The protein encoded by this gene is one of the three catalytic subunits of protein phosphatase 1 (PP1). PP1 is a serine/threonine specific protein phosphatase known to be involved in the regulation of a variety of cellular processes, such as cell division, glycogen metabolism, muscle contractility, protein synthesis, and HIV-1 viral transcription. Increased PP1 activity has bee... See more...

Aliases for PPP1CA Gene

Aliases for PPP1CA Gene

  • Protein Phosphatase 1 Catalytic Subunit Alpha 2 3 5
  • PP-1A 2 3 4
  • Serine/Threonine-Protein Phosphatase PP1-Alpha Catalytic Subunit 3 4
  • Protein Phosphatase 1, Catalytic Subunit, Alpha Isoform 2 3
  • Protein Phosphatase 1, Catalytic Subunit, Alpha Isozyme 2 3
  • EC 3.1.3.16 4 51
  • PP1alpha 2 3
  • PPP1A 3 4
  • PP1A 2 3
  • Serine/Threonine Protein Phosphatase PP1-Alpha 1 Catalytic Subunit 3
  • Testicular Tissue Protein Li 155 3
  • PPP1CA 5

External Ids for PPP1CA Gene

Previous HGNC Symbols for PPP1CA Gene

  • PPP1A

Previous GeneCards Identifiers for PPP1CA Gene

  • GC11M069698
  • GC11M068861
  • GC11M066941
  • GC11M066922
  • GC11M067165
  • GC11M063494

Summaries for PPP1CA Gene

Entrez Gene Summary for PPP1CA Gene

  • The protein encoded by this gene is one of the three catalytic subunits of protein phosphatase 1 (PP1). PP1 is a serine/threonine specific protein phosphatase known to be involved in the regulation of a variety of cellular processes, such as cell division, glycogen metabolism, muscle contractility, protein synthesis, and HIV-1 viral transcription. Increased PP1 activity has been observed in the end stage of heart failure. Studies in both human and mice suggest that PP1 is an important regulator of cardiac function. Mouse studies also suggest that PP1 functions as a suppressor of learning and memory. Three alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for PPP1CA Gene

PPP1CA (Protein Phosphatase 1 Catalytic Subunit Alpha) is a Protein Coding gene. Diseases associated with PPP1CA include Venezuelan Equine Encephalitis and Encephalitis. Among its related pathways are Signaling by GPCR and Signaling by BMP. Gene Ontology (GO) annotations related to this gene include hydrolase activity and phosphoprotein phosphatase activity. An important paralog of this gene is PPP1CC.

UniProtKB/Swiss-Prot Summary for PPP1CA Gene

  • Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase 1 (PP1) is essential for cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Involved in regulation of ionic conductances and long-term synaptic plasticity. May play an important role in dephosphorylating substrates such as the postsynaptic density-associated Ca(2+)/calmodulin dependent protein kinase II. Component of the PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase. Regulates NEK2 function in terms of kinase activity and centrosome number and splitting, both in the presence and absence of radiation-induced DNA damage. Regulator of neural tube and optic fissure closure, and enteric neural crest cell (ENCCs) migration during development. In balance with CSNK1D and CSNK1E, determines the circadian period length, through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation. May dephosphorylate CSNK1D and CSNK1E. Dephosphorylates the 'Ser-418' residue of FOXP3 in regulatory T-cells (Treg) from patients with rheumatoid arthritis, thereby inactivating FOXP3 and rendering Treg cells functionally defective (PubMed:23396208). Dephosphorylates CENPA (PubMed:25556658). Dephosphorylates the 'Ser-139' residue of ATG16L1 causing dissociation of ATG12-ATG5-ATG16L1 complex, thereby inhibiting autophagy (PubMed:26083323).
  • (Microbial infection) Necessary for alphaviruses replication.

Tocris Summary for PPP1CA Gene

  • Protein Ser/Thr phosphatases are a group of enzymes that catalyze the removal of phosphate groups from serine and/or threonine residues by hydrolysis of phosphoric acid monoesters. They oppose the action of kinases and phosphorylases and are involved in signal transduction.

