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Aliases for PPM1F Gene

Aliases for PPM1F Gene

  • Protein Phosphatase, Mg2+/Mn2+ Dependent 1F 2 3 5
  • Ca(2+)/Calmodulin-Dependent Protein Kinase Phosphatase 2 3 4
  • Partner Of PIX 2 2 3 4
  • Protein Phosphatase 1F (PP2C Domain Containing) 2 3
  • CaM-Kinase Phosphatase 3 4
  • Protein Fem-2 Homolog 3 4
  • CaMKPase 3 4
  • POPX2 3 4
  • Protein Phosphatase, Mg2+/Mn2+ Dependent, 1F 2
  • Protein Phosphatase 1F 3
  • PP2C Phosphatase 3
  • EC 4
  • KIAA0015 4
  • HFEM-2 3
  • HFem-2 4
  • CAMKP 3
  • FEM-2 3

External Ids for PPM1F Gene

Previous GeneCards Identifiers for PPM1F Gene

  • GC22M018973
  • GC22M020598
  • GC22M022273
  • GC22M005230

Summaries for PPM1F Gene

Entrez Gene Summary for PPM1F Gene

  • The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase can interact with Rho guanine nucleotide exchange factors (PIX), and thus block the effects of p21-activated kinase 1 (PAK), a protein kinase mediating biological effects downstream of Rho GTPases. Calcium/calmodulin-dependent protein kinase II gamma (CAMK2G/CAMK-II) is found to be one of the substrates of this phosphatase. The overexpression of this phosphatase or CAMK2G has been shown to mediate caspase-dependent apoptosis. An alternatively spliced transcript variant has been identified, but its full-length nature has not been determined. [provided by RefSeq, Jul 2008]

GeneCards Summary for PPM1F Gene

PPM1F (Protein Phosphatase, Mg2+/Mn2+ Dependent 1F) is a Protein Coding gene. Among its related pathways are Development Dopamine D2 receptor transactivation of EGFR and Regulation of CFTR activity (norm and CF). Gene Ontology (GO) annotations related to this gene include phosphatase activity and calmodulin-dependent protein phosphatase activity. An important paralog of this gene is PPM1E.

UniProtKB/Swiss-Prot for PPM1F Gene

  • Dephosphorylates and concomitantly deactivates CaM-kinase II activated upon autophosphorylation, and CaM-kinases IV and I activated upon phosphorylation by CaM-kinase kinase. Promotes apoptosis.

Gene Wiki entry for PPM1F Gene

Additional gene information for PPM1F Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PPM1F Gene

Genomics for PPM1F Gene

GeneHancer (GH) Regulatory Elements for PPM1F Gene

Promoters and enhancers for PPM1F Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH22J021936 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 669.6 +8.1 8131 17.5 HDGF PKNOX1 CLOCK SMAD1 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 PPM1F ENSG00000224086 TOP3BP1 TOP3B LZTR1 IGLV5-52 PPIL2 ENSG00000234630 ENSG00000272779 THAP7
GH22J021734 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 15.7 +217.3 217314 2.1 HDGF PKNOX1 SMAD1 ATF1 ARNT SIN3A YY1 POLR2B GATA2 E2F8 YPEL1 TOP3B IGLV5-52 LZTR1 PPIL2 ENSG00000234630 PPM1F ENSG00000225544 THAP7 CCDC116
GH22J021814 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 16 +135.6 135562 6.2 PKNOX1 PTBP1 BMI1 BATF SCRT2 ATF7 FOS ETV6 IKZF2 RUNX3 ENSG00000224086 IGLV5-52 LZTR1 ENSG00000272779 TOP3B PPIL2 THAP7-AS1 THAP7 PPM1F ENSG00000234630
GH22J021760 Enhancer 1.1 ENCODE dbSUPER 21.6 +188.6 188590 7.4 HDGF PKNOX1 BMI1 FEZF1 BATF IRF4 ZNF366 SCRT2 ATF7 FOS ENSG00000224086 PPM1F TOP3B TOP3BP1 RNA5SP493 YPEL1 MAPK1
GH22J021927 Enhancer 0.6 dbSUPER 29.8 +24.5 24535 1.1 SP1 POLR2A RXRA TSC22D4 ZNF24 HNF4A HMGN3 NR2F2 ENSG00000224086 PPM1F TOP3B YPEL1 GC22P022065
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around PPM1F on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the PPM1F gene promoter:
  • p53
  • Roaz
  • Elk-1
  • Pax-2

Genomic Locations for PPM1F Gene

Genomic Locations for PPM1F Gene
33,460 bases
Minus strand
33,459 bases
Minus strand

Genomic View for PPM1F Gene

Genes around PPM1F on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PPM1F Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PPM1F Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PPM1F Gene

Proteins for PPM1F Gene

  • Protein details for PPM1F Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein phosphatase 1F
    Protein Accession:
    Secondary Accessions:
    • A8K6G3
    • B7Z2C3
    • Q96PM2

