Aliases for PPM1L Gene
External Ids for PPM1L Gene
Previous GeneCards Identifiers for PPM1L Gene
The protein encoded by this gene is a magnesium or manganese-requiring phosphatase that is involved in several signaling pathways. The encoded protein downregulates apoptosis signal-regulating kinase 1, a protein that initiates a signaling cascade that leads to apoptosis when cells are subjected to cytotoxic stresses. This protein also is an endoplasmic reticulum transmembrane protein that helps regulate ceramide transport from the endoplasmic reticulum to the Golgi apparatus. Finally, this gene may be involved in adiposity since it is upregulated in adipose tissues. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2015]
GeneCards Summary for PPM1L Gene
PPM1L (Protein Phosphatase, Mg2+/Mn2+ Dependent 1L) is a Protein Coding gene. Diseases associated with PPM1L include Inflammatory Bowel Disease 7 and Inflammatory Bowel Disease 4. Among its related pathways are Sphingolipid metabolism and AMPK Enzyme Complex Pathway. Gene Ontology (GO) annotations related to this gene include protein serine/threonine phosphatase activity. An important paralog of this gene is PPM1K.
UniProtKB/Swiss-Prot Summary for PPM1L Gene
Acts as a suppressor of the SAPK signaling pathways by associating with and dephosphorylating MAP3K7/TAK1 and MAP3K5, and by attenuating the association between MAP3K7/TAK1 and MAP2K4 or MAP2K6.