Gene Wiki entry for PPP1CA Gene

Additional gene information for PPP1CA Gene

No data available for CIViC Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for PPP1CA Gene

Genomics for PPP1CA Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for PPP1CA Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PPP1CA on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for PPP1CA

Top Transcription factor binding sites by QIAGEN in the PPP1CA gene promoter:
  • AhR
  • ARP-1
  • HEN1
  • Lmo2
  • p53
  • Sp1

Genomic Locations for PPP1CA Gene

Genomic Locations for PPP1CA Gene
chr11:67,398,183-67,421,183
(GRCh38/hg38)
Size:
23,001 bases
Orientation:
Minus strand
chr11:67,165,652-67,188,654
(GRCh37/hg19)
Size:
23,003 bases
Orientation:
Minus strand

Genomic View for PPP1CA Gene

Genes around PPP1CA on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PPP1CA Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PPP1CA Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PPP1CA Gene

Proteins for PPP1CA Gene

  • Protein details for PPP1CA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P62136-PP1A_HUMAN
    Recommended name:
    Serine/threonine-protein phosphatase PP1-alpha catalytic subunit
    Protein Accession:
    P62136
    Secondary Accessions:
    • A6NNR3
    • B2R908
    • P08129
    • P20653
    • P22802
    • Q07161

    Protein attributes for PPP1CA Gene

    Size:
    330 amino acids
    Molecular mass:
    37512 Da
    Cofactor:
    Name=Fe cation; Xref=ChEBI:CHEBI:24875;
    Cofactor:
    Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
    Quaternary structure:
    • PP1 comprises a catalytic subunit, PPP1CA, PPP1CB or PPP1CC, which is folded into its native form by inhibitor 2 and glycogen synthetase kinase 3, and then complexed to one or several targeting or regulatory subunits. PPP1R12A, PPP1R12B and PPP1R12C mediate binding to myosin. PPP1R3A (in skeletal muscle), PPP1R3B (in liver), PPP1R3C, PPP1R3D and PPP1R3F (in brain) mediate binding to glycogen. Interacts with PPP1R39 (By similarity). Interacts with BTBD10 (By similarity). Interacts with KCTD20 (By similarity). Interacts with PPP1R9A and PPP1R9B. Part of a complex containing PPP1R15B, PP1 and NCK1/2. Interacts with PHACTR4; which acts as an activator of PP1 activity (By similarity). Interacts with PPP1R15A and PPP1R15B; the interactions mediate binding to EIF2S1. Interacts with PPP1R7. Interacts with YLPM1. Forms a complex with ILF2, ILF3, YLPM1, KHDRBS1, RBMX and NCOA5. Interacts with NOM1 and PPP1R8. Interacts with PPP1R16B. Interacts with RPSA only in the presence of PPP1R16B. Component of the PTW/PP1 phosphatase complex, composed of PPP1R10/PNUTS, TOX4, WDR82, and PPP1CA or PPP1CB or PPP1CC. Interacts with PPP1R10/PNUTS and PPP1R8. Interacts with WDR82 in the presence of PPP1R10/PNUTS. Interacts with TRIM28; the interaction dephosphorylates TRIM28 on 'Ser-824' and forms a complex at the p21 promoter site. Interacts with isoform 1 and isoform 4 of NEK2. Interacts with FER; this promotes phosphorylation at Thr-320. Interacts with DAB2; the interaction is mutually exclusive with the AXIN1:PPP1CA interaction. Interacts with FOXP3 (PubMed:23396208). Interacts with CENPA (PubMed:25556658). Interacts with ATG16L1 (PubMed:26083323). Found in a complex with PPP1CA, PPP1CC, SHC1 and PEAK1 (PubMed:23846654).
    • (Microbial infection) Interacts with HHV-1 ICP34.5.
    • (Microbial infection) Interacts with Venezuelan equine encephalitis virus (VEEV) capsid protein; this interaction dephosphorylates the capsid protein, which increases its ability to bind to the viral genome.

    Three dimensional structures from OCA and Proteopedia for PPP1CA Gene

    Alternative splice isoforms for PPP1CA Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PPP1CA Gene

Selected DME Specific Peptides for PPP1CA Gene

P62136:
  • KIKYPENFF
  • PGKNVQL
  • RPTDVPD
  • VVEDGYEFF
  • CSFQILK
  • DLLWSDP
  • YGFYDEC
  • FSAPNYCGEFDN
  • IFCCHGGLSP
  • ETICLLLAYK
  • GRPITPPR
  • CKRRYNI
  • NFFLLRGNHE
  • DLICRAH
  • GWGENDRGVS
  • CGDIHGQ
  • DLLRLFEYGGFPP
  • GDYVDRG
  • GLLCDLLW
  • FTDCFNCLP
  • GEFDNAGAMM
  • LLELEAP

