GPCR and Focal Adhesion. Gene Ontology (GO) annotations related to this gene include protein kinase binding and phosphatase activity. An important paralog of this gene is PPP1CA.
UniProtKB/Swiss-Prot Summary for PPP1CB Gene
-
Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase (PP1) is essential for cell division, it participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Involved in regulation of ionic conductances and long-term synaptic plasticity. Component of the PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase. In balance with CSNK1D and CSNK1E, determines the circadian period length, through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation. May dephosphorylate CSNK1D and CSNK1E. Dephosphorylates the 'Ser-418' residue of FOXP3 in regulatory T-cells (Treg) from patients with rheumatoid arthritis, thereby inactivating FOXP3 and rendering Treg cells functionally defective (PubMed:23396208).
-
Protein Ser/Thr phosphatases are a group of enzymes that catalyze the removal of phosphate groups from serine and/or threonine residues by hydrolysis of phosphoric acid monoesters. They oppose the action of kinases and phosphorylases and are involved in signal transduction.
Additional gene information for PPP1CB Gene
- HGNC(9282)
- Entrez Gene(5500)
- Ensembl(ENSG00000213639)
- OMIM(600590)
- UniProtKB(P62140)
- Open Targets Platform(ENSG00000213639)
- Monarch Initiative
- Search for PPP1CB at DataMed
- Search for PPP1CB at HumanCyc
No data available for CIViC Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PPP1CB Gene
Genomics for PPP1CB Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for PPP1CB Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around PPP1CB on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for PPP1CB
- Top Transcription factor binding sites by QIAGEN in the PPP1CB gene promoter:
-
- COMP1
- GATA-3
- HNF-3beta
- Pax-5
- TBP
Genomic Locations for PPP1CB Gene
Genomic Locations for PPP1CB Gene
- chr2:28,751,640-28,802,940
- (GRCh38/hg38)
- Size:
- 51,301 bases
- Orientation:
- Plus strand
- chr2:28,974,506-29,025,806
- (GRCh37/hg19)
- Size:
- 51,301 bases
- Orientation:
- Plus strand
Genomic View for PPP1CB Gene
Genes around PPP1CB on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 2p23.2 by HGNC
- 2p23.2 by Entrez Gene
- 2p23.2 by Ensembl
PPP1CB Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for PPP1CB Gene
Proteins for PPP1CB Gene
-
Protein details for PPP1CB Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P62140-PP1B_HUMAN
- Recommended name:
- Serine/threonine-protein phosphatase PP1-beta catalytic subunit
- Protein Accession:
- P62140
- B2R5V4
- D6W565
- P37140
- Q5U087
- Q6FG45
Protein attributes for PPP1CB Gene
- Size:
- 327 amino acids
- Molecular mass:
- 37187 Da
- Cofactor:
- Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
- Quaternary structure:
-
- PP1 comprises a catalytic subunit, PPP1CA, PPP1CB or PPP1CC, which is folded into its native form by inhibitor 2 and glycogen synthetase kinase 3, and then complexed to one or several targeting or regulatory subunits. The targeting or regulatory subunits determine the substrate specificity of PP1. PPP1R12A, PPP1R12B and PPP1R12C mediate binding to myosin. PPP1R3A (in skeletal muscle), PPP1R3B (in liver), PPP1R3C, PPP1R3D and PPP1R3F (in brain) mediate binding to glycogen. Part of a complex containing PPP1R15B, PP1 and NCK1/2 (By similarity). Interacts with PPP1R7 and PPP1R12C. PPP1R15A and PPP1R15B mediate binding to EIF2S1. Interacts with PPP1R16B. Component of the PTW/PP1 phosphatase complex, composed of PPP1R10/PNUTS, TOX4, WDR82, and PPP1CA or PPP1CB or PPP1CC. Interacts with PPP1R8. Interacts with TRIM28; the interaction is weak. Interacts with PPP1R12A and NUAK1; the interaction is direct. Interacts with FOXP3. Interacts with RRP1B (PubMed:20926688). Interacts with SERPINE1 (PubMed:28296156). Interacts with LZTR1 (PubMed:30368668).
