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The protein encoded by this gene is one of the three catalytic subunits of protein phosphatase 1 (PP1). PP1 is a serine/threonine specific protein phosphatase known to be involved in the regulation of a variety of cellular processes, such as cell division, glycogen metabolism, muscle contractility, protein synthesis, and HIV-1 viral transcription. Mouse studies suggest that PP1 functions as a suppressor of learning and memory. Two alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]
PPP1CB (Protein Phosphatase 1 Catalytic Subunit Beta) is a Protein Coding gene. Diseases associated with PPP1CB include Noonan Syndrome-Like Disorder With Loose Anagen Hair 2 and Noonan Syndrome-Like Disorder With Loose Anagen Hair 1. Among its related pathways are Signaling by GPCR and Focal Adhesion. Gene Ontology (GO) annotations related to this gene include protein kinase binding and phosphatase activity. An important paralog of this gene is PPP1CA.
Protein Ser/Thr phosphatases are a group of enzymes that catalyze the removal of phosphate groups from serine and/or threonine residues by hydrolysis of phosphoric acid monoesters. They oppose the action of kinases and phosphorylases and are involved in signal transduction.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0004721 | phosphoprotein phosphatase activity | IEA | -- |
GO:0004722 | protein serine/threonine phosphatase activity | IBA | 21873635 |
GO:0005515 | protein binding | IPI | 11067852 |
GO:0016787 | hydrolase activity | IEA | -- |
GO:0016791 | phosphatase activity | ISS | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000164 | protein phosphatase type 1 complex | IEA | -- |
GO:0000784 | colocalizes_with nuclear chromosome, telomeric region | IDA | 24270157 |
GO:0005634 | nucleus | IBA | 21873635 |
GO:0005654 | nucleoplasm | TAS | -- |
GO:0005730 | nucleolus | IEA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Regulation of lipid metabolism Insulin signaling-generic cascades |
Regulation of lipid metabolism Insulin signaling-generic cascades
.59
Translation Insulin regulation of translation
.59
|
Translation Regulation of EIF2 activity
.47
|
2 | Regulation of PLK1 Activity at G2/M Transition |
.50
|
|
3 | Cytoskeleton remodeling Regulation of actin cytoskeleton by Rho GTPases |
Cell adhesion Integrin-mediated cell adhesion and migration
.49
Cytoskeleton remodeling Regulation of actin cytoskeleton by Rho GTPases
.49
|
Development MAG-dependent inhibition of neurite outgrowth
.42
|
4 | cGMP-PKG signaling pathway | ||
5 | Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 |
.35
|
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000086 | G2/M transition of mitotic cell cycle | TAS | -- |
GO:0005975 | carbohydrate metabolic process | IEA | -- |
GO:0005977 | glycogen metabolic process | IEA | -- |
GO:0005979 | regulation of glycogen biosynthetic process | IEA | -- |
GO:0005981 | regulation of glycogen catabolic process | IEA | -- |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
---|---|---|---|---|---|---|
Glycogen |
|
9005-79-2 |
|
|||
Phosphate |
|
14066-19-4, 14265-44-2 |
|
|||
FK 506 |
|
104987-11-3 |
|
|
Compound | Action | Cas Number |
---|---|---|
Calcineurin Autoinhibitory Peptide | Selective calcineurin inhibitor | 148067-21-4 |