Post-translational modifications for PPP1CA Gene

  • Phosphorylated. Dephosphorylated at Thr-320 in the presence of ionizing radiation.
  • Ubiquitination at Lys6, Lys26, and Lys305
  • Modification sites at PhosphoSitePlus

Other Protein References for PPP1CA Gene

Antibody Products

  • Abcam antibodies for PPP1CA

Domains & Families for PPP1CA Gene

Gene Families for PPP1CA Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Plasma proteins
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for PPP1CA Gene

GenScript: Design optimal peptide antigens:
  • Serine/threonine-protein phosphatase (A6NNR3_HUMAN)
  • Protein phosphatase 1, catalytic subunit, alpha isoform (C0STL0_HUMAN)
  • Protein phosphatase 1, catalytic subunit, alpha (C4TNW5_HUMAN)
  • Protein phosphatase 1, catalytic subunit, alpha (C4TNW6_HUMAN)
  • Serine/threonine-protein phosphatase (E9PDP1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P62136

UniProtKB/Swiss-Prot:

PP1A_HUMAN :
  • Belongs to the PPP phosphatase family. PP-1 subfamily.
Family:
  • Belongs to the PPP phosphatase family. PP-1 subfamily.
genes like me logo Genes that share domains with PPP1CA: view

Function for PPP1CA Gene

Molecular function for PPP1CA Gene

UniProtKB/Swiss-Prot Function:
Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase 1 (PP1) is essential for cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Involved in regulation of ionic conductances and long-term synaptic plasticity. May play an important role in dephosphorylating substrates such as the postsynaptic density-associated Ca(2+)/calmodulin dependent protein kinase II. Component of the PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase. Regulates NEK2 function in terms of kinase activity and centrosome number and splitting, both in the presence and absence of radiation-induced DNA damage. Regulator of neural tube and optic fissure closure, and enteric neural crest cell (ENCCs) migration during development. In balance with CSNK1D and CSNK1E, determines the circadian period length, through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation. May dephosphorylate CSNK1D and CSNK1E. Dephosphorylates the 'Ser-418' residue of FOXP3 in regulatory T-cells (Treg) from patients with rheumatoid arthritis, thereby inactivating FOXP3 and rendering Treg cells functionally defective (PubMed:23396208). Dephosphorylates CENPA (PubMed:25556658). Dephosphorylates the 'Ser-139' residue of ATG16L1 causing dissociation of ATG12-ATG5-ATG16L1 complex, thereby inhibiting autophagy (PubMed:26083323).
UniProtKB/Swiss-Prot Function:
(Microbial infection) Necessary for alphaviruses replication.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=H2O + O-phospho-L-seryl-[protein] = L-seryl-[protein] + phosphate; Xref=Rhea:RHEA:20629, Rhea:RHEA-COMP:9863, Rhea:RHEA-COMP:11604, ChEBI:CHEBI:15377, ChEBI:CHEBI:29999, ChEBI:CHEBI:43474, ChEBI:CHEBI:83421; EC=3.1.3.16; Evidence={ECO:0000269|PubMed:26083323};.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate; Xref=Rhea:RHEA:47004, Rhea:RHEA-COMP:11060, Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15377, ChEBI:CHEBI:30013, ChEBI:CHEBI:43474, ChEBI:CHEBI:61977; EC=3.1.3.16; Evidence={ECO:0000269|PubMed:26083323};.
UniProtKB/Swiss-Prot Induction:
Up-regulated in synovial fluid mononuclear cells and peripheral blood mononuclear cells from patients with rheumatoid arthritis.
UniProtKB/Swiss-Prot EnzymeRegulation:
The phosphatase activity of the PPP1R15A-PP1 complex toward EIF2S1 is specifically inhibited by Salubrinal, a drug that protects cells from endoplasmic reticulum stress.
GENATLAS Biochemistry:
serine/threonine protein phosphatase 1,catalytic subunit,alpha,involved in mitotic exit

Enzyme Numbers (IUBMB) for PPP1CA Gene

Phenotypes From GWAS Catalog for PPP1CA Gene

Gene Ontology (GO) - Molecular Function for PPP1CA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004721 phosphoprotein phosphatase activity IEA,ISS --
GO:0004722 protein serine/threonine phosphatase activity IEA,TAS 10640627
GO:0005515 protein binding IPI 10807923
GO:0008157 protein phosphatase 1 binding IEA --
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with PPP1CA: view
genes like me logo Genes that share phenotypes with PPP1CA: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PPP1CA