Protein Expression for PPP1CB Gene
Selected DME Specific Peptides for PPP1CB Gene
- P62140:
-
- KIKYPENFF
- RPTDVPD
- TFGADVV
- VVEDGYEFF
- CSFQILK
- DLLWSDP
- YGFYDEC
- FSAPNYCGEFDN
- IFCCHGGLSP
- ETICLLLAYK
- RPVTPPR
- NFFLLRGNHE
- DLICRAH
- GWGENDRGVS
- LITRLLEVRGCRPGK
- CGDIHGQ
- DLLRLFEYGGFPP
- GDYVDRG
- VQMTEAEVRGLC
- GLLCDLLW
- DVVSKFLNRH
- FTDCFNCLP
- LLELEAP
Post-translational modifications for PPP1CB Gene
Other Protein References for PPP1CB Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- G Biosciences Immunotag™ PPP1CB Antibody
-
Custom Antibody ServicesOriGene Antibodies for PPP1CB
- Novus Biologicals Antibodies for PPP1CB
-
Abcam antibodies for PPP1CB
- Invitrogen Antibodies for PPP1CB (AFLGC-Ppp1cb)
-
Santa Cruz Biotechnology (SCBT) Antibodies for PPP1CB
Protein Products
- Search Origene for MassSpec and Protein Over-expression Lysates for PPP1CB
- Origene Custom Protein Services for PPP1CB
-
Abcam proteins for PPP1CB
Domains & Families for PPP1CB Gene
Gene Families for PPP1CB Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Disease related genes
- Enzymes
- Plasma proteins
- Potential drug targets
- Predicted intracellular proteins
Protein Domains for PPP1CB Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for PPP1CB Gene
- GenScript: Design optimal peptide antigens:
-
- Serine/threonine-protein phosphatase (C9J9S3_HUMAN)
- Serine/threonine-protein phosphatase (C9JP48_HUMAN)
- Serine/threonine-protein phosphatase (E7ETD8_HUMAN)
- Serine/threonine-protein phosphatase PP1-beta catalytic subunit (PP1B_HUMAN)
Graphical View of Domain Structure for InterPro Entry
P62140- Family:
-
- Belongs to the PPP phosphatase family. PP-1 subfamily.
Function for PPP1CB Gene
Molecular function for PPP1CB Gene
- UniProtKB/Swiss-Prot Function:
- Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase (PP1) is essential for cell division, it participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Involved in regulation of ionic conductances and long-term synaptic plasticity. Component of the PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase. In balance with CSNK1D and CSNK1E, determines the circadian period length, through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation. May dephosphorylate CSNK1D and CSNK1E. Dephosphorylates the 'Ser-418' residue of FOXP3 in regulatory T-cells (Treg) from patients with rheumatoid arthritis, thereby inactivating FOXP3 and rendering Treg cells functionally defective (PubMed:23396208).
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=H2O + O-phospho-L-seryl-[protein] = L-seryl-[protein] + phosphate; Xref=Rhea:RHEA:20629, Rhea:RHEA-COMP:9863, Rhea:RHEA-COMP:11604, ChEBI:CHEBI:15377, ChEBI:CHEBI:29999, ChEBI:CHEBI:43474, ChEBI:CHEBI:83421; EC=3.1.3.16;.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate; Xref=Rhea:RHEA:47004, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15377, ChEBI:CHEBI:30013, ChEBI:CHEBI:43474, ChEBI:CHEBI:61977; EC=3.1.3.16;.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=[myosin light chain]-O-phospho-L-serine + H2O = [myosin light chain]-L-serine + phosphate; Xref=Rhea:RHEA:12849, Rhea:RHEA-COMP:13684, Rhea:RHEA-COMP:13685, ChEBI:CHEBI:15377, ChEBI:CHEBI:29999, ChEBI:CHEBI:43474, ChEBI:CHEBI:83421; EC=3.1.3.53;.
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=[myosin light chain]-O-phospho-L-threonine + H2O = [myosin light chain]-L-threonine + phosphate; Xref=Rhea:RHEA:53988, Rhea:RHEA-COMP:13686, Rhea:RHEA-COMP:13687, ChEBI:CHEBI:15377, ChEBI:CHEBI:30013, ChEBI:CHEBI:43474, ChEBI:CHEBI:61977; EC=3.1.3.53;.