    Protein attributes for PPM1F Gene

    454 amino acids
    Molecular mass:
    49831 Da
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
    Quaternary structure:
    • Associates with FEM1B.
    • Sequence=BAA02803.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for PPM1F Gene


neXtProt entry for PPM1F Gene

Post-translational modifications for PPM1F Gene

  • Ubiquitination at Lys334
  • Modification sites at PhosphoSitePlus

Other Protein References for PPM1F Gene

No data available for DME Specific Peptides for PPM1F Gene

Domains & Families for PPM1F Gene

Gene Families for PPM1F Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for PPM1F Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the PP2C family.
  • Belongs to the PP2C family.
genes like me logo Genes that share domains with PPM1F: view

Function for PPM1F Gene

Molecular function for PPM1F Gene

UniProtKB/Swiss-Prot Function:
Dephosphorylates and concomitantly deactivates CaM-kinase II activated upon autophosphorylation, and CaM-kinases IV and I activated upon phosphorylation by CaM-kinase kinase. Promotes apoptosis.
UniProtKB/Swiss-Prot CatalyticActivity:
[a protein]-serine/threonine phosphate + H(2)O = [a protein]-serine/threonine + phosphate.

Enzyme Numbers (IUBMB) for PPM1F Gene

Phenotypes From GWAS Catalog for PPM1F Gene

Gene Ontology (GO) - Molecular Function for PPM1F Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004721 phosphoprotein phosphatase activity IEA --
GO:0004722 protein serine/threonine phosphatase activity IMP,IEA 20016286
GO:0005515 protein binding IPI 11559703
GO:0016787 hydrolase activity IEA --
GO:0033192 calmodulin-dependent protein phosphatase activity IDA 11559703
genes like me logo Genes that share ontologies with PPM1F: view
genes like me logo Genes that share phenotypes with PPM1F: view

Animal Models for PPM1F Gene

MGI Knock Outs for PPM1F:

Animal Model Products

  • Taconic Biosciences Mouse Models for PPM1F

CRISPR Products

miRNA for PPM1F Gene

miRTarBase miRNAs that target PPM1F

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PPM1F

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PPM1F Gene

Localization for PPM1F Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PPM1F gene
Compartment Confidence
cytosol 5
nucleus 3
plasma membrane 2
cytoskeleton 1
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (2)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for PPM1F Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol IEA,IDA 11559703
GO:0032991 protein-containing complex IDA 11864573
GO:0048471 perinuclear region of cytoplasm IEA --
genes like me logo Genes that share ontologies with PPM1F: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for PPM1F Gene

Pathways & Interactions for PPM1F Gene

genes like me logo Genes that share pathways with PPM1F: view

Pathways by source for PPM1F Gene

SIGNOR curated interactions for PPM1F Gene


Gene Ontology (GO) - Biological Process for PPM1F Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006469 negative regulation of protein kinase activity IDA 11864573
GO:0006470 protein dephosphorylation IEA --
GO:0006915 apoptotic process IEA --
GO:0010628 positive regulation of gene expression IMP 20016286
GO:0010634 positive regulation of epithelial cell migration IMP 20016286
genes like me logo Genes that share ontologies with PPM1F: view

Drugs & Compounds for PPM1F Gene

(7) Drugs for PPM1F Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phosphoric acid Approved Pharma 0
Water Approved Pharma 0
calcium Approved Nutra 0
Magnesium Approved Nutra 0
Manganese Approved Nutra 37

(1) Additional Compounds for PPM1F Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • [po(OH)3]
  • Acide phosphorique
  • Acidum phosphoricum
  • H3PO4
  • Orthophosphoric acid
genes like me logo Genes that share compounds with PPM1F: view

Transcripts for PPM1F Gene

mRNA/cDNA for PPM1F Gene

Unigene Clusters for PPM1F Gene

Protein phosphatase, Mg2+/Mn2+ dependent, 1F:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for PPM1F

Alternative Splicing Database (ASD) splice patterns (SP) for PPM1F Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c · 5d ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b · 12c
SP1: - - - - - - - -
SP2: - - -
SP3: - - - - - -
SP4: - - - - -
SP5: - - - - - - -
SP6: -
SP7: - -
SP8: -

Relevant External Links for PPM1F Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PPM1F Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PPM1F Gene

mRNA differential expression in normal tissues according to GTEx for PPM1F Gene

This gene is overexpressed in Whole Blood (x6.7).