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PPP1CA Gene

Localization for PPP1CA Gene

Subcellular locations from UniProtKB/Swiss-Prot for PPP1CA Gene

Cytoplasm. Nucleus. Nucleus, nucleoplasm. Nucleus, nucleolus. Note=Primarily nuclear and largely excluded from the nucleolus. Highly mobile in cells and can be relocalized through interaction with targeting subunits. NOM1 plays a role in targeting this protein to the nucleolus. In the presence of PPP1R8 relocalizes from the nucleus to nuclear speckles. Shuttles toward the cytosol during infection with VEEV (PubMed:29769351). {ECO:0000269 PubMed:29769351}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PPP1CA gene
Compartment Confidence
plasma membrane 5
nucleus 5
cytosol 5
extracellular 4
cytoskeleton 2
mitochondrion 2
endoplasmic reticulum 2
endosome 2
golgi apparatus 2
peroxisome 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Nucleoplasm (3)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for PPP1CA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000164 protein phosphatase type 1 complex IEA --
GO:0000784 colocalizes_with nuclear chromosome, telomeric region IDA 24270157
GO:0005634 nucleus IBA,IDA 11739654
GO:0005654 nucleoplasm IEA,IDA --
GO:0005730 nucleolus IEA --
genes like me logo Genes that share ontologies with PPP1CA: view

Pathways & Interactions for PPP1CA Gene

genes like me logo Genes that share pathways with PPP1CA: view

Pathways by source for PPP1CA Gene

7 GeneGo (Thomson Reuters) pathways for PPP1CA Gene
  • Apoptosis and survival BAD phosphorylation
  • Neurophysiological process Glutamate regulation of Dopamine D1A receptor signaling
  • Regulation of lipid metabolism Insulin signaling-generic cascades
  • Signal transduction Calcium signaling
  • Transcription CREB pathway
1 Tocris pathway for PPP1CA Gene
1 Cell Signaling Technology pathway for PPP1CA Gene

SIGNOR curated interactions for PPP1CA Gene

Activates:
Inactivates:
Is activated by:
Is inactivated by:
Other effect:

Gene Ontology (GO) - Biological Process for PPP1CA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005975 carbohydrate metabolic process IEA --
GO:0005977 glycogen metabolic process IEA --
GO:0005979 regulation of glycogen biosynthetic process IEA --
GO:0005981 regulation of glycogen catabolic process IEA --
GO:0006470 protein dephosphorylation IEA,ISS --
genes like me logo Genes that share ontologies with PPP1CA: view

Drugs & Compounds for PPP1CA Gene

(12) Drugs for PPP1CA Gene - From: DrugBank, ApexBio, DGIdb, HMDB, and Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Cantharidin Approved, Investigational Pharma Inhibitor of protein phosphatases 1/2A 16
Iron Approved, Experimental Pharma 1560
Phosphoric acid Approved Pharma 0
Water Approved Pharma 0
Manganese Approved Nutra 56

(3) Additional Compounds for PPP1CA Gene - From: HMDB and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Glycogen
  • Animal starch
  • Liver starch
  • Lyoglycogen
  • Phytoglycogen
9005-79-2
Phosphate
  • [po(OH)3]
  • Acide phosphorique
  • Acidum phosphoricum
  • H3PO4
  • Orthophosphoric acid
14066-19-4, 14265-44-2
FK 506
104987-11-3

(4) Tocris Compounds for PPP1CA Gene

Compound Action Cas Number
Calcineurin Autoinhibitory Peptide Selective calcineurin inhibitor 148067-21-4
Cyclosporin A Calcineurin inhibitor 59865-13-3
FK 506 Potent calcineurin inhibitor; immunosuppressant 104987-11-3
INCA-6 Inhibitor of calcineurin-substrate association 3519-82-2

(2) ApexBio Compounds for PPP1CA Gene

Compound Action Cas Number
Cantharidin Inhibitor of protein phosphatases 1/2A 56-25-7
Sal 003 Cellular phosphatase complex inhibitor 1164470-53-4
genes like me logo Genes that share compounds with PPP1CA: view

Drug Products

Transcripts for PPP1CA Gene

mRNA/cDNA for PPP1CA Gene

3 REFSEQ mRNAs :
18 NCBI additional mRNA sequence :
11 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PPP1CA

Alternative Splicing Database (ASD) splice patterns (SP) for PPP1CA Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b · 3c ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b · 7c · 7d · 7e ^ 8a · 8b · 8c · 8d ^ 9a · 9b
SP1: - - -
SP2: - - -
SP3: - - - - -
SP4: - -
SP5: - - - -
SP6: - -
SP7: -
SP8:
SP9: - - - -
SP10:

Relevant External Links for PPP1CA Gene

GeneLoc Exon Structure for
PPP1CA

Expression for PPP1CA Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for PPP1CA Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PPP1CA Gene

This gene is overexpressed in Whole Blood (x5.1).