- UniProtKB/Swiss-Prot Induction:
- Up-regulated in synovial fluid mononuclear cells and peripheral blood mononuclear cells from patients with rheumatoid arthritis.
- UniProtKB/Swiss-Prot EnzymeRegulation:
- Inhibited by the toxins okadaic acid, tautomycin and microcystin Leu-Arg (By similarity). The phosphatase activity of the PPP1R15A-PP1 complex toward EIF2S1 is specifically inhibited by Salubrinal, a drug that protects cells from endoplasmic reticulum stress.
- GENATLAS Biochemistry:
- serine/threonine protein phosphatase 1,catalytic subunit,beta
Enzyme Numbers (IUBMB) for PPP1CB Gene
Phenotypes From GWAS Catalog for PPP1CB Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004721 | phosphoprotein phosphatase activity | IEA | -- |
| GO:0004722 | protein serine/threonine phosphatase activity | IBA | 21873635 |
| GO:0005515 | protein binding | IPI | 11067852 |
| GO:0016787 | hydrolase activity | IEA | -- |
| GO:0016791 | phosphatase activity | ISS | -- |
Phenotypes for PPP1CB Gene
- MGI mutant phenotypes for PPP1CB:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for PPP1CB:
-
- Decreased hepcidin::fluc mRNA expression
- no effect
- Decreased vaccinia virus (VACV) infection
- Dynamic nuclei (hole, folded or small irregular)
- Increased cell number in G2M, increased nuclei size in G2M
- Negative genetic interaction between BLM-/- and BLM+/+
- Decreased Salmonella enterica Typhimurium invasion
- Reduced mammosphere formation
- Decreased shRNA abundance (Z-score < -2)
- Increased shRNA abundance (Z-score > 2)
- Two nuclei (binuclear)
- Downregulation of NF-kappaB pathway after LMP1 stimulation
- Downregulation of NF-kappaB pathway after TNFalpha stimulation
- Increased G1 length
- Increased S length
- Downregulation of NF-kappaB pathway after IL-1beta stimulation
- Increased epidermal growth factor (EGF) endocytosis, decreased endosome-nucleus distance (endosomes clustered in the perinuclear region)
- Decreased viability after TNF/CHX stimulation
- Decreased focal adhesion (FA) abundance, increased peripheral FA formation
- Nuclear pre-40S maturation defects
Animal Model Products
-
Taconic Biosciences Mouse Models for PPP1CB
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for PPP1CB - Select products 50% OFF >
- * PPP1CB CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for PPP1CB
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for PPP1CB
-
Santa Cruz Biotechnology (SCBT) CRISPR for PPP1CB
miRNA for PPP1CB Gene
- miRTarBase miRNAs that target PPP1CB
-
- mmu-miR-301b-3p (MIRT007888)
- mmu-miR-181a-5p (MIRT014119)
- hsa-miR-215-5p (MIRT024868)
- hsa-miR-192-5p (MIRT026142)
- hsa-miR-18a-5p (MIRT031341)
- hsa-miR-615-3p (MIRT040166)
- hsa-miR-92b-3p (MIRT040560)
- hsa-miR-505-3p (MIRT041041)
- hsa-miR-23b-3p (MIRT046264)
- hsa-miR-15b-5p (MIRT046516)
- hsa-miR-548c-3p (MIRT206304)
- hsa-miR-3148 (MIRT206320)
- hsa-miR-4668-5p (MIRT206323)
- hsa-miR-5584-5p (MIRT206325)
- hsa-miR-4503 (MIRT206332)
- hsa-miR-7856-5p (MIRT302383)
- hsa-miR-548t-3p (MIRT377094)
- hsa-miR-548aa (MIRT377095)
- hsa-miR-548ap-3p (MIRT377096)
- hsa-miR-548as-3p (MIRT377097)
- hsa-miR-548at-3p (MIRT377098)
- hsa-miR-548ay-3p (MIRT377099)
- hsa-miR-33a-3p (MIRT389126)
- hsa-miR-99a-5p (MIRT437757)
- hsa-miR-99b-5p (MIRT437758)
- hsa-miR-100-5p (MIRT437759)
- hsa-miR-607 (MIRT535075)
- hsa-miR-3671 (MIRT535076)