Cyclosporin A | Calcineurin inhibitor | 59865-13-3 |
FK 506 | Potent calcineurin inhibitor; immunosuppressant | 104987-11-3 |
INCA-6 | Inhibitor of calcineurin-substrate association | 3519-82-2 |
Compound | Action | Cas Number |
---|---|---|
Cantharidin | Inhibitor of protein phosphatases 1/2A | 56-25-7 |
Sal 003 | Cellular phosphatase complex inhibitor | 1164470-53-4 |
This gene was present in the common ancestor of eukaryotes.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Platypus (Ornithorhynchus anatinus) |
Mammalia | PPP1CB 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | PPP1CB 31 |
|
OneToOne | |
Chimpanzee (Pan troglodytes) |
Mammalia | PPP1CB 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | PPP1CB 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | PPP1CB 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Ppp1cb 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Ppp1cb 30 |
|
||
Chicken (Gallus gallus) |
Aves | PPP1CB 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | PPP1CB 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | ppp1cb 30 |
|
||
Str.106 30 |
|
||||
Zebrafish (Danio rerio) |
Actinopterygii | ppp1cbl 31 |
|
OneToOne | |
ppp1cb 30 |
|
||||
-- 30 |
|
||||
Fruit Fly (Drosophila melanogaster) |
Insecta | Pp1-13C 32 |
|
|
|
Pp1-87B 32 |
|
|
|||
Pp1alpha-96A 32 |
|
|
|||
Pp1-Y2 32 |
|
|
|||
flw 30 31 32 |
|
OneToOne | |||
PpY-55A 32 |
|
|
|||
PpN58A 32 |
|
|
|||
PpD5 32 |
|
|
|||
PpD6 32 |
|
|
|||
Pp1rY1 32 |
|
|
|||
African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP003114 30 |
|
||
Worm (Caenorhabditis elegans) |
Secernentea | gsp-1 30 31 |
|
OneToOne | |
C25A6.1 32 |
|
|
|||
F25B3.4 32 |
|
|
|||
F52H3.6 32 |
|
|
|||
T03F1.5 32 |
|
|
|||
W09C3.6 32 |
|
|
|||
ZK354.9 32 |
|
|
|||
C34D4.2 32 |
|
|
|||
C47A4.3 32 |
|
|
|||
F23B12.1 32 |
|
|
|||
C09H5.7 32 |
|
|
|||
C23G10.1a 32 |
|
|
|||
C23G10.1b 32 |
|
|
|||
C24H11.1 32 |
|
|
|||
C24H11.2 32 |
|
|
|||
C06A1.3 32 |
|
|
|||
W03D8.2 32 |
|
|
|||
F58G1.3 32 |
|
|
|||
R13A5.11 32 |
|
|
|||
F22D6.9 32 |
|
|
|||
F49E11.7 32 |
|
|
|||
T25B9.2 32 |
|
|
|||
C27B7.6 32 |
|
|
|||
R08A2.2 32 |
|
|
|||
Y40H4A.2 32 |
|
|
|||
Y69E1A.4 32 |
|
|
|||
F42G8.8 32 |
|
|
|||
C30A5.4 32 |
|
|
|||
Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | GLC7 31 |
|
OneToMany | |
Thale Cress (Arabidopsis thaliana) |
eudicotyledons | TOPP3 30 |
|
||
Alicante grape (Vitis vinifera) |
eudicotyledons | Vvi.10387 30 |
|
||
Rice (Oryza sativa) |
Liliopsida | Os06g0164100 30 |
|
||
Os.12164 30 |
|
SNP ID | Clinical significance and condition | Chr 02 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
667025 | Benign: not specified | 28,778,825(+) | A/G | SYNONYMOUS_VARIANT | |
736677 | Likely Benign: not provided | 28,799,291(+) | G/A | SYNONYMOUS_VARIANT | |
747303 | Benign: not provided | 28,776,842(+) | G/A | INTRON_VARIANT | |
774811 | Likely Benign: not provided | 28,752,151(+) | C/T | SYNONYMOUS_VARIANT | |
845288 | Uncertain Significance: not provided | 28,776,877(+) | G/A | MISSENSE_VARIANT |
Disorder | Aliases | PubMed IDs |
---|---|---|
noonan syndrome-like disorder with loose anagen hair 2 |
|
|
noonan syndrome-like disorder with loose anagen hair 1 |
|
|
loose anagen hair syndrome |
|
|
cardiofaciocutaneous syndrome 1 |
|
|
rheumatoid arthritis |
|
|