Protein differential expression in normal tissues from HIPED for PPP1CA Gene

This gene is overexpressed in Lymph node (8.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for PPP1CA Gene



Protein tissue co-expression partners for PPP1CA Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for PPP1CA

SOURCE GeneReport for Unigene cluster for PPP1CA Gene:

Hs.183994

Evidence on tissue expression from TISSUES for PPP1CA Gene

  • Lung(4.8)
  • Muscle(4.7)
  • Blood(4.7)
  • Pancreas(4.7)
  • Liver(4.6)
  • Nervous system(4.6)
  • Skin(4.1)
  • Intestine(3.9)
  • Kidney(3.6)
  • Eye(3.3)
  • Heart(3)
  • Stomach(2.8)
  • Lymph node(2.8)
  • Spleen(2.6)
  • Bone marrow(2.5)
  • Thyroid gland(2.4)
  • Adrenal gland(2.3)
genes like me logo Genes that share expression patterns with PPP1CA: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PPP1CA Gene

Orthologs for PPP1CA Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PPP1CA Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia PPP1CA 30 31
  • 99.7 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia PPP1CA 30 31
  • 93.03 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia PPP1CA 30
  • 92.93 (n)
Rat
(Rattus norvegicus)
Mammalia Ppp1ca 30
  • 90.3 (n)
Mouse
(Mus musculus)
Mammalia Ppp1ca 30 17 31
  • 90.1 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia PPP1CA 31
  • 85 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia PPP1CA 31
  • 82 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia PPP1CA 31
  • 99 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia ppp1ca-prov 30
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia Str.6652 30
Zebrafish
(Danio rerio)
Actinopterygii ppp1cab 31
  • 89 (a)
ManyToMany
ppp1caa 30 31
  • 78.25 (n)
ManyToMany
Rainbow Trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9837 30
Fruit Fly
(Drosophila melanogaster)
Insecta Pp1-87B 31 32
  • 93 (a)
ManyToMany
Pp1-13C 31 32
  • 91 (a)
ManyToMany
Pp1alpha-96A 31 32
  • 88 (a)
ManyToMany
flw 32
  • 84 (a)
Pp1-Y2 32
  • 74 (a)
PpD5 32
  • 64 (a)
PpY-55A 32
  • 64 (a)
PpN58A 32
  • 63 (a)
PpD6 32
  • 60 (a)
Pp1rY1 32
  • 59 (a)
Worm
(Caenorhabditis elegans)
Secernentea gsp-2 30
  • 74.67 (n)
C25A6.1 32
  • 55 (a)
F25B3.4 32
  • 55 (a)
F52H3.6 32
  • 54 (a)
W09C3.6 32
  • 54 (a)
F23B12.1 32
  • 53 (a)
T03F1.5 32
  • 53 (a)
ZK354.9 32
  • 53 (a)
C34D4.2 32
  • 52 (a)
C47A4.3 32
  • 52 (a)
C09H5.7 32
  • 48 (a)
C24H11.1 32
  • 48 (a)
C24H11.2 32
  • 48 (a)
C06A1.3 32
  • 47 (a)
W03D8.2 32
  • 47 (a)
Y71G12B.30 31
  • 46 (a)
ManyToMany
C23G10.1a 32
  • 46 (a)
C23G10.1b 32
  • 46 (a)
F58G1.3 32
  • 43 (a)
R13A5.11 32
  • 42 (a)
C27B7.6 32
  • 41 (a)
T25B9.2 32
  • 41 (a)
Y69E1A.4 32
  • 41 (a)
F22D6.9 32
  • 40 (a)
F49E11.7 32
  • 38 (a)
R08A2.2 32
  • 38 (a)
Y40H4A.2 32
  • 38 (a)
F42G8.8 32
  • 36 (a)
ZC477.2 32
  • 33 (a)
C30A5.4 32
  • 32 (a)
A. gosspyii yeast
(Eremothecium gossypii)
Saccharomycetes AGOS_AFR166C 30
  • 75.27 (n)
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes GLC7 30 31
  • 65.89 (n)
OneToMany
PPQ1 33
K. Lactis Yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F12496g 30
  • 65.77 (n)
Thale Cress
(Arabidopsis thaliana)
eudicotyledons TOPP2 30
  • 68.37 (n)
Rice
(Oryza sativa)
Liliopsida Os02g0820000 30
  • 69.82 (n)
Os.6359 30
Barley
(Hordeum vulgare)
Liliopsida Hv.1740 30
Wheat
(Triticum aestivum)
Liliopsida Ta.14255 30
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.7187 31
  • 92 (a)
OneToMany
Bread mold
(Neurospora crassa)
Ascomycetes NCU00043 30
  • 75.03 (n)
Fission Yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes dis2 30
  • 68.35 (n)
Sea Vase
(Ciona intestinalis)
Ascidiacea Cin.11530 30
Species where no ortholog for PPP1CA was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Beta proteobacteria (Neisseria meningitidis)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for PPP1CA Gene

