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Aliases for PPM1N Gene

Aliases for PPM1N Gene

  • Protein Phosphatase, Mg2+/Mn2+ Dependent 1N (Putative) 2 3 5
  • Protein Phosphatase, Mg2+/Mn2+ Dependent, 1N (Putative) 2
  • EC 3.1.3.16 4

External Ids for PPM1N Gene

Previous GeneCards Identifiers for PPM1N Gene

  • GC19P045992
  • GC19P042431

Summaries for PPM1N Gene

GeneCards Summary for PPM1N Gene

PPM1N (Protein Phosphatase, Mg2+/Mn2+ Dependent 1N (Putative)) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include magnesium ion binding and manganese ion binding. An important paralog of this gene is PPM1A.

Additional gene information for PPM1N Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PPM1N Gene

Genomics for PPM1N Gene

GeneHancer (GH) Regulatory Elements for PPM1N Gene

Promoters and enhancers for PPM1N Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19I045498 Promoter/Enhancer 1.3 EPDnew ENCODE 557 +10.5 10491 1.6 HDGF SIN3A ZNF48 KLF7 BCLAF1 SP3 SP5 USF2 SP1 SMARCA4 PPM1N ENSG00000268810 SYMPK IRF2BP1 ZNF180 ENSG00000267114 QPCTL GC19P045503 RTN2
GH19I045505 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 27.9 +19.1 19069 5.6 HDGF PKNOX1 SMAD1 FOXA2 ARNT ARID4B SIN3A FEZF1 YBX1 ZBTB7B VASP CCDC61 CLASRP PPM1N ENSG00000269148 FBXO46 ENSG00000268810 SYMPK BLOC1S3 ZNF296
GH19I045492 Promoter/Enhancer 2.2 EPDnew FANTOM5 Ensembl ENCODE 29.6 +4.4 4415 2.1 HDGF PKNOX1 ATF1 FOXA2 ARID4B ZNF121 POLR2B ZNF766 GLIS2 ZNF143 RTN2 PPM1N CLASRP CCDC61 ZNF180 NKPD1 NANOS2 EXOC3L2
GH19I045496 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 29.4 +8.3 8260 1.3 HDGF ATF1 ZFP64 ARID4B SIN3A ZBTB7B ZNF48 SLC30A9 POLR2B GLIS2 RTN2 PPM1N
GH19I045512 Enhancer 1.5 FANTOM5 ENCODE dbSUPER 21.6 +26.0 26019 3.9 HDGF MLX ARID4B DMAP1 ZNF48 ZNF121 CBX5 ZNF143 ATF7 RUNX3 PPM1N VASP CLASRP MARK4 FOSB BLOC1S3 GIPR GC19P045560
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around PPM1N on UCSC Golden Path with GeneCards custom track

Genomic Locations for PPM1N Gene

Genomic Locations for PPM1N Gene
chr19:45,488,777-45,502,510
(GRCh38/hg38)
Size:
13,734 bases
Orientation:
Plus strand
chr19:45,992,035-46,005,768
(GRCh37/hg19)

Genomic View for PPM1N Gene

Genes around PPM1N on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PPM1N Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PPM1N Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PPM1N Gene

Proteins for PPM1N Gene

  • Protein details for PPM1N Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N819-PPM1N_HUMAN
    Recommended name:
    Probable protein phosphatase 1N
    Protein Accession:
    Q8N819
    Secondary Accessions:
    • Q6P662

    Protein attributes for PPM1N Gene

    Size:
    430 amino acids
    Molecular mass:
    46170 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for PPM1N Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PPM1N Gene

Post-translational modifications for PPM1N Gene

No Post-translational modifications

No data available for DME Specific Peptides for PPM1N Gene

Domains & Families for PPM1N Gene

Gene Families for PPM1N Gene

HGNC:
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for PPM1N Gene

Suggested Antigen Peptide Sequences for PPM1N Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8N819

UniProtKB/Swiss-Prot:

PPM1N_HUMAN :
  • Belongs to the PP2C family.
Family:
  • Belongs to the PP2C family.
genes like me logo Genes that share domains with PPM1N: view

Function for PPM1N Gene

Molecular function for PPM1N Gene

UniProtKB/Swiss-Prot CatalyticActivity:
[a protein]-serine/threonine phosphate + H(2)O = [a protein]-serine/threonine + phosphate.