- hsa-miR-100-3p (MIRT535077)
- hsa-miR-203a-3p (MIRT547018)
- hsa-miR-4776-3p (MIRT547019)
- hsa-miR-2909 (MIRT547020)
- hsa-miR-4659b-5p (MIRT547021)
- hsa-miR-4659a-5p (MIRT547022)
- hsa-miR-5590-5p (MIRT547023)
- hsa-miR-3162-5p (MIRT547024)
- hsa-miR-9500 (MIRT547025)
- hsa-miR-6822-5p (MIRT547026)
- hsa-miR-6750-5p (MIRT547027)
- mmu-miR-1199-5p (MIRT593731)
- mmu-miR-574-5p (MIRT593732)
- hsa-miR-542-5p (MIRT712261)
- hsa-miR-452-3p (MIRT712262)
- hsa-miR-466 (MIRT712263)
- hsa-miR-4672 (MIRT712264)
- hsa-miR-3941 (MIRT712265)
- hsa-miR-3160-5p (MIRT712266)
- hsa-miR-3134 (MIRT712267)
- hsa-miR-5683 (MIRT712268)
- hsa-miR-6768-5p (MIRT712269)
- hsa-miR-497-3p (MIRT712270)
- hsa-miR-323a-3p (MIRT712271)
- hsa-miR-6833-3p (MIRT721605)
- hsa-miR-4768-5p (MIRT721606)
- hsa-miR-6873-3p (MIRT721607)
- hsa-miR-4799-5p (MIRT721608)
- hsa-miR-6868-3p (MIRT721609)
- hsa-miR-2117 (MIRT721610)
- hsa-miR-6845-3p (MIRT721611)
- hsa-miR-1248 (MIRT721612)
- hsa-miR-1237-3p (MIRT721613)
- hsa-miR-148a-5p (MIRT721614)
- hsa-miR-4668-3p (MIRT721615)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for PPP1CB
- Browse OriGene Inhibitory RNA Products For PPP1CB
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PPP1CB
Clone Products
- Applied Biological Materials (abm): Clones for PPP1CB - Select products 50% OFF >
- * PPP1CB as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
- MG204795
- MR204795
- MR204795L3
- MR204795L4
- RC201142
- RC201142L1
- RC201142L2
- RC201142L3
- RC201142L4
- RC215893
- RC215893L1
- RC215893L2
- RC215893L3
- RC215893L4
- RG201142
- RG215893
- RR212543
- RR212543L3
- RR212543L4
- MR204795L3V
- MR204795L4V
- RC201142L1V
- RC201142L2V
- RC201142L3V
- RC201142L4V
- RC215893L1V
- RC215893L2V
- RC215893L3V
- RC215893L4V
- RR212543L3V
- RR212543L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for PPP1CB
- Addgene plasmids for PPP1CB
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for PPP1CB
No data available for Animal Models , Transcription Factor Targets and HOMER Transcription for PPP1CB Gene
Localization for PPP1CB Gene
Subcellular locations from UniProtKB/Swiss-Prot for PPP1CB Gene
- Cytoplasm. Nucleus. Nucleus, nucleoplasm. Nucleus, nucleolus. Note=Highly mobile in cells and can be relocalized through interaction with targeting subunits. In the presence of PPP1R8 relocalizes from the nucleus to nuclear speckles. {ECO:0000269 PubMed:11739654}.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| nucleus | 5 |
| cytosol | 5 |
| extracellular | 4 |
| cytoskeleton | 2 |
| mitochondrion | 1 |
| peroxisome | 1 |
| endoplasmic reticulum | 1 |
| endosome | 1 |
| lysosome | 1 |
| golgi apparatus | 1 |
- Cytosol (4)
- Nucleoplasm (4)
- Plasma membrane (4)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000164 | protein phosphatase type 1 complex | IEA | -- |
| GO:0000784 | colocalizes_with nuclear chromosome, telomeric region | IDA | 24270157 |
| GO:0005634 | nucleus | IBA | 21873635 |
| GO:0005654 | nucleoplasm | TAS | -- |
| GO:0005730 | nucleolus | IEA | -- |
Pathways & Interactions for PPP1CB Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Regulation of lipid metabolism Insulin signaling-generic cascades |
Regulation of lipid metabolism Insulin signaling-generic cascades
.59
Translation Insulin regulation of translation
.59
|