ENSEMBL:
Gene Tree for PPP1CA (if available)
TreeFam:
Gene Tree for PPP1CA (if available)
Aminode:
Evolutionary constrained regions (ECRs) for PPP1CA: view image

Paralogs for PPP1CA Gene

(10) SIMAP similar genes for PPP1CA Gene using alignment to 7 proteins:

  • PP1A_HUMAN
  • C0STL0_HUMAN
  • C4TNW5_HUMAN
  • C4TNW6_HUMAN
  • E9PMD7_HUMAN
  • F5H037_HUMAN
  • F5H1L6_HUMAN

Pseudogenes.org Pseudogenes for PPP1CA Gene

genes like me logo Genes that share paralogs with PPP1CA: view

Variants for PPP1CA Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for PPP1CA Gene

SNP ID Clinical significance and condition Chr 11 pos Variation AA Info Type
rs367543169 Not Provided: not provided 67,399,598(-) C/T SYNONYMOUS_VARIANT
rs367543170 Not Provided: not provided 67,400,699(-) G/A SYNONYMOUS_VARIANT
rs367543171 Not Provided: not provided 67,400,821(-) T/G SYNONYMOUS_VARIANT

Additional dbSNP identifiers (rs#s) for PPP1CA Gene

Structural Variations from Database of Genomic Variants (DGV) for PPP1CA Gene

Variant ID Type Subtype PubMed ID
dgv1977n54 CNV loss 21841781
dgv52n111 CNV deletion 26073780
nsv516453 CNV loss 19592680

Variation tolerance for PPP1CA Gene

Residual Variation Intolerance Score: 13.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.15; 3.45% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PPP1CA Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PPP1CA

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PPP1CA Gene

Disorders for PPP1CA Gene

MalaCards: The human disease database

(7) MalaCards diseases for PPP1CA Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
venezuelan equine encephalitis
  • venezuelan equine fever
encephalitis
coronavirus infectious disease
  • coronavirus infection
noonan syndrome 7
  • ns7
noonan syndrome 6
  • ns6
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for PPP1CA

genes like me logo Genes that share disorders with PPP1CA: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PPP1CA Gene

Publications for PPP1CA Gene

  1. ATG16L1 phosphorylation is oppositely regulated by CSNK2/casein kinase 2 and PPP1/protein phosphatase 1 which determines the fate of cardiomyocytes during hypoxia/reoxygenation. (PMID: 26083323) Song H … Zhang Z (Autophagy 2015) 3 4
  2. Phosphorylation of FOXP3 controls regulatory T cell function and is inhibited by TNF-α in rheumatoid arthritis. (PMID: 23396208) Nie H … Zhang JZ (Nature medicine 2013) 3 4
  3. Protein phosphatase 1 (PP1) is a post-translational regulator of the mammalian circadian clock. (PMID: 21712997) Schmutz I … Albrecht U (PloS one 2011) 3 4
  4. Identification and characterization of a novel human PP1 phosphatase complex. (PMID: 20516061) Lee JH … Skalnik DG (The Journal of biological chemistry 2010) 3 4
  5. SUMOylation of the transcriptional co-repressor KAP1 is regulated by the serine and threonine phosphatase PP1. (PMID: 20424263) Li X … Ann DK (Science signaling 2010) 3 4

Products for PPP1CA Gene

  • Signalway ELISA kits for PPP1CA
  • Signalway Proteins for PPP1CA

Sources for PPP1CA Gene