PPP1CB Gene (Protein Coding)

Protein Phosphatase 1 Catalytic Subunit Beta

GC02P028752
GIFtS:
47
The protein encoded by this gene is one of the three catalytic subunits of protein phosphatase 1 (PP1). PP1 is a serine/threonine specific protein phosphatase known to be involved in the regulation of a variety of cellular processes, such as cell division, glycogen metabolism, muscle contractility, protein synthesis, and HIV-1 viral transcription. Mouse studies suggest that PP1... See more...

Aliases for PPP1CB Gene

Aliases for PPP1CB Gene

  • Protein Phosphatase 1 Catalytic Subunit Beta 2 3 5
  • PP-1B 2 3 4
  • Serine/Threonine-Protein Phosphatase PP1-Beta Catalytic Subunit 3 4
  • Protein Phosphatase 1, Catalytic Subunit, Beta Isozyme 2 3
  • Myosin Phosphatase 2 3
  • EC 3.1.3.16 4 50
  • PPP1beta 2 3
  • PP1beta 2 3
  • PPP1CD 3 4
  • PP1B 2 3
  • PP1c 2 3
  • MP 2 3
  • Protein Phosphatase 1, Catalytic Subunit, Beta Isoform 2
  • Epididymis Secretory Sperm Binding Protein Li 80p 3
  • Protein Phosphatase 1-Delta 3
  • Protein Phosphatase 1-Beta 3
  • EC 3.1.3.53 4
  • HEL-S-80p 3
  • PPP1CB 5
  • NSLH2 3

External Ids for PPP1CB Gene

Previous GeneCards Identifiers for PPP1CB Gene

  • GC02P028895
  • GC02P029067
  • GC02P028949
  • GC02P028886
  • GC02P028829
  • GC02P028974
  • GC02P028716

Summaries for PPP1CB Gene

Entrez Gene Summary for PPP1CB Gene

  • The protein encoded by this gene is one of the three catalytic subunits of protein phosphatase 1 (PP1). PP1 is a serine/threonine specific protein phosphatase known to be involved in the regulation of a variety of cellular processes, such as cell division, glycogen metabolism, muscle contractility, protein synthesis, and HIV-1 viral transcription. Mouse studies suggest that PP1 functions as a suppressor of learning and memory. Two alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]

GeneCards Summary for PPP1CB Gene

PPP1CB (Protein Phosphatase 1 Catalytic Subunit Beta) is a Protein Coding gene. Diseases associated with PPP1CB include Noonan Syndrome-Like Disorder With Loose Anagen Hair 2 and Noonan Syndrome-Like Disorder With Loose Anagen Hair. Among its related pathways are Integrin Pathway and Proteoglycans in cancer. Gene Ontology (GO) annotations related to this gene include protein kinase binding and phosphatase activity. An important paralog of this gene is PPP1CA.

UniProtKB/Swiss-Prot Summary for PPP1CB Gene

  • Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase (PP1) is essential for cell division, it participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Involved in regulation of ionic conductances and long-term synaptic plasticity. Component of the PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase. In balance with CSNK1D and CSNK1E, determines the circadian period length, through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation. May dephosphorylate CSNK1D and CSNK1E. Dephosphorylates the 'Ser-418' residue of FOXP3 in regulatory T-cells (Treg) from patients with rheumatoid arthritis, thereby inactivating FOXP3 and rendering Treg cells functionally defective (PubMed:23396208).

Tocris Summary for PPP1CB Gene

  • Protein Ser/Thr phosphatases are a group of enzymes that catalyze the removal of phosphate groups from serine and/or threonine residues by hydrolysis of phosphoric acid monoesters. They oppose the action of kinases and phosphorylases and are involved in signal transduction.