Translation Regulation of EIF2 activity
.47
|
| 2 | Regulation of PLK1 Activity at G2/M Transition |
.50
|
|
| 3 | Cytoskeleton remodeling Regulation of actin cytoskeleton by Rho GTPases |
Cell adhesion Integrin-mediated cell adhesion and migration
.49
Cytoskeleton remodeling Regulation of actin cytoskeleton by Rho GTPases
.49
|
Development MAG-dependent inhibition of neurite outgrowth
.42
|
| 4 | cGMP-PKG signaling pathway | ||
| 5 | Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 |
.35
|
|
Pathways by source for PPP1CB Gene
4 BioSystems pathways for PPP1CB Gene
19 Reactome pathways for PPP1CB Gene
21 KEGG pathways for PPP1CB Gene
13 GeneGo (Thomson Reuters) pathways for PPP1CB Gene
- Cell adhesion Integrin-mediated cell adhesion and migration
- Cytoskeleton remodeling Regulation of actin cytoskeleton by Rho GTPases
- Cytoskeleton remodeling Role of PKA in cytoskeleton reorganisation
- Development MAG-dependent inhibition of neurite outgrowth
- Immune response CCR3 signaling in eosinophils
1 Tocris pathway for PPP1CB Gene
9 Qiagen pathways for PPP1CB Gene
- Actin-Based Motility by Rho Family GTPases
- Activation of PKC through GPCR
- CCR3 Pathway in Eosinophils
- Cellular Effects of Sildenafil
- G-AlphaI Signaling
Interacting Proteins for PPP1CB Gene
Selected Interacting proteins:
P62140-PP1B_HUMAN
ENSP00000378769
for PPP1CB Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for PPP1CB
SIGNOR curated interactions for PPP1CB Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000086 | G2/M transition of mitotic cell cycle | TAS | -- |
| GO:0005975 | carbohydrate metabolic process | IEA | -- |
| GO:0005977 | glycogen metabolic process | IEA | -- |
| GO:0005979 | regulation of glycogen biosynthetic process | IEA | -- |
| GO:0005981 | regulation of glycogen catabolic process | IEA | -- |
Drugs & Compounds for PPP1CB Gene
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| Glycogen |
|
9005-79-2 |
|
|||
| Phosphate |
|
14066-19-4, 14265-44-2 |
|
|||
| FK 506 |
|
104987-11-3 |
|
|
(4) Tocris Compounds for PPP1CB Gene
| Compound | Action | Cas Number |
|---|---|---|
| Calcineurin Autoinhibitory Peptide | Selective calcineurin inhibitor | 148067-21-4 |
| Cyclosporin A | Calcineurin inhibitor | 59865-13-3 |
| FK 506 | Potent calcineurin inhibitor; immunosuppressant | 104987-11-3 |
| INCA-6 | Inhibitor of calcineurin-substrate association | 3519-82-2 |
(2) ApexBio Compounds for PPP1CB Gene
| Compound | Action | Cas Number |
|---|---|---|
| Cantharidin | Inhibitor of protein phosphatases 1/2A | 56-25-7 |
| Sal 003 | Cellular phosphatase complex inhibitor | 1164470-53-4 |
Transcripts for PPP1CB Gene
mRNA/cDNA for PPP1CB Gene
- 3 REFSEQ mRNAs :
- 24 NCBI additional mRNA sequence :
- 9 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000296122 3527 nts (view in UCSC)
- ENST00000358506 4771 nts (view in UCSC)
- ENST00000395366 4916 nts (view in UCSC)
- ENST00000418910 281 nts (view in UCSC)
- ENST00000420282 570 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for PPP1CB - Select products 50% OFF >
- * PPP1CB CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for PPP1CB
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for PPP1CB
-
Santa Cruz Biotechnology (SCBT) CRISPR for PPP1CB
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for PPP1CB
- Browse OriGene Inhibitory RNA Products For PPP1CB
