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This gene encodes the serine/threonine protein phosphatase. The mouse homolog of this gene apparently belongs to the protein phosphatase 2C family of genes. The exact function of this gene is not yet known. [provided by RefSeq, Jul 2008]
PPM1J (Protein Phosphatase, Mg2+/Mn2+ Dependent 1J) is a Protein Coding gene. Among its related pathways are Direct p53 effectors and Wnt Signaling Pathway and Pluripotency. Gene Ontology (GO) annotations related to this gene include protein serine/threonine phosphatase activity. An important paralog of this gene is PPM1H.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0003824 | catalytic activity | IEA | -- |
GO:0004721 | phosphoprotein phosphatase activity | IEA | -- |
GO:0004722 | protein serine/threonine phosphatase activity | IEA,IBA | 21873635 |
GO:0004724 | magnesium-dependent protein serine/threonine phosphatase activity | IBA | 21873635 |
GO:0004741 | [pyruvate dehydrogenase (lipoamide)] phosphatase activity | IBA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005739 | mitochondrion | IBA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Direct p53 effectors | ||
2 | Wnt Signaling Pathway and Pluripotency |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006470 | protein dephosphorylation | IEA | -- |
GO:1904184 | positive regulation of pyruvate dehydrogenase activity | IBA | -- |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
---|---|---|---|---|---|---|
Phosphate |
|
14066-19-4, 14265-44-2 |
|
ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | ^ | 7 | ^ | 8a | · | 8b | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12a | · | 12b | · | 12c |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | |||||||||||||||||||||||||||||||
SP2: | - | - | |||||||||||||||||||||||||||||||
SP3: | |||||||||||||||||||||||||||||||||
SP4: |
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | PPM1J 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | PPM1J 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | PPM1J 30 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Ppm1j 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Ppm1j 30 17 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | PPM1J 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | PPM1J 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | PPM1J 31 |
|
OneToOne | |
Zebrafish (Danio rerio) |
Actinopterygii | ppm1j 31 |
|
OneToOne | |
Fruit Fly (Drosophila melanogaster) |
Insecta | CG17598 31 |
|
OneToMany | |
Worm (Caenorhabditis elegans) |
Secernentea | C42C1.2 31 |
|
OneToMany |
SNP ID | Clinical significance and condition | Chr 01 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs10857971 | - | p.Val236Ile | |||
rs34611728 | - | p.Leu213Phe |
No disorders were found for PPM1J Gene.