Protein differential expression in normal tissues from HIPED for PPM1F Gene

This gene is overexpressed in Peripheral blood mononuclear cells (10.3) and Lymph node (9.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for PPM1F Gene

Protein tissue co-expression partners for PPM1F Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of PPM1F Gene:


SOURCE GeneReport for Unigene cluster for PPM1F Gene:


Evidence on tissue expression from TISSUES for PPM1F Gene

  • Nervous system(4.8)
  • Bone marrow(4.2)
genes like me logo Genes that share expression patterns with PPM1F: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for PPM1F Gene

Orthologs for PPM1F Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PPM1F Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia PPM1F 34 33
  • 99.41 (n)
(Canis familiaris)
Mammalia PPM1F 34 33
  • 84.62 (n)
(Mus musculus)
Mammalia Ppm1f 16 34 33
  • 82.96 (n)
(Rattus norvegicus)
Mammalia Ppm1f 33
  • 82.52 (n)
(Bos Taurus)
Mammalia PPM1F 34 33
  • 80.54 (n)
(Monodelphis domestica)
Mammalia PPM1F 34
  • 58 (a)
(Gallus gallus)
Aves PPM1F 34 33
  • 63.1 (n)
(Anolis carolinensis)
Reptilia PPM1F 34
  • 50 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia ppm1f 33
  • 59.77 (n)
(Danio rerio)
Actinopterygii ppm1f 34 33
  • 55.94 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002147 33
  • 51.14 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG10376 34 33
  • 49.42 (n)
(Caenorhabditis elegans)
Secernentea fem-2 34
  • 22 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PTC1 34
  • 32 (a)
(Oryza sativa)
Liliopsida Os06g0526800 33
  • 48.79 (n)
Species where no ortholog for PPM1F was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PPM1F Gene

Gene Tree for PPM1F (if available)
Gene Tree for PPM1F (if available)
Evolutionary constrained regions (ECRs) for PPM1F: view image

Paralogs for PPM1F Gene

Paralogs for PPM1F Gene

(3) SIMAP similar genes for PPM1F Gene using alignment to 8 proteins:

  • A8MX49_HUMAN
  • B7Z2C3_HUMAN
  • C9J2F3_HUMAN
  • C9JL74_HUMAN
genes like me logo Genes that share paralogs with PPM1F: view

Variants for PPM1F Gene

Sequence variations from dbSNP and Humsavar for PPM1F Gene

SNP ID Clin Chr 22 pos Variation AA Info Type
VAR_036520 A colorectal cancer sample p.Arg296Gln
VAR_036521 A breast cancer sample p.Gln417Lys
rs1000031883 -- 21,934,353(-) A/G intron_variant
rs1000126366 -- 21,951,982(-) G/C intron_variant
rs1000198697 -- 21,920,589(-) G/C 3_prime_UTR_variant, genic_downstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for PPM1F Gene

Variant ID Type Subtype PubMed ID
dgv20e196 CNV duplication 17116639
dgv22e196 CNV deletion 17116639
dgv23e196 CNV deletion 17116639
dgv4492n100 CNV gain 25217958
dgv4493n100 CNV gain 25217958
dgv4494n100 CNV gain 25217958
dgv4495n100 CNV gain 25217958
dgv4496n100 CNV loss 25217958
dgv7997n54 CNV gain 21841781
esv2422338 CNV deletion 17116639
esv2422374 CNV duplication 17116639
esv2422476 CNV deletion 17116639
esv2758826 CNV gain+loss 17122850
esv2763701 CNV gain+loss 21179565
esv3647323 CNV loss 21293372
esv3893447 CNV gain 25118596
nsv1056286 CNV gain 25217958
nsv1058144 CNV gain 25217958
nsv1059265 CNV gain 25217958
nsv1062641 CNV gain 25217958
nsv3566 CNV insertion 18451855
nsv469782 CNV gain 16826518
nsv516394 CNV gain+loss 19592680
nsv7350 OTHER inversion 18451855
nsv828966 CNV loss 20364138
nsv834146 CNV gain 17160897

Variation tolerance for PPM1F Gene

Residual Variation Intolerance Score: 56.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.36; 76.88% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for PPM1F Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PPM1F Gene

Disorders for PPM1F Gene

Additional Disease Information for PPM1F

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for PPM1F Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PPM1F Gene

Publications for PPM1F Gene

  1. The p21-activated kinase PAK is negatively regulated by POPX1 and POPX2, a pair of serine/threonine phosphatases of the PP2C family. (PMID: 11864573) Koh CG … Lim L (Current biology : CB 2002) 2 3 4 22 58
  2. The Caenorhabditis elegans sex-determining protein FEM-2 and its human homologue, hFEM-2, are Ca2+/calmodulin-dependent protein kinase phosphatases that promote apoptosis. (PMID: 11559703) Tan KM … Yu VC (The Journal of biological chemistry 2001) 2 3 4 22 58
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  4. Functional interactions between phosphatase POPX2 and mDia modulate RhoA pathways. (PMID: 18230650) Xie Y … Koh CG (Journal of cell science 2008) 3 22 58
  5. Molecular genetics of adult ADHD: converging evidence from genome-wide association and extended pedigree linkage studies. (PMID: 18839057) Lesch KP … Jacob C (Journal of neural transmission (Vienna, Austria : 1996) 2008) 3 44 58

Products for PPM1F Gene

Sources for PPM1F Gene

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