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PPP1CB
Clone Products
- Applied Biological Materials (abm): Clones for PPP1CB - Select products 50% OFF >
- * PPP1CB as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
- MG204795
- MR204795
- MR204795L3
- MR204795L4
- RC201142
- RC201142L1
- RC201142L2
- RC201142L3
- RC201142L4
- RC215893
- RC215893L1
- RC215893L2
- RC215893L3
- RC215893L4
- RG201142
- RG215893
- RR212543
- RR212543L3
- RR212543L4
- MR204795L3V
- MR204795L4V
- RC201142L1V
- RC201142L2V
- RC201142L3V
- RC201142L4V
- RC215893L1V
- RC215893L2V
- RC215893L3V
- RC215893L4V
- RR212543L3V
- RR212543L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for PPP1CB
- Addgene plasmids for PPP1CB
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for PPP1CB
Relevant External Links for PPP1CB Gene
- GeneLoc Exon Structure for
- PPP1CB
Expression for PPP1CB Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Blood (Hematopoietic System)
-
Inner Cell Mass (Early Embryonic Tissues)
- Inner Cell Mass Cells Inner Cell Mass
-
Limb (Muscoskeletal System)
- Zone Of Polarizing Activity Cells Limb Bud
-
Mesoderm (Gastrulation Derivatives)
- Zone Of Polarizing Activity Cells Limb Bud
-
Gonad (Reproductive System)
- Primordial Germ Cells Primitive Gonad
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for PPP1CB Gene
- Elite partner
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for PPP1CB
SOURCE GeneReport for Unigene cluster for PPP1CB Gene:
Hs.702907Evidence on tissue expression from TISSUES for PPP1CB Gene
- Nervous system(5)
- Blood(4.5)
- Lung(3.7)
- Intestine(3.7)
- Muscle(3.4)
- Kidney(3.4)
- Heart(3.2)
- Liver(3.2)
- Eye(2.9)
- Spleen(2.8)
- Skin(2.7)
- Stomach(2.5)
- Thyroid gland(2.3)
- Lymph node(2.2)
- Bone marrow(2)
Primer Products
-
OriGene qPCR primer pairs for PPP1CB
-
OriGene qPCR primer pairs and template standards for PPP1CB
Gene Expression Assay Products
No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PPP1CB Gene
Orthologs for PPP1CB Gene
This gene was present in the common ancestor of eukaryotes.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Platypus (Ornithorhynchus anatinus) |
Mammalia | PPP1CB 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | PPP1CB 31 |
|
OneToOne | |
| Chimpanzee (Pan troglodytes) |
Mammalia | PPP1CB 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | PPP1CB 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | PPP1CB 30 31 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Ppp1cb 30 17 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Ppp1cb 30 |
|
||
| Chicken (Gallus gallus) |
Aves | PPP1CB 30 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | PPP1CB 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | ppp1cb 30 |
|
||
| Str.106 30 |
|
||||
| Zebrafish (Danio rerio) |
Actinopterygii | ppp1cbl 31 |
|
OneToOne | |
| ppp1cb 30 |
|
||||
| -- 30 |
|
||||
| Fruit Fly (Drosophila melanogaster) |
Insecta | Pp1-13C 32 |
|
|
|
| Pp1-87B 32 |
|
|
|||
| Pp1alpha-96A 32 |
|
|
|||
| Pp1-Y2 32 |
|
|
|||
| flw 30 31 32 |
|
OneToOne | |||
| PpY-55A 32 |
|
|
|||
| PpN58A 32 |
|
|
|||
| PpD5 32 |
|
|
|||
| PpD6 32 |
|
|
|||
| Pp1rY1 32 |
|
|
|||
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP003114 30 |
|
||
| Worm (Caenorhabditis elegans) |
Secernentea | gsp-1 30 31 |
|
OneToOne | |
| C25A6.1 32 |
|
|
|||