Gene Wiki entry for PPP1CB Gene

Additional gene information for PPP1CB Gene

No data available for CIViC Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PPP1CB Gene

Genomics for PPP1CB Gene

GeneHancer (GH) Regulatory Elements Pubs

Download GeneHancer 2017 data
Promoters and enhancers for PPP1CB Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PPP1CB on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for PPP1CB

Top Transcription factor binding sites by QIAGEN in the PPP1CB gene promoter:
  • COMP1
  • GATA-3
  • HNF-3beta
  • Pax-5
  • TBP

Genomic Locations for PPP1CB Gene

Latest Assembly
chr2:28,751,604-28,802,940
(GRCh38/hg38)
Size:
51,337 bases
Orientation:
Plus strand

Previous Assembly
chr2:28,974,470-29,025,806
(GRCh37/hg19 by Entrez Gene)
Size:
51,337 bases
Orientation:
Plus strand

chr2:28,974,506-29,025,806
(GRCh37/hg19 by Ensembl)
Size:
51,301 bases
Orientation:
Plus strand

Genomic View for PPP1CB Gene

Genes around PPP1CB on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PPP1CB Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PPP1CB Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for PPP1CB Gene

Proteins for PPP1CB Gene

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  • Protein details for PPP1CB Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P62140-PP1B_HUMAN
    Recommended name:
    Serine/threonine-protein phosphatase PP1-beta catalytic subunit
    Protein Accession:
    P62140
    Secondary Accessions:
    • B2R5V4
    • D6W565
    • P37140
    • Q5U087
    • Q6FG45

    Protein attributes for PPP1CB Gene

    Size:
    327 amino acids
    Molecular mass:
    37187 Da
    Cofactor:
    Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
    Quaternary structure:
    • PP1 comprises a catalytic subunit, PPP1CA, PPP1CB or PPP1CC, which is folded into its native form by inhibitor 2 and glycogen synthetase kinase 3, and then complexed to one or several targeting or regulatory subunits. The targeting or regulatory subunits determine the substrate specificity of PP1. PPP1R12A, PPP1R12B and PPP1R12C mediate binding to myosin. PPP1R3A (in skeletal muscle), PPP1R3B (in liver), PPP1R3C, PPP1R3D and PPP1R3F (in brain) mediate binding to glycogen. Part of a complex containing PPP1R15B, PP1 and NCK1/2 (By similarity). Interacts with PPP1R7 and PPP1R12C. PPP1R15A and PPP1R15B mediate binding to EIF2S1. Interacts with PPP1R16B. Component of the PTW/PP1 phosphatase complex, composed of PPP1R10/PNUTS, TOX4, WDR82, and PPP1CA or PPP1CB or PPP1CC. Interacts with PPP1R8. Interacts with TRIM28; the interaction is weak. Interacts with PPP1R12A and NUAK1; the interaction is direct. Interacts with FOXP3. Interacts with RRP1B (PubMed:20926688). Interacts with SERPINE1 (PubMed:28296156). Interacts with LZTR1 (PubMed:30368668).

neXtProt entry for PPP1CB Gene

Protein Expression for PPP1CB Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Selected DME Specific Peptides for PPP1CB Gene

P62140:
  • KIKYPENFF
  • RPTDVPD
  • TFGADVV
  • VVEDGYEFF
  • CSFQILK
  • DLLWSDP
  • YGFYDEC
  • FSAPNYCGEFDN
  • IFCCHGGLSP
  • ETICLLLAYK
  • RPVTPPR
  • NFFLLRGNHE
  • DLICRAH
  • GWGENDRGVS
  • LITRLLEVRGCRPGK
  • CGDIHGQ
  • DLLRLFEYGGFPP
  • GDYVDRG
  • VQMTEAEVRGLC
  • GLLCDLLW
  • DVVSKFLNRH
  • FTDCFNCLP
  • LLELEAP

Post-translational modifications for PPP1CB Gene

  • Ubiquitination at Lys25 and Lys303
  • Modification sites at PhosphoSitePlus

Other Protein References for PPP1CB Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for PPP1CB Gene

Gene Families for PPP1CB Gene

HGNC:
Human Protein Atlas (HPA):
  • Disease related genes
  • Enzymes
  • Plasma proteins
  • Potential drug targets
  • Predicted intracellular proteins