Enzyme Numbers (IUBMB) for PPM1N Gene

Phenotypes From GWAS Catalog for PPM1N Gene

Gene Ontology (GO) - Molecular Function for PPM1N Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000287 magnesium ion binding IEA --
GO:0003824 catalytic activity IEA --
GO:0004721 phosphoprotein phosphatase activity IEA --
GO:0004722 protein serine/threonine phosphatase activity IEA --
GO:0016787 hydrolase activity IEA --
genes like me logo Genes that share ontologies with PPM1N: view
genes like me logo Genes that share phenotypes with PPM1N: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PPM1N Gene

Localization for PPM1N Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PPM1N gene
Compartment Confidence
mitochondrion 2
nucleus 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for PPM1N Gene

Pathways & Interactions for PPM1N Gene

SuperPathways for PPM1N Gene

No Data Available

Gene Ontology (GO) - Biological Process for PPM1N Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006470 protein dephosphorylation IEA --
genes like me logo Genes that share ontologies with PPM1N: view

No data available for Pathways by source and SIGNOR curated interactions for PPM1N Gene

Drugs & Compounds for PPM1N Gene

(2) Drugs for PPM1N Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phosphoric acid Approved Pharma 0
Water Approved Pharma 0
genes like me logo Genes that share compounds with PPM1N: view

Transcripts for PPM1N Gene

Unigene Clusters for PPM1N Gene

Protein phosphatase, Mg2+/Mn2+ dependent, 1N (putative):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for PPM1N Gene

No ASD Table

Relevant External Links for PPM1N Gene

GeneLoc Exon Structure for
PPM1N
ECgene alternative splicing isoforms for
PPM1N

Expression for PPM1N Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PPM1N Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PPM1N Gene

This gene is overexpressed in Whole Blood (x6.1) and Spleen (x5.1).

Protein differential expression in normal tissues from HIPED for PPM1N Gene

This gene is overexpressed in Fetal heart (50.4) and Retina (18.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for PPM1N Gene



Protein tissue co-expression partners for PPM1N Gene

NURSA nuclear receptor signaling pathways regulating expression of PPM1N Gene:

PPM1N

SOURCE GeneReport for Unigene cluster for PPM1N Gene:

Hs.532872

Evidence on tissue expression from TISSUES for PPM1N Gene

  • Nervous system(4.1)
genes like me logo Genes that share expression patterns with PPM1N: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PPM1N Gene

Orthologs for PPM1N Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for PPM1N Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia PPM1N 33 34
  • 85.4 (n)
cow
(Bos Taurus)
Mammalia MGC148938 34
  • 81 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ppm1n 33 16 34
  • 76.95 (n)
rat
(Rattus norvegicus)
Mammalia Ppm1n 33
  • 76.37 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 14 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia PPM1N 34
  • 45 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii ppm1nb 34
  • 40 (a)
OneToMany
ppm1na 34
  • 36 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta alph 34
  • 38 (a)
ManyToMany
CG6036 34
  • 35 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea ppm-1 34
  • 26 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PTC2 34
  • 23 (a)
ManyToMany
PTC3 34
  • 22 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 35 (a)
OneToMany
Species where no ortholog for PPM1N was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for PPM1N Gene

ENSEMBL:
Gene Tree for PPM1N (if available)
TreeFam:
Gene Tree for PPM1N (if available)

Paralogs for PPM1N Gene

Paralogs for PPM1N Gene

(3) SIMAP similar genes for PPM1N Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with PPM1N: view

Variants for PPM1N Gene

Sequence variations from dbSNP and Humsavar for PPM1N Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000057452 -- 45,501,428(+) A/G genic_downstream_transcript_variant, intron_variant
rs1000306761 -- 45,501,879(+) A/C genic_downstream_transcript_variant, intron_variant
rs1000534620 -- 45,501,710(+) G/A genic_downstream_transcript_variant, intron_variant
rs1001466568 -- 45,502,989(+) A/T downstream_transcript_variant
rs1001731680 -- 45,501,805(+) G/A genic_downstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for PPM1N Gene

Variant ID Type Subtype PubMed ID
nsv833848 CNV loss 17160897

Variation tolerance for PPM1N Gene

Gene Damage Index Score: 1.66; 31.80% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PPM1N Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
PPM1N

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PPM1N Gene

Disorders for PPM1N Gene

Additional Disease Information for PPM1N

No disorders were found for PPM1N Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PPM1N Gene

Publications for PPM1N Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  2. Genome-scale RNAi screen for host factors required for HIV replication. (PMID: 18976975) Zhou H … Espeseth AS (Cell host & microbe 2008) 3 58
  3. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J … Lucas SM (Nature 2004) 4 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 58
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 58

Products for PPM1N Gene

Sources for PPM1N Gene

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