| F25B3.4 32 |
|
|
|||
| F52H3.6 32 |
|
|
|||
| T03F1.5 32 |
|
|
|||
| W09C3.6 32 |
|
|
|||
| ZK354.9 32 |
|
|
|||
| C34D4.2 32 |
|
|
|||
| C47A4.3 32 |
|
|
|||
| F23B12.1 32 |
|
|
|||
| C09H5.7 32 |
|
|
|||
| C23G10.1a 32 |
|
|
|||
| C23G10.1b 32 |
|
|
|||
| C24H11.1 32 |
|
|
|||
| C24H11.2 32 |
|
|
|||
| C06A1.3 32 |
|
|
|||
| W03D8.2 32 |
|
|
|||
| F58G1.3 32 |
|
|
|||
| R13A5.11 32 |
|
|
|||
| F22D6.9 32 |
|
|
|||
| F49E11.7 32 |
|
|
|||
| T25B9.2 32 |
|
|
|||
| C27B7.6 32 |
|
|
|||
| R08A2.2 32 |
|
|
|||
| Y40H4A.2 32 |
|
|
|||
| Y69E1A.4 32 |
|
|
|||
| F42G8.8 32 |
|
|
|||
| C30A5.4 32 |
|
|
|||
| Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | GLC7 31 |
|
OneToMany | |
| Thale Cress (Arabidopsis thaliana) |
eudicotyledons | TOPP3 30 |
|
||
| Alicante grape (Vitis vinifera) |
eudicotyledons | Vvi.10387 30 |
|
||
| Rice (Oryza sativa) |
Liliopsida | Os06g0164100 30 |
|
||
| Os.12164 30 |
|
- Species where no ortholog for PPP1CB was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
Evolution for PPP1CB Gene
- ENSEMBL:
- Gene Tree for PPP1CB (if available)
- TreeFam:
- Gene Tree for PPP1CB (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for PPP1CB: view image
Paralogs for PPP1CB Gene
Paralogs for PPP1CB Gene
(10) SIMAP similar genes for PPP1CB Gene using alignment to 6 proteins:
- PP1B_HUMAN
- C9J9S3_HUMAN
- C9JP48_HUMAN
- E7ETD8_HUMAN
- F8WE71_HUMAN
- H0Y3Y6_HUMAN
Variants for PPP1CB Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for PPP1CB Gene
| SNP ID | Clinical significance and condition | Chr 02 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 667025 | Benign: not specified | 28,778,825(+) | A/G | SYNONYMOUS_VARIANT | |
| 736677 | Likely Benign: not provided | 28,799,291(+) | G/A | SYNONYMOUS_VARIANT | |
| 747303 | Benign: not provided | 28,776,842(+) | G/A | INTRON_VARIANT | |
| 774811 | Likely Benign: not provided | 28,752,151(+) | C/T | SYNONYMOUS_VARIANT | |
| 845288 | Uncertain Significance: not provided | 28,776,877(+) | G/A | MISSENSE_VARIANT |
Residual Variation Intolerance Score:
40.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.10;
2.16% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for PPP1CB Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for PPP1CB Gene
Disorders for PPP1CB Gene
(6) MalaCards diseases for PPP1CB Gene - From: UniProtKB/Swiss-Prot, OMIM, ClinVar, GTR, Orphanet, DISEASES, and GeneCards
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| noonan syndrome-like disorder with loose anagen hair 2 |
|
|
| noonan syndrome-like disorder with loose anagen hair 1 |
|
|
| loose anagen hair syndrome |
|
|
| cardiofaciocutaneous syndrome 1 |
|
|
| rheumatoid arthritis |
|
|
Search PPP1CB in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
PP1B_HUMAN- Noonan syndrome-like disorder with loose anagen hair 2 (NSLH2) [MIM:617506]: A syndrome characterized by Noonan dysmorphic features such as macrocephaly, high forehead, hypertelorism, palpebral ptosis, low-set and posteriorly rotated ears, short and webbed neck, pectus anomalies, in association with pluckable, sparse, thin and slow-growing hair. {ECO:0000269 PubMed:27264673, ECO:0000269 PubMed:27681385, ECO:0000269 PubMed:27868344, ECO:0000269 PubMed:28211982, ECO:0000269 PubMed:30368668}. Note=The disease is caused by mutations affecting the gene represented in this entry.
Additional Disease Information for PPP1CB
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No data available for Genatlas for PPP1CB Gene
Publications for PPP1CB Gene
- Phosphorylation of a novel myosin binding subunit of protein phosphatase 1 reveals a conserved mechanism in the regulation of actin cytoskeleton. (PMID: 11399775) Tan I … Leung T (The Journal of biological chemistry 2001) 3 4 23
- Molecular and linkage analysis of type-1 protein phosphatase catalytic beta-subunit gene: lack of evidence for its major role in insulin resistance in Pima Indians. (PMID: 7796987) Prochazka M … Bogardus C (Diabetologia 1995) 3 4 23
- Three genes for protein phosphatase 1 map to different human chromosomes: sequence, expression and gene localisation of protein serine/threonine phosphatase 1 beta (PPP1CB). (PMID: 8312365) Barker HM … Cohen PT (Biochimica et biophysica acta 1994) 2 3 4
- Delineation of LZTR1 mutation-positive patients with Noonan syndrome and identification of LZTR1 binding to RAF1-PPP1CB complexes. (PMID: 30368668) Umeki I … Aoki Y (Human genetics 2019) 3 4
- PAI1: a novel PP1-interacting protein that mediates human plasma's anti-apoptotic effect in endothelial cells. (PMID: 28296156) Yao H … Deng X (Journal of cellular and molecular medicine 2017) 3 4
ExternalLinks
Products for PPP1CB Gene
- Custom Antibody ServicesOriGene Antibodies for PPP1CB
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for MassSpec and Protein Over-expression Lysates for PPP1CB
- Origene Custom Protein Services for PPP1CB
- Origene shrna, sirna, and RNAi products in human, mouse, rat for PPP1CB
- Browse OriGene Inhibitory RNA Products For PPP1CB
- OriGene qPCR primer pairs for PPP1CB
- OriGene qPCR primer pairs and template standards for PPP1CB
- OriGene CRISPR knockouts for PPP1CB
- MG204795
- MR204795
- MR204795L3
- MR204795L4
- RC201142
- RC201142L1
- RC201142L2
- RC201142L3
- RC201142L4
- RC215893
- RC215893L1
- RC215893L2
- RC215893L3
- RC215893L4
- RG201142
- RG215893
- RR212543
- RR212543L3
- RR212543L4
- MR204795L3V
- MR204795L4V
- RC201142L1V
- RC201142L2V
- RC201142L3V
- RC201142L4V
- RC215893L1V
- RC215893L2V
- RC215893L3V
- RC215893L4V
- RR212543L3V
- RR212543L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For PPP1CB
- Sino Biological Human cDNA Clone for PPP1CB
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for PPP1CB
- Novus Biologicals proteins and lysates for PPP1CB
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Abcam antibodies for PPP1CB
- Abcam proteins for PPP1CB
- Find your target
- Browse Primary Antibodies
- Browse Conjugated Primary Antibodies
- Browse Secondary Antibodies
- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- Taconic Biosciences Mouse Models for PPP1CB
- Find your next knockout model in the Taconic Knockout Repository
- Genetically Engineered Models Available Immediately
- Humanized Mice
- Invitrogen Antibodies for PPP1CB (AFLGC-Ppp1cb)
- ApexBio compounds for PPP1CB
- VectorBuilder Custom and pre-made DNA vectors for PPP1CB (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for PPP1CB (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for PPP1CB (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for PPP1CB CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for PPP1CB
- Addgene plasmids for PPP1CB
- antibodies-online: Show 49 available PPP1CB Antibodies ranked by validation data
- Compare Top PPP1CB Antibodies
- antibodies-online: Search results for available PPP1CB related products ranked by validation data
- antibodies-online: Show 14 available PPP1CB Proteins ranked by validation data
- Compare Top PPP1CB Proteins
- Santa Cruz Biotechnology (SCBT) Antibodies for PPP1CB
- Search Santa Cruz Biotechnology (SCBT) for PPP1CB siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for PPP1CB
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for PPP1CB
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for PPP1CB
- Search GeneCopoeia for miRNA 3'UTR Target clone products for PPP1CB
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PPP1CB
Sources for PPP1CB Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) Genetics Home Reference
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131)