Protein Domains for PPP1CB Gene

InterPro:

Suggested Antigen Peptide Sequences for PPP1CB Gene

GenScript: Design optimal peptide antigens:
  • Serine/threonine-protein phosphatase (C9J9S3_HUMAN)
  • Serine/threonine-protein phosphatase (C9JP48_HUMAN)
  • Serine/threonine-protein phosphatase (E7ETD8_HUMAN)
  • Serine/threonine-protein phosphatase PP1-beta catalytic subunit (PP1B_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P62140

UniProtKB/Swiss-Prot:

PP1B_HUMAN :
  • Belongs to the PPP phosphatase family. PP-1 subfamily.
Family:
  • Belongs to the PPP phosphatase family. PP-1 subfamily.
genes like me logo Genes that share domains with PPP1CB: view

Function for PPP1CB Gene

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  6. Cell Lines for research

Molecular function for PPP1CB Gene

UniProtKB/Swiss-Prot Function:
Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase (PP1) is essential for cell division, it participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Involved in regulation of ionic conductances and long-term synaptic plasticity. Component of the PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase. In balance with CSNK1D and CSNK1E, determines the circadian period length, through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation. May dephosphorylate CSNK1D and CSNK1E. Dephosphorylates the 'Ser-418' residue of FOXP3 in regulatory T-cells (Treg) from patients with rheumatoid arthritis, thereby inactivating FOXP3 and rendering Treg cells functionally defective (PubMed:23396208).
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=H2O + O-phospho-L-seryl-[protein] = L-seryl-[protein] + phosphate; Xref=Rhea:RHEA:20629, Rhea:RHEA-COMP:9863, Rhea:RHEA-COMP:11604, ChEBI:CHEBI:15377, ChEBI:CHEBI:29999, ChEBI:CHEBI:43474, ChEBI:CHEBI:83421; EC=3.1.3.16;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate; Xref=Rhea:RHEA:47004, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15377, ChEBI:CHEBI:30013, ChEBI:CHEBI:43474, ChEBI:CHEBI:61977; EC=3.1.3.16;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=H2O + O-phospho-L-seryl-[myosin light chain] = L-seryl-[myosin light chain] + phosphate; Xref=Rhea:RHEA:12849, Rhea:RHEA-COMP:13684, Rhea:RHEA-COMP:13685, ChEBI:CHEBI:15377, ChEBI:CHEBI:29999, ChEBI:CHEBI:43474, ChEBI:CHEBI:83421; EC=3.1.3.53;.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=H2O + O-phospho-L-threonyl-[myosin light chain] = L-threonyl-[myosin light chain] + phosphate; Xref=Rhea:RHEA:53988, Rhea:RHEA-COMP:13686, Rhea:RHEA-COMP:13687, ChEBI:CHEBI:15377, ChEBI:CHEBI:30013, ChEBI:CHEBI:43474, ChEBI:CHEBI:61977; EC=3.1.3.53;.
UniProtKB/Swiss-Prot Induction:
Up-regulated in synovial fluid mononuclear cells and peripheral blood mononuclear cells from patients with rheumatoid arthritis.
UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited by the toxins okadaic acid, tautomycin and microcystin Leu-Arg (By similarity). The phosphatase activity of the PPP1R15A-PP1 complex toward EIF2S1 is specifically inhibited by Salubrinal, a drug that protects cells from endoplasmic reticulum stress.
GENATLAS Biochemistry:
serine/threonine protein phosphatase 1,catalytic subunit,beta

Enzyme Numbers (IUBMB) for PPP1CB Gene

Phenotypes From GWAS Catalog for PPP1CB Gene

Gene Ontology (GO) - Molecular Function for PPP1CB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004721 phosphoprotein phosphatase activity IEA --
GO:0004722 protein serine/threonine phosphatase activity IBA 21873635
GO:0005515 protein binding IPI 11067852
GO:0016787 hydrolase activity IEA --
GO:0016791 phosphatase activity ISS --
genes like me logo Genes that share ontologies with PPP1CB: view
genes like me logo Genes that share phenotypes with PPP1CB: view

Human Phenotype Ontology for PPP1CB Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for research

  • Taconic Biosciences Mouse Models for PPP1CB

miRNA for PPP1CB Gene

miRTarBase miRNAs that target PPP1CB

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PPP1CB

No data available for Animal Models , Transcription Factor Targets and HOMER Transcription for PPP1CB Gene

Localization for PPP1CB Gene

Subcellular locations from UniProtKB/Swiss-Prot for PPP1CB Gene

Cytoplasm. Nucleus. Nucleus, nucleoplasm. Nucleus, nucleolus. Note=Highly mobile in cells and can be relocalized through interaction with targeting subunits. In the presence of PPP1R8 relocalizes from the nucleus to nuclear speckles. {ECO:0000269 PubMed:11739654}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PPP1CB gene
Compartment Confidence
plasma membrane 5
nucleus 5
cytosol 5
extracellular 4
cytoskeleton 2
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1
endosome 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Nucleoplasm (3)
  • Plasma membrane (1)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for PPP1CB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000164 protein phosphatase type 1 complex IEA --
GO:0000781 colocalizes_with chromosome, telomeric region IDA 24270157
GO:0005634 nucleus IBA 21873635
GO:0005654 nucleoplasm TAS --
GO:0005730 nucleolus IEA --
genes like me logo Genes that share ontologies with PPP1CB: view

Pathways & Interactions for PPP1CB Gene

PathCards logo

SuperPathways for PPP1CB Gene

SuperPathway Contained pathways
1 Regulation of lipid metabolism Insulin signaling-generic cascades
Regulation of lipid metabolism Insulin signaling-generic cascades
.59
Translation Insulin regulation of translation
.59
Translation Regulation of EIF2 activity
.47
Insulin signaling pathway
.32
2 Regulation of PLK1 Activity at G2/M Transition
Regulation of PLK1 Activity at G2/M Transition
.80
G2/M Transition
.49
Mitotic G2-G2/M phases
.49
3 Cytoskeleton remodeling Regulation of actin cytoskeleton by Rho GTPases
Cell adhesion Integrin-mediated cell adhesion and migration
.49
Cytoskeleton remodeling Regulation of actin cytoskeleton by Rho GTPases
.49
Development MAG-dependent inhibition of neurite outgrowth
.42
4 cGMP-PKG signaling pathway
Adrenergic signaling in cardiomyocytes
.32
cGMP-PKG signaling pathway
.32
5 Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
RHO GTPases activate PKNs
.72
Alcoholism
.35
genes like me logo Genes that share pathways with PPP1CB: view

Pathways by source for PPP1CB Gene

13 GeneGo (Thomson Reuters) pathways for PPP1CB Gene
  • Cell adhesion Integrin-mediated cell adhesion and migration
  • Cytoskeleton remodeling Regulation of actin cytoskeleton by Rho GTPases
  • Cytoskeleton remodeling Role of PKA in cytoskeleton reorganisation
  • Development MAG-dependent inhibition of neurite outgrowth
  • Immune response CCR3 signaling in eosinophils
1 Tocris pathway for PPP1CB Gene
9 Qiagen pathways for PPP1CB Gene
  • Actin-Based Motility by Rho Family GTPases
  • Activation of PKC through GPCR
  • CCR3 Pathway in Eosinophils
  • Cellular Effects of Sildenafil
  • G-AlphaI Signaling

SIGNOR curated interactions for PPP1CB Gene

Activates:
Inactivates:
Other effect:

Gene Ontology (GO) - Biological Process for PPP1CB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000086 G2/M transition of mitotic cell cycle TAS --
GO:0005975 carbohydrate metabolic process IEA --
GO:0005977 glycogen metabolic process IEA --
GO:0005979 regulation of glycogen biosynthetic process IEA --
GO:0005981 regulation of glycogen catabolic process IEA --
genes like me logo Genes that share ontologies with PPP1CB: view

Drugs & Compounds for PPP1CB Gene

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(10) Drugs for PPP1CB Gene - From: ApexBio, HMDB, and Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Cantharidin Approved, Investigational Pharma Inhibitor of protein phosphatases 1/2A 16
Water Approved Pharma 0
Manganese Approved Nutra 65
Cyclosporin A Approved, Investigational, Vet_approved Pharma Immunosuppressive agent, Calcineurin inhibitor 0
Fe2+ Experimental Pharma 0

(2) Additional Compounds for PPP1CB Gene - From: HMDB and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Glycogen
  • Animal starch
  • Liver starch
  • Lyoglycogen
  • Phytoglycogen
 9005-79-2
FK 506
104987-11-3

(4) Tocris Compounds for PPP1CB Gene

Compound Action Cas Number
Calcineurin Autoinhibitory Peptide Selective calcineurin inhibitor 148067-21-4
Cyclosporin A Calcineurin inhibitor 59865-13-3
FK 506 Potent calcineurin inhibitor; immunosuppressant 104987-11-3
INCA-6 Inhibitor of calcineurin-substrate association 3519-82-2

(2) ApexBio Compounds for PPP1CB Gene

Compound Action Cas Number
Cantharidin Inhibitor of protein phosphatases 1/2A 56-25-7
Sal 003 Cellular phosphatase complex inhibitor 1164470-53-4
genes like me logo Genes that share compounds with PPP1CB: view

Drug products for research

Transcripts for PPP1CB Gene

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mRNA/cDNA for PPP1CB Gene

3 REFSEQ mRNAs :
24 NCBI additional mRNA sequence :
9 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PPP1CB

Alternative Splicing Database (ASD) splice patterns (SP) for PPP1CB Gene

No ASD Table

Relevant External Links for PPP1CB Gene

GeneLoc Exon Structure for
PPP1CB

Expression for PPP1CB Gene

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mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PPP1CB Gene

mRNA expression in normal human tissues for PPP1CB Gene
mRNA expression by GTEx for PPP1CB GenemRNA expression by BioGPS for PPP1CB Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for PPP1CB Gene



Protein tissue co-expression partners for PPP1CB Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for PPP1CB

SOURCE GeneReport for Unigene cluster for PPP1CB Gene:

Hs.702907

Evidence on tissue expression from TISSUES for PPP1CB Gene

  • Nervous system(5)
  • Blood(4.5)
  • Lung(3.7)
  • Intestine(3.6)
  • Muscle(3.3)
  • Kidney(3.3)
  • Heart(3.1)
  • Liver(3.1)
  • Eye(2.9)
  • Spleen(2.8)
  • Skin(2.6)
  • Stomach(2.4)
  • Thyroid gland(2.2)
  • Lymph node(2.1)
genes like me logo Genes that share expression patterns with PPP1CB: view

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PPP1CB Gene

Orthologs for PPP1CB Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PPP1CB Gene

Organism Taxonomy Gene Similarity Type Details
Platypus
(Ornithorhynchus anatinus)
 Mammalia PPP1CB 30
  • 100 (a)
 OneToOne
Oppossum
(Monodelphis domestica)
 Mammalia PPP1CB 30
  • 100 (a)
 OneToOne
Chimpanzee
(Pan troglodytes)
 Mammalia PPP1CB 29 30
  • 99.69 (n)
 OneToOne
Dog
(Canis familiaris)
 Mammalia PPP1CB 29 30
  • 96.64 (n)
 OneToOne
Cow
(Bos Taurus)
 Mammalia PPP1CB 29 30
  • 95.82 (n)
 OneToOne
Mouse
(Mus musculus)
 Mammalia Ppp1cb 29 16 30
  • 94.6 (n)
 OneToOne
Rat
(Rattus norvegicus)
 Mammalia Ppp1cb 29
  • 93.88 (n)
Chicken
(Gallus gallus)
 Aves PPP1CB 29 30
  • 87.56 (n)
 OneToOne
Lizard
(Anolis carolinensis)
 Reptilia PPP1CB 30
  • 100 (a)
 OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
 Amphibia ppp1cb 29
  • 82.16 (n)
Str.106 29
Zebrafish
(Danio rerio)
 Actinopterygii ppp1cbl 30
  • 100 (a)
 OneToOne
ppp1cb 29
  • 79.41 (n)
-- 29
Fruit Fly
(Drosophila melanogaster)
 Insecta Pp1-13C 31
  • 88 (a)
Pp1-87B 31
  • 88 (a)
Pp1alpha-96A 31
  • 85 (a)
Pp1-Y2 31
  • 74 (a)
flw 29 30 31
  • 71.44 (n)
 OneToOne
PpY-55A 31
  • 63 (a)
PpN58A 31
  • 62 (a)
PpD5 31
  • 61 (a)
PpD6 31
  • 59 (a)
Pp1rY1 31
  • 58 (a)
African malaria mosquito
(Anopheles gambiae)
 Insecta AgaP_AGAP003114 29
  • 69.83 (n)
Worm
(Caenorhabditis elegans)
 Secernentea gsp-1 29 30
  • 75.27 (n)
 OneToOne
C25A6.1 31
  • 56 (a)
F25B3.4 31
  • 55 (a)
F52H3.6 31
  • 55 (a)
T03F1.5 31
  • 54 (a)
W09C3.6 31
  • 54 (a)
ZK354.9 31
  • 54 (a)
C34D4.2 31
  • 52 (a)
C47A4.3 31
  • 52 (a)
F23B12.1 31
  • 52 (a)
C09H5.7 31
  • 48 (a)
C23G10.1a 31
  • 48 (a)
C23G10.1b 31
  • 48 (a)
C24H11.1 31
  • 48 (a)
C24H11.2 31
  • 48 (a)
C06A1.3 31
  • 47 (a)
W03D8.2 31
  • 47 (a)
F58G1.3 31
  • 43 (a)
R13A5.11 31
  • 43 (a)
F22D6.9 31
  • 41 (a)
F49E11.7 31
  • 40 (a)
T25B9.2 31
  • 40 (a)
C27B7.6 31
  • 38 (a)
R08A2.2 31
  • 38 (a)
Y40H4A.2 31
  • 38 (a)
Y69E1A.4 31
  • 37 (a)
F42G8.8 31
  • 36 (a)
C30A5.4 31
  • 33 (a)
Baker's yeast
(Saccharomyces cerevisiae)
 Saccharomycetes GLC7 30
  • 81 (a)
 OneToMany
Thale Cress
(Arabidopsis thaliana)
 eudicotyledons TOPP3 29
  • 68.8 (n)
Alicante grape
(Vitis vinifera)
 eudicotyledons Vvi.10387 29
Rice
(Oryza sativa)
 Liliopsida Os06g0164100 29
  • 68.28 (n)
Os.12164 29
Species where no ortholog for PPP1CB was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for PPP1CB Gene

ENSEMBL:
Gene Tree for PPP1CB (if available)
TreeFam:
Gene Tree for PPP1CB (if available)
Aminode:
Evolutionary constrained regions (ECRs) for PPP1CB: view image
Alliance of Genome Resources:
Additional Orthologs for PPP1CB

Paralogs for PPP1CB Gene

Paralogs for PPP1CB Gene

(10) SIMAP similar genes for PPP1CB Gene using alignment to 6 proteins:

  • PP1B_HUMAN
  • C9J9S3_HUMAN
  • C9JP48_HUMAN
  • E7ETD8_HUMAN
  • F8WE71_HUMAN
  • H0Y3Y6_HUMAN
genes like me logo Genes that share paralogs with PPP1CB: view

Variants for PPP1CB Gene

Products:

  1. SNP Genotyping and Copy Number Assays for research

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for PPP1CB Gene

SNP ID Clinical significance and condition Chr 02 pos Variation AA Info Type
845288 Uncertain Significance: not provided 28,776,877(+) G/A
NM_002709.3(PPP1CB):c.79G>A (p.Val27Met) 		MISSENSE
974912 Likely Pathogenic: Noonan syndrome; Noonan syndrome-like disorder with loose anagen hair 2 28,783,931(+) T/A
NM_002709.3(PPP1CB):c.545T>A (p.Met182Lys) 		MISSENSE
981574 Likely Benign: Noonan syndrome 28,752,155(+) C/G
NM_002709.3(PPP1CB):c.31C>G (p.Leu11Val) 		MISSENSE
981575 Likely Pathogenic: Noonan syndrome 28,783,930(+) A/G
NM_002709.3(PPP1CB):c.544A>G (p.Met182Val) 		MISSENSE
985982 Uncertain Significance: Inborn genetic diseases 28,793,944(+) G/T
NM_002709.3(PPP1CB):c.826G>T (p.Asp276Tyr) 		MISSENSE

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for PPP1CB Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Variation tolerance for PPP1CB Gene

Residual Variation Intolerance Score: 40.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.10; 2.16% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PPP1CB Gene

Human Gene Mutation Database (HGMD)
PPP1CB
SNPedia medical, phenotypic, and genealogical associations of SNPs for
PPP1CB
Leiden Open Variation Database (LOVD)
PPP1CB

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for PPP1CB Gene

Disorders for PPP1CB Gene

MalaCards: The human disease database

(10) MalaCards diseases for PPP1CB Gene - From: OMI, CVR, GTR, ORP, SWI, COP, and GCD

- elite association - COSMIC cancer census association via MalaCards

UniProtKB/Swiss-Prot

PP1B_HUMAN
  • Noonan syndrome-like disorder with loose anagen hair 2 (NSLH2) [MIM:617506]: A syndrome characterized by Noonan dysmorphic features such as macrocephaly, high forehead, hypertelorism, palpebral ptosis, low-set and posteriorly rotated ears, short and webbed neck, pectus anomalies, in association with pluckable, sparse, thin and slow-growing hair. {ECO:0000269 PubMed:27264673, ECO:0000269 PubMed:27681385, ECO:0000269 PubMed:27868344, ECO:0000269 PubMed:28211982, ECO:0000269 PubMed:30368668}. Note=The disease is caused by variants affecting the gene represented in this entry.

Additional Disease Information for PPP1CB

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with PPP1CB: view

No data available for Genatlas for PPP1CB Gene

Publications for PPP1CB Gene

  1. The recurrent PPP1CB mutation p.Pro49Arg in an additional Noonan-like syndrome individual: Broadening the clinical phenotype. (PMID: 28211982) Bertola D … Kim C (American journal of medical genetics. Part A 2017) 3 4 72
  2. A novel rasopathy caused by recurrent de novo missense mutations in PPP1CB closely resembles Noonan syndrome with loose anagen hair. (PMID: 27264673) Gripp KW … Dobyns WB (American journal of medical genetics. Part A 2016) 3 4 72
  3. Phosphorylation of a novel myosin binding subunit of protein phosphatase 1 reveals a conserved mechanism in the regulation of actin cytoskeleton. (PMID: 11399775) Tan I … Leung T (The Journal of biological chemistry 2001) 3 4 22
  4. Molecular and linkage analysis of type-1 protein phosphatase catalytic beta-subunit gene: lack of evidence for its major role in insulin resistance in Pima Indians. (PMID: 7796987) Prochazka M … Bogardus C (Diabetologia 1995) 3 4 22
  5. Three genes for protein phosphatase 1 map to different human chromosomes: sequence, expression and gene localisation of protein serine/threonine phosphatase 1 beta (PPP1CB). (PMID: 8312365) Barker HM … Cohen PT (Biochimica et biophysica acta 1994) 2 3 4

ExternalLinks

View latest publications for PPP1CB gene in Mastermind

Products for PPP1CB Gene

Sources for PPP